Synthetic Polymers in Drug and Biotherapeutics Delivery
- 1st Edition - September 26, 2024
- Imprint: Woodhead Publishing
- Editors: Rangasamy Jayakumar, Mar Masson, Deepagan Veerasikku Gopal
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 5 2 3 3 - 0
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 5 2 3 4 - 7
Synthetic Polymers in Drug and Biotherapeutics Delivery covers new polymers that are fast replacing obsolete polymers in the field of drug delivery. Each chapter focuses on a spec… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteSynthetic Polymers in Drug and Biotherapeutics Delivery covers new polymers that are fast replacing obsolete polymers in the field of drug delivery. Each chapter focuses on a specific polymer, detailing its design, synthesis, fabrication techniques, and applications in drug and biotherapeutics delivery.
Synthetic polymers provide a unique set of opportunities in drug and biotherapeutics delivery due to their chemical versatility and tunable physicochemical properties. Such polymers can be formulated into nanoparticles, nanofibers, nanogels, microparticles, beads, hydrogels, and scaffolds to suit specific needs such as drug release rate, and biodegradation with low toxicity. This book covers new polymers that are fast replacing obsolete polymers in the field of drug delivery. Each chapter will focus on a specific polymer detailing its design, synthesis, fabrication techniques, and applications in drug and biotherapeutics delivery.
This book provides a thorough review of the latest research in this rapidly changing field and would be of interest to materials scientists, pharmaceutical scientists, biomedical engineers, chemical engineers, and clinicians with an interest in materials development.
- Details the immunological aspects of synthetic polymeric materials, helping the reader prepare for, and even avoid, unwanted side effects of use
- Reviews each polymer sub-type, chapter-by-chapter, ensuring thorough coverage and detailed analysis of each
- Explores a range of applications in drug and biotherapeutics delivery, including treatments for cardiovascular, neurological and gastrointestinal diseases
Researchers and postgraduate students in the fields of materials science, biomedical engineering, regenerative medicine, pharmaceutical science and nanotechnology, Chemical engineers and clinical scientists interested in materials development for drug delivery
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Preface
- Chapter 1. Role and challenges of synthetic biopolymers in drug/biotherapeutic delivery
- Abstract
- 1.1 Introduction
- 1.2 Classification
- 1.3 Applications
- 1.4 Surface modification
- 1.5 Challenges and future direction
- References
- Chapter 2. Poly(caprolactone) in nanodrug delivery
- Abstract
- 2.1 Introduction
- 2.2 Synthesis
- 2.3 Engineering core of the poly(caprolactone)-based carriers
- 2.4 Engineering shell of poly(caprolactone)-based carriers
- 2.5 Engineering core–shell interface of the poly(caprolactone)-based carriers
- 2.6 Conclusions and outlook
- References
- Chapter 3. Poly(lactic-co-glycolic acid) in drug delivery and tissue engineering applications
- Abstract
- 3.1 Introduction
- 3.2 Fabrication of PLGA-based formulations
- 3.3 Surface modifications of PLGA nanoformulations
- 3.4 Biomedical applications of PLGA-based formulations
- 3.5 3D printing
- 3.6 Regenerative medicine
- 3.7 PLGA-based nanosystems for imaging and diagnostics
- 3.8 Commercial PLGA products
- 3.9 Conclusion and future perspectives
- References
- Further reading
- Chapter 4. Poly(amidoamine)-based dendrimers for biomedical applications
- Abstract
- 4.1 Introduction
- 4.2 Poly(amidoamine) synthesis
- 4.3 Surface modifications of poly(amidoamine)
- 4.4 Biomedical applications
- 4.5 Conclusion
- References
- Chapter 5. pH-responsive synthetic polymers for drug delivery applications
- Abstract
- 5.1 Introduction
- 5.2 Amide bond
- 5.3 Imine bond
- 5.4 Acetal bond
- 5.5 Ester bond
- 5.6 Hydrazone bond
- 5.7 Noncleaving pH responsiveness
- 5.8 Other stimuli-responsive polymers
- 5.9 Conclusion and outlook
- References
- Chapter 6. Chemistry, properties, and role of polyoxazoline in drug delivery
- Abstract
- 6.1 Oxazolines and their chemistry
- 6.2 Polyoxazolines
- 6.3 Drug-polyoxazoline conjugations
- 6.4 Polyoxazoline nanoparticles
- 6.5 Methodologies of drug delivery
- 6.6 Conclusion
- References
- Further reading
- Chapter 7. Poly(amides) in drug and biotherapeutics delivery
- Abstract
- 7.1 General introduction of synthetic poly(amides)
