Textbook of Medical Physiology
- 4th Edition - September 3, 2024
- Imprint: Elsevier India
- Authors: Indu Khurana, Arushi Khurana, Narayan Gurukripa Kowlgi
- Language: English
- Paperback ISBN:9 7 8 - 8 1 - 3 1 2 - 6 8 6 5 - 0
- eBook ISBN:9 7 8 - 8 1 - 3 1 2 - 6 8 6 6 - 7
The fourth edition of this well-known book has been thoroughly revised and updated as per the suggestions and feedback from students and teachers. The text has been arranged in… Read more
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Request a sales quoteThe fourth edition of this well-known book has been thoroughly revised and updated as per the suggestions and feedback from students and teachers. The text has been arranged in three parts and each part has been further subdivided in twelve sections and seventy-eight chapters:
Part I: General Physiology includes one section having five chapters.
Part II: Systemic Physiology has been arranged into ten sections, one on each body system.
Part III: Specialized integrated physiology includes one section comprising of eight chapters.
Part I: General Physiology includes one section having five chapters.
Part II: Systemic Physiology has been arranged into ten sections, one on each body system.
Part III: Specialized integrated physiology includes one section comprising of eight chapters.
New to This Edition
• Addition of a new chapter on Physiology of Yoga explains effectual relationship between aspects of yoga practice and human physiology.
• New applied aspects to emphasize the clinical significance of physiology have been included.
• Additional important notes have been threaded, re-emphasizing the core concepts.
• Self-assessment of the topics studied have been introduced at the end of each chapter helps revision.
• Clinical cases are presented for problem-based learning and knowledge at the end of chapters.
Salient Features
• Extensive revision of chapters as per the basis on scientific advancement and subject requirement.
• 1140 Illustrations in the form of line diagrams, flowcharts, clinical photographs incorporated to enhance visual representation.
• Applied aspects, highlighted in the boxes presented with recent molecular concepts on pathophysiology, advances in investigative and therapeutic principles.
• Important notes highlight the additional valuable information, wherever relevant for quick revision.
Online resource at www.medenact.com
• Complimentary access to full ebook.
• Addition of a new chapter on Physiology of Yoga explains effectual relationship between aspects of yoga practice and human physiology.
• New applied aspects to emphasize the clinical significance of physiology have been included.
• Additional important notes have been threaded, re-emphasizing the core concepts.
• Self-assessment of the topics studied have been introduced at the end of each chapter helps revision.
• Clinical cases are presented for problem-based learning and knowledge at the end of chapters.
Salient Features
• Extensive revision of chapters as per the basis on scientific advancement and subject requirement.
• 1140 Illustrations in the form of line diagrams, flowcharts, clinical photographs incorporated to enhance visual representation.
• Applied aspects, highlighted in the boxes presented with recent molecular concepts on pathophysiology, advances in investigative and therapeutic principles.
• Important notes highlight the additional valuable information, wherever relevant for quick revision.
Online resource at www.medenact.com
• Complimentary access to full ebook.
Primarily meant for PG medical students, but also useful for MBBS, MSc, PhD, etc.
