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Books in Pharmacology

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mRNA Therapeutics

  • 1st Edition
  • Anya Hillery
  • Anya Hillery
  • September 1, 2024
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 2 8 9 3 4 - 7
  • eBook
    9 7 8 - 0 - 4 4 3 - 2 8 9 3 5 - 4
mRNA Therapeutics: Fundamentals and Applications summarizes the scientific development of mRNA vaccines that have revolutionized the way we treat disease. These vaccines work by delivering instructions to our cells to produce proteins, which then trigger an immune response. This approach has the potential to treat a wide range of diseases, including COVID-19, cancer, and infectious diseases. The first section of the book introduces mRNA vaccines, including their history, mechanism of action, and potential applications. The second section delves into the science of mRNA vaccines, covering topics such as the structure of mRNA, the delivery of mRNA to cells, and the immune response to mRNA vaccines. The third section discusses the future of mRNA technology, exploring potential applications such as cancer therapy, prevention of infectious diseases, and replacement of missing or damaged proteins. mRNA Therapeutics: Fundamentals and Applications is a valuable resource for scientists, researchers, and clinicians who are interested in the latest developments in mRNA technology. It is also a useful reference for students and professionals who are working in the fields of biotechnology, pharmaceutical science, and vaccine development.
mRNA Therapeutics

The Discovery of New Medicines in Academia

  • 1st Edition
  • Volume 100
  • Diane Peters + 1 more
  • Diane Peters and Barbara S. Slusher
  • August 1, 2024
  • English
  • Hardback
    9 7 8 - 0 - 4 4 3 - 2 9 3 2 4 - 5
  • eBook
    9 7 8 - 0 - 4 4 3 - 2 9 3 2 5 - 2
The Discovery of New Medicines in Academia, Volume 100 highlight examples of discoveries originating in academia that have been successfully translated into promising therapeutics that have advanced into clinical trials. Chapters in this release cover Design and Discovery of Itaconate prodrugs for Alopecia Areata, Hydroxyl-Dendrimer Delivery System for Neurological Disease, Development of allosteric modulators of G protein-coupled receptors for Psychiatric Disease, Targeting the constitutively active ERK1/2 signaling kinase for cancer, mRNA reprogramming of myeloid cells for tumor immunotherapy, Development of novel drugs targeting protein-protein interactions, and much more.Additional sections cover Neuro-steroids and analogs for the treatment of epilepsy, Development of inhibitors of eukaryotic translation, Discovery/development of antiviral, anticancer and/or anti-inflammatory agents, Discovery of novel anti-infective agents, Targeting proliferating cell nuclear antigen (PCNA) for cancer, and Implementation and Evolution of Quantitative Systems Pharmacology to Patient Digital Twins and Biomimetic Twins.
The Discovery of New Medicines in Academia

TRP Channels as Therapeutic Targets

  • 2nd Edition
  • Arpad Szallasi
  • Arpad Szallasi
  • July 1, 2024
  • English
  • Hardback
    9 7 8 - 0 - 4 4 3 - 1 8 6 5 3 - 0
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 8 6 5 4 - 7
TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use, Second Edition is a comprehensive reference on the roles of TRP Channels in health and disease states. Chapters are completely updated, withe new topics on TRP channels biology, the crystalline structure of TRP channels, targeting TRP channels for pain relief, the relationship with migraine, emerging pain targets, a comprehensive view of the role of TRP channels in respiratory diseases and COVID complications, anxiety relief, renal disease, arthritis, and therapeutic opportunities for thermal regulation. This is a great reference for broad segments of the scientific and medical community. Researchers working on TRP channel drug discovery will benefit from the overview of applications to conditions in specific organ systems. Clinicians interested in new drugs in the pipeline will also find this book helpful for biologic principles of action.
TRP Channels as Therapeutic Targets

