Books in Pharmaceutical sciences

431-440 of 465 results in All results

Advances in Medicinal Chemistry

1st Edition
Volume 4
April 1, 1999
B.E. Maryanoff + 1 more
English
Hardback
9 7 8 - 0 - 7 6 2 3 - 0 0 6 4 - 8
eBook
9 7 8 - 0 - 0 8 - 0 5 2 6 3 7 - 9

Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol® (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers.

Medical Applications of Liposomes

1st Edition
July 22, 1998
D.D. Lasic + 1 more
English
Hardback
9 7 8 - 0 - 4 4 4 - 8 2 9 1 7 - 7
eBook
9 7 8 - 0 - 0 8 - 0 5 3 6 0 8 - 8

The development of liposomes as a drug delivery system has fluctuated since its introduction in the late 1960's by A.D. Bangham. While academic research of liposomes as a model membrane system has always flourished, as the exponential growth of papers can testify, the application of these findings to medically useful products has gone through several crises. Following the original optimism in the 70's and early 80's, a period of severe skepticism ensued at the end of the 80's and beginning of the 90's, culminating in a moderate but real optimism in the mid 90's, as a result of a successful launch of the first products in the US and Europe.In this collection of papers, the editors have gathered the most promising ideas, approaches, applications and commercial developments, thereby presenting an up-to-date compilation of the present status of the field. This includes such broad areas as anti-cancer chemotherapy immune stimulation and infectious diseases. Currently, the major areas of progress are in delivery of anti-fungal agents by conventional liposomes or lipid-based carriers and systemic anticancer therapy using long-circulating liposomes. The future applications as characterized by the direction of present day research is in specific targeting and delivery of informational molecules such as DNA plasmids (genes), antisense oligonucleotides or ribozymes. Other future developments may be in topical delivery, vaccination and in diagnostics.Features of this book:• Contributions from almost all the leading labs in the field• Up-to-date, critical reviews bridged by editors' introductions• Organized into a logical framework.

Analytical Profiles of Drug Substances and Excipients

1st Edition
Volume 25
March 2, 1998
Harry G. Brittain
English
Hardback
9 7 8 - 0 - 1 2 - 2 6 0 8 2 5 - 4
eBook
9 7 8 - 0 - 0 8 - 0 8 6 1 2 0 - 3

Although the official compendia define a drug substance as to identity, purity, strength, and quality, they normally do not provide other physical or chemical data, nor do they list methods of synthesis or pathways of physical or biological degradation and metabolism. Such information is scattered throughout the scientific literature and the files of pharmaceutical laboratories. Edited by the Associate Director of Analytical Research and Development for the American Association of Pharmaceutical Scientists, Analytical Profiles of Drug Substances and Excipients brings this information together into one source. The scope of the series has recently been expanded to include profiles of excipient materials.

The Many Faces of RNA

1st Edition
December 19, 1997
D. S. Eggleston + 2 more
English
Hardback
9 7 8 - 0 - 1 2 - 2 3 3 2 1 0 - 4
eBook
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The Many Faces of RNA is the subject for the eighth SmithKline Beecham Pharmaceuticals Research Symposia. It highlights a rapidly developing area of scientific investigation. The style and format are deliberately designed to promote in-depth presentations and discussions and to facilitate the forging of collaborations between academic and industrial partners.This symposium focuses on several of the many fundamental, advancing strategies for exploring RNA and its functions. It emphasizes the interplay between biology, chemistry, genomics, and molecular biology which is leading to exciting new insights and avenues of investigation. The book explores RNA as a therapeutic target, RNA as a tool, RNA and its interactions, along with chemical, computational, and structural investigations.

Stable Isotopes in Pharmaceutical Research

1st Edition
Volume 26
December 18, 1997
T.R. Browne
English
Hardback
9 7 8 - 0 - 4 4 4 - 8 1 9 4 1 - 3

Stable isotope techniques offer advantages in safety, sensitivity, specificity, and economy for many types of pharmaceutical investigations when compared to conventional techniques. Nevertheless, pharmaceutical researchers are slow to embrace stable isotope techniques.This book assembles in one place comprehensive reviews of the many applications of stable isotopes and the background material necessary to understand the application. This approach is a deliberate attempt to encourage the usage of stable isotopes in pharmaceutical research. A bonus to the reader is the high standard of contributions from a very talented and diverse group of investigators.