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Preface to the fourth edition
- Preface to the third edition
- List of Illustrations
- List of Tables
- Part I. General Physiology
- Section 1. General Physiology
- Introduction
- Introduction
- 1.1. Functional organization, composition and internal environment of human body
- Functional organization of the human body
- Body composition
- Internal environment and homeostasis
- 1.2. The cell physiology
- Cell structure
- The cell membrane
- Intercellular junctions
- Methods to study the functional activity of cells
- 1.3. Transport through cell membrane
- Passive transport
- Active transport
- Vesicular transport
- Other transport processes
- 1.4. Membrane potential
- Introduction
- Genesis of membrane potential
- Recording of membrane potential
- 1.5. Genetics: An overview
- Introduction
- Structural and functional characteristics of substrate for genetics
- Part II. Systemic Physiology
- Section 2. Nerve Muscle Physiology
- Introduction
- Introduction
- 2.1. The nerve
- Functional anatomy
- Biological activities
- Electrical properties of nerve fibre
- Physiological properties of nerve fibres
- Nerve fibre types
- Degeneration and regeneration of neurons
- Factors promoting neuronal growth
- 2.2. Neuromuscular junction
- Structure of neuromuscular junction
- Neuromuscular transmission
- Drugs affecting neuromuscular junction
- 2.3. Skeletal muscle
- Introduction
- Functional anatomy and organization
- Process of muscle excitability and contractility
- Characteristics of muscle excitability and contractility
- Some characteristics of the skeletal muscles in the intact body
- Electromyography and common disorders of muscles
- Source of energy and metabolic phenomenon during muscle contraction
- 2.4. Smooth muscle and cardiac muscle
- Smooth muscle
- Cardiac muscle
- Comparison of skeletal, smooth and cardiac muscles
- Section 3. Blood and immune system
- Introduction
- Introduction
- Functions of blood
- Immune system
- 3.1. Plasma and plasma proteins
- Plasma
- Plasma proteins
- 3.2. Red blood cells and anaemias
- Characteristic features of red blood cells
- Formation of red blood cells
- Haemoglobin
- Red cell fragility
- Lifespan and fate of red blood cells
- Bilirubin and jaundice
- Anaemias
- 3.3. White blood cells
- White blood cell types and their counts
- Formation of white blood cells
- Morphology, functions, lifespan and variations in counts of WBCs
- 3.4. Immune mechanisms
- Introduction
- Architecture (components) of immune system
- Immunity
- Antigens
- Antibodies
- Development of immune response
- Other immune mechanism–related aspects
- 3.5. Platelets, haemostasis and blood coagulation
- Platelets
- Haemostasis
- Blood coagulation
- Antihaemostatic mechanisms
- 3.6. Blood groups and blood transfusion
- Blood groups
- Blood transfusion
- Section 4. Cardiovascular system
- Introduction
- Introduction
- 4.1. Functional anatomy of heart and physiology of cardiac muscle
- Functional anatomy of heart
- Physiology of cardiac muscle
- 4.2. Origin and spread of cardiac impulse and electrocardiography
- Origin and spread of cardiac impulse
- Electrocardiography
- 4.3. Heart as a pump: Cardiac cycle, cardiac output and venous return
- Cardiac cycle
- Cardiac output and venous return
- 4.4. Dynamics of circulation: Pressure and flow of blood and lymph
- Introduction
- Functional organization and structure of vascular system
- Haemodynamics
- Pressure and flow in various functional segments of systemic vascular tree
- Blood pressure
- 4.5. Cardiovascular regulation
- Introduction
- Neural control mechanism
- Humoral control mechanisms
- Local control mechanisms
- 4.6. Regional circulation
- Introduction
- Coronary circulation
- Cerebral circulation
- Cutaneous circulation
- Skeletal muscle circulation
- Splanchnic circulation
- 4.7. Cardiovascular homeostasis in health and disease
- Cardiovascular homeostasis in health
- Cardiovascular homeostasis in diseases
- Section 5. Respiratory system
- Introduction
- Introduction
- 5.1. Respiratory tract: Structure and functions
- Functional anatomy
- Functions of the respiratory system
- 5.2. Pulmonary ventilation
- Introduction
- Mechanics of pulmonary ventilation
- Lung volumes and capacities
- Pulmonary elastance and compliance
- Work of breathing
- 5.3. Pulmonary circulation
- Functional anatomy
- Characteristic features of pulmonary circulation
- Functions of pulmonary circulation
