Smith and Aitkenhead's Textbook of Anaesthesia
- 8th Edition - January 1, 2025
- Imprint: Elsevier
- Editors: Jonathan Thompson, Iain Moppett, Matthew Wiles
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 2 6 6 8 - 0
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 2 6 4 6 - 8
For over 40 years, this award-winning textbook has been the core text for anaesthetists new to the specialty and other healthcare professionals involved in perioperative care. Now… Read more
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Request a sales quoteFor over 40 years, this award-winning textbook has been the core text for anaesthetists new to the specialty and other healthcare professionals involved in perioperative care. Now in its eighth edition, this high quality, clinically relevant resource continues to offer essential reading covering all aspects of anaesthesia in surgery.
Covering day-to-day clinical practice in anaesthesia and perioperative medicine, from preoperative assessment and optimisation to clinical anaesthesia and postoperative care, this practical guide also contains an overview of the scientific principles that underpin these practices. It includes topics such as relevant pharmacology and basic physiology; data analysis and statistics; physics; equipment and monitoring; safety and quality assurance; general, regional and local anaesthetic techniques for a full range of surgical specialties. In combining these aspects, it has been an invaluable resource for generations of anaesthetists.
Fully updated and now accompanied by ancillary videos, this book is ideal for all trainee anaesthetists including candidates for the Fellowship of Royal College of Anaesthetists and similar examinations.
Covering day-to-day clinical practice in anaesthesia and perioperative medicine, from preoperative assessment and optimisation to clinical anaesthesia and postoperative care, this practical guide also contains an overview of the scientific principles that underpin these practices. It includes topics such as relevant pharmacology and basic physiology; data analysis and statistics; physics; equipment and monitoring; safety and quality assurance; general, regional and local anaesthetic techniques for a full range of surgical specialties. In combining these aspects, it has been an invaluable resource for generations of anaesthetists.
Fully updated and now accompanied by ancillary videos, this book is ideal for all trainee anaesthetists including candidates for the Fellowship of Royal College of Anaesthetists and similar examinations.
- Highly regarded internationally
- Aligned to the FRCA syllabus – including the updated FRCA syllabus references linked to the relevant content of each chapter in the online ebook
- Offers clear, concise and practical coverage of all aspects of anaesthesia and perioperative care, including intensive care and chronic pain management
- Chapters extensively cross referenced for the reader
Trainee anaesthetists both at novice and intermediate level;
- Cover image
- Title page
- Copyright
- Table of Contents
- List of Contributors
- Acknowledgements
- Preface
- Section 1 Basic Sciences
- CHAPTER 1 General principles of pharmacology
- Syllabus References
- Basic principles
- How do drugs act?
- How does the body process drugs (pharmacokinetics)?
- Pharmacokinetic principles
- Pharmacological variability
- Pharmacogenetics
- Drug interactions and adverse drug effects
- Further reading
- CHAPTER 2 Data, statistics and clinical trials
- Syllabus References
- Types of data
- Summarising data
- Sampling
- Probability
- Data distributions
- Testing
- Types of error
- Confidence intervals
- Bayesian statistics
- Predictive testing and scoring systems
- Bias
- Risk scoring
- Survival analysis
- Clinical trials
- Specific aspects of trial conduct
- Evidence-based medicine
- Audit, research and service evaluation
- Further reading
- CHAPTER 3 Inhalational anaesthetic agents and medical gases
- Syllabus References
- Mechanism of action
- Pharmacokinetics of inhaled anaesthetic agents
- Individual inhalational anaesthetic agents
- Medical gases
- Inhalational anaesthetic agents and the environment
- Further reading
- CHAPTER 4 Intravenous anaesthetic and sedative drugs
- Syllabus References
- Intravenous anaesthetic drugs
- Mechanism of action
- Pharmacokinetics
- Offset of effect
- Precautions when using i.v. anaesthetics
- Pharmacology of individual intravenous anaesthetic drugs
- Maintenance of anaesthesia using i.v. anaesthetic drugs
- Practical techniques for i.v. maintenance of anaesthesia
