Spirooxindole
Chemistry, Synthesis, Characterization and Biological Significance
- 1st Edition - June 14, 2024
- Imprint: Elsevier
- Editors: Gautam Patel, Vraj R. Shah, Tuan Anh Nguyen, Kalim Deshmukh
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 2 2 3 2 4 - 2
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 2 3 2 5 - 9
Spirooxindole: Chemistry, Synthesis, Characterization and Biological Significance examines the current state-of-the-art, recent progress, and new challenges associated with the… Read more
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Spirooxindole: Chemistry, Synthesis, Characterization and Biological Significance examines the current state-of-the-art, recent progress, and new challenges associated with the development of spirooxindole derivatives for various medicinal applications. Owing to their exceptional properties, these compounds can be used in various fields, including chemical and pharma industries, and in clinical research. This book has chapters written by experts in several different areas. It serves as a useful reference book for scientists, industrial practitioners, graduate students, and other professionals in the field of hetrocyclic chemistry, medicinal chemistry, organic synthesis clinical research and chemical sciences.
The growing interest among the academics and industrial researchers in the field of organic chemistry and medicinal chemistry is the driving force for the presentation of this edited book.
- Consolidates information on each aspect of this novel compound and its applications in various fields, covering the entire spectrum of up-to-date literature citations, current market, and patents
- Provides a comprehensive, in-depth description of spirooxindole derivatives as well as multipurpose scaffolds
- Highlights green synthesis and nanocatalysis
- Describes in-depth various medicinal applications
- Covers both synthesis and applications
Graduate students and researchers working with Medicinal Chemistry, Organic Synthesis, Nanocatalysis etc.
1 Introduction of Spirooxindole
1.1 Brief history of spirooxindole
1.2 Natural resources of Spirooxindole
1.3 Physical and chemical properties of spirooxindole
1.4 General synthesis &characterization
1.5 Conclusion
1.6 References
2 Synthesis of spirooxindole and its derivatives using green and nano technology
2.1 introduction of green methods
2.2 Necessity of green method in organic synthesis over conventional routes
2.3 types of greener routes available for the synthesis of spirooxindole
2.3.1 Pot, atom, and step economy (PASE) synthesis
2.3.2 Multicomponent synthesis (MCR)
2.3.3 Asymmetric synthesis
2.4 key challenges and future Perspectives
2.5 Synthesis of spirooxindole by utilizing various nanocatalysts
2.6 Future challenges
2.7 Conclusion
2.8 References
3 Stereoselective synthesis of spirooxindole scaffold
3.1 Introduction
3.2 Medicinal importance of stereoselective synthesis (diastereo- and enantio-)
3.3 Various reactions involved to synthesis stereoselective based spirooxindole derivatives
3.4 Medicinal application of stereoselective spirooxindole
3.5 Future challenges
3.6 Conclusion
3.7 References
4 Characterization techniques for synthesised spirooxindole scaffold
4.1 Introduction of characterization techniques
4.2 Description of various characterizations methods used to identify structural presence of spirooxindole and its derivatives
4.3 Advances in characterization techniques
4.4 Future scope and challenges
4.5 Conclusion
4.6 References
5 Spirooxindole as a precursor
5.1 Spirooxindole as a precursor
5.2 Reactions involved spirooxindole as a starting material
5.3 spirooxindole as an API (Active pharmaceutical ingredient) & other applications
