Stimuli-Responsive Nanocarriers for Targeted Drug Delivery
- 1st Edition - September 30, 2024
- Imprint: Woodhead Publishing
- Authors: Muhammad Raza Shah, Tooba Jabri, Maria Khalid
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 2 2 3 8 9 - 1
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 2 3 8 8 - 4
Stimuli-Responsive Nanocarriers for Targeted Drug Delivery presents a comprehensive overview of the most significant physical and chemical stimuli-responsive drug delivery system… Read more
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Request a sales quoteStimuli-Responsive Nanocarriers for Targeted Drug Delivery presents a comprehensive overview of the most significant physical and chemical stimuli-responsive drug delivery systems. This book reviews targeted and controlled drug delivery systems and how nanocarriers can be used to improve the pharmacokinetics of drugs in biological systems, such as increasing utilization rate and reducing toxicity and side effects. After a key introduction to the topic, a range of nanocarrier types is assessed before exploring the clinical translation challenges and considerations involved.
This book is a useful resource for researchers and postgraduate students in the fields of materials science, nanotechnology, pharmaceutical science, and medicinal chemistry.
This book is a useful resource for researchers and postgraduate students in the fields of materials science, nanotechnology, pharmaceutical science, and medicinal chemistry.
- Offers an in-depth look at the basic and fundamental aspects of stimuli-responsive materials, mechanisms, structure, synthesis and properties
- Provides information about well-defined categorization for stimuli-responsive drug delivery system based on different triggering mechanisms to its reader
- Reviews basic concepts and the latest research involving advances in stimuli-responsive drug delivery systems in controlled-release drugs
- Discusses novel approaches and challenges for scaling-up and commercialization of stimuli-responsive polymers
Researchers and postgraduate students in the fields of materials science, nanotechnology, pharmaceutical science, and medicinal chemistry
- Cover image
- Title page
- Table of Contents
- Copyright
- About the authors
- Preface
- Acknowledgments
- Chapter 1. Introduction
- Abstract
- 1.1 Diseases, drugs, and the art and science of drug delivery
- 1.2 The advent of stimuli-responsive materials and the evolution of the concept of stimuli-responsive drug delivery systems
- 1.3 Why does drug delivery demand smart solutions? The inherent need to be smart
- 1.4 Qualities of stimuli-responsive materials for effective drug delivery systems
- 1.5 Conclusion
- Video links
- AI disclosure
- References
- Chapter 2. Endogenous and exogenous stimuli-responsive nanoscale drug delivery systems
- Abstract
- 2.1 Endogenous and exogenous stimuli-responsive drug delivery systems
- 2.2 Mechanism of drug release from a stimuli-responsive drug delivery system
- 2.3 Endogenous stimuli
- 2.4 Exogenous stimuli
- 2.5 Design of endogenous and exogenous stimuli-responsive nanoscale drug delivery system
- 2.6 Conclusion
- Video links
- References
- Chapter 3. pH-responsive nanocarriers for drug delivery
- Abstract
- 3.1 Adapting to the microenvironment: triggered release by pH-responsive nanocarrier
- 3.2 pH-responsive drug delivery at various levels
- 3.3 Response modes of pH-responsive nanocarriers
- 3.4 pH-triggered materials
- 3.5 pH-responsive nanocarriers
- 3.6 Applications of pH-triggered nanocarriers
- 3.7 Conclusion
- Video link
- References
- Chapter 4. Temperature-responsive nanocarriers for drug delivery
- Abstract
- 4.1 Temperature, thermoresponsivity, and temperature as an endogenous and exogenous stimulus
- 4.2 Origin of thermoresponsivity in polymeric materials
- 4.3 Mechanism of critical solution temperature
- 4.4 Temperature-triggered nanocarriers for drug delivery systems
- 4.5 Applications of temperature-triggered nanocarriers
- 4.6 Conclusion
- References
- Chapter 5. Light-responsive nanocarriers for drug delivery
- Abstract
- 5.1 Brightening therapeutic horizons: exploring photoresponsive nanocarriers for drug delivery
- 5.2 Light-triggered mechanism
- 5.3 Light-triggered nanocarriers for drug delivery
- 5.4 Applications of photo-triggered nanocarriers
- 5.5 Conclusion
- References
- Chapter 6. Redox-responsive nanocarriers for drug delivery
- Abstract
- 6.1 Oxidation and reduction
- 6.2 Redox reactions in living organisms
- 6.3 Oxidants and antioxidants (reductants) in the living systems
- 6.4 Physiological redox homeostasis
- 6.5 Disturbance in redox homeostasis and the pathology of disease
- 6.6 Design of redox-responsive drug carriers
- 6.7 Redox-responsive nanocarriers
- 6.8 Conclusion
- Video links
- References
- Chapter 7. Enzyme responsive nanocarriers for drug delivery
- Abstract
- 7.1 Catalyzing change: enzyme-responsive nanomaterials and advancement in drug delivery system
- 7.2 Enzymatic-triggers for controlled drug delivery systems
- 7.3 Enzyme-responsive nanocarriers
- 7.4 Applications of enzyme-responsive nanocarriers in dual-responsive systems
- 7.5 Conclusion
- References
- Chapter 8. Ultrasound-responsive nanocarriers for drug delivery
