Stress and The Brain: Evidence from Molecular Mechanisms to Interventions and Therapies

1st Edition, Volume 291 - April 16, 2025
Imprint: Academic Press
Editors: Nasrollah Moradikor, Chinna Orish
Language: English
Hardback ISBN:
9 7 8 - 0 - 4 4 3 - 3 4 4 2 5 - 1
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 3 4 4 2 6 - 8

Stress and The Brain: Evidence from Molecular Mechanisms to Interventions and Therapies is a comprehensive exploration of how stress affects the brain at a molecular level and it… Read more

Purchase options

BLOOM INTO SPRING SAVINGS

Save up to 25% on books and eBooks!

Shop now

Institutional subscription on ScienceDirect

Request a sales quote

Stress and The Brain: Evidence from Molecular Mechanisms to Interventions and Therapies is a comprehensive exploration of how stress affects the brain at a molecular level and its broader implications for mental and neurological health. The book delves into the mechanisms by which stress triggers changes in brain function, including the activation of the hypothalamic-pituitary-adrenal (HPA) axis, synaptic plasticity alterations, oxidative stress, neuroinflammation, and mitochondrial dysfunction. It examines how these molecular processes contribute to conditions such as neurodegeneration, anxiety, depression, and other stress-related disorders. Furthermore, the book provides an in-depth analysis of current therapeutic interventions, both pharmacological and behavioral, as well as natural antidotes that aim to mitigate the adverse effects of stress on the brain. By synthesizing evidence from cutting-edge research, this book offers valuable insights for scientists, clinicians, and mental health professionals seeking to understand and address the complex interplay between stress and brain health.

