Stimuli-Responsive Hydrogels for Ophthalmic Drug Delivery

1st Edition - May 8, 2024
Authors: Dipankar Chattopadhyay, Jonathan Tersur Orasugh, Anjan Adhikari, Suprakas Sinha Ray
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 1 5 6 - 8
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 3 5 9 - 3

Stimuli-Responsive Hydrogels for Ophthalmic Drug Delivery covers fundamental aspects in the preparation of polymeric in-situ, stimuli-responsive hydrogels, including propertie… Read more

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Stimuli-Responsive Hydrogels for Ophthalmic Drug Delivery covers fundamental aspects in the preparation of polymeric in-situ, stimuli-responsive hydrogels, including properties, characterization, chemistry, and fabrication of these hydrogels. The book will help the reader select the most appropriate material and design for the desired application. The book goes on to review applications in ophthalmic drug delivery, covering in vitro and in vivo models, animal models, preclinical testing, patents, and more. This is a must-have reference for researchers and academics in the fields of materials science, biomaterials, pharmacology and polymer science, with an interest in clinical aspects of hydrogel design and application.

Cover image
Title page
Table of Contents
Copyright
Dedication
Preface
Part I. Preparation and properties of in situ hydrogel-based biomaterial: Ophthalmic drug delivery
Chapter 1. Introduction
1.1. Introduction
1.2. Convincing adoptive usage of OP-based in situ forming hydrogel systems
1.3. Conclusions and future prospects
Chapter 2. Introduction to polymeric in situ forming hydrogels for ophthalmic drug delivery
2.1. Introduction
2.2. Stimuli-responsive in situ gelling hydrogels
2.3. Low-molecular-weight polymeric hydrogels
2.4. Cyclodextrin/poly(ethylene glycol)–based polymeric hydrogels
2.5. In situ forming hydrogel-based microneedles
2.6. Clinical trials and proven marketed stimuli-responsive hydrogels-based ophthalmic formulations
2.7. Recent advancements and emerging trends
2.8. Challenges and innovations
2.9. Conclusions and perspectives
Chapter 3. Biopolymers for in situ–forming hydrogels, synthesis, characterization, toxicity issues, and application
3.1. Introduction
3.2. Natural and partially synthetic derived polymers
3.3. Synthetic polymeric matrices
3.4. Characterization
3.5. Evaluating the tolerance of ophthalmic gels for the eyes
3.6. Toxicity issues
3.7. Applications
3.8. Recent advances and emerging trends in in situ gelling polymeric hydrogels
3.9. Challenges and future prospect
3.10. Conclusions along with viewpoints
Chapter 4. Biopolymer stimuli-responsive in situ hydrogels, chemistry, and their potential applications in ODDS
4.1. Introduction
4.2. Biopolymer stimuli-responsive in situ gels
4.3. Chemistry of biopolymer stimuli-responsive in situ hydrogels
4.4. Ionically triggered polymeric matrices
4.5. Potential applications of biopolymer stimuli-responsive in situ hydrogels in ophthalmology
4.6. Conclusion
Chapter 5. Fabrication of biopolymer in situ–forming hydrogels
5.1. Introduction
5.2. Preparation of in situ–forming polymeric hydrogels
5.3. Challenges
5.4. Conclusions and future prospects
Chapter 6. Modeling: Process optimization for design, engineering, and fabrication of biopolymer in situ–forming hydrogels
6.1. Introduction
6.2. Designed/optimization of in situ–forming hydrogels
6.3. Challenges and suggested way forward
6.4. Conclusions
Chapter 7. Properties of biopolymeric in situ hydrogel-based biomaterials
7.1. Introduction
7.2. Conclusion
Chapter 8. Swelling and drug release kinetics of biopolymer in situ–forming hydrogels for ophthalmic drug delivery
8.1. Introduction
8.2. Swelling and drug release kinetics of biopolymer in situ–forming hydrogels for ophthalmic drug delivery
8.3. Conclusion
Chapter 9. Structural load-bearing characteristics of biopolymer in situ–forming hydrogels for ophthalmic drug delivery
9.1. Introduction
9.2. Structural characteristic
9.3. Load-bearing
9.4. Implications of structural load-bearing properties in the context of ophthalmic drug delivery of biopolymer in situ–forming hydrogels
9.5. Challenges and way forward
9.6. Conclusion
Chapter 10. Functionalization and its effect on the properties of in situ–forming biopolymer hydrogels
10.1. Introduction
10.2. Functionalization and its effect on the properties of in situ–forming biopolymer hydrogels
10.3. Conclusion and future outlook
Chapter 11. Application of biopolymer in situ–forming hydrogels in ophthalmic drug delivery system and others
11.1. Introduction
11.2. General biopolymeric in situ–forming hydrogels application areas
11.3. Applications beyond ophthalmology
11.4. Summary and perspective
Part II. Applications of biopolymers in situ-forming hydrogels for ophthalmic drug delivery
