Tailor-Made and Functionalized Biopolymer Systems
For Drug Delivery and Biomedical Applications
- 1st Edition - July 28, 2021
- Imprint: Woodhead Publishing
- Editors: Hriday Bera, Buddhadev Layek, Jagdish Singh
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 1 4 3 7 - 4
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 1 4 5 7 - 2
Tailor-Made and Functionalized Biopolymer Systems: For Drug Delivery and Biomedical Applications covers the design and application of these functionalized and tailor-made biopol… Read more
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Request a sales quoteTailor-Made and Functionalized Biopolymer Systems: For Drug Delivery and Biomedical Applications covers the design and application of these functionalized and tailor-made biopolymers and biopolymer systems intended for drug delivery and biomedical applications. Various concepts, design protocols and biomedical applications of tailor-made biopolymer systems are covered, guiding the reader from theoretical knowledge to practical application. Authored by an array of experts from global institutions, this book offers an interdisciplinary approach to how tailor-made biopolymers lead to novel drug delivery and treatment solutions. This will be a useful reference to a broad audience, including biomedical engineers, materials scientists, pharmacologists and chemists.
- Provides a concise overview of tailor-made and functionalized biopolymer systems for biomedical applications
- Covers a range of modified biopolymers, biopolymeric composites and biopolymer-based systems in drug delivery, development of artificial organs, diagnostic applications, and more
- Describes characterization, synthesis and functionalization of biopolymers and biopolymers systems
Postgraduate research students from various disciplines such as materials science, biomedical science and engineering, pharmacy, molecular medicine, and chemistry. This book would also serve as a resource of information for faculty, instructors and research supervisors working in academia and industrial researchers from biomedical and pharmaceutical industries
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- 1. Introduction to tailor-made biopolymers in drug delivery applications
- Abstract
- 1.1 Introduction
- 1.2 Biopolymers from plant and animal kingdom
- 1.3 Chemical modifications of biopolymers
- 1.4 Tailor-made biopolymers as pharmaceutical excipients
- 1.5 Conclusion
- References
- Section 1: Modified biopolymers
- 2. Thiolated biopolymers in drug delivery and biomedical applications
- Abstract
- 2.1 Introduction
- 2.2 Thiolated biopolymers in drug delivery applications
- 2.3 Thiolated biopolymers in biomedical applications
- 2.4 Conclusion and future perspectives
- Acknowledgments
- References
- 3. Smart biopolymers for controlled drug delivery applications
- Abstract
- 3.1 Introduction
- 3.2 Different types of smart biopolymers
- 3.3 Conclusion
- Acknowledgments
- References
- 4. Alginate-based systems for protein and peptide delivery
- Abstract
- 4.1 Introduction
- 4.2 Alginate: sources, physicochemical and biological properties
- 4.3 Modifications of alginate for protein and peptide delivery
- 4.4 Alginate-based systems for protein and peptide delivery
- 4.5 Conclusion
- References
- 5. Chitosan-based polyelectrolyte complexes in biomedical applications
- Abstract
- 5.1 Introduction
- 5.2 Polyelectrolyte complexes
- 5.3 Applications of chitosan-based polyelectrolyte complexes
- 5.4 Conclusion
- References
- 6. Tailor-made cyclodextrin-based nanomaterials as drug carriers
- Abstract
- 6.1 Introduction
- 6.2 Modification of cyclodextrins
- 6.3 Cyclodextrin-based nanomaterials
- 6.4 Pharmaceutical and biomedical applications of tailor-made CD-based nanomaterials
- 6.5 Conclusion and future prospects
- References
- Section 2: Biopolymeric conjugates/composites
- 7. Biopolymer–metal oxide composites in biomedical applications
- Abstract
- 7.1 Introduction
