Stress: Immunology and Inflammation
Handbook of Stress Series Volume 5
- 1st Edition - August 22, 2023
- Editor: George Fink
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 1 7 5 5 8 - 3
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 1 7 5 5 9 - 0
Volume Five in the Handbook of Stress series offers comprehensive cover of the interactions between stress, the immune system, immune responses, and Inflammation. The volume provi… Read more
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Request a sales quoteVolume Five in the Handbook of Stress series offers comprehensive cover of the interactions between stress, the immune system, immune responses, and Inflammation. The volume provides easy and in-depth access to these themes, both for research and clinical practice.
There have been significant advances in our understanding of the interaction of stress, inflammation and the immune response to viral, bacterial and other challenges. Integrated closely with new behavioral findings and relevant to human conditions, this volume offers readers cutting-edge information of prime interest for neuroscientists, psychiatrists, neurologists, neuroendocrinologists, endocrinologists immunologists and general physicians, and researchers, and students, in similar and related themes.
The Handbook of Stress series, comprised of self-contained volumes that each focus on a specific stress area, covers the significant advances made since the publication of Elsevier’s Encyclopedia of Stress (2000 and 2007). Volume 5 is ideal for graduate students, post-doctoral fellows, faculty, and clinicians interested in the interactions between stress, the immune system and inflammation.
- Articles carefully selected by eminent stress researchers and prepared by contributors representing outstanding scholarship in the field, with each chapter fully vetted for reliable expert knowledge
- Richly illustrated with explanatory figures and tables
- Each chapter includes a boxed “Key points” call out section
- The volume is fully indexed
- All chapters are electronically available via ScienceDirect
- Affordably priced, self-contained volume for readers specifically interested in the interaction between stress inflammation and the immune response, obviating the need to purchase the whole Handbook series
Neuroscientists, neuroendocrinologists, neurologists, neuroimmunologists, and researchers, graduate students, undergraduates, and post-doctoral fellows in neuroscience, psychology and the biomedical sciences
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- References
- Acknowledgments
- Chapter 1: Toward identifying individual stress susceptibility
- Abstract
- Key points
- Introduction
- Defining sources of psychological stress in our society
- Clinical impact of excessive stress on health
- Impact of excessive stress on immune parameters
- Genetic variations in immune responses
- Genetic variations in immune response affected by various stressors
- Impact of psychiatric conditions characterized by excessive stress
- Proposed approach to Identifying stress susceptibility
- Future directions
- References
- Chapter 2: Plant immune system: Mechanisms and resilience
- Abstract
- Acknowledgments
- Introduction
- Plant-pathogen interactions and signatures of plant immunity
- The machinery of plant pathogen recognition
- Receptor-like kinases and receptor-like proteins
- RLKs and RLPs involved in plant immunity
- Pathogen effector’s potential to manipulate RLP and RLK signaling
- Salicylic acid–mediated defense networks for plant immunity
- The nonexpression of pathogenesis-related genes (NPR1) dependent and independent pathways
- Conclusions
- References
- Chapter 3: Effects of stress on immune cell distribution
- Abstract
- Acknowledgments
- Introduction
- Stress
- The immune system
- Stress-induced changes in blood leukocyte numbers
- Hormones mediating a stress-induced decrease in blood leukocyte numbers
- A stress-induced decrease in blood leukocyte numbers represents a redistribution rather than a destruction or net loss of blood leukocytes
- Target organs of a stress-induced redistribution of blood leukocytes
- Stress-induced redistribution of blood leukocytes: Molecular mechanisms
- Stress-induced redistribution of blood leukocytes: Functional implications
- Conclusion
- References
- Chapter 4: Stress-induced enhancement of immune function
- Abstract
- Acknowledgments
- Introduction
- Stress
- The immune system
- General assumption: Stress suppresses immune function and is detrimental for health—Reasons for modifying this general assumption
- Studies showing stress-induced enhancement of immune function
- Functional implications
- Clinical implications
- The stress spectrum
- Conclusion
- References
- Chapter 5: Immune suppression
- Abstract
- Summary
- Cell-mediated immune
- Humoral immune
- Metabolic—Hormonal: Sterol family
- Neural
- Conclusion
- References
- Chapter 6: SARS-CoV-2 immune suppression
- Abstract
- Summary
- Viral evasion
- Virus-induced transient T cell suppression
- Virally induced autoimmunity
- Implications for COVID-19: The stress of viral infection with SARS-CoV-2
- References
