Structure and Function of the Extracellular Matrix
A Multiscale Quantitative Approach
- 1st Edition - November 27, 2021
- Imprint: Academic Press
- Author: Bela Suki
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 1 9 7 1 6 - 5
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 2 6 0 5 - 6
Structure and Function of the Extracellular Matrix: A Multiscale Quantitative Approach introduces biomechanics and biophysics with applications to understand the biologica… Read more
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Request a sales quoteStructure and Function of the Extracellular Matrix: A Multiscale Quantitative Approach introduces biomechanics and biophysics with applications to understand the biological function of the extracellular matrix in health and disease. A general multiscale approach is followed by investigating behavior from the scale of single molecules, through fibrils and fibers, to tissues of various organ systems. Through mathematical models and structural information, quantitative description of the extracellular matrix function is derived with tissue specific details. The book introduces the properties and organization of extracellular matrix components and quantitative models of the matrix, and guides the reader through predicting functional properties.
This book integrates evolutionary biology with multiscale structure to quantitatively understand the function of the extracellular matrix. This approach allows a fresh look into normal functioning as well as the pathological alterations of the extracellular matrix. Professor Suki’s book is written to be useful to undergraduates, graduate students, and researchers interested in the quantitative aspects of the extracellular matrix. Researchers working in mechanotransduction, respiratory and cardiovascular mechanics, and multiscale biomechanics of tendon, cartilage, skin, and bone may also be interested in this book.
- Examines the evolutionary origins and consequences of the extracellular matrix
- Delivers the first book to quantitatively treat the extracellular matrix as a multiscale system
- Presents problems and a set of computational laboratory projects in various chapters to aid teaching and learning
- Provides an introduction to the properties and organization of the extracellular matrix components
Upper level undergraduates, graduate students, post-doctoral fellows, and researchers working in the general area of mechanotransduction, respiratory and cardiovascular mechanics, and multiscale biomechanics of tendon, cartilage, skin and bone
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Preface
- Definition of symbols
- Chapter 1
- Chapter 2
- Chapter 3
- Chapter 4
- Chapter 5
- Chapter 6
- Chapter 7
- Chapter 8
- Chapter 9
- Chapter 10
- Chapter 1: Introduction to structure-function relationships
- Abstract
- What is structure?
- What is function?
- What are structure-function relations?
- The multiscale nature of structure-function relations
- Evolutionary aspects
- Implications for science and medicine
- References
- Chapter 2: Extracellular matrix background material: Building blocks, general structure, mechanics, relation to cells, and evolutionary aspects
- Abstract
- The building blocks and the structure of proteins
- General properties and organization of the ECM
- Mechanical forces, stresses, and stiffness
- Relation of the ECM to cells
- ECM and evolution
- References
- Chapter 3: The collagen molecule
- Abstract
- Collagen classification
- A brief evolutionary history of the collagen family
- Structure of the collagen molecule
- Biosynthesis
- Collagen functions
- Collagen binding properties
- Collagen elasticity
- Polymer-based modeling: The mechanical properties of the molecule
- Structural models of the collagen molecule
- Effects of mutations on molecular structure and function
- References
- Chapter 4: Collagen supramolecular structures: Evolution, organization, and biogenesis
- Abstract
- Evolution of the fibril and the diversification of the collagen family
- Multiscale nature of fibril structure
- Network structure of type IV collagen
- Fibril formation
- Modeling fibril growth
- References
- Chapter 5: Collagen suprastructures: The data and the models
- Abstract
- Structure and function of type IV collagen networks
- Quantitative analysis of structure-function relations in the glomerular basement membrane of the kidney
- Structure-function of elastic networks from the point of view of percolation: Implications for tissue engineering
- Microscopic structure-function relations of the collagen fibril
- Multiscale mechanical properties of the collagen fibril: The data
- Modeling fibril function: From simple to complex
- Is fibril viscoelasticity a signature of hidden complexity?
- References
- Chapter 6: Selected examples of tissue-level collagen suprastructures: Tendon, bone, and skin
- Abstract
- Basic structure and function of the tendon
- Modeling the recruitment of wavy fibrils during tendon stretching
- Modeling tendon rupture
- A brief introduction to the evolutionarily shaped structure and function of the bone
- Examples of multiscale structure-function relation in bones
- The evolution and basic function of the skin
- Multiscale mechanics and tear resistance of the skin
- A note on the biological significance of recruitment
- References
- Chapter 7: Small leucine-rich proteoglycans: The tiny controllers of the extracellular matrix
- Abstract
- Basic structure and evolution of SLRPs
- Biological functions of SLRPs
- The PG interaction network
- Physiological functions of SLRPs
- Influence of GAGs on lung parenchymal mechanics
- Summary
- References
- Chapter 8: Hyaluronan and hyalectans: The good, the bad, and the ugly
- Abstract
- Evolutionary history
- The structure of the HA-hyalectan aggregate
- Binding and molecular to cellular functions
- Microscale physiological functions
- Structure and function of the endothelial glycocalyx
- Physiological functions
- The bad and the ugly
- Summary
- References
- Chapter 9: Elastic fibers: The near ideal linear springs of the extracellular matrix
- Abstract
- Evolution of elastin
- The tropoelastin gene structure
- Structure, disorder, and aggregation
- Mechanical properties of tropoelastin
- Microfibrils
- Elastogenesis: How to build a network of elastic fibers
- Elastic fibers: Are they ideal linear springs?
- A brief summary on organ-level function and its breakdown
- Final notes on the near ideal spring
- References
- Chapter 10: Modeling maintenance and repair: The matrix loaded
- Abstract
- Evolution of homeostasis and repair
- A continuum approach to ECM growth and remodeling
- Dynamics of homeostasis and structural remodeling
- Fluctuation-driven homeostasis
- A toy model of self-healing
- Agent-based modeling: The network paradigm
- The uninvited aging: Maintenance and repair slipping out of control
- What have we learned?
- References
- Chapter 11: Outlook
- Index
- Edition: 1
- Published: November 27, 2021
- Imprint: Academic Press
- No. of pages: 282
- Language: English
- Paperback ISBN: 9780128197165
- eBook ISBN: 9780128226056
BS
Bela Suki
He earned an MS in physics (1982) and PhD in biomechanics and respiratory physiology (1987). He is now a professor of Biomedical Engineering at Boston University. Over the last 3 decades, he has worked in various areas of the life sciences including respiratory and vascular physiology and biomechanics, cell and tissue mechanics, computational fluid and solid mechanics applied to various physiological problems and complexity in physiology and biology. He has published over 230 papers, reviews and book chapters. He developed 3 relevant courses: 1) Structure and function of the extracellular matrix (BE 549); 2) Respiratory and cardiovascular engineering (BE 508); and 3) Nonlinear systems in biomedical engineering (BE 567).
Affiliations and expertise
Professor of Biomedical Engineering, Department of Biomedical Engineering, Boston University, USARead Structure and Function of the Extracellular Matrix on ScienceDirect