Synthesis and Applications of Isotopically-Labelled Compounds
Recent Advances and Emerging Topics
- 1st Edition - September 1, 2025
- Imprint: Elsevier
- Editor: David Hesk
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 9 1 5 4 - 1
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 5 3 5 6 - 3
Synthesis and Applications of Isotopically-Labelled Compounds: Recent Advances and Emerging Topics delves into the transformative developments in isotopic labelling, a crucia… Read more
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Synthesis and Applications of Isotopically-Labelled Compounds: Recent Advances and Emerging Topics delves into the transformative developments in isotopic labelling, a crucial field underpinning advancements in chemistry, biology, and medicine. The book emphasizes innovative methodologies for synthesizing compounds labelled with isotopes such as tritium, carbon-14, and various stable isotopes. It also discusses the tools and technologies refined over recent years to enhance analytical precision in their study. By combining theory with practical applications, it serves as an invaluable resource for researchers and professionals seeking deeper insights into isotopic synthesis and utilization.
Additionally, the book explores emerging topics, including novel applications in drug development, environmental tracing, and biochemical research. It integrates findings that push the boundaries of isotopic analysis, offering perspectives on future trends and challenges in the field.
Additionally, the book explores emerging topics, including novel applications in drug development, environmental tracing, and biochemical research. It integrates findings that push the boundaries of isotopic analysis, offering perspectives on future trends and challenges in the field.
- Provides a complete review of the synthesis of isotopically labelled compounds
- Reviews the emerging field of deuterated pharmaceuticals as therapeutics
- Covers recent advances in the field of tritium, carbon-14, and stable isotope compound synthesis
Analytical and synthetic organic chemists who are involved in the synthesis, purification, and analysis of isotopically labelled compounds. These chemists will be located primarily in the pharmaceutical industry, but there will be a significant portion from academia. Users of isotopically labelled compounds in fields such as drug metabolism and reaction mechanism studies will also find this book useful. Furthermore, a review of the emerging field of deuterated pharmaceuticals will be of interest
1. General Introduction
2. Recent advances in tritium chemistry
3. Recent advances in carbon-14 chemistry
4. Recent advances in the chemistry of PET and SPECT isotopes
5. Recent advances in the chemistry of stable isotopes
6. Preclinical and clinical studies of pharmaceuticals supported by labelled compounds
7. Non pharmaceutical applications of labelled compounds
8. Emerging new fields in the chemistry of isotopes and their application
9. Deuterated APIs
10. Recent advances in the analysis of isotopically labelled compounds
11. Radiolabeling of large molecules
12. Summary and outlook
2. Recent advances in tritium chemistry
3. Recent advances in carbon-14 chemistry
4. Recent advances in the chemistry of PET and SPECT isotopes
5. Recent advances in the chemistry of stable isotopes
6. Preclinical and clinical studies of pharmaceuticals supported by labelled compounds
7. Non pharmaceutical applications of labelled compounds
8. Emerging new fields in the chemistry of isotopes and their application
9. Deuterated APIs
10. Recent advances in the analysis of isotopically labelled compounds
11. Radiolabeling of large molecules
12. Summary and outlook
- Edition: 1
- Published: September 1, 2025
- Imprint: Elsevier
- Language: English
DH
David Hesk
David Hesk is Director of Radiochemistry in the Center for Drug Discovery at RTI International. After obtaining his Ph.D. studying hydrogen isotope exchange chemistry under the direction of Professor J.R. Jones, Dr. Hesk worked for 27 years in the Radiochemistry and Labeled Compound Synthesis groups at Schering-Plough and Merck where he was responsible for the synthesis, purification, and analysis of isotopically labelled compounds in support of pharmaceutical research. There he maintained his interest in hydrogen isotope exchange labelling (HIE) and published the first example of the application of Crabtree’s catalyst in HIE in 1995.
Affiliations and expertise
Director, Chemistry, Center for Drug Discovery, USA