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Stem Cells and Signaling Pathways
- 1st Edition - September 28, 2023
- Editors: Surajit Pathak, Antara Banerjee
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 8 8 0 0 - 8
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 8 8 0 1 - 5
Stem Cells and Signaling Pathways brings together chapters exploring the mechanism of stem cells and the signaling pathways. This book is a very concise and easy-to-use book. It… Read more
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Request a sales quoteStem Cells and Signaling Pathways brings together chapters exploring the mechanism of stem cells and the signaling pathways. This book is a very concise and easy-to-use book. It serves as an ideal reference to guide investigators towards further valuable answers on the role of stem cells and will aid basic researchers and scientists in biomedical sciences and tissue engineering and regenerative medicine with a wide variety of interests in stem cell biology linking basic signal transduction for possible future therapies directed to treatments and different diseases.
Significant information on signaling has been presented here. Sufficient knowledge has been provided on therapeutic approaches for the treatment of different degenerative disorders.
• Provides a detailed and updated view of stem cell biology.
• Covers a wide range of areas within basic and translational research appropriate for scientists
and clinicians engaged in studying the treatments for diseases from interdisciplinary perspectives.
• Highlights the use of different models for stem cell research, significance of stem cell signaling in drug discovery.
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- List of contributors
- Preface
- Chapter 1. Regulation of mesenchymal stem cell differentiation by key cell signaling pathways
- Abstract
- 1.1 Introduction
- 1.2 Mesenchymal stem cells
- 1.3 Dedifferentiation versus metaplasia versus transdifferentiation
- 1.4 Transdifferentiation of mesenchymal stem cells
- 1.5 Signaling pathways involved in transdifferentiation of mesenchymal stem cells
- 1.6 Challenges in transdifferentiation of mesenchymal stem cells
- 1.7 Therapeutic implications of transdifferentiation of mesenchymal stem cells
- 1.8 Conclusion
- Acknowledgments
- References
- Chapter 2. Stem signaling molecules and pathways: implications in the regulation of fate and proliferation potential
- Abstract
- 2.1 Introduction
- 2.2 Signaling pathways
- 2.3 Regulation of fate
- 2.4 Conclusion
- References
- Chapter 3. The role of Yamanaka factors in induced pluripotent stem cells and embryonic stem cell signaling
- Abstract
- 3.1 Introduction
- 3.2 Stem cells
- 3.3 Evolution of stem cells reprogramming to iPSCs
- 3.4 Role of Yamanaka factors in stem cells
- 3.5 Signaling pathways in stem cells
- 3.6 Cancer stem cells
- 3.7 Applications of iPSCs as therapeutics
- 3.8 Conclusion
- Acknowledgments
- References
- Chapter 4. Purinergic signaling in stem cell growth
- Abstract
- 4.1 Overview of the purinergic signaling cascade
- 4.2 From purinergic ligands to cellular response
- 4.3 Adenosine and adenosinergic signaling in stem cells
- 4.4 Conclusion
- References
- Chapter 5. Cutaneous homeostasis: a balancing cross-talk between epidermal stem cell pool and regulatory pathways
- Abstract
- 5.1 Introduction
- 5.2 Cutaneous homeostasis: a balancing act
- 5.3 Epidermal stem cell pool
- 5.4 Signaling pathways—regulators of epidermal homeostasis
- 5.5 Epidermal stem cells in homeostatic regulation
- 5.6 Rejuvenated constancy: stem cell therapy for dermal wound healing
- 5.7 A stem cell remedial therapy for hair growth
- 5.8 Pivotal role of stem cells in aging
- 5.9 Conclusion
- References
- Chapter 6. Role of stem cells in cardiac bioengineering
- Abstract
- 6.1 Introduction
- 6.2 Why stem cells appear promising for cardiac repair?