- Chapter 7: Interleukin-1 beta in psychosocial stress
- Abstract
- Introduction
- IL-1β signaling pathways in the CNS
- IL-1β signaling to neurons and neural progenitor cells during stress
- IL-1β signaling to brain endothelial cells during stress
- IL-1β impact on hypothalamic-pituitary-adrenal axis
- Potential therapeutics
- Conclusions
- References
- Chapter 8: Inflammation and traumatic stress
- Abstract
- Introduction
- Early-life adversity and inflammation
- Inflammation and PTSD
- Potential causes and consequences of inflammation in relation to traumatic stress
- Conclusions and future perspectives
- References
- Chapter 9: Stress in psoriasis
- Abstract
- Introduction and immunology
- Risk factors and comorbidities
- Psychological stress in psoriasis
- Therapy and management
- References
- Chapter 10: Natural killer (NK) cells
- Abstract
- Introduction
- Phenotypic characteristics of NK cells
- Functional characteristics of NK cells
- Measurement of NK cells
- Biological importance of NK cells
- NK cells in human disease
- Exploiting human NK cells in cancer therapy
- NK cells and stress
- NK cells and acute stress
- NK cells and chronic stress
- References
- Chapter 11: Psychoneuroimmunology
- Abstract
- Historical perspective
- Elements of the communication between the nervous system and the immune system
- Functional aspects of the relationship between the immune system and the nervous system
- Conclusion and perspectives
- References
- Chapter 12: Stress, aging, and inflammation
- Abstract
- Acute and chronic inflammation
- Neuroinflammation
- Inflammaging: Age-related increase in chronic low-grade inflammation
- Physiological mechanisms
- Stress-related increases in systemic inflammation
- Acute stress and inflammation
- Chronic stress and inflammation
- Mechanisms underlying the relationship between stress and inflammaging
- Physiological mechanisms
- Negative emotion, depression, and inflammation
- Sleep
- Physical activity
- Diet
- Obesity
- Social relationships
- References
- Chapter 13: The chaperone system in autoimmunity, inflammation, and virus-induced diseases: Role of chaperonins
- Abstract
- Acknowledgment
- Introduction
- Objective and scope
- The chaperone system
- Chaperonopathies
- The chaperonins in inflammation and autoimmunity
- Chaperones and viruses
- Viruses and inflammation, autoimmunity, and disease
- Perspectives
- Coda
- References
- Chapter 14: Steroid hormone receptors and regulation of ACE2 and COVID-19 disease outcomes
- Abstract
- Introduction
- SARS-CoV-2 and ACE2
- RAAS and RAAS inhibitors in SARS-CoV-2 infection and COVID-19 disease
- Steroid hormone receptors
- Mineralocorticoid receptor antagonists (MRAs)
- Androgens and COVID-19
- Estrogen action and the inflammatory response to SARS-CoV-2 infection
- Changes to estrogen levels and the risk of thrombosis in patients with severe COVID-19 disease
- Estrogen-related therapies for COVID-19
- Progesterone actions and the inflammatory response to SARS-CoV-2 infection
- Corticosteroids, SARS-CoV-2, and COVID-19 disease
- The HPA axis, glucocorticoid receptor, and COVID-19 disease
- Long COVID: A dysfunctional HPA axis?
- Corticosteroids in the treatment of COVID-19 disease
- Mechanisms of corticosteroid action in COVID-19 disease
- Vitamin D and COVID-19
- Conclusions and questions
- References
- Chapter 15: Immune, inflammatory, and neural systems in neuropsychiatric disease
- Abstract
- Introduction
- Basic science
- Brain development
- The role of immune-neuron interaction in psychiatric and neuropsychiatric conditions
- Two neuropsychiatric syndromes: Imitators or exemplars
- References
- Chapter 16: Stress responses modulate bacterial competitive fitness in polymicrobial communities
- Abstract
- Acknowledgments
- Introduction
- Diverse general and specific stress responses
- Antimicrobial molecules and protein machineries for competition
- Specific and general protection
- Environmental factors modulate competition
- Future perspective
- References
- Chapter 17: Mitigating viral invasion: mTORC2’s role in neuroprotection and immunity
- Abstract
- Introduction
- The mTOR complex
- Functions of mTORC1
- mTORC2
- Functions of mTORC2
- Future perspective
- References
- Chapter 18: Microglia regulate cognition and stress-related cognitive disorders
- Abstract
- Acknowledgments
- Introduction
- Stress, neuronal plasticity, and cognition
- Microglia, neuronal plasticity, and cognition
- Microglia regulate cognition under stress
- Summary and future perspective
- References
- Chapter 19: Prenatal-induced psychopathologies: All roads lead to microglia
- Abstract
- Acknowledgments
- Introduction
- Microglial mechanisms of disturbance in brain development
- Prenatal models that induce microglial activation
- Summary
- References
- Chapter 20: The environmental mismatch model of bipolar disorder: The role of stress, gut microbiota, lifestyle factors, and neuroinflammation
- Abstract
- Bipolar disorder
- Bipolar disorder as a disease of modern lifestyles
- Mechanisms behind manic episodes
- Mechanisms behind depressive episodes
- Gut microbiota and bipolar disorder