Drug-Drug Interactions: Scientific and Regulatory Perspectives

1st Edition
Volume 43
October 2, 1997
Albert Li + 4 more
English
Hardback
9 7 8 - 0 - 1 2 - 0 3 2 9 4 4 - 1
eBook
9 7 8 - 0 - 0 8 - 0 5 8 1 3 5 - 4

Drug–Drug Interactions is a comprehensive review of the scientific and regulatory perspectives of drug–drug interactions from the point-of-view of academia, industry, and government regulatory agencies. This book is intended for professionals in the pharmaceutical industry, health care, and governmental regulatory agencies. Topics of interest include the mechanistic understanding of drug–drug interactions, the prediction of drug–drug interaction potential of new drugs, and the avoidance of clinically significant drug–drug interaction in patients.

Advances in Drug Research

1st Edition
Volume 29
July 21, 1997
Bernard Testa + 1 more
English
eBook
9 7 8 - 0 - 0 8 - 0 5 2 6 7 2 - 0

This volume continues the trend for Advances in Drug Research of shorter, but more frequent volumes. In line with the tradition of the series, chapters on general themes are interspersed with chapters on specific drug classes and targets.

Serotonin Receptors and their Ligands

1st Edition
Volume 27
July 10, 1997
B. Olivier + 2 more
English
eBook
9 7 8 - 0 - 0 8 - 0 5 4 1 1 1 - 2

An international group of authors have produced an overview of the progress made in the medicinal chemistry of compounds (selectively) acting at serotonin receptors or serotonin transporters either as agonists, partial agonists or antagonists.Structure - affinity relationships and structure - activity relationships of agonists, partial agonists, and antagonists of 5-HT receptors and uptake sites, are discussed. Structure, sequence homology and the effect of site-directed mutations of 5-HT receptors and the reuptake site on the binding of ligands show the tremendous impact of molecular biology on medicinal chemistry research. Also discussed is the pharmacology and (potential) clinical applications of ligands for the 5-HT receptors and the reuptake site. By developing elegant techniques of cloning and expression of serotonin receptor subtypes, their mutants and chimeras, a unique opportunity was offered to study the binding mode of serotoninergic ligands to their receptors and transporters.The distribution, structure and homologies of serotonin receptor subtypes and the structure of the serotonin transporter are also taken into account.The (potential) therapeutic applications of ligands of the different subtypes are described.Altogether an excellent addition to the Pharmacochemical Library series.

Approaches to Design and Synthesis of Antiparasitic Drugs

1st Edition
Volume 25
July 10, 1997
N. Anand + 1 more
English
Hardback
9 7 8 - 0 - 4 4 4 - 8 9 4 7 6 - 2
eBook
9 7 8 - 0 - 0 8 - 0 5 2 7 5 2 - 9

This book presents a comprehensive and up to date account of the chemotherapy of parasitic diseases, both human and veterinary. The book starts with an overview of parasitic diseases. The body of the book is divided into two parts: antihelminthic drugs, and antiprotozoal drugs. Both parts start with chapters highlighting the 'biochemical targets' available for chemotherapeutic interference. Individual chapters deal with one chemical class of compounds and describe their origin, structure-activity relationship, mode of action, and methods of synthesis and their status both in clinical and veterinary practice. The book will be useful to a wide spectrum of readers: students embarking on a research career in parasitic chemotherapy, clinicians (and veterinarians) and clinical pharmacologists desiring detailed information about the drugs currently in use, and pharmaceutical technologists wanting to update their knowledge of the methods of manufacture.

Side Effects of Drugs Annual

1st Edition
Volume 19
December 12, 1996
C.J. van Boxtel + 1 more
English
Hardback
9 7 8 - 0 - 4 4 4 - 8 2 5 3 1 - 5

The very latest information on adverse drug effects from the international literature, compiled by an international team of experts.New reports are presented of adverse drug effects, critically analysed in context, in terms of clinical relevance and importance, and cross-referring to previous reports where necessary. New adverse effects are reported and evaluated, and previously reported adverse effects are re-evaluated in the light of the most recent information.Unique features:Reviews in which selected adverse effects are discussed in depth.Two separate indexes enhance the use of the book, allowing the reader to access information by drug name or by, adverse effects.