
Spine Phenotypes
- 1st Edition - July 8, 2022
- Imprint: Academic Press
- Editors: Dino Samartzis, Jaro I. Karppinen, Frances M.K. Williams
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 2 2 7 7 8 - 7
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 2 7 7 9 - 4
The era of big data and personalized spine care has arrived. Within that, imaging and clinical phenotypes are key in establishing personalized algorithms for patient care. This is… Read more

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Request a sales quoteThe era of big data and personalized spine care has arrived. Within that, imaging and clinical phenotypes are key in establishing personalized algorithms for patient care. This is particularly important in developing novel diagnostics and therapeutics as well as predicting outcomes and establishing preventative measures for various spinal disorders. Spine Phenotypes is a comprehensive resource that outlines phenotype descriptions, their imaging measurements and classifications, and provides an in-depth discussion regarding spine pathology and its clinical relevance.
Multiauthored, with multidisciplinary contributions from world leaders in the field of imaging, spine research, and clinical practice, each chapter is rich in visual depiction of imaging phenotypes, providing examples of some established phenotypic measurements with a range of normal and pathologic images and their clinical implications.
Spine Phenotypes
will be a first of its kind reference for spine researchers, clinicians, and industry.- Book chapters devoted to specific imaging phenotypes with discussion of their clinical correlates
- Imaging phenotypes provided with examples of established phenotypic measurements and a range of normal and pathologic images
- Multiauthor, multidisciplinary contributions comprising world leaders in the field of spine imaging, research, and clinical practice
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Foreword
- Foreword by Jeremy Fairbank MD FRCS, Professor of Spine Surgery and Honorary Departmental Senior Research Fellow, NDORMS, University of Oxford, UK
- Preface
- Acknowledgments
- Acknowledgment
- 1. Anatomy of the spine
- Introduction
- Osseous spine
- Joints, discs, and ligaments
- Muscles and fasciae
- Neurovasculature
- Conclusions
- 2. Biomechanics of the spine
- Introduction
- The spinal anatomy in vertebrates and humans
- The intervertebral disc
- Zygapophyseal/facet joints
- Spinal ligaments
- Biomechanics of degeneration-related phenotypes in the human lumbar spine
- 3. Biomechanical models to study spinal phenotypes
- Introduction
- Intervertebral disc degeneration phenotypes
- Intervertebral injury models
- Broader context and implications for repair
- Conclusion
- 4. Animal models to study spinal intervertebral disc phenotypes
- Introduction
- Anatomy
- Conclusions
- 5. Imaging technologies of the spinal discs
- Introduction
- Computed tomography
- MRI methods to investigate morphology
- Conclusion
- 6. Intervertebral disc degeneration
- Degeneration and low back pain
- Etiological factors of intervertebral disc degeneration
- Methods for assessing the phenotypes of disc degeneration
- Classification schemes of disc degeneration
- Conclusions
- 7. Disc space narrowing and osteophytes
- Introduction
- Pathogenesis
- Radiological features
- Epidemiology
- Osteophyte epidemiology
- IVD narrowing epidemiology
- Association with facet joint arthropathy
- Influence of osteophytes and IVD space narrowing on low back pain
- Complications/sequela of osteophytosis and IVD space narrowing
- High-intensity zones
- IVD calcification
- Clinical management
- Diffuse idiopathic skeletal hyperostosis
- Conclusions
- 8. Displacement of intervertebral discs
- Introduction
- Anatomy
- Pathogenesis
- Imaging
- Morphologic phenotypes of IVD displacement
- Clinical phenotypes of disc displacement—evaluation and treatment
- Conclusions
- 9. High-intensity zones and annular tears
- Background
- Pathology of HIZs
- Biomechanics of HIZs
- Epidemiology
- Clinical implications of HIZ
- Risk factor for HIZ
- Phenotype
- Association with other MRI phenotypes
- Conclusions
- 10. Vertebral endplate abnormalities, defects, and changes
- The vertebral endplate during development
- Structure and composition of the endplate
- Endplate function
- Endplate and back pain
- Endplate classification schemes
- Conclusions
- 11. Vertebral bone marrow (Modic) changes
- Introduction
- Pathogenesis
- Manifestations and natural history
- Clinical presentation
- Imaging and diagnostic studies
- Management
- Conclusions
- 12. Ossification of the posterior longitudinal ligament
- Introduction
- Epidemiology
- Etiology and pathogenesis
- Clinical manifestations
- Management
- Conclusions
- 13. Lumbar spinal stenosis
- Introduction
- Pathogenesis
- Manifestations and natural history
- Clinical phenotypes
- Imaging phenotypes
- Management
- Conclusions
- 14. Facet joints
- Introduction
- Facet joint degeneration
- Grading of facet joint degeneration
- Conclusion
- 15. Paraspinal muscles
- Introduction
- Anatomy and function
- Assessments on medical images
- Factors affecting muscle morphometry other than low back pain
- Relations between muscle morphometry and other spinal degeneration
- Relationship between paraspinal muscle morphometry and LBP/LBP-related disability
- Exercises for restoring morphometry and their effects on LBP
- Clinical implications from the relationship between paraspinal muscles and LBP
- Future research
- 16. Spinal alignment
- Introduction
- History
- Basic radiographic parameters—thoracic and lumbar spine
- The contribution of pelvic anatomy to global alignment
- Cervical alignment contribution to global spinal balance
- Thoracic and lumbar contribution to global spinal balance
- Regional differences in thoracolumbar balance: patterns of alignment
- Clinical impact of sagittal alignment and balance
- Changes in pelvic morphology with aging
- Postsurgical positive sagittal balance
- Spinal surgery surgical planning
- Conclusions
- Index
- Edition: 1
- Published: July 8, 2022
- Imprint: Academic Press
- No. of pages: 416
- Language: English
- Hardback ISBN: 9780128227787
- eBook ISBN: 9780128227794
DS
Dino Samartzis
JK
Jaro I. Karppinen
FW