- Sedative and anxiolytic drugs
- Drugs used as sedatives
- α2-Adrenoceptor agonists
- Opioids
- Further reading
- CHAPTER 5 Local anaesthetics
- Syllabus References
- Mechanism of action of local anaesthetics
- Local anaesthetic structure
- Pharmacological properties of local anaesthetics
- Pharmacokinetics
- Clinical preparation of local anaesthetics
- Enantiomer pharmacology
- Pharmacology of individual local anaesthetics
- Local anaesthetic toxicity
- Management of severe local anaesthetic toxicity
- Further reading
- CHAPTER 6 Physiology and pharmacology of pain
- Syllabus References
- Mechanisms of pain
- Pain pathways
- Pharmacology of analgesic drugs
- Opioids
- Opioid antagonists
- Paracetamol
- Non-steroidal anti-inflammatory drugs (NSAIDs)
- COX-2–specific inhibitors
- Conclusions
- Further reading
- CHAPTER 7 Nausea and vomiting
- Syllabus References
- Definitions
- Mechanisms of nausea and vomiting
- Identifying patients at risk
- Pharmacology
- Management
- Further reading
- CHAPTER 8 Muscle function and neuromuscular block
- Syllabus References
- Physiology of neuromuscular transmission
- Pharmacology of neuromuscular transmission
- Depolarising neuromuscular blocking drugs
- Non-depolarising neuromuscular blocking drugs
- Reversal agents
- Neuromuscular monitoring
- Further reading
- CHAPTER 9 Cardiovascular system
- Syllabus References
- The autonomic nervous system
- Cardiovascular physiology
- Cardiovascular pharmacology
- Further reading
- CHAPTER 10 Respiratory system
- Syllabus References
- Control of breathing
- Respiratory system mechanics
- Pulmonary circulation
- Regional ventilation and perfusion
- Oxygen and carbon dioxide transport
- Respiratory effects of general anaesthesia
- Positive pressure ventilation
- Alternative modes of ventilation
- Respiratory physiology at high altitude
- Further reading
- CHAPTER 11 Renal system
- Syllabus References
- Renal anatomy
- Glomerular anatomy, filtration and tubular feedback
- Renin–angiotensin–aldosterone system and vasopressin
- Tubular function and urine formation
- Pharmacology of drugs acting on the kidney
- Assessment of renal function
- Acute kidney injury
- Further reading
- CHAPTER 12 Fluid, electrolyte and acid–base balance
- Syllabus References
- Physiology of electrolytes and water balance
- Basic definitions
- Compartmental distribution of total body water
- Solute composition of body fluid compartments
- Water homeostasis
- Practical fluid balance
- Sodium, potassium, chloride, phosphate and magnesium
- Acid–base balance
- Considerations in paediatrics
- CHAPTER 13 Metabolism, stress responses and thermoregulation
- Syllabus References
- Metabolism
- Carbohydrates
- Proteins
- Lipids
- Basic nutritional requirements
- Starvation
- The effects of chronic malnutrition on anaesthesia
- The effects of obesity on anaesthesia
- The stress response to surgery
- Thermoregulation and anaesthesia
- Further reading
- CHAPTER 14 Blood, coagulation and transfusion
- Syllabus References
- The physiology of blood
- Disorders of coagulation
- Monitoring of coagulation
- Anticoagulants and their reversal
- Antiplatelet drugs and their perioperative management
- Blood products, factor concentrates and transfusion
- Major haemorrhage and massive transfusion protocols
- Thrombosis and acute ischaemic events
- Interventional procedures and regional anaesthesia in patients with coagulopathy
- Patient blood management
- Further reading
- Section 2 Physics and apparatus
- CHAPTER 15 Basic physics for the anaesthetist
- Syllabus References
- Basic definitions
- Basic mathematical functions
- Fluids
- Pressure
- Gas regulators
- The Venturi, injector and Bernoulli principle
- Heat
- Vaporisation
- Humidity and humidification
- Solubility of gases
- Electricity
- Electrical safety
- Radiation
- Magnetic resonance imaging
- Ultrasound
- Lasers
- Optical fibres
- Fires and explosions
- Further reading
- CHAPTER 16 Anaesthetic apparatus
- Syllabus References
- Gas supplies
- The anaesthetic machine
- Vaporisers
- Breathing systems
- Ventilators
- Scavenging
- Reservoir bags
- Protecting the breathing system in anaesthesia
- Suction apparatus
- Infusion pumps
- Perioperative warming devices
- Decontamination of anaesthetic equipment
- Further reading
- CHAPTER 17 Clinical measurement and monitoring
- Syllabus References
- Process of clinical measurement
- Biological electrical signals
- Biological mechanical signals
- Monitors in clinical practice
- The respiratory system
- Gas and vapour analysis
- Blood gas analysis