5.4 Growth and development of spirooxindole in the upcoming years
5.5 Conclusion
5.6 References
6 Medicinal applications of Spirooxindole and its derivatives- An Introduction
6.1 chemical modifications influencing the pharmacokinetic properities
6.2 introduction of
spirooxindole as an inhibitory active moiety
6.3 various biological activities
6.4 Introduction of mechanism of action (MOA), & structural activity relationship (SAR) etc.
6.5 silico screening for hit finding
6.6 Future trend of
spirooxindole in the field of
medicinal chemistry
6.5 Conclusion
6.6 References
7 Spirooxindole derivatives as an anti-cancer agent
7.1 Introduction
7.2 Spirooxindole scaffold mechanism of action as an anti-cancer agent
7.3 Examples of various spirooxindole derivatives utilized as an anti-cancer inhibitor
7.4 Key challenges and future outcomes
7.5 Conclusion
7.6 References
8 Spirooxindole derivatives as kinase based anti-cancer agents
8.1 Introduction
8.2 Examples Utilization of spirooxindole derivatives as kinase-based anticancer agents
8.3 Key and future challenges
8.4 Conclusion
8.5 References
9 Spirooxindole derivatives as an anti-viral agent
9.1 Introduction
9.2 Spirooxindole scaffold mechanism of action as an anti-viral agent
9.3 Examples of various spirooxindole derivatives utilized as an anti-viral inhibitor
9.4 Recent advances in anti-viral agents consists of spirooxindole scaffold
9.5 Key challenges and future outcomes
9.6 Conclusion
9.7 References
10 Spirooxindole derivatives as an anti-bacterial agent
10.1 Introduction
10.2 Spirooxindole scaffold mechanism of action as an antibacterial agent
10.3 Examples of various spirooxindole derivatives utilized as an antibacterial inhibitor
10.4 Key challenges and future outcomes
10.5 Conclusion
10.6 References
11 Spirooxindole derivatives as an anti-oxidant agent
11.1 Introduction
11.2 Spirooxindole scaffold mechanism of action as an antioxidant agent
11.3 Examples of various spirooxindole derivatives utilized as an antioxidant inhibitor
11.4 Key challenges and future outcomes
11.5 Conclusion
11.6 References
12 Spirooxindole derivatives as an anti-inflammatory agent
12.1 Introduction
12.2 Spirooxindole scaffold mechanism of action as an anti-inflammatory agent
12.3 Examples of various spirooxindole derivatives utilized as an anti-inflammatory inhibitor
12.4 Key challenges and future outcomes
12.5 Conclusion
12.6 References
13 Other Medicinal Applications
13.1 Introduction
13.2 Advanced literature with regards to other biological applications of spirooxindole derivatives
13.3 Research direction for future researchers
13.4 Conclusion
13.5 References
14 A case study of the use of spirooxindole derivatives in the novel drug discovery
14.1 Introduction
14.2 Examples of drugs bearing spirooxindole scaffold
14.2.1 Synthesis of spirooxindole utilized as potent drug candidate
14.2.2 hits identification, hits-to-leads, lead discovery, lead optimization
14.2.3 Pharmacokinetics study (PK) of the potent drug candidate
14.2.4 Drug discovery through utilization of spirooxindole scaffold
14.3 Challenges associated with discovered drug
14.5 Conclusion
14.6 References
1.1 Brief history of spirooxindole
1.2 Natural resources of Spirooxindole
1.3 Physical and chemical properties of spirooxindole
1.4 General synthesis &characterization
1.5 Conclusion
1.6 References
2 Synthesis of spirooxindole and its derivatives using green and nano technology
2.1 introduction of green methods
2.2 Necessity of green method in organic synthesis over conventional routes
2.3 types of greener routes available for the synthesis of spirooxindole
2.3.1 Pot, atom, and step economy (PASE) synthesis
2.3.2 Multicomponent synthesis (MCR)
2.3.3 Asymmetric synthesis
2.4 key challenges and future Perspectives
2.5 Synthesis of spirooxindole by utilizing various nanocatalysts
2.6 Future challenges
2.7 Conclusion
2.8 References
3 Stereoselective synthesis of spirooxindole scaffold
3.1 Introduction
3.2 Medicinal importance of stereoselective synthesis (diastereo- and enantio-)
3.3 Various reactions involved to synthesis stereoselective based spirooxindole derivatives
3.4 Medicinal application of stereoselective spirooxindole
3.5 Future challenges
3.6 Conclusion
3.7 References
4 Characterization techniques for synthesised spirooxindole scaffold
4.1 Introduction of characterization techniques
4.2 Description of various characterizations methods used to identify structural presence of spirooxindole and its derivatives
4.3 Advances in characterization techniques
4.4 Future scope and challenges
4.5 Conclusion
4.6 References
5 Spirooxindole as a precursor
5.1 Spirooxindole as a precursor
5.2 Reactions involved spirooxindole as a starting material
5.3 spirooxindole as an API (Active pharmaceutical ingredient) & other applications