- Regulation of pulmonary blood flow
- 5.4. Pulmonary diffusion
- Introduction
- Physics of gas diffusion and gas partial pressures
- Alveolar ventilation
- Alveolar ventilation–perfusion ratio (V/Q)
- Alveolar air
- Diffusion of gases through the respiratory membrane
- 5.5. Transport of gases
- Introduction
- Transport of oxygen
- Transport of carbon dioxide
- 5.6. Regulation of respiration
- Introduction
- Neural regulation of respiration
- Afferent impulses to respiratory centres
- Chemical regulation of respiration
- 5.7. Respiration: Applied aspects
- Introduction
- Respiratory adjustments to stresses in health
- Disturbances of respiration
- Artificial respiration and cardiopulmonary resuscitation
- Pulmonary function tests
- Section 6. Excretory system
- Introduction
- Introduction
- Functions of excretory organs
- Overview of excretory system
- 6.1. Kidneys: Functional anatomy and blood flow
- Functional anatomy of kidneys
- Renal blood flow
- 6.2. Mechanism of urine formation: Glomerular filtration and tubular transport
- Introduction
- Glomerular filtration
- Tubular reabsorption and secretion
- 6.3. Concentration, dilution and acidification of urine
- Concentration and dilution of urine: A mechanism to regulate urine volume and osmolality
- Acidification of urine
- 6.4. Regulation of body fluid osmolality, composition and volume
- Introduction
- Body fluid compartments
- Control of body fluid osmolality
- Regulation of extracellular fluid volume and composition
- Defence of specific ion composition
- Disturbances of volume and concentration of body fluid
- 6.5. Applied renal physiology including renal function tests
- Pathophysiology of common renal disorders
- Diuretics
- Renal function tests
- Dialysis and renal transplantation
- 6.6. Physiology of micturition
- Urinary bladder and urethra
- Physiology of micturition
- Section 7. Gastrointestinal system
- Introduction
- Introduction
- Functions of gastrointestinal system
- Physiology of gastrointestinal tract
- 7.1. Functional anatomy and general principles of functions of gastrointestinal system
- Functional anatomy
- General principles of gastrointestinal functions
- 7.2. Physiological activities in mouth, pharynx and oesophagus
- Introduction
- Mastication
- Lubrication of food by saliva
- Deglutition (swallowing)
- 7.3. Physiological activities in stomach
- Functional anatomy
- Physiology of gastric secretion
- Physiology of gastric motility
- Functions of stomach
- Gastric function tests
- 7.4. Pancreas, liver and gall bladder
- Introduction
- Pancreas
- Liver and gall bladder
- 7.5. Physiological activities in small intestine
- Functional anatomy
- Small intestinal secretions
- Motility of small intestine
- Functions of small intestine
- 7.6. Physiological activities in large intestine
- Functional anatomy
- Large intestinal secretions and bacterial activity
- Motility of large intestine
- Defaecation
- Functions of large intestine
- 7.7. Digestion and absorption
- Digestion and absorption of carbohydrates
- Digestion and absorption of proteins
- Digestion and absorption of fats
- Absorption of water, electrolytes, minerals and vitamins
- Section 8. Endocrinal system
- Introduction
- Introduction
- Relationship between endocrine and neural physiology
- Organization of endocrine system
- 8.1. General principles of endocrinal system
- Hormones: Definition and classification
- Hormones: General considerations
- Hormone: Receptors and mechanism of action
- Measurement of hormones
- 8.2. Endocrinal functions of hypothalamus and pituitary gland
- Introduction and functional anatomy
- Endocrinal aspects of hypothalamus
- Anterior pituitary hormones
- Posterior pituitary hormones
- 8.3. Thyroid gland
- Functional anatomy
- Thyroid hormones
- 8.4. Endocrinal control of calcium metabolism and bone physiology
- Introduction
- Calcium, phosphorus and magnesium metabolism
- Bone physiology
- Calcitropic hormones
- 8.5. Adrenal glands
- Functional anatomy
- Hormones of adrenal cortex
- Hormones of adrenal medulla
- 8.6. Pancreatic and gastrointestinal hormones
- Endocrine pancreas
- Gastrointestinal hormones
- 8.7. Endocrinal functions of other organs and local hormones
- Hormones of the heart
- Hormones of the kidney
- Pineal gland
- Thymus
- Local hormones
- Section 9. Reproductive system
- Introduction
- Introduction
- 9.1. Sexual growth and development
- Prepubertal sexual growth and development
- Puberty and adolescence
- 9.2. Male reproductive physiology
