Synthesis of Bionanomaterials for Biomedical Applications

1st Edition - January 11, 2023
Imprint: Elsevier
Editors: Munir Ozturk, Arpita Roy, Rouf Ahmad Bhat, Fazilet Vardar Sukan, Fernanda Maria Policarpo Tonelli
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 1 9 5 - 5
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 8 4 3 - 7

Synthesis of Bionanomaterials for Biomedical Applications summarizes a range of procedures, including green synthesis of metal nanoparticles, metal oxide nanoparticles, and other… Read more

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Synthesis of Bionanomaterials for Biomedical Applications summarizes a range of procedures, including green synthesis of metal nanoparticles, metal oxide nanoparticles, and other types of nanoparticles while also exploring the appropriate use of these nanoparticles in various therapeutic applications such as anticancer, antibacterial, antifungal, drug delivery, and more. The book provides important information for materials scientists and pharmaceutical scientists on the synthesis of various nanoparticles using a variety of eco-friendly bionanomaterials. As concern has arisen regarding the environmental impact caused by some of nanomaterials, as well as their possible toxicity to cells, this book presents information on a new generation of eco-friendly materials.

In addition, the green synthesis of nanoparticles shows how environmentally-friendly nanoparticles can be synthesized from different biological sources, such as microbes, fungi, algae and plants.