- 6.3 Stem cell therapy for subjects with ischemic heart disease and heart failure
- 6.4 Human embryonic stem cells
- 6.5 Induced pluripotent stem cells
- 6.6 Maturity issues associated with hPSC-CMs
- 6.7 Teratoma formation
- 6.8 Acquisition of sufficient stem cells and maintenance of continuous pool of stem cells
- 6.9 Low survival rate of cardiomyocytes
- 6.10 Various bioengineering strategies for stem cell therapeutics
- 6.11 Conclusion and future perspectives
- Acknowledgment
- References
- Chapter 7. Stem cell signaling molecules and pathways in liver regeneration
- Abstract
- 7.1 Introduction
- 7.2 Physiology of hepatic regeneration
- 7.3 Signaling molecules
- 7.4 Signaling pathways
- 7.5 Conclusion
- Acknowledgments
- References
- Chapter 8. Role of stem cells in osteoblastic miRNA and bone tissue regeneration
- Abstract
- 8.1 Introduction
- 8.2 Stem cells
- 8.3 Bone and bone cells
- 8.4 Mesenchymal stem cells into osteoblast
- 8.5 MiRNA
- 8.6 Stem cells and miRNA
- 8.7 miRNAs’ role in osteogenesis
- 8.8 Osteoblastic inhibitory and stimulatory effects of miRNAs
- 8.9 Cellular signaling molecule’s role in osteoblastogenisis through miRNA
- 8.10 Exosome-derived miRNA and bone formation
- 8.11 Conclusions and future directions
- Acknowledgment
- References
- Chapter 9. Stem cells and signaling pathways in human reproductive system
- Abstract
- 9.1 Introduction
- 9.2 Primordial germ cells and signaling pathways
- 9.3 Folliculogenesis, stem cells, and signaling pathways in the ovaries
- 9.4 Uterine stem cells and signaling pathways
- 9.5 Spermatogonial stem cells and spermatogenesis
- 9.6 Development of embryo and embryonic stem cells
- 9.7 Conclusion
- References
- Chapter 10. Hormonal impacts on stem cell lineages and related signaling pathways
- Abstract
- 10.1 Introduction
- 10.2 Hormones affecting stem cells
- 10.3 Melatonin
- 10.4 Growth hormone
- 10.5 Calcitonin
- 10.6 Luteinizing hormone
- 10.7 Follicle stimulating hormone
- 10.8 Conclusion
- References
- Chapter 11. Unravelling the crosstalk of Hedgehog with Wnt, Notch and TGF-β signaling pathways
- Abstract
- 11.1 Stem cell signaling pathways
- 11.2 Hedgehog signaling pathway
- 11.3 WNT signaling pathway
- 11.4 Notch signaling
- 11.5 TGF-β signaling pathway
- 11.6 Conclusion
- References
- Chapter 12. Stem cell aging: role of signaling pathways and microRNAs
- Abstract
- 12.1 Introduction
- 12.2 Aging of stem cells
- 12.3 Genes involved in aging
- 12.4 Regulation of growth factors in aging
- 12.5 Signaling pathways involved in stem cell aging
- 12.6 Regulation of microRNAs in aging
- 12.7 Conclusion
- References
- Chapter 13. Slowdown of aging and neurodegenerative diseases by extremolytes
- Abstract
- 13.1 Introduction
- 13.2 Neurodegenerative disorders
- 13.3 Extremophiles
- 13.4 Extremolytes
- 13.5 Effect of extremolytes on aging
- 13.6 Role of extremolytes in neurodegenerative disorders
- 13.7 Conclusion
- Acknowledgement
- References
- Chapter 14. Stem cells and therapy: cancer stem cells and targeted therapy with DNA repair inhibitors
- Abstract
- 14.1 Normal stem cells and cancer stem cells: similarities and differences
- 14.2 History and origin of cancer stem cells
- 14.3 The role of cancer stem cells in therapy resistance
- 14.4 DNA damage repair in cancer stem cells
- 14.5 Base excision repair and cancer stem cells molecular properties
- 14.6 Targeting the cancer stem cell DNA repair pathways
- 14.7 Conclusions
- References
- Chapter 15. The potential role of stem cells in multiple sclerosis therapies
- Abstract
- 15.1 Introduction
- 15.2 Stem cells types
- 15.3 Role of stem cells in neurodegenerative disease therapies
- 15.4 Role of stem cells in multiple sclerosis therapies
- 15.5 Therapeutic mechanisms of mesenchymal stem cells in multiple sclerosis
- 15.6 Application of mesenchymal stem cells in multiple sclerosis
- 15.7 Future challenges and perspective
- 15.8 Conclusion
- References
- Chapter 16. Stem cells signaling pathways and surface receptors: implications for multiple sclerosis treatment
- Abstract
- 16.1 Introduction
- 16.2 Molecular mechanisms underlying demyelination and remyelination in MS
- 16.3 Induced pluripotent stem cell (iPSCs) and neural stem cells (NSCs)
- 16.4 Immunomodulatory signaling pathways of MSCs in multiple sclerosis
- 16.5 Haematopoietic stem cell for treatment of multiple sclerosis
- References
- Chapter 17. Mechanistic role of stem cells in the pathogenesis and treatment of oral diseases: current insights and future directions