- An overview of male reproductive system
- Functional anatomy of testes
- Functions of testes
- 9.3. Female reproductive physiology
- An overview of female reproductive system
- Ovaries
- Female sexual cycle
- 9.4. Physiology of coitus, pregnancy and parturition
- Physiology of coitus
- Physiology of pregnancy
- Physiology of parturition
- Summary
- 9.5. Physiology of lactation
- Development and functional anatomy of breast
- Physiology of lactation
- 9.6. Physiology of contraception
- Introduction
- Contraceptive methods in females
- Contraceptive methods in males
- Section 10. Nervous system
- Introduction
- Introduction
- 10.1. Physiological anatomy, functions and lesions of spinal cord and brainstem
- Physiological anatomy and functions of spinal cord
- Physiological anatomy and functions of brainstem
- Tracts of spinal cord and brainstem
- 10.2. Physiological anatomy, functions and lesions of cerebellum and basal ganglia
- Cerebellum
- Basal ganglia
- 10.3. Physiological anatomy, functions and lesions of thalamus and hypothalamus
- Thalamus
- Hypothalamus
- 10.4. Physiological anatomy and functions of cerebral cortex and white matter of cerebrum
- Cerebral cortex
- White matter of cerebrum
- 10.5. Autonomic nervous system
- Anatomical considerations
- Physiological considerations
- 10.6. Meninges, cerebrospinal fluid, blood–brain barrier and cerebral blood flow
- Meninges of the brain
- Cerebrospinal fluid
- Blood–brain barrier and blood–CSF barrier
- Cerebral blood flow
- 10.7. Synaptic transmission
- Synapse: Definition and types
- Chemical synapse
- Neurotransmitters
- 10.8. Somatosensory system
- General sensory mechanism
- Somatosensory system
- 10.9. Somatic motor system
- Introduction
- Components of somatic motor control system
- Skeletal muscles: The effector organ of somatic motor system
- Reflex activity
- Regulation of posture
- Vestibular apparatus and equilibrium
- 10.10. Limbic system and physiology of emotional, behavioural and motivational mechanisms
- Limbic system
- Physiology of emotions
- Physiology of motivation
- Monoaminergic neuronal tracts and physiological basis of psychotic disorders
- 10.11. Reticular formation, electrical activity of the brain, and alert behaviour and sleep
- Reticular formation and reticular activating system
- Electrical activity of the brain
- Wakefulness and sleep
- 10.12. Some higher functions of nervous system
- Language and speech
- Learning and memory
- Higher intellectual functions of the prefrontal association cortex
- Section 11. Special senses
- Introduction
- Introduction
- 11.1. Sense of vision
- Introduction and functional anatomy
- Maintenance of clear refractive media of the eye
- Image-forming mechanism
- Physiology of vision
- Field of vision and binocular vision
- Physiology of ocular motility
- Aqueous humour and intraocular pressure
- Physiology of pupil
- 11.2. Sense of hearing
- Functional anatomy
- Auditory pathways
- Physiology of hearing
- Conduction of sound waves
- Transduction of sound waves
- Neural transmission of signals
- Neural processing of auditory information
- 11.3. Chemical senses: Smell and taste
- Sense of smell
- Sense of taste
- Part III. Specialized Integrative Physiology
- Section 12. Specialized Integrative Physiology
- Introduction
- Introduction
- 12.1. Physiology of exercise and sports
- Introduction
- Responses to exercise
- Effects of training
- 12.2. Environmental physiology
- High-altitude physiology
- Physiology of high atmospheric pressure
- 12.3. Physiology of acid–base balance
- General considerations
- Maintenance of blood pH
- Analysis and clinical evaluation of acid–base disorders
- 12.4. Physiology of body temperature regulation
- Body temperature
- Heat balance
- Regulation of body temperature
- 12.5. Physiology of growth and behavioural development
- Growth and development
- Behavioural development
- 12.6. Physiology of fetus, neonate and childhood
- Introduction
- Role of placenta in fetal physiology
- Systemic physiology of fetus, newborn and childhood
- 12.7. Geriatric physiology
- Introduction
- Age-related changes in different organ systems
- Theories of ageing
- Modulating the process of ageing
- 12.8. Physiology of yoga
- Introduction
- Physiological aspects of yoga
- Role of yoga in preventing ageing
- Index
- Edition: 4
- Published: September 3, 2024
- Imprint: Elsevier India
- No. of pages: 1260
- Language: English
- Paperback ISBN: 9788131268650
- eBook ISBN: 9788131268667