- 7.2 Applications of biopolymer–metal oxide composites
- 7.3 Conclusion
- References
- 8. Biopolymer–drug conjugates as biomaterials
- Abstract
- 8.1 Introduction
- 8.2 Biopolymer–drug conjugates
- 8.3 Conclusion
- References
- 9. Functionalized biopolymer–clay-based composites as drug-cargos
- Abstract
- 9.1 Introduction
- 9.2 Structure and properties of clays
- 9.3 Biopolymer–clay intercalations
- 9.4 Properties of biopolymer–clay-based composites as drug-delivery systems
- 9.5 Biopolymer–clay-based composites as drug-delivery systems
- 9.6 Conclusion
- References
- 10. Mesoporous silica-biopolymer-based systems in drug delivery applications
- Abstract
- 10.1 Introduction
- 10.2 Classification of MSNs, their structures and properties
- 10.3 Different synthesis techniques of mesoporous silica nanoparticles
- 10.4 Functionalization of mesoporous silica nanoparticles using synthetic polymers/biopolymers
- 10.5 Different biopolymer-MSN systems in drug delivery applications
- 10.6 Stability and degradation profiles
- 10.7 Biocompatibility, pharmacology, and toxicological profiles
- 10.8 Conclusion, challenges, and future prospects
- Acknowledgments
- References
- Section 3: Modified biopolymer based biomaterials
- 11. Micellar drug-delivery systems based on amphiphilic block and graft polysaccharides
- Abstract
- 11.1 Introduction
- 11.2 Micellization and drug-loading methods
- 11.3 Characterization techniques of drug-free and drug-loaded micellar systems
- 11.4 Polysaccharide-based micellar drug-delivery systems
- 11.5 Conclusions and perspectives
- References
- 12. Engineering of biopolymer-based nanofibers for medical uses
- Abstract
- 12.1 Introduction
- 12.2 Tissue engineering
- 12.3 Drug delivery
- 12.4 Stem cells
- 12.5 Sensors
- 12.6 Conclusion and future perspectives
- References
- Further reading
- 13. Engineered protein and protein-polysaccharide cages for drug delivery and therapeutic applications
- Abstract
- 13.1 Introduction
- 13.2 Proteins
- 13.3 Protein cages: engineering and therapeutic applications
- 13.4 Protein-polysaccharide cages: engineering and therapeutic applications
- 13.5 Conclusion and future perspectives
- References
- 14. Biopolymeric hydrogels prepared via click chemistry as carriers of therapeutic modalities
- Abstract
- 14.1 Introduction
- 14.2 Properties of biopolymeric hydrogels
- 14.3 Chemically cross-linked hydrogels
- 14.4 Applications of biopolymeric click hydrogels in drug delivery
- 14.5 Conclusion and future prospects
- Acknowledgement
- References
- 15. Biopolymeric nanocrystals in drug delivery and biomedical applications
- Abstract
- 15.1 Introduction
- 15.2 Generalized synthesis methods for biopolymeric nanocrystals
- 15.3 Biopolymeric nanocrystals and their drug delivery and biomedical applications
- 15.4 Conclusion and future prospects
- References
- Section 4: Biopolymeric systems in biomedical applications
- 16. Functionalized biopolymers for colon-targeted drug delivery
- Abstract
- 16.1 Introduction
- 16.2 Biopolymeric systems as colon-targeted drug carriers
- 16.3 Conclusion
- References
- 17. Modified biopolymer-based systems for drug delivery to the brain
- Abstract
- 17.1 Introduction
- 17.2 BBB and other common hurdles in brain drug delivery
- 17.3 Brain drug delivery by invasive methods
- 17.4 Brain drug delivery by the noninvasive methods
- 17.5 Biopolymer-based systems for targeted drug delivery to the brain
- 17.6 Conclusion and future perspectives
- Contributions
- References
- 18. Modified biopolymer-based chronotherapeutic drug-delivery systems
- Abstract
- 18.1 Introduction
- 18.2 Concepts and terminologies used in chronotherapeutics
- 18.3 Common disease states under chronotherapy
- 18.4 Drug-delivery strategies as chronopharmaceuticals
- 18.5 Biopolymer-based drug-delivery strategies as chronopharmaceuticals
- 18.6 Conclusion
- References
- 19. Biopolymeric systems for the delivery of nucleic acids
- Abstract
- 19.1 Introduction
- 19.2 Types of nucleic acids used in gene therapy