Cover image
Title page
Table of Contents
Copyright
Contributors
Chapter 1. Strategies involved in bio-inspired synthesis of metallic nanomaterials and their applications—A comprehensive account
1.1. Introduction
1.2. Nanofabrication
1.3. Top–bottom approach
1.4. Bottom–top approach
1.5. Biological (green) synthesis of metallic and metal oxide NPs/NMs
1.6. Plants and phytochemical-mediated biosynthesis
1.7. Microbial-mediated biosynthesis
1.8. Bacteria and actinomycetes
1.9. Fungi and yeast
1.10. Algae
1.11. Viruses
1.12. Factors inﬂuencing the biosynthesis of metallic NPs
1.13. Effect of extracts and concentrations
1.14. Effect of pH
1.15. Effect of reaction temperature
1.16. Effect of incubation time
1.17. Challenges associated with the biological synthesis of NPs
1.18. Applications of biosynthesized metallic NPs
1.19. Biomedical applications
1.20. Antimicrobial applications
1.21. Agricultural applications
1.22. Bio-sensing applications
1.23. Environmental monitoring and remediation
1.24. Current status and prospects
1.25. Concluding remarks
Chapter 2. Bionanomaterials to avoid the environmental hazards of conventional nanoparticles
2.1. Introduction
2.2. Routes of nanoparticles into the ecosystem
2.3. Green nanotechnology
2.4. Biological nanoparticles
2.5. Nanotoxicity
2.6. Evaluation of the toxicity of nanoparticles
2.7. Biological approach for the synthesis of metal NPs
2.8. Synthesis by plants
2.9. Synthesis by animals
2.10. Microbial synthesis
2.11. DNA template synthesis
2.12. Protein template synthesis
2.13. Green fillers of bionanocomposites
2.14. Waste materials
2.15. A comparison between chemical and biological synthesis
2.16. Conclusion
Chapter 3. Synthesis methods of nanoparticles and their key applications
3.1. Introduction
3.2. Synthesis methods of nanomaterials
3.3. Conclusion
Chapter 4. Biomass for bionanomaterials green synthesis
4.1. Introduction
4.2. Diversity of plants used for green synthesis of bionanomaterials worldwide
4.3. Use of algae for the manufacture of bionanomaterials
4.4. Conclusions
Chapter 5. Phyconanofabrication—algae as bio-templates for commercially applicable nanomaterials
5.1. Introduction
5.2. Scope of the chapter
5.3. Algal nanomaterial synthesis
5.4. Recent research trends on synthetic routes
5.5. Applications of nanomaterials synthesized using algae
5.6. Phyconanosynthesis—special mentions
5.7. Patents
5.8. Conclusions and future perspectives
Chapter 6. Plant-derived synthesis of bionanomaterials
6.1. Introduction
6.2. Nanoparticle synthesis using plants
6.3. Assertions and considerations affecting nanoparticle formation
6.4. pH
6.5. Temperature
6.6. Biomolecules
6.7. Applications of biological nanoparticles from plants
6.8. Critical parameters and scale-up challenges
6.9. Experimental conditions
6.10. Environmental and economic considerations
6.11. Concluding remarks and future perspective
Chapter 7. Genetically modified organisms use in green synthesizes nanomaterials
7.1. Introduction
7.2. Genetically modified organisms and nanotechnology
7.3. Synthesis of nanoparticles—mechanism
7.4. Bacteria-mediated synthesis of nanoparticles
7.5. Nanoparticle synthesis using fungi
7.6. Nanoparticle synthesis using cyanobacteria (blue-green algae)
7.7. Nanoparticle synthesis using plants
7.8. Challenges and opportunities
7.9. Case studies
7.10. Conclusion
Chapter 8. Green synthesized nanomaterials: structure and functions for biomedical applications
8.1. Introduction
8.2. Nutraceutical delivery
8.3. Tissue engineering
8.4. Cancer therapy
8.5. Interaction of nanoparticles with protein
8.6. Nanotechnology in HIV/AIDS
8.7. Biomedical imaging
8.8. Conclusion
Chapter 9. Functionalization of green synthesized bionanomaterials
9.1. Introduction
9.2. Advantages of the functionalization of bionanomaterials
9.3. Functionalized green gold nanoparticles
9.4. Functionalized green silver nanostructures
9.5. Functionalized green graphene nanostructures
9.6. Functionalized green zinc oxide (ZnO) nanoparticles
9.7. Functionalized green manganese nanoparticles
9.8. Functionalized green copper and copper oxide nanoparticles
9.9. Other functionalized nanoparticles
9.10. Conclusion and prospects
Chapter 10. Biocompatibility of green synthesized nanomaterials
10.1. Nanotechnology field and green synthesis
10.2. Green synthesized nanomaterials and their main functions
10.3. Nanomaterials and biocompatibility
10.4. Biocompatibility of green synthesized nanomaterials
10.5. Conclusions
10.6. Future perspectives
Chapter 11. Green synthesized nanoparticles in hepatic disorder
11.1. Introduction
11.2. Nanoparticles and green synthesis
11.3. Nanomedicine
11.4. Nanomedicine and the liver
11.5. Hepatic clearance of nanoparticles (NPs)
11.6. Nanomedicines in liver disorders
11.7. Nanotherapeutic strategies for liver diseases
11.8. Traditional concept of nanomedicines and their perspective in the modern era
11.9. Advantages of a nanoparticle drug-delivery system
11.10. Limitations of nanoparticles
11.11. Conclusions and future prospective
Chapter 12. Stability and validation of bionanomaterials
12.1. Introduction
12.2. Bionanomaterials
12.3. Other biocompatible nanomaterials
12.4. Application of bionanomaterials
12.5. Stability and validation of bionanomaterials
12.6. Conclusion
Chapter 13. Green synthesized nanomaterials for bioimaging
13.1. Introduction
13.2. Methods for the synthesis of nanomaterials
13.3. Bioimaging for green synthesis
13.4. Conclusion
Chapter 14. Green synthesized nanomaterials as antiviral substances
14.1. Viruses and their characteristics
14.2. DNA viruses
14.3. RNA viruses
14.4. Reverse transcribing viruses
14.5. Mechanism of viral infections
14.6. Viral diseases
14.7. Available antiviral treatments
14.8. Need for alternative treatments
14.9. Antiviral nanomaterials
14.10. Green nanomaterials as antiviral agents
14.11. Antiviral mechanisms of green nanoparticles
14.12. Antiviral mechanism of green nanomaterials
14.13. Conclusion
Chapter 15. Green synthesized nanomaterials as antioxidant and antiinflammatory substances
15.1. Introduction
15.2. Green synthesis of nanomaterials
15.3. Microorganism-mediated synthesis of nanomaterials
15.4. Bacteria
15.5. Fungi
15.6. Yeast
15.7. Algae
15.8. Viruses
15.9. Plant-mediated synthesis of nanomaterials
15.10. Parameters that affect the synthesis of nanomaterials
15.11. Antioxidants
15.12. Antioxidant functionalized NPs
15.13. Hazardous effects of synthetic antioxidants
15.14. Antiinflammation
15.15. Mechanism of antiinflammatory activity of NPs
15.16. Toxicity of nanoparticles
15.17. Conclusion
Chapter 16. Green synthesized nanomaterials for drug delivery
16.1. Introduction
16.2. Biological components for green synthesis
16.3. Bacteria
16.4. Fungi
16.5. Plants
16.6. Mechanism of green synthesis for metals and their oxide nanoparticles
16.7. Synthesis of gold nanoparticles using plant extracts
16.8. An essential role of plant metabolites in the binding and reduction of metal ions
16.9. Nanoparticles as drug-delivery vehicles
16.10. Silver nanoparticles as drug-delivery vehicles
16.11. Silver nanoparticles with nucleic acids
Chapter 17. Green synthesized nanomaterials for biosensors
17.1. Introduction
17.2. Green (nano)material synthesis
17.3. Green nanomaterials in analytical (bio)sensing
17.4. Industrial applications of (bio)sensing devices
17.5. Conclusion
Chapter 18. Biological applications of plant-derived gold nanoparticles
18.1. Introduction
18.2. Biological methods of nanoparticle synthesis
18.3. Plant-mediated gold nanoparticle synthesis
18.4. Properties of gold nanoparticles
18.5. Applications of gold nanoparticles
18.6. Conclusion
Chapter 19. Harnessing biomedical applications of bionanomaterials through omics approach
19.1. Introduction
19.2. Applications of bionanomaterials in the modern biomedical area
19.3. Obstacles and challenges in designing bionanomaterials
19.4. Harnessing biomedical applications of bionanomaterials through omics approaches
19.5. Nanobioinformatics
19.6. Conclusions
Chapter 20. Biomedical application of anodic nanomaterials
20.1. Introduction
20.2. Synthesis methods of anodic nanomaterials
20.3. Characterization of anodic Ti oxide for biomedical applications
20.4. Advantages and challenges of anodic nanomaterials
20.5. Application of anodic nanomaterials in biomedical devices
20.6. Future of anodic nanomaterials in biomedical application
Chapter 21. Biological applications of green bionanomaterials: diagnosis applications
21.1. Introduction
21.2. Different methods of diagnosis
21.3. Green synthesis of nanomaterials
21.4. Diagnostic application of green synthesized nanomaterials
21.5. Conclusion
Chapter 22. Nanotechnology in agriculture for plant control and as biofertilizer
22.1. Introduction
22.2. Approaches for nanoparticle synthesis
22.3. Classification, characterization, and factors affecting nanoparticles
22.4. Biological synthesis of nanoparticles
22.5. Nanomaterials as smart delivery systems for plant control
22.6. Role of nano- and biofertilizer in agriculture
22.7. Case studies on nanotechnology research activities in the agricultural sector
22.8. Conclusions: new insights into nano- and biofertilizers for sustainable agriculture
Chapter 23. Environmental impacts of nanoparticles: pros, cons, and future prospects
23.1. Introduction
23.2. Emission of nanoparticles
23.3. Legislation
23.4. Environmental pros of nanoparticles
23.5. Environmental cons of nanoparticles
23.6. Conclusion and recommendations
Chapter 24. Green synthesized metallic and nonmetallic nanoparticles and their properties toward different applications and safety improvements
24.1. Introduction
24.2. Literature review
24.3. Copper nanoparticles (CuNPs)
24.4. Gold nanoparticles
24.5. Zinc nanoparticles
24.6. Platinum nanoparticles (PtNPs)
24.7. Palladium nanoparticles
24.8. Inorganic nonmetallic nanparticles and carbon-based nanomaterials titanium dioxide nanoparticles (TIO2)
24.9. Zinc oxide nanoparticles (ZnO)
24.10. Cadmium oxide nanoparticles (CdO)
24.11. Silicon and carbon-based nanomaterials
24.12. Multiwalled carbon nanotubes (MWCNTs)
24.13. Nanoparticles: a safe and sound strategy
24.14. Conclusions
Index