Chapter 12. Eye anatomy, physiology, and ocular barriers
12.1. Introduction
12.2. Eye anatomy and ocular structures
12.3. Physiology of the eye
12.4. Ophthalmic pharmacokinetics
12.5. Barriers to ophthalmic drug delivery
12.6. Absorption pathways, both corneal and noncorneal
12.7. Ocular medication administration route
12.8. Barriers to in situ–forming OP DDS
12.9. Recent approaches adopted in in situ–forming hydrogels for overcoming ocular barriers to effective drug delivery
12.10. Conclusion
Chapter 13. Models/techniques to evaluate ophthalmic drug delivery formulations
13.1. Introduction
13.2. In vitro and in vivo models/techniques to evaluate ophthalmic drug delivery formulations
13.3. Emerging technologies and cutting-edge methodologies
13.4. Conclusions
Chapter 14. Formulation/design concepts based on the features/barriers of ocular drug deliveries
14.1. Introduction
14.2. Formulation/design concepts based on the features/barriers of the different ocular drug delivery routes (e.g., topical, transscleral, suprachoroidal, etc.)
14.3. Conclusion
Chapter 15. Clinical indications that need a thermoresponsive hydrogel
15.1. Introduction
15.2. Clinical indications that need a thermoresponsive hydrogel
15.3. Obstacles and way forward
15.4. Conclusion
Chapter 16. An overview on materials/polymers suitable for stimuli-responsive hydrogels: Natural or synthetic
16.1. Introduction
16.2. Carbohydrates
16.3. Poly(N-isopropylacrylamide) copolymers
16.4. Poloxamer systems (Fig. 16.3)
16.5. Poly(ethylene oxide)/poly(d,l-lactic acid-co-glycolic acid)
16.6. Liposomes that are thermosensitive operate as a physical barrier between reactive species
16.7. Others
16.8. Emerging trends and future prospects
16.9. Conclusion
Chapter 17. Viscoelastic characteristics and gelation kinetics of in situ–forming hydrogels
17.1. Introduction
17.2. Viscoelastic characteristics of in situ–forming hydrogels
17.3. Gelation kinetics of in situ–forming hydrogels
17.4. Challenges
17.5. Future prospects
17.6. Conclusion
Chapter 18. Degradation kinetics of in situ–forming hydrogels
18.1. Introduction
18.2. Degradation kinetics of in situ–forming hydrogels
18.3. Challenges associated with in situ–forming hydrogel degradation
18.4. Conclusion
Chapter 19. Cell-laden stimuli-responsive hydrogels, their fabrication, and application
19.1. Introduction
19.2. Cell-laden in situ–forming biopolymeric hydrogels
19.3. Instances of cell-laden hydrogels as per literature
19.4. In vivo optical sensing
19.5. Final thoughts and opinions
Chapter 20. Animal models and preclinical tests to evaluate in situ–forming hydrogels
20.1. Introduction
20.2. Animal models and preclinical trial
20.3. Challenges
20.4. Challenges and ways forward
20.5. Conclusions
Chapter 21. Biopolymer-based in situ–forming hydrogels: From laboratory to practical application
21.1. Introduction
21.2. Laboratory research
21.3. Clinical/practical application
21.4. Regulatory aspects
21.5. Challenges and suggestions for scaling up in situ–forming hydrogels
21.6. Conclusion
Chapter 22. Commercially available in situ gelling hydrogels for biomedical applications
22.1. Introduction
22.2. Challenges and considerations
22.3. Conclusion
Chapter 23. Challenges, suggestive way out, and future of perspective of biopolymer in situ hydrogels in biomedical applications
23.1. General introduction
23.2. Summary of the challenges, suggested solutions, and the future of biopolymer in situ hydrogels in biomedical applications
Chapter 24. Patents for biopolymer in situ–forming hydrogels for ophthalmic drug delivery and tissue regeneration
24.1. Introduction
24.2. Patents for biopolymer in situ–forming hydrogels from ophthalmic drug delivery
24.3. Present as well as forthcoming advancements
24.4. Challenges and way forward
24.5. Conclusion
References
Index

Dipankar Chattopadhyay

Prof. Dipankar Chattopadhyay is an eminent professor currently working in the Department of Polymer Science & Technology, University of Calcutta, India since 2006 and also a former HOD. Earlier, he worked as a lecturer at the Vidhyasagar University and Shahid Bhagat Singh College, Punjab, India. He obtained his B.Tech in Plastics & Rubber Technology from University of Calcutta, India and M.Tech in Polymer Science and Engineering, IIT, New Delhi with Ph.D. (Polymer Science) from the IACS, India. He is an experienced research professional with expertise in polymers nanocomposites, biomaterials, and nanomaterials. He has ~22 years of research experience with completed 10 research project and collaborative projects with industries. He is an active reviewer for various Journals and supervised >20 scholars and five post-doctorate students. He has 127 publications and has 3 patents. He is an Executive Member in the Society for Polymer Science, India; MRSI, Calcutta Chapter and many more.