Quality Assurance Management

  • 1st Edition
  • Gayathri De Lanerolle, Evette Sebastien Roberts + 2 more
  • Gayathri De Lanerolle, Evette Sebastien Roberts, Athar Haroon + 1 more
  • June 1, 2024
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 2 2 7 3 2 - 9
  • eBook
    9 7 8 - 0 - 1 2 - 8 2 2 7 3 3 - 6
Quality Assurance Management: A Comprehensive Overview of Real-World Applications for High Risk Specialties demonstrates how to best design and implement standard operating procedures (SOPs) to ensure protocol and regulation adherence. The book showcases similarities and differences between healthcare and academic quality assurance systems, resulting in counter-productivity and performance issues, in addition to regulatory inspection preparedness. It uses the processes and standards of the UK to demonstrate how to combine QA and research building into ‘building blocks’ that share a common pathway for effective project design, analysis and unbiased interpretation of collated data.This book fills a gap, providing original research in QA that especially focuses on specialist areas. It will be of use to research and clinical staff working in clinical research within healthcare, academia and industry.
Quality Assurance Management

Essentials of Translational Pediatric Drug Development

  • 1st Edition
  • Elke Gasthuys, Karel Allegaert + 2 more
  • Elke Gasthuys, Karel Allegaert, Lien Dossche + 1 more
  • June 1, 2024
  • English
  • Paperback
    9 7 8 - 0 - 3 2 3 - 8 8 4 5 9 - 4
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 0 4 2 9 - 2
Essentials of Translational Pediatric Drug Development: From Past Needs to Future Opportunities provides integrated and up-to-date insights relevant for both translational researchers and clinicians active in the field of pediatric drug development. The book covers all key aspects from different stakeholder perspectives, providing a literature overview and careful reflection on state-of-the-art approaches. It will be an ideal guide for researchers in the field who are designing and performing high quality, innovative pediatric-adapted drug development by helping them define needs/challenges and possible solutions that advance and harmonize pediatric drug development.Despite the broad consensus that children merit the same quality of drug treatment as any other age group, children remain frequently neglected during drug research and development. Even with the adoption of multiple legislations addressing this problem, the lack of efficacy and safety data of marketed as well as newly developed drugs still remain in the pediatric population.
Essentials of Translational Pediatric Drug Development

The Diagnosis and Treatment of Protozoan Diseases

  • 1st Edition
  • Tarun Kumar Bhatt
  • Tarun Kumar Bhatt
  • June 1, 2024
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 1 9 1 6 1 - 9
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 5 2 4 5 - 0
The Diagnosis and Treatment of Protozoan Diseases discusses major protozoan diseases such as Malaria, Leishmaniasis, etc., including other clinically minor protozoan diseases. This book provides all essential information to professional researchers and medical personnel about the disease, causative organism, and their lifecycle, diagnostics, and treatments, including drugs and vaccine, resistance, and key points of future research. Infectious diseases are accountable for millions of deaths every year throughout the globe. Among them, significant contributors are protozoan parasites.Despite the many research group working on the various protozoan diseases, there are still major gaps to fill. The authors of this book have critically reviewed all the aspects of major protozoan diseases, their diagnostics, and treatments, including resistance.
The Diagnosis and Treatment of Protozoan Diseases

Planning, Writing and Reviewing Medical Device Clinical and Performance Evaluation Reports (CERs/PERs)

  • 1st Edition
  • Joy Frestedt
  • Joy Frestedt
  • June 1, 2024
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 2 2 0 6 3 - 0
  • eBook
    9 7 8 - 0 - 4 4 3 - 2 2 0 6 4 - 7
A Practical Guide to Planning, Writing, and Reviewing Medical Device Clinical Evaluation Reports guides readers through clinical data evaluation of medical devices that is in compliance with the EU MDR requirements and other similar regulatory requirements throughout the world. This book brings together knowledge learned as the author constructed hundreds of CERs and taught thousands of learners on how to conduct clinical data evaluations. This book will support training for clinical engineers, clinical evaluation scientists, and experts reviewing medical device CERs, and will help individual writers, teams and companies to develop stronger, more robust CERs.
Planning, Writing and Reviewing Medical Device Clinical and Performance Evaluation Reports (CERs/PERs)