- Lifestyle changes that might improve bipolar disorder symptoms by lowering inflammation
- References
- Chapter 21: Beta cell stress and type 1 diabetes
- Abstract
- Acknowledgments
- Introduction
- Inherent and accumulated ER stress
- Cytokine and metabolic stress
- Genetic underpinnings of a defective stress response
- Immunologic effects of stress
- Functional effects of stress
- A stress-centric model of T1D
- Diagnostic and therapeutic implications
- Conclusions
- References
- Chapter 22: General adaptation in critical illness 1: The glucocorticoid signaling system as master rheostat of homeostatic corrections in concerted action with nuclear factor-κB
- Abstract
- Introduction
- Critical illness, species evolution, and individual development
- Innate immunity and nuclear factor-κB
- Glucocorticoid-glucocorticoid receptor-alpha interactions
- Glucocorticoid receptor-alpha and homeostatic corrections
- Glucocorticoid receptor-alpha in critical illness
- Variability in cellular sensitivity
- Endothelium
- Conclusions and implications for glucocorticoid treatment
- References
- Chapter 23: General adaptation in critical illness 2: The glucocorticoid signaling system as a master rheostat of homeostatic corrections in concerted action with mitochondrial and essential micronutrient support
- Abstract
- Cellular energetics—Mitochondrial function
- Mitochondrial cacostatic load, oxidative stress, and mitochondrial damage
- Mitochondria and HPA axis crosstalk
- Oxidative stress and critical illness-related corticosteroid insufficiency
- Hypovitaminoses
- Conclusions and implications for glucocorticoid treatment
- Funding
- References
- Chapter 24: Prolonged glucocorticoid treatment in ARDS: Pathobiological rationale and pharmacological principles
- Abstract
- Introduction
- Pharmacological principles of glucocorticoid actions
- Factors affecting response independent of the protocol design
- Micronutrients
- Conclusions and future directions
- References
- Chapter 25: The role of stress in mediating inflammation in the context of neurodegeneration
- Abstract
- Introduction
- The role of stress in neuroinflammation
- The molecular mechanisms controlled by cortisol that alter neuroinflammatory responses
- Stress mediates neuroinflammation in neurodegenerative diseases
- Conclusions
- References
- Index
- No. of pages: 400
- Language: English
- Edition: 1
- Published: August 22, 2023
- Imprint: Academic Press
- Hardback ISBN: 9780128175583
- eBook ISBN: 9780128175590
GF
George Fink
Dr. Fink is Honorary Professor in the University of Melbourne and Professorial Research Fellow at the Florey Institute of Neuroscience and Mental Health. Formerly, he was Scientific Director of the Mental Health Research Institute, Melbourne, Australia. Before returning to Melbourne in 2003, Dr. Fink was University Lecturer in Human Anatomy and Fellow in Physiology and Medicine at Brasenose College and the University of Oxford and served for nearly 20 years as CEO and Director of the UK Medical Research Council’s Brain Metabolism Unit in Edinburgh. He gained distinction through his seminal research discoveries in neuroendocrinology and psychopharmacology published in over 360 scientific papers. Dr. Fink served as President of the European Neuroendocrine Association. His distinctions include Fellow of the Royal Society of Edinburgh, Fellow of the Royal College of Physicians of Edinburgh, Fellow of the Royal Biological Society, Fellow of the Physiological Society, and Honorary Member of the British Society for Neuroendocrinology. Fink was Honorary Professor in the University of Edinburgh, delivered the inaugural Geoffrey Harris Prize Lecture of the British Physiological Society, and the Wolfson Lecture. In 1979 he was awarded the Royal Society - Israel Academy Exchange Fellowship which enabled him to spend a research year at the Weizmann Institute of Science, Rehovot Israel. In 2000 he was awarded the Lifetime Achievement Award of the International Society of Psychoneuroendocrinology. His membership of learned societies includes Emeritus member of the Society for Neuroscience, the Endocrine Society and the Genetics Society of America.
Dr. Fink has edited several scientific books with Elsevier, including Stress Science: Neuroendocrinology (2009), Stress Consequences: Mental, Neuropsychological and Socioeconomic (2009), Stress of War, Conflict and Disaster (2010), the Handbook of Neuroendocrinology (2011), and most notably the 4-volume second edition of the Encyclopedia of Stress (2007) on which this new Handbook of Stress series is based. He was founding Editor-in-Chief of the first edition of the Encyclopedia of Stress (2000) which was awarded the 2001 British Medical Association commendation for its contribution to Mental Health. The first volume of his Handbook of Stress series, entitled “Stress: Concepts, Cognition, Emotion, and Behavior”, received the BMA High Commendation in the Health and Social Care category as one of the top titles in its discipline.
Affiliations and expertise
Professorial Research Fellow and Hon Professor, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, AustraliaRead Stress: Immunology and Inflammation on ScienceDirect