Munir Ozturk

Dr. Munir Ozturk (Ph.D) holds Ph.D. and D.Sc. degrees from the Ege University, Turkiye. He is currently acting as the “Vice President of the Islamic World Academy of Sciences”and is also Fellow of the Islamic World Academy of Science. Dr. Ozturk has been honored as the “Foreign Fellow Pakistan Academy of Science”. He has served at the Ege University-Turkiye for more than 50 years in different positions, has been Founder Director of the Centre for Environmental Studies, Ege University, and Chairman of the Botany Department and Director of the Botanical Garden. Sideritis ozturkii and Verbascum ozturkii are 2 newly recorded endemic plant species from Turkiye in his name. His fields of scientific interest are; pollution & biomonitoring; biosaline agriculture; plant ecophysiology, medicinal and aromatic plants conservation. Dr. Ozturk has published almost 60 books with internationally known publishers including Springer, Elsevier,Taylor & Francis, Wiley and few others. His biodata shows more than 90 book chapters and 200 papers in international journals; 120 with impact factor. He has also presented 125 papers at the International Meetings and 85 at the National Meetings. Dr. Munir has served as a guest editor for more than 13 journals; holds more than 20 Memberships of “Institutions and Professional Bodies”; has been recognized by more than 12 “National and International Bodies”; has received fellowships from the globally recognized Alexander von Humboldt Foundation, Japanese Society for Promotion of Science, and the National Science Foundation of the USA. He has also worked as consultant fellow at the Faculty of Forestry, Universiti Putra Malaysia, Malaysia; and as Distinguished Visiting Scientist at International Centre for Chemical and Biological Sciences, ICCBS-TWAS, Karachi University, Pakistan.