- The nervous system
- Temperature
- Near-patient testing
- Monitoring standards
- Alarms
- General guidelines for monitoring during anaesthesia
- Further reading
- Section 3 Fundamentals of Anaesthesia & perioperative medicine
- CHAPTER 18 Quality and safety in anaesthesia
- Syllabus References
- Quality and safety core concepts
- Tools that support human factors
- Human factors design
- Incidents and errors
- Safety culture
- Quality indicators and improvement
- Measurement of safety and quality
- Further reading
- CHAPTER 19 Preoperative assessment and preparation
- Syllabus References
- The process of preoperative assessment
- Risk assessment and optimisation
- Optimisation
- Preparation for elective surgery
- Further reading
- CHAPTER 20 Intercurrent disease and anaesthesia
- Syllabus References
- Cardiovascular disease
- Respiratory disease
- Haematological disorders
- Gastrointestinal disease
- Liver disease
- Renal disease
- Diabetes mellitus
- Other endocrine disorders
- Neurological disease
- Psychiatric disease
- Connective tissue disorders
- Human immunodeficiency virus
- Myeloma
- Porphyria
- Further reading
- CHAPTER 21 Consent and information for patients
- Syllabus References
- Capacity
- Voluntariness
- Types of consent
- Information
- The Mental Capacity Act and incapacity
- Consent in special circumstances
- Teaching and learning
- Summary
- Further reading
- CHAPTER 22 The practical conduct of anaesthesia
- Syllabus References
- Preparation for anaesthesia
- Monitoring the patient during anaesthesia
- Trained ancillary staff
- Induction of anaesthesia
- Maintenance of anaesthesia
- Positioning the patient for surgery
- Emergence and recovery
- Infection prevention and control
- Further reading
- CHAPTER 23 Airway management
- Syllabus References
- Anaesthetic airway equipment
- Supraglottic airway devices
- Second-generation SADs
- Laryngoscopes
- Tracheal tubes
- Other apparatus
- Routine airway management
- Tracheal intubation
- Difficult tracheal intubation
- Airway assessment
- Airway management during emergency anaesthesia
- Management of the difficult airway
- Management of the unanticipated difficult airway
- Management of unanticipated difficult tracheal intubation
- Emergency front of neck airway
- Management of the predicted difficult airway
- Tracheal extubation and recovery
- The difficult airway in other locations
- After difficult airway management
- CHAPTER 24 Pain management
- Syllabus References
- Pain
- Acute pain
- Chronic pain
- Further reading
- CHAPTER 25 Local and regional anaesthetic techniques
- Syllabus References
- Assessment and selection of patients
- Selection of technique
- Regional block equipment
- Inadvertent wrong-sided block
- Supplementary techniques
- Aftercare
- Continuous perineural infusion of local anaesthetics
- Block failure
- Intravenous regional anaesthesia
- Central nerve blocks
- Combined spinal-epidural anaesthesia
- Peripheral blocks
- Special situations
- Further reading
- CHAPTER 26 Complications during anaesthesia
- Syllabus References
- Causes of complications
- Avoidance of complications
- Management of complications
- Medicolegal aspects of complications
- Common complications
- Further reading
- CHAPTER 27 Management of critical incidents
- Syllabus References
- Further reading
- CHAPTER 28 Resuscitation
- Syllabus References
- Science and guidelines
- Epidemiology
- Prevention
- Cardiopulmonary resuscitation
- Advanced life support
- Periarrest arrhythmias
- Postresuscitation care
- Decisions relating to cardiopulmonary resuscitation
- National Cardiac Arrest Audit
- Acknowledgement
- Further reading
- CHAPTER 29 Point-of-care ultrasound
- Syllabus References
- Conclusions
- Further reading
- CHAPTER 30 Postoperative and recovery room care
- Syllabus References
- Postanaesthesia care unit facilities
- Common early postoperative complications
- Other complications
- Further reading
- CHAPTER 31 Sustainability
- Syllabus References
- Sustainability in Anaesthesia
- Further Reading
- Section 4 Clinical anaesthesia
- CHAPTER 32 Anaesthesia for the older person and/or those living with frailty
- Syllabus References
- Ageing: geriatric syndromes
- Ageing: multiple long-term conditions (MLTCs)
- Ageing: physiological decline
- Using comprehensive geriatric assessment in the preoperative setting
- Intraoperative considerations
- Postoperative care in older surgical patients
- Further reading
- CHAPTER 33 Anaesthesia for the patient with obesity
- Syllabus References
- Measuring obesity
- Obesity and the metabolic syndrome