5.4 Growth and development of spirooxindole in the upcoming years
5.5 Conclusion
5.6 References
6 Medicinal applications of Spirooxindole and its derivatives- An Introduction
6.1 chemical modifications influencing the pharmacokinetic properities
6.2 introduction of
spirooxindole as an inhibitory active moiety
6.3 various biological activities
6.4 Introduction of mechanism of action (MOA), & structural activity relationship (SAR) etc.
6.5 silico screening for hit finding
6.6 Future trend of
spirooxindole in the field of
medicinal chemistry
6.5 Conclusion
6.6 References
7 Spirooxindole derivatives as an anti-cancer agent
7.1 Introduction
7.2 Spirooxindole scaffold mechanism of action as an anti-cancer agent
7.3 Examples of various spirooxindole derivatives utilized as an anti-cancer inhibitor
7.4 Key challenges and future outcomes
7.5 Conclusion
7.6 References
8 Spirooxindole derivatives as kinase based anti-cancer agents
8.1 Introduction
8.2 Examples Utilization of spirooxindole derivatives as kinase-based anticancer agents
8.3 Key and future challenges
8.4 Conclusion
8.5 References
9 Spirooxindole derivatives as an anti-viral agent
9.1 Introduction
9.2 Spirooxindole scaffold mechanism of action as an anti-viral agent
9.3 Examples of various spirooxindole derivatives utilized as an anti-viral inhibitor
9.4 Recent advances in anti-viral agents consists of spirooxindole scaffold
9.5 Key challenges and future outcomes
9.6 Conclusion
9.7 References
10 Spirooxindole derivatives as an anti-bacterial agent
10.1 Introduction
10.2 Spirooxindole scaffold mechanism of action as an antibacterial agent
10.3 Examples of various spirooxindole derivatives utilized as an antibacterial inhibitor
10.4 Key challenges and future outcomes
10.5 Conclusion
10.6 References
11 Spirooxindole derivatives as an anti-oxidant agent
11.1 Introduction
11.2 Spirooxindole scaffold mechanism of action as an antioxidant agent
11.3 Examples of various spirooxindole derivatives utilized as an antioxidant inhibitor
11.4 Key challenges and future outcomes
11.5 Conclusion
11.6 References
12 Spirooxindole derivatives as an anti-inflammatory agent
12.1 Introduction
12.2 Spirooxindole scaffold mechanism of action as an anti-inflammatory agent
12.3 Examples of various spirooxindole derivatives utilized as an anti-inflammatory inhibitor
12.4 Key challenges and future outcomes
12.5 Conclusion
12.6 References
13 Other Medicinal Applications
13.1 Introduction
13.2 Advanced literature with regards to other biological applications of spirooxindole derivatives
13.3 Research direction for future researchers
13.4 Conclusion
13.5 References
14 A case study of the use of spirooxindole derivatives in the novel drug discovery
14.1 Introduction
14.2 Examples of drugs bearing spirooxindole scaffold
14.2.1 Synthesis of spirooxindole utilized as potent drug candidate
14.2.2 hits identification, hits-to-leads, lead discovery, lead optimization
14.2.3 Pharmacokinetics study (PK) of the potent drug candidate
14.2.4 Drug discovery through utilization of spirooxindole scaffold
14.3 Challenges associated with discovered drug
14.5 Conclusion
14.6 References
- Edition: 1
- Published: June 14, 2024
- Imprint: Elsevier
- Language: English
GP
Gautam Patel
Gautam Patel obtained PG from Institute of Science and Technology for Advanced Studies and Research (ISTAR), Vallabh Vidya Nagar and Doctoral degree from the M. S. University of Baroda, India. He is the Head and an Associate Professor at the Chemistry Department, Parul Institute of Applied Science, Parul University, India. His area of specialization is organic synthesis, green chemistry, nanosciences and nanotechnology. He has 3 patents to his name.
Affiliations and expertise
Head and Associate Professor, Parul University, IndiaVS
Vraj R. Shah
Vraj R. Shah has received his B.Sc. in Industrial Chemistry from ITM Vocational University and M.Sc. degrees in Industrial Chemistry from ITM (SLS) Baroda University, Vadodara. Following his graduation, he is currently working as a graduate research assistant at the department of Chemical and Biological Engineering at The University of Alabama, USA. He has published 5 research papers in the peer-review international journals. He has contributed 8 book chapters with peer reviewed books of international publishers. His research interest mainly focuses on organic synthesis, medicinal chemistry, computational simulations, membrane synthesis, and nanotechnology. In addition, he has also received the prestigious GCF fellowship from University of Alabama to pursue his doctoral degree. Moreover, he has also been awarded “Best young researcher presentation ” from Sardar Vallabhbhai Patel National Institute of Technology (SVNIT).
Affiliations and expertise
Department of Applied Chemistry, School of Science, ITM (SLS) Baroda University, IndiaTN
Tuan Anh Nguyen
Tuan Anh Nguyen is a Senior Principal Research Scientist at the Institute for Tropical Technology, Vietnam Academy of Science and Technology, Hanoi, Vietnam. He received a BS in physics from Hanoi University in 1992, a BS in economics from Hanoi National Economics University in 1997, and a PhD in chemistry from the Paris Diderot University, France, in 2003. He was a Visiting Scientist at Seoul National University, South Korea, in 2004, and the University of Wollongong, Australia, in 2005. He then worked as a Postdoctoral Research Associate and Research Scientist at Montana State University, United States in 2006-09. In 2012 he was appointed as the Head of the Microanalysis Department at the Institute for Tropical Technology. His research areas of interest include smart sensors, smart networks, smart hospitals, smart cities, complexiverse, and digital twins. He has edited more than 74 books for Elsevier, 12 books for CRC Press, 1 book for Springer, 1 book for RSC, and 2 books for IGI Global. He is the Editor-in-Chief of Kenkyu Journal of Nanotechnology & Nanoscience.
Affiliations and expertise
Senior Principal Research Scientist, Institute for Tropical Technology, Vietnam Academy of Science and Technology, Hanoi, VietnamKD
Kalim Deshmukh
Dr. Kalim Deshmukh is Senior Researcher at the New Technologies-Research Centre, University of West Bohemia, Pilsen, Czech Republic. He has over 20 years of research experience working with a wide variety of nanomaterials and polymeric materials, especially polymer blends, nanocomposites, and nanohybrids for various applications. His research interest is mainly focused on the synthesis, characterization, and property investigations of novel polymer nanocomposites reinforced with different nanofillers, including various nanomaterials including carbon-based materials such as carbon black, carbon nanotubes, graphene and its derivatives and MXenes for energy storage, energy harvesting, gas sensing, EMI shielding and high-k dielectric applications.
Affiliations and expertise
Senior Researcher, New Technologies - Research Centre, University of West Bohemia, Czech RepublicRead Spirooxindole on ScienceDirect