Affiliations and expertise

Professor / Researcher, Ege University, Bornova Izmir, Turkey

Arpita Roy

Dr. Arpita Roy (Ph.D) is working as an Assistant Professor in Sharda University, Greater Noida, India. Her specialization is in plant biotechnology, nanobiotechnology, environmental biotechnology and microbiology. She has been teaching graduate and post graduate students of biotechnology. She has taught topics related to plant biotechnology, microbiology, bioprocess engineering and solid waste management. She has authored more than 50 scientific articles and 18 book chapters from international publishers and edited 2 books. She has presented and participated in numerous state, national and international conferences, seminars, workshops and symposium. She has received the Commendable Research Award for excellence in research during the year 2019 and 2020- DTU. She has served as editorial board member and reviewer of reputed international journals.

Affiliations and expertise

Assistant Professor, Sharda University, Greater Noida, India

Rouf Ahmad Bhat

Dr. Rouf Ahmad Bhat is working in Cluster University Srinagar (J&K), India in the capacity of Assistant Professor and his specialisation is in Limnology, Toxicology, Phyto-chemistry and Phytoremediation. He is an author of more than 53 scientific articles and 35 book chapters, and has published 18 books with international publishers. Dr. Bhat has worked as an Associate Environmental Expert in World Bank funded Flood Recovery Project and also Environmental Support Staff in Asian Development Bank (ADB) funded development projects. He has received many awards, appreciations and recognitions for his services to the science of water testing, air and noise analysis.

Affiliations and expertise

Renowned Researcher and Instructor in Environmental Sciences, Department of School Education, Jammu and Kashmir, India

Fazilet Vardar Sukan

Fazilet Vardar Sukan is Professor in the Faculty of Engineering and Natural Sciences at Sabanci University, Istanbul, Turkey. Her area of research is mass and momentum transfer and scale-up in bioreactors, foaming and its control in bioprocesses, utilization of agro-industrial wastes and surpluses for the production of high added value materials, micro-algal production, and science and technology policies and technology transfer in emerging economies.

Affiliations and expertise

Professor, Faculty of Engineering and Natural Sciences, and Director of Nanotechnology Research and Application Centre, Sabanci University, Istanbul, Turkey

Fernanda Maria Policarpo Tonelli

Dr. Fernanda Maria Policarpo Tonelli (Ph.D) is specialized in biotechnology/molecular biology and has been studying nanomaterials applications such as delivery and remediation. She has worked with engineered viral particles and nanomaterials functionalized by different protocols (gold nanorods, carbon nanotubes, carbon-dots, nanoparticles, nanographene oxide) that resulted in 10 patent applications. She teaches topics related to biochemistry and biotechnology/molecular biology to graduate students as an associate professor at Federal University of São João del Rei. Dr. Tonelli has edited and/or authored 3 books, has reviewed various articles/book proposals, has authored 12 scientific articles and more than 20 book chapters from international publishers. The main topics addressed in the publications are: nanomaterials, gene delivery strategies, remediation strategies and cell signaling. She has presented and participated in numerous national and international conferences and has also had the opportunity to contribute to the organization of various scientific events. Dr. Tonelli has also dedicated herself to promote Science and Technology co-funding an ONG with this purpose and also joining a scientific divulgation group composed only by women. She has had her efforts as a researcher recognized by various awards (including For Women in Science Brazil-L’Oreal/UNESCO/ABC and Under30 Brazil – Forbes) and certificates of merit.

Affiliations and expertise

Professor / Researcher, Federal University of São João del Rei, Minas Gerais, Brazil

Life Sciences

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Synthesis of Bionanomaterials for Biomedical Applications

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Munir Ozturk

Arpita Roy

Rouf Ahmad Bhat

Fazilet Vardar Sukan

Fernanda Maria Policarpo Tonelli

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