Skip to main content
Elsevier

Textbook of Arterial Stiffness and Pulsatile Hemodynamics in Health and Disease

  • 1st Edition - March 28, 2022
  • Latest edition
  • Editor: Julio A. Chirinos
  • Language: English

Textbook of Arterial Stiffness and Pulsatile Hemodynamics in Health and Disease, Two Volume Set covers the principles, physiology, biologic pathways, clinical implicati… Read more

Data Mining & ML

Unlock the cutting edge

Up to 20% on trusted resources. Build expertise with data mining, ML methods.

Explore now

Description

Textbook of Arterial Stiffness and Pulsatile Hemodynamics in Health and Disease, Two Volume Set covers the principles, physiology, biologic pathways, clinical implications and therapeutics surrounding arterial stiffness and pulsatile hemodynamics, along with a thorough overview of the field. The book presents complex engineering concepts in a way that those in science and medicine can more easily understand. It includes detailed illustrations. Additionally, it presents advanced bioengineering concepts in boxes for readers who wants more in-depth biophysical knowledge. This is a must-have reference for students, researchers and clinicians interested in learning more about this field.

Key features

  • Incorporates case studies and calculations/worked examples with mathematical principles explained in a conceptual manner without complicated formulas
  • Features chapter contributions from leading international researchers and clinicians
  • Covers principles, physiology, biologic pathways, clinical implications and therapeutics

Readership

Researchers, clinicians (cardiologists, hypertension specialists, general internists, nephrologists, neurologists, geriatricians) and bioengineers interested in physiology, arterial stiffness and pulsatile hemodynamics

Table of contents

Section I. Biophysical and Technical Principles

1. Basic Principles of pulsatile pressure and flow phenomena in elastic vessels

2. Measurements of arterial pressure and flow in vivo

3. Essential Principles of Pulsatile Pressure-flow relations in the arterial tree

4. Magnetic Resonance Imaging for the assessment of aortic stiffness and pulsatile hemodynamics

5. Computed tomography of the aorta

6. Radionuclide-based Imaging of the aortic wall

7. Arterial wall stiffness: basic principles and methods of measurement in vivo

8. Ambulatory measurements of pulsatile hemodynamics

9. Animal Models and Ex-vivo Methods to Study Arterial Stiffness

Section II. Basic and Applied Physiology

10. Hemodynamic role of the Aorta

11. Wave Reflections in the arterial tree

12. Linking Arterial Stiffness to Microvascular Remodeling

13. Myocardial function: from myofilaments to cardiac pump

14. Systolic-diastolic coupling

15. Ventricular-arterial coupling: The pressure-volume plane

16. Myocardial wall stress and the systolic loading sequence

17. Assessment of Ventricular Arterial Interactions via arterial pressure-flow relations in humans

18. Hemodynamic Determinants of Myocardial Oxygen Demand and Supply

Section III. Biologic pathways leading to arterial stiffness and dysfunctional pulsatile hemodynamics

19. Role of elastin and elastin-derived peptides in arterial stiffness: from synthesis to potential therapeutic interventions

20. Inflammation and arterial stiffness

21. Mechanisms of Aortic Wall Calcification

22. Vascular smooth muscle dysfunction and arterial stiffness

23. Endothelial cell dysfunction and Senescence: Biologic mechanisms and Hemodynamic consequences

24. Autonomic and neuroendocrine modulation of arterial stiffness and hemodynamics

25. Cellular mechanisms of ageing and their impact on the aortic/arterial wall

SECTION IV. Clinical significance of arterial stiffness and pulsatile hemodynamics

26. Normal Aging: Arterial Stiffness and remodeling over the life course

27. Early Vascular Aging and Supernormal Vascular Aging: Genetics, Epigenetics, and Environment

28. Ethnic differences in arterial stiffness and central aortic hemodynamics

29. Arterial Stiffness and Pulsatile hemodynamics in Systemic Hypertension

30. Arterial Stiffness and Pulsatile hemodynamics in Diabetes and Obesity

31. Cardiovascular Risk Prevention in Clinical Practice: Current Guidelines in the USA and Europe

32. Cardiovascular Risk Prevention in Clinical Practice: Current Guidelines in Asia

33. Arterial Stiffness, Cardiovascular Risk and Strategies for enhancing risk Stratification

34. Role of the arterial tree in Physiologic Adaptations to exercise

35. Invasive Hemodynamic Assessments during exercise: Normal patterns and clinical value

36. Arterial Stiffness and Pulsatile hemodynamics in Heart Failure with Reduced and Preserved Ejection Fraction

37. Ventricular-Arterial Coupling and Arterial Load in Aortic Valvular Disease

38. Arterial Stiffness and Atherosclerosis: Mechanistic and Pathophysiologic Interactions

39. Arterial Stiffness and Pulsatile hemodynamics in Coronary Artery Disease and other forms of Atherosclerotic vascular diseases