Affiliations and expertise

Professor, Department of Polymer Science and Technology, University Colleges of Science and Technology, University of Calcutta, India

Jonathan Tersur Orasugh

Dr. Jonathan Tersur Orasugh is currently a postdoctoral researcher at the Department of Chemical Sciences, University of Johannesburg, Doornfontein 2028, Johannesburg, South Africa, and Centre for Nanostructures and Advanced Materials, DSI-CSIR Nanotechnology Innovation Centre, Council for Scientific & Industrial Research, CSIR, Pretoria 0001, South Africa. His research focus is in nanoscience and nanotechnology, Textiles, and Fibres. Presently, Dr. Jonathan is working on EMI shielding materials design and fabrication at CSIR, Pretoria in affiliation with the University of Johannesburg. He has also, carried out successful research work on synthesis of nano crystalline cellulose and its application in edible packaging, transdermal and ophthalmic drug delivery, and published articles in reputed high impact factor scientific journals along with several, presentation at international conferences. Dr. Jonathan has Ph.D. (Nanoscience and Nanotechnology) and MTech (Technical Textiles: Fibre Technology) from University of Calcutta, Kolkata, and B.Tech. (Textile Technology) from Kaduna Polytechnic, Kaduna, Nigeria. He has published more than 10 research articles in diverse international journals along with several books and book chapters with publishers of high repute. He is an active editor with few international journals and a reviewer with different international journals. He has more than 7yrs of research experience in the field of polymer composites and nanocomposites, synthesis, and surface treatment of nanomaterials along with their potential applications. He has carried out industrial-based research at to a satisfactory and implementable stage at the pilot plant scale. He is also an executive board member and research head at EL-YOTEK NIG. LTD. He is also a research consultant with AMER-SIL KETEX PVT LTD., India.

Affiliations and expertise

Department of Chemical Sciences, University of Johannesburg, Doornfontein 2028, Johannesburg, South Africa, and Centre for Nanostructures and Advanced Materials, DSI-CSIR Nanotechnology Innovation Centre, Council for Scientific & Industrial Research, CSIR, Pretoria 0001, South Africa

Anjan Adhikari

Dr. Anjan Adhikari is a practicing medical doctor and Head of Pharmacology Department at the Coochbehar Govt. Medical College & Hospital. Dr A. Adhikari is a member of several medical and pharmacological committees, including the Pharmacovigilance and Institutional Ethics committees at Coochbehar Government Medical College & Hospital; he is also a member of the Pharmacovigilance Programme of India (PvPI), Indian Pharmacopeia Commission, Govt. of India, Gaziabad, India and of the Subject Expert Committee (SEO), Central Drug Standard Control Organization (CDSCO), Govt. of India, New Delhi. Dr. Adhikari is a part of the Indian Council of Medical Research (ICMR), New Delhi. Dr. A. Adhikari is the Editor of the Rational Drug Bulletin, India and a reviewer for the Indian Journal of Pharmacology, as well as a number of National and International Journals.

Affiliations and expertise

Professor & Head, Department of Pharmacology, Coochbehar Government Medical College & Hospital

Suprakas Sinha Ray

Professor Suprakas Sinha Ray is a Chief Research Scientist and Manager of the Centre for Nanostructures and Advanced Materials, DSI-CSIR Nanotechnology Innovation Centre, Council for Scientific and Industrial Research, Pretoria, South Africa. His current research focuses on the applications of advanced nanostructured & polymeric materials. He is one of the most active and highly cited authors in the field of polymer nanocomposite materials, and he has recently been rated by Thomson Reuters as being one of the top 1% most impactful and influential scientists and top 50 high impact chemists. He is the author of 7 authored books, co-author of 5 edited books, 32 book chapters on various aspects of polymer-based nanostructured materials & their applications, and author and co-author of 430 articles in high-impact international journals.

Affiliations and expertise

Chief Research Scientist and Manager of the Centre for Nanostructures and Advanced Materials, DSI-CSIR Nanotechnology Innovation Centre, Council for Scientific and Industrial Research, Pretoria, South Africa; Department of Chemical Sciences, University of Johannesburg, Johannesburg, South Africa

Life sciences

Physical sciences & Engineering

Social sciences & Humanities

Health

Stimuli-Responsive Hydrogels for Ophthalmic Drug Delivery

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Dipankar Chattopadhyay

Jonathan Tersur Orasugh

Anjan Adhikari

Suprakas Sinha Ray