- Abstract
- 17.1 Introduction
- 17.2 Oral cavity stem cells
- 17.3 Dental pulp stem cells
- 17.4 Stem cells from periodontal ligament
- 17.5 MSCs and their immunomodulatory potential
- 17.6 Conclusion
- References
- Chapter 18. Stem cell–based approach in treatment of periodontitis
- Abstract
- 18.1 Introduction
- 18.2 Periodontium
- 18.3 Periodontal disease
- 18.4 Risk factors
- 18.5 Pathophysiology of periodontal disease
- 18.6 Treatment of periodontal disease
- 18.7 Stem cell therapy
- 18.8 Dental stem cells and periodontal treatment
- 18.9 Periodontal regeneration and challenges
- 18.10 Conclusion and future perspectives
- References
- Chapter 19. Role of probiotics in modulation of stem cell progeny in human gastrointestinal disorders
- Abstract
- 19.1 Introduction
- 19.2 Stem cells in gastrointestinal tract
- 19.3 Gut microbiota
- 19.4 Probiotics
- 19.5 Man–microbe interaction at gastrointestinal tract and probiotics
- 19.6 What happens when homeostasis is dwindled? Or origin of dysbiosis
- 19.7 Dysbiosis and gastrointestinal disorders
- 19.8 Modulation by probiotics in different gastrointestinal disorders
- 19.9 Cell types of the IESC niche
- 19.10 Intestinal epithelial stem cells
- 19.11 Enteroendocrine cells
- 19.12 Stromal cells
- 19.13 Enteric nervous system
- 19.14 Interaction of gut microbiota and probiotics with IESCs
- 19.15 Research and development for understanding the intractions between microbiota and IESCs/IESC niche
- 19.16 Concluding remarks
- Acknowledgment
- Conflict of interest
- References
- Chapter 20. Implications of stem cell–associated signals in pathogenesis of lipid disorders
- Abstract
- 20.1 Introduction
- 20.2 Lipid metabolism and associated processes
- 20.3 Stem cells and their properties
- 20.4 Lipid disorders and the potential role of stem cell signaling therapies in lipid disorders
- 20.5 Stem cells in therapeutic interventions of lipid disorders
- 20.6 Applying stem cells to the treatment of lipid diseases
- 20.7 Limitations and shortcomings of using stem cells to treat lipid diseases
- 20.8 Conclusion
- References
- Chapter 21. Stem cell’s potential role in the treatment of diabetes mellitus
- Abstract
- 21.1 Introduction
- 21.2 Generation of beta-cells of islets of langerhans from human pluripotent stem cells, embryonic stem cells, and mesenchymal stem cells
- 21.3 Conclusion
- References
- Chapter 22. Mesenchymal stem cells in chronic kidney disease and therapeutic signaling pathways
- Abstract
- 22.1 Introduction
- 22.2 Chronic kidney disease (CKD)
- 22.3 Mesenchymal stem cells sources for chronic kidney disease
- 22.4 Therapeutic strategies and mechanism of actions
- 22.5 Conclusion
- References
- Chapter 23. Current advances and challenges in stem cell–based therapy for chronic kidney disease
- Abstract
- 23.1 Introduction
- 23.2 Stem cells for cell-based therapy
- 23.3 Experimental therapy using pluripotent stem cells for chronic kidney disease
- 23.4 Adult cell–based treatment for chronic kidney disease in a research setting
- 23.5 Therapies with stem cell–derived bio products
- 23.6 Promoting stem cell clinical trials for chronic kidney disease
- 23.7 Conclusions and future direction
- References
- Chapter 24. Stem cell therapeutic approaches and signaling pathways in rheumatoid arthritis and osteoarthritis
- Abstract
- 24.1 Introduction
- 24.2 Origin of stem cells
- 24.3 Rheumatoid arthritis
- 24.4 Osteoarthritis
- 24.5 Conclusion
- References
- Further reading
- Chapter 25. Potential role of stem cells in the pathogenesis of endometriosis
- Abstract
- 25.1 Introduction
- 25.2 Theories and origin of endometriosis
- 25.3 Pathogenesis of endometriosis
- 25.4 A role for stem cells in endometriosis
- 25.5 Endometrium and endometriosis stem cells
- 25.6 Pathogenesis of endometriotic stem cells
- 25.7 Genetics and epigenetics of endometriosis
- 25.8 Conclusion
- Acknowledgment
- References
- Chapter 26. Potential role of traditional medicine in stem cell research
- Abstract
- 26.1 Introduction to traditional medicine
- 26.2 Tissue repair, rejuvenation, and regeneration: ayurveda and TCM perspectives
- 26.3 Traditional medicine in stem cell research
- 26.4 Conclusion
- References
- Index
- No. of pages: 512
- Language: English
- Edition: 1
- Published: September 28, 2023
- Imprint: Academic Press
- Paperback ISBN: 9780443188008
- eBook ISBN: 9780443188015
SP
Surajit Pathak
AB