Cover image
Title page
Table of Contents
Series Page
Copyright
Contributors
Preface
Chapter One: Introduction to neurobiology and pharmacology of stress
Abstract
1 Introduction
2 Neurobiology of stress
3 Conclusion
References
Chapter Two: Mechanisms underlying stress effects on the brain: Basic concepts and clinical implications
Abstract
1 Introduction
2 Neurobiology of stress
3 Neuroendocrine response to stress
4 Stress-induced changes in brain structure and function
5 Genetic mechanisms
6 Future technologies
7 Conclusion
References
Further reading
Chapter Three: Early life stress and brain development: Neurobiological and behavioral effects of chronic stress
Abstract
1 Introduction
2 Behavioral effects of chronic stress
3 Conclusions
References
Chapter Four: Molecular mechanism underlying stress response and adaptation
Abstract
1 Introduction
2 Stress signaling pathways
3 Glucocorticoids and their receptors
4 Cellular and molecular mechanisms of stress response
5 Epigenetic and genomic modifications in stress response
6 Neurobiological aspects of stress
7 Mechanisms of stress adaptation and resilience: Concept of allostasis
8 Effects of chronic stress
9 Therapeutic interventions to chronic stress
10 Potential therapies for chronic stress
11 Conclusion and future directions
References
Chapter Five: Effects of stress on cognitive performance
Abstract
Abbreviations
1 Introduction
2 Stress categorization
3 Causes of stress
4 Prevalence of stress
5 Symptoms of stress
6 Physiology of stress
7 Physiological impact of stress
8 Impact of stress on brain morphology
9 Job stress and cognitive performance
10 Effects of stress on cognitive performance
11 Impact of stress hormones on cognitive performance
12 Impact of stress on academic performance
13 Mitigation strategies
14 Conclusion and future interventions
References
Chapter Six: Understanding the connection between stress and sleep: From underlying mechanisms to therapeutic solutions
Abstract
1 Introduction
2 Neuroanatomy and physiology of stress and sleep
3 Stress and sleep: Neurocircuitry untangled
4 The role of neuroinflammation in stress-related sleep dysregulation
5 Conclusion
References
Chapter Seven: Stress-related psychiatric disorders
Abstract
1 Introduction
2 Conclusion
References
Chapter Eight: Stress and the gut microbiota-brain axis
Abstract
Highlights
Graphical abstract
1 Introduction
2 Stress-gut -microbiota relationship
3 Influence of the stress on gut microbiome
4 Stress and intestinal microbiota-brain connection
5 Prospective research avenues and challenges
6 Conclusions
References
Chapter Nine: Epigenetic regulation of stress
Abstract
1 Introduction to epigenetics of stress
2 Epigenetic mechanisms in stress response
3 Developmental impact of stress-induced epigenetic changes
4 Epigenetics of stress-related disorders
5 Environmental and lifestyle factors modulating stress epigenetics
6 Future directions and therapeutic potential
7 Conclusions
References
Chapter Ten: Mapping brain neural networks in stress brain connectivity
Abstract
1 Introductions
2 How stress affects brain networks
3 Regions involved in neural network connectivity
4 Mapping neural networks in stress connectivity using artificial intelligence
5 Conclusion
References
Chapter Eleven: Stress-related neurodegenerative diseases: Molecular mechanisms implicated in neurodegeneration and therapeutic strategies
Abstract
Abbreviations
1 Introduction
2 Relationship between neurodegeneration and stress
3 Molecular mechanisms implicated in neurodegeneration
4 Potential stress targeted neuroprotective therapeutic perspective in neurodegenerative disorders
5 Conclusion
References
Chapter Twelve: The stress-immune system axis: Exploring the interplay between stress and immunity
Abstract
1 Understanding the stress response
2 The immune system: A complex defense mechanism
3 The interrelationship between stress and immunity
Declaration
References
Chapter Thirteen: Stress and gender differences in brain development
Abstract
1 Introduction
2 The impacts of stress on brain development
3 Stressors and their effects
4 The neurobiological mechanism
5 Overview of brain development
6 Gender differences
7 Anatomical differences in males and females during brain development
8 Amygdala
9 Hippocampus
10 Gray matter
11 Neurochemical differences
12 Intersection of stress and gender in brain development
13 Protective factors in stress and gender differences in brain development
14 Resilence
15 Coping mechanism
16 Implications and future directions
17 Conclusion
References
Chapter Fourteen: Models developed to explain the effects of stress on brain and behavior
Abstract
1 Overview of stress as a biological and psychological phenomenon
2 Define stress and its physiological effects
3 Overview of brain regions involved in stress response
4 Role of glutamate in stress related plasticity and neurotoxicity
5 Role of GABA in stress related anxiety and depression
6 Role of Dopamine in stress related reward dysfunction
7 Concluding remarks
Refrences
Chapter Fifteen: Stress in specific population: Cognitive decline in aging, occupational challenges, strategies for medical professionals
Abstract
1 Introduction
2 Cognitive decline in aging
3 Occupational challenges
4 Strategies for medical professionals
5 Conclusion
References
Chapter Sixteen: Addiction and stress: Exploring the reward pathways in brain affected by different drugs
Abstract
1 Introduction
2 Understanding addiction
3 The brain’s reward pathways
4 Stress and its impact on addiction
5 Different drugs and their effects on reward pathways
6 Conclusion
References
Chapter Seventeen: Stress-induced neurodegeneration and behavioral alterations in Caenorhabditis elegans: Insights into the evolutionary conservation of stress-related pathways and implications for human health
Abstract
1 Introduction
2 Evolutionary conservation of stress-related pathways
3 Stress-induced neurodegeneration in C. elegans
4 Behavioral alterations in C. elegans under stress
5 Impact of stress on copulation behavior in C. elegans
6 Lifespan and stress in C. elegans
7 Implications for human health
8 Conclusion
Acknowledgments
References
Chapter Eighteen: The neuroscientific basis of post-traumatic stress disorder (PTSD): From brain to treatment
Abstract
1 Introduction
2 From Trauma to disorder: The developmental pathway of PTSD
3 Phases of PTSD: From early manifestation to chronicity
4 The building blocks of PTSD: Risk factors for disorder development
5 PTSD and high-exposure groups: A focus on vulnerability
6 Breaking Down PTSD: Key symptoms and behavioral manifestations
7 Exploring the brain-body connection in post-traumatic stress disorder
8 The search for PTSD biomarkers: Neuroimaging, genetics, and beyond
9 Current and emerging treatment approaches
10 The future of PTSD research: Challenges and new horizons
11 Conclusion
References
Further Reading
Chapter Nineteen: Effect of stress on neuronal cell: Morphological to molecular approach
Abstract
1 Introduction
2 Morphological effects of stress on neuron
3 Dendritic atrophy and its role in stress-induced neural remodeling
4 Chronic stress-induced region-specific synaptic plasticity alterations
5 Neurogenesis suppression
6 Molecular mechanism of stress-induced neuronal damage
7 Glucocorticoid receptor signaling
8 Oxidative stress and mitochondrial dysfunction
9 Brain-derived neurotrophic factor
10 Cell adhesion molecules in dendritic plasticity
11 Stress-induced epigenetic modifications in neurons
12 Stress-related neurological disorders
13 Therapeutic approach to combatstress-induced neuronal damage
14 Conclusion
Acknowledgment
References

