Synthesis and Applications of Isotopically-Labelled Compounds
Recent Advances and Emerging Topics
- 1st Edition - September 1, 2025
- Imprint: Elsevier
- Editor: David Hesk
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 9 1 5 4 - 1
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 5 3 5 6 - 3
Synthesis and Applications of Isotopically-Labelled Compounds: Recent Advances and Emerging Topics reviews recent advances in the field of tritium, carbon-14, and stable isotop… Read more
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Request a sales quoteSynthesis and Applications of Isotopically-Labelled Compounds: Recent Advances and Emerging Topics reviews recent advances in the field of tritium, carbon-14, and stable isotope compound synthesis along with their analysis. The emerging field of the development of deuterated pharmaceuticals is also discussed, along with the application of isotopically labelled compounds in drug metabolism studies. There book presents a comprehensive guide to the field for the community, as well as newcomers, interested parties, or collaborators who need to be able to communicate with labeling groups. This book fills this gap and provides a "one-stop shop" by having a comprehensive review of recent developments. Sections cover analytical chemistry in depth and include new sections on methods of stable isotope analysis. Analytical chemistry aspects of these specific areas are also covered.
- Provides a complete review of the synthesis of isotopically labelled compounds in a single volume
- Reviews the emerging field of deuterated pharmaceuticals as therapeutics
- Covers recent advances in the field of tritium, carbon-14, and stable isotope compound synthesis
Analytical and synthetic organic chemists who are involved in the synthesis, purification, and analysis of isotopically labelled compounds. These chemists will be located primarily in the pharmaceutical industry, but there will be a significant portion from academia. Users of isotopically labelled compounds in fields such as drug metabolism and reaction mechanism studies will also find this book useful. Furthermore, a review of the emerging field of deuterated pharmaceuticals will be of interest
1. General Introduction
2. Recent advances in tritium chemistry
3. Recent advances in carbon-14 chemistry
4. Recent advances in the chemistry of PET and SPECT isotopes
5. Recent advances in the chemistry of stable isotopes
6. Preclinical and clinical studies of pharmaceuticals supported by labelled compounds
7. Non pharmaceutical applications of labelled compounds
8. Emerging new fields in the chemistry of isotopes and their application
9. Deuterated APIs
10. Recent advances in the analysis of isotopically labelled compounds
11. Radiolabeling of large molecules
12. Summary and outlook
2. Recent advances in tritium chemistry
3. Recent advances in carbon-14 chemistry
4. Recent advances in the chemistry of PET and SPECT isotopes
5. Recent advances in the chemistry of stable isotopes
6. Preclinical and clinical studies of pharmaceuticals supported by labelled compounds
7. Non pharmaceutical applications of labelled compounds
8. Emerging new fields in the chemistry of isotopes and their application
9. Deuterated APIs
10. Recent advances in the analysis of isotopically labelled compounds
11. Radiolabeling of large molecules
12. Summary and outlook
- Edition: 1
- Published: September 1, 2025
- No. of pages (Paperback): 250
- Imprint: Elsevier
- Language: English
- Paperback ISBN: 9780443191541
- eBook ISBN: 9780443153563
DH
David Hesk
David Hesk is Director of Radiochemistry in the Center for Drug Discovery at RTI International. After obtaining his Ph.D. studying hydrogen isotope exchange chemistry under the direction of Professor J.R. Jones, Dr. Hesk worked for 27 years in the Radiochemistry and Labeled Compound Synthesis groups at Schering-Plough and Merck where he was responsible for the synthesis, purification, and analysis of isotopically labelled compounds in support of pharmaceutical research. There he maintained his interest in hydrogen isotope exchange labelling (HIE) and published the first example of the application of Crabtree’s catalyst in HIE in 1995.
Affiliations and expertise
Director, Chemistry, Center for Drug Discovery, USA