- Abstract
- 8.1 The acoustic spectrum and ultrasound
- 8.2 Advantages of ultrasound for drug delivery
- 8.3 Ultrasound action on materials and living tissues
- 8.4 Acoustic cavitation: thermal and mechanical effects and the ultrasound mechanism of drug delivery
- 8.5 Synthetic cavitation nuclei or bubbles to amplify the effect of ultrasound
- 8.6 Ultrasound impact on other precirculating drug carriers
- 8.7 Ultrasound-responsive nanocarriers
- 8.8 Ultrasound-mediated drug delivery in various diseases
- 8.9 Conclusion
- Video links
- References
- Chapter 9. Magnetic field responsive nanocarriers for drug delivery
- Abstract
- 9.1 Magnetic nanoparticles and magnetic field stimulus
- 9.2 Magnetic drug delivery systems
- 9.3 Attributes of magnetic drug delivery system
- 9.4 Drug release mechanism from magnetic drug delivery system
- 9.5 Surface functionalization of magnetic drug delivery system
- 9.6 Applications of magnetic field triggered nanocarriers
- 9.7 Conclusion
- Video link
- References
- Chapter 10. Electrical responsive nanocarriers for drug delivery
- Abstract
- 10.1 Electric field stimulus
- 10.2 Advancements in electric field pulse applications: from intracellular delivery to tissue ablation
- 10.3 Electroresponsivity
- 10.4 Electroactive/electro-responsive materials
- 10.5 Pharmacological potential of electric fields
- 10.6 Electric field responsive nanocarriers
- 10.7 Conclusion
- References
- Chapter 11. Dual and multiple stimuli-responsive nanocarriers for drug delivery
- Abstract
- 11.1 Multistimuli responsiveness in drug delivery systems: exploring the potential and need
- 11.2 Multiple stimuli-responsive drug delivery system and their advantages
- 11.3 Advantages of multiple stimuli-responsive drug delivery systems
- 11.4 Diverse potential interactions in multistimuli-responsive drug delivery system: orthogonal/parallel, serial, and causal dynamics
- 11.5 Classes of multiple stimuli-responsive drug delivery systems
- 11.6 Strategies for engineering multistimuli-responsive nanocarriers
- 11.7 Multistimuli-responsive nanocarriers
- 11.8 Conclusion
- Video link
- References
- Chapter 12. Stimuli-responsive nanocarriers in clinical translation
- Abstract
- 12.1 Clinical translation: the process and its goals
- 12.2 Steps of clinical translation
- 12.3 Clinical translation of stimuli responsive drug delivery systems
- 12.4 Challenges for effective and practical clinical translation- from bench to bedside
- 12.5 Insights and future perspectives
- Video links
- References
- Glossary
- Index
- Edition: 1
- Published: September 30, 2024
- Imprint: Woodhead Publishing
- No. of pages: 400
- Language: English
- Paperback ISBN: 9780443223891
- eBook ISBN: 9780443223884
MS
Muhammad Raza Shah
Muhammad Raza Shah is a full professor at the International Center for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Pakistan. He is also the Head of the Center for Bioequivalence Studies and Clinical Research. He is a recipient of several awards, including the Tamgha-i-Imtiaz Award from the President of Pakistan, the Salam Prize, the Professor Atta ur Rahman Gold Medal, and the Dr M Raziuddin Siddiqi Prize, by the Pakistan Academy of Sciences, for scientists under 40 years of age, in the field of chemistry. Professor Shah has authored six books and edited four books, in addition to contributing over 350 peer-reviewed journal papers. One of his authored books was declared as best book of 2017 by the Government of Pakistan’s Higher Education Commission.
Affiliations and expertise
Professor, International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry University, Karachi, PakistanTJ
Tooba Jabri
Tooba Jabri is a Ph.D scholar at H.E.J Research Institute of Chemistry, University of Karachi, in Pakistan. Her specialization is in organic chemistry. Her research interests include design and development of nanomaterials, drug delivery, organic synthesis and polymeric materials. She has series of publications and patents and is involved in several writing projects and has been part of the design and editing of a handbook on laboratory safety (currently under publication). She worked as a secondment in INFUSION project HORIZON 2020 at Cardiff University, UK. She has also received an indigenous scholarship from the Higher Education Commission Pakistan.
Affiliations and expertise
International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry, University of Karachi W4VF+J4R, ICCBS, Karachi City, Sindh, PakistanMK
Maria Khalid
Maria Khalid is currently pursuing her Ph.D in Organic Chemistry at H.E.J Research Institute of Chemistry, University of Karachi. Her research Interests include nanomaterials, soft polymeric materials, peptides, and drug delivery. She has a number of publications and patents in the abovementioned areas. Maria has authored the primary science textbook series “Explore your world” (ERI Publication). She has also been a part of the development of “Handbook of Laboratory safety” by Elsevier.
Affiliations and expertise
Ph.D Scholar, International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry, University of Karachi W4VF+J4R, ICCBS, Karachi City, Sindh, PakistanRead Stimuli-Responsive Nanocarriers for Targeted Drug Delivery on ScienceDirect