40. Arterial Stiffness and Pulsatile hemodynamics in Renal disease

41. Arterial Stiffness, Pulsatile hemodynamics, Cognitive dysfunction

42. Arterial Stiffness and Pulsatile hemodynamics in pregnancy and pregnancy-related vascular complications

43. Arterial Stiffness and Pulsatile Hemodynamics in Pediatric populations

44. Aortopathies and Arteriopathies

45. Pulsatile hemodynamics and arterial stiffness in primary aortopathies

46. Arterial Hemodynamics and Pulsatile Hemodynamics in Congenital Heart Disease

47. Arterial Stiffness and Pulsatile Hemodynamics in Acute and Chronic Infectious Diseases

48. Arterial Stiffness, Hemodynamics and Microvascular Complications in conditions characterized by low arterial pulsatility

SECTION V. Therapeutic approaches to improve arterial stiffness and pulsatile hemodynamics

49. Effects of common antihypertensive treatments on pulsatile arterial hemodynamics

50. Pharmacologic approaches to reduce arterial stiffness

51. Organic and dietary nitrates, inorganic nitrite, NO donors, and sGC stimulation

52. Effect of Exercise Training and Weight Loss on Arterial Stiffness and Pulsatile Hemodynamics

53. Dietary Salt and Arterial Stiffness

54. Role of Arterial Stiffness and Central Hemodynamics in Personalized medicine in hypertension

Section VI. Arterial Stiffness and Pulsatile Hemodynamics in the Pulmonary Circulation

55. Pulsatile hemodynamics and Ventricular-Arterial Interactions in the pulmonary circulation: Physiologic Concepts

56. Pulmonary arterial load and its impact on the right ventricle in pulmonary hypertension

57. Biologic mechanisms and consequences of pulmonary artery stiffening in Pulmonary Hypertension

58. Therapeutic approaches to improve right ventricular load

Product details

  • Edition: 1
  • Latest edition
  • Published: August 18, 2022
  • Language: English

About the editor

JC

Julio A. Chirinos

Dr. Julio A. Chirinos, MD, PhD, is an Associate Professor of Medicine and Director of the Arterial Hemodynamics and Cardiac Imaging Quantification Core Laboratory at the University of Pennsylvania Perelman School of Medicine. Dr. Chirinos directs an NIH-funded research program focused on the role of arterial stiffness and ventricular arterial interactions in heart disease, mechanisms of human heart failure and the use of proteomics to discern mechanisms of human heart failure. He currently leads clinical studies and trials designed to therapeutically target the arterial tree in order to reduce maladaptive cardiac remodeling, diastolic dysfunction, and to treat patients with Heart Failure and Preserved Ejection Fraction, an epidemic condition for which no effective proven pharmacologic therapies are currently available. He also leads various cohort studies with deep cardiovascular phenotyping aimed at characterizing phenotypic profiles in humans. Dr. Chirinos also directs a core analysis laboratory for assessments of cardiac and arterial structure and function with non-invasive imaging, which has served as the core lab for various multicenter studies. His laboratory utilizes a combination of imaging modalities (including arterial tonometry, echocardiography and cardiac MRI) coupled with modeling approaches to characterize arterial physiology and ventricular-arterial interactions in humans. Dr. Chirinos has published >200 papers, chapters, reviews, and editorials and has been an invited speaker in >120 scientific sessions. He has participated in various clinical expert committees for the American Heart Association, American Society of Echocardiography, European Society of Cardiology, American Society of Hypertension, European Association of Cardiovascular Imaging and the Lancet Commission for Hypertension. Dr. Chirinos is currently the Vice-President of the North American Artery society, which promotes the study of arterial function as a determinant of cardiovascular disease. He is an Associate Editor of Circulation Heart Failure and a former Editor of the Cochrane Group (Cochrane Collaboration), Senior Consulting Editor of the Journal of the American College of Cardiology – Cardiovascular Imaging, Associate Editor for the Journal of Clinical Hypertension and member of the editorial board of Pulse and the Journal of Geriatric Cardiology. He is also a Visiting Professor at the University of Ghent in Belgium, where he maintains an active collaboration with the Asklepios Investigators aimed at characterizing arterial aging at the population level.
Affiliations and expertise
Associate Professor of Medicine, University of Pennsylvania Perelman School of Medicine, USA; Director, Arterial Hemodynamics and Cardiac Imaging Quantification Core Laboratory; Visiting Professor, University of Ghent, Ghent, Belgium

View book on ScienceDirect

Read Textbook of Arterial Stiffness and Pulsatile Hemodynamics in Health and Disease on ScienceDirect