Progress and Prospect of Nanocarriers

  • 1st Edition
  • Sushil K. Kashaw, Samaresh Sau + 1 more
  • Sushil K. Kashaw, Samaresh Sau and Arun Iyer
  • May 1, 2024
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 1 9 9 7 9 - 4
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 0 3 1 1 - 0
Progress and Prospect of Nanocarriers: Design, Concept, and Recent Advances examines the different nanocarriers that are currently being developed for specific applications in biomedical drug delivery, disease management, diagnosis and therapy. Nanosized drug delivery systems have gained tremendous amounts of clinical interest due to their effective bio-distribution and enhanced pharmacokinetic and selective targeting capability which results in high therapeutic potential, low side effects, and the generation of cost-effective drug delivery systems. Numerous effective nanocarriers have been evolving, including polymeric nanoparticles, liposomes, microspheres, dendrimers, and carbon nanotubes.This book is a helpful reference for scientists and students in the fields of drug delivery, biomaterials and nanomedicine, as well as scientists and engineers in industrial disciplines of drug delivery and drug formulation.
Progress and Prospect of Nanocarriers

Human Microbiome Drug Targets

  • 1st Edition
  • Genevieve Dable-Tupas, Rohini Karunakaran + 2 more
  • Genevieve Dable-Tupas, Rohini Karunakaran, Peter Paul C Lim + 1 more
  • April 1, 2024
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 1 5 4 3 5 - 5
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 5 4 3 6 - 2
Human Microbiome Drug Targets: Modern Approaches in Disease Management presents fundamental information on the human microbiome, looking into the relationship between the microbiome and how it changes with specific diseases. Delving into the multifaceted roles of the microbiome in health and disease, the book's chapters discuss the role of the human microbiome in the pathophysiologic understanding of relevant diseases or disorders and their management. As changes in the human microbiome can provide clues to the probable cause and effect of diseases or disorders, as well as the impacts of therapy or intervention, this book is a welcomed addition to the existing research.Explaining how a better understanding of the microbiome and its impact on health and disease can pave the way for future discoveries leading to better health outcomes, this book will be of interest to drug developers, medicinal chemists, microbiologists, infectious disease specialists, biochemists, and students.
Human Microbiome Drug Targets

Advancement of Phenolic Acids in Drug Discovery

  • 1st Edition
  • Naresh Kumar, Nidhi Goel + 1 more
  • Naresh Kumar, Nidhi Goel and Jesus Simal Gandara
  • April 1, 2024
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 1 8 5 3 8 - 0
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 8 5 3 9 - 7
Advancement of Phenolic Acids in Drug Discovery: Fundamental and Applications offers comprehensive coverage of the ADMET profiles of phenolic acids, their extraction method and prospects for drug design and development. Chapters overview phenolic acids and their characterization, discuss the role of phenolic acids in plant systems, present sources and detailed extraction methods of phenolic acids, and cover phenolic acid mechanisms of action as it relates to several key diseases and health conditions, including their role as antioxidant agents, anti-inflammatory and analgesic drugs, anti-microbial drugs, anti-viral drugs, anti-cancer drugs, diabetes and metabolic dysfunctions, neurological disorders, cardiovascular diseases. The book’s final chapters cover nanoscience aspects of phenolic acids, biomedical applications, and concludes with challenges and opportunities presented by phenolic acids. This is the ideal reference for researchers in the fields of drug development, both in academia and corporate settings. Researchers of related areas like food science and medicinal chemistry will also benefit from this in-depth profiling of therapeutical properties of phenolic acids.
Advancement of Phenolic Acids in Drug Discovery