Nasrollah Moradikor

Dr. Nasrollah Moradikor is currently the research director and principal investigator at the International Center for Neuroscience Research in Tbilisi, Georgia. He has demonstrated exceptional leadership skills in promoting applied neuroscience research and establishing fruitful collaborations among scientists worldwide. Dr. Nasrallah's research program is dedicated to developing interventions for the prevention and treatment of neurological disorders. His team investigates the molecular mechanisms and therapeutics of brain disorders, including Parkinson's and Alzheimer's diseases, employing both clinical and experimental models. In 2021, Dr. Nasrollah founded a new community platform named “Neuroscience Network” to support and develop neuroscience in the world. His ability to create a supportive and intellectually stimulating environment has been instrumental in promoting the development of aspiring neuroscientists. He established robust international research collaborations with institutions in the USA, Australia, Canada, France, Germany, South Korea, and Malaysia. He has over 15 years of research and teaching experience in the field of brain health. Nasrollah has been on the scientific advisory board and evaluation committees of several institutions abroad. He currently serves as an editor, editorial board member and section editor of several reputed journals in the field of neuroscience. His contributions to the scientific community are evident through his publications, as well as more than 15 years of editorial expertise. He is an active professional member of IBRO, FENS, EBBS, ISN, ESN, ENCP, MNS, and MDS.

Affiliations and expertise

International Center for Neuroscience Research, Georgia

Chinna Orish

Dr. Chinna Orish is an MBBS graduate with a PhD in Anatomy and is a Senior Faculty member at the University of Port Harcourt, Nigeria. She completed her postdoctoral fellowship in Neurotoxicology at the National Center for Toxicological Research, USA, from 2016 to 2017. She is the founder of Women in Neuroscience and the Youth Neuroscience Association of Nigeria, where she is dedicated to empowering young minds and promoting gender equality in the field of neuroscience. Additionally, she serves as the lead investigator at the Neuro-Provictoire Research Laboratory, spearheading pioneering research initiatives. She coordinates the Neuroscience Group at the University of Port Harcourt, Nigeria, significantly contributing to the academic and research environment. Her active involvement in international scientific communities is evident through her memberships in prestigious organizations such as the International Society of Neurochemistry, the American Society of Neurochemistry, the Society for Neuroscience, and the Neuroscience Society of Nigeria. These affiliations reflect her commitment to staying at the forefront of global developments in neuroscience. Her research focuses on understanding sexual dimorphism in the molecular mechanisms of heavy metal-induced environmental toxicants in neurodegenerative and neurodevelopmental disorders, using both animal and Drosophila models. Her work has also shed light on the potential therapeutic roles of natural products in mitigating the adverse effects of environmental toxins on the nervous system. This research is crucial as it bridges the gap between basic neuroscience and practical therapeutic applications, offering hope for new treatments and preventative strategies in neurodegenerative diseases. Her expertise is also recognized in the academic publishing world, where she serves as an editor for several prestigious journals, including the American Journal of Psychiatry and Neuroscience, the Journal of Life Neuroscience (NeuroLife), the British Journal of Medicine and Medical Research, the Journal of Human Anatomy, and Clinical and Experimental Anatomy. Chinna's contributions to neuroscience have been acknowledged through numerous awards from reputable organizations, including the International Brain Research Organization (IBRO) and the International Society for Neurochemistry (ISN). These accolades highlight her impact on the field and her ongoing commitment to advancing neuroscience research and education. She has several publications in reputable journals, contributing valuable knowledge and insights to the scientific world.

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health