- 7.2 Types of general synthetic poly(amides)
- 7.3 Stimuli-responsive poly(amides)
- 7.4 Recent advances in poly(amides)-based drug and biotherapeutics delivery
- 7.5 Perspective on challenges and future directions of poly(amide)-based drug delivery systems
- 7.6 Conclusions
- References
- Chapter 8. Polyethyleneimine-based biomaterials for therapy and diagnostic applications
- Abstract
- 8.1 Introduction
- 8.2 Polyethylenimine-based nanosystems as delivery agents
- 8.3 Tissue engineering and regeneration
- 8.4 Biosensing
- 8.5 Conclusion
- References
- Chapter 9. Polyethylene glycol: structure, properties, and biomedical applications
- Abstract
- 9.1 Introduction
- 9.2 PEGylation—strategies and conformation
- 9.3 Role of PEGylation in deciding the fate of nanoparticles
- 9.4 Biomedical applications of PEGylation
- 9.5 FDA-approved PEGylated formulations in the market
- 9.6 Limitations and hurdles faced in clinical translation of PEGylated nanoformulations
- References
- Chapter 10. Poly(N-isopropyl acrylamide): a thermo-responsive polymer for biotherapeutic applications
- Abstract
- 10.1 Introduction
- 10.2 Poly(N-isopropyl acrylamide)
- 10.3 Novel application of poly(N-isopropyl acrylamide-based hydrogel with composite polymers
- 10.4 Future outlook
- 10.5 Conclusion
- References
- Chapter 11. Poly(2-hydroxyethyl methacrylate): a new leap to accelerate the effective biotherapeutic and drug delivery systems
- Abstract
- 11.1 Introduction
- 11.2 Synthesis of pHEMA
- 11.3 Applications
- 11.4 Conclusions
- 11.5 Future perspectives
- References
- Chapter 12. Poly(N-(2-hydroxypropyl)methacrylamide)
- Abstract
- 12.1 Introduction
- 12.2 EPR effect
- 12.3 Structure
- 12.4 Properties of PHPMA
- 12.5 Method of polymer synthesis
- 12.6 Advantages of HPMA and its copolymers
- 12.7 Disadvantages of HPMA and its copolymers
- 12.8 Poly(N-(2-hydroxypropyl)methacrylamide) as an alternative to PEG
- 12.9 PHPMA drug delivery system based on shape
- 12.10 Applications of PHPMA in drug delivery
- 12.11 Conclusion
- References
- Chapter 13. Polydioxanone: applications in surgery and tissue engineering
- Abstract
- 13.1 Introduction
- 13.2 Synthesis of polydioxanone
- 13.3 Applications
- 13.4 Conclusion
- References
- Chapter 14. Poly(lactide)
- Abstract
- 14.1 Introduction
- 14.2 Lactic acid monomer
- 14.3 PLA synthesis
- 14.4 Properties of PLA
- 14.5 Biomedical and pharmaceutical applications of PLA
- 14.6 Conclusion
- References
- Chapter 15. Blending techniques and formulation strategies
- Abstract
- 15.1 Introduction
- 15.2 Mechanism of blending
- 15.3 Need for novel formulation strategies
- 15.4 Conclusions
- References
- Chapter 16. Clinical application, regulatory status, and future perspective of synthetic biopolymers in drug/bio-therapeutics delivery
- Abstract
- 16.1 Introduction
- 16.2 Clinical applications
- 16.3 Biopolymer market and regulatory status
- 16.4 Challenges and future perspectives
- 16.5 Synthetic biopolymers degradation
- 16.6 Conclusion
- References
- Index
- Edition: 1
- Published: September 26, 2024
- Imprint: Woodhead Publishing
- No. of pages: 450
- Language: English
- Paperback ISBN: 9780323952330
- eBook ISBN: 9780323952347
RJ
Rangasamy Jayakumar
Rangasamy Jayakumar is a Professor at the Centre for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham (Deemed University), Kerala, India. He received his PhD degree in polymer chemistry from Anna University, Chennai, India (2002) and MSc degree from Bharathidasan University.
Affiliations and expertise
Professor, Centre for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham (Deemed University), Kerala, IndiaMM
Mar Masson
Már Másson is a Professor of medicinal chemistry at the Faculty of Pharmaceutical Sciences in the University of Iceland. He graduated as a Doctor of Engineering (biotechnology) from Tokyo Institute of Technology, Japan, in 1995 and with a Cand. Scient (MS) in organic chemistry from Copenhagen University, Denmark, in 1990.
Affiliations and expertise
Professor, Faculty Pharmaceutical Sciences, University of Iceland, Reykjavík, IcelandDG
Deepagan Veerasikku Gopal
Deepagan Veerasikku Gopal is a Research Fellow at Monash Institute of Pharmaceutical Sciences, Australia, since March 2018. He completed his PhD in polymer science and engineering at Sungkyunkwan University, Republic of Korea, and Masters in nanomedicine at Amrita University, India.
Affiliations and expertise
Research Fellow (Post-doc), Monash Institute of Pharmaceutical Sciences, AustraliaRead Synthetic Polymers in Drug and Biotherapeutics Delivery on ScienceDirect