- 19.3 Biopolymers used in gene delivery
- 19.4 Conclusion
- References
- 20. Stimuli-responsive biopolymeric systems for drug delivery to cancer cells
- Abstract
- 20.1 Introduction
- 20.2 Stimuli-responsive biopolymeric systems
- 20.3 Conclusion
- References
- 21. Biopolymeric systems for diagnostic applications
- Abstract
- 21.1 Introduction
- 21.2 Biopolymers used for various diseases
- 21.3 Conclusion
- References
- 22. Functionalized biopolymer-based drug delivery systems: current status and future perspectives
- Abstract
- 22.1 Introduction
- 22.2 Summary of topics
- 22.3 Conclusions and future perspectives
- Acknowledgment
- References
- Index
- Edition: 1
- Published: July 28, 2021
- No. of pages (Paperback): 788
- No. of pages (eBook): 788
- Imprint: Woodhead Publishing
- Language: English
- Paperback ISBN: 9780128214374
- eBook ISBN: 9780128214572
HB
Hriday Bera
Dr. Hriday Bera completed his Masters study at Jadavpur University, Kolkata, India and Ph.D at National University of Singapore, Singapore. He is presently working as Post-doctoral Fellow at Shenyang Pharmaceutical University, China and Nano Medical Engineering Laboratory, RIKEN, Wako, Japan. The major focus of his current research is the conceptual design, fabrication and evaluation of chemically modified naturally-occurring polymer based systems intended for drug delivery and other biomedical applications. As a part of his research career, he published 36 peer-reviewed articles (including 23 first-author articles) in various international journals of repute with a total SCI citation of 546, h-index of 15 and i10-index of 20. Moreover, he penned 20 book chapters for various international publishers. Furthermore, as a principal investigator, he has received highly competitive research grants from AICTE, Govt. of India; Ministry of Higher Education, Govt. of Malaysia; National Natural Science Foundation, China and Tekada Science Foundation, Japan.
Affiliations and expertise
Post-doctoral Fellow/International Young Scientist, Shenyang Pharmaceutical University, Shenyang, Liaoning, ChinaBL
Buddhadev Layek
Dr. Buddhadev Layek received his Master of Pharmacy degree from Jadavpur University in Kolkata, India and Ph.D. in Pharmaceutical Sciences from North Dakota State University in Fargo, USA. He is currently working as Assistant Professor at North Dakota State University, USA. His primary research interests include tumor-targeted drug delivery, modulating the tumor microenvironment to improve outcomes of cancer therapy, and designing multifunctional, polymeric nanomaterials for drug andgene delivery. Layek has published 22 peer-reviewed articles in high impact journals and 6 book chapters for various international publishers. He has also served as a guest editor for special issues on “Cell-Penetrating Peptides” and “Surface-Functionalized Nanoparticles as Drug Carriers” in the International Journal of Molecular Sciences.
Affiliations and expertise
Assistant Professor at North Dakota State University, USA.JS
Jagdish Singh
Dr. Singh is Professor and Chair of the Department of Pharmaceutical Sciences at NDSU School of Pharmacy, and a Fellow of American Association of Pharmaceutical Scientists (AAPS) and Fellow, Association of Biotechnology and Pharmacy. Dr. Singh’s research efforts focus on the mechanistic studies for developing and testing novel delivery technologies to deliver biotechnologically derived molecules (e.g., peptide, protein, and gene), using smart polymers, nanomicelles and nanoparticles for the prevention and treatment of neurodegenerative diseases, other brain disorders, and diabetes. National Institutes of Health, US Department of Defense, PhRMA Foundation, and AFPE have funded Dr. Singh’s research. Dr. Singh has published over 175 peer-reviewed papers and 350 abstracts.
Affiliations and expertise
Professor and Chair, North Dakota State University, Fargo, USARead Tailor-Made and Functionalized Biopolymer Systems on ScienceDirect