- Obesity: pathophysiology, comorbidity and management of anaesthesia
- Management of anaesthesia
- Pharmacology
- Practical aspects of anaesthesia for patients with obesity
- Bariatric operations
- Postoperative care of the patient having bariatric surgery
- Management of patients who have undergone previous bariatric surgery
- Further reading
- CHAPTER 34 Paediatric anaesthesia
- Syllabus References
- Anatomy and physiology
- Preoperative considerations
- Day of surgery
- Intraoperative anaesthesia
- Postoperative care
- Specific challenges
- Anaesthesia for common paediatric procedures
- Further reading
- CHAPTER 35 Anaesthesia for day surgery
- Syllabus References
- Preoperative assessment
- Assessing suitability for day surgery
- Postoperative nausea and vomiting
- Airway management
- Regional anaesthesia
- Sedation
- Recovery in day surgery
- Management and organisation of the day surgery unit
- Current issues in day surgery
- Further reading
- CHAPTER 36 Anaesthesia for general, gynaecological and genitourinary surgery
- Syllabus References
- Considerations for anaesthesia
- Specific procedures
- Further reading
- CHAPTER 37 Anaesthesia for orthopaedic surgery
- Syllabus References
- Preoperative assessment and optimisation
- Techniques of anaesthesia
- Specific surgical procedures
- Spinal surgery
- Further reading
- CHAPTER 38 Anaesthesia for ear, nose and throat, maxillofacial and dental surgery
- Syllabus References
- Airway management for shared airway surgery
- ENT surgery
- Oral and maxillofacial surgery
- Anaesthesia for head and neck cancer surgery
- Dental anaesthesia
- Further reading
- CHAPTER 39 Anaesthesia for ophthalmic surgery
- Syllabus References
- Anatomy and physiology of the eye
- Conditions for intraocular surgery
- Choice of anaesthesia
- Ophthalmic regional blocks
- Ophthalmic procedures requiring general anaesthesia
- Further reading
- CHAPTER 40 Anaesthesia for vascular, endocrine and plastic surgery
- Syllabus References
- General considerations
- Abdominal aortic aneurysm
- Surgery for occlusive peripheral vascular disease
- Carotid artery surgery
- Cardioversion
- Surgery for tumours of the endocrine system
- Plastic and reconstructive surgery
- Further reading
- CHAPTER 41 Anaesthesia for neurosurgery
- Syllabus References
- Applied anatomy and physiology
- General principles of neurosurgical anaesthesia
- Anaesthesia for intracranial surgery
- Anaesthesia for surgery of the spine and spinal cord
- Anaesthesia for emergency intracranial surgery
- Management of the brain-injured patient
- Intensive care management of patients who are brain-injured
- Anaesthesia for CT and MRI scanning
- CHAPTER 42 Anaesthesia for thoracic surgery
- Syllabus References
- Anatomy
- Thoracic procedures and their indications
- Further reading
- CHAPTER 43 Anaesthesia for cardiac surgery
- Syllabus References
- Ischaemic heart disease
- Valvular disease
- Arrhythmias
- Implantable rhythm management devices
- Congenital heart disease
- Cardiopulmonary bypass
- Preoperative assessment
- Monitoring
- Pathophysiology
- Anaesthesia for cardiac surgery
- Postoperative care
- Specific procedures
- Extracorporeal membrane oxygenation
- Ventricular assist devices
- Heart and lung transplantation
- Further reading
- CHAPTER 44 Obstetric anaesthesia
- Syllabus References
- Physiology in pregnancy
- Anatomy in pregnancy
- Pharmacology in pregnancy
- Basic obstetrics
- Analgesia during labour
- Anaesthesia for delivery
- Complications of regional anaesthesia and analgesia in obstetrics
- General anaesthesia for delivery
- Emergencies in obstetric anaesthesia
- Anaesthesia for interventions outside of the peripartum period
- Further reading
- CHAPTER 45 Emergency and trauma anaesthesia
- Syllabus References
- Preoperative assessment
- The full stomach
- Conduct of anaesthesia
- Emergency laparotomy in the older patient
- Major trauma
- Trauma anaesthesia
- Further reading
- CHAPTER 46 Anaesthesia in resource-poor areas
- Syllabus References
- Background
- Challenges to the provision of anaesthesia
- Population and procedures
- Anaesthesia without electricity or pressurised gas supplies
- CHAPTER 47 Anaesthesia outside the operating theatre
- Syllabus References
- General considerations and principles
- Anaesthesia in the radiology department
- Anaesthesia for radiotherapy
- Anaesthesia for electroconvulsive therapy
- Anaesthesia in the emergency department
- CHAPTER 48 Anaesthesia and organ transplantation
- Syllabus References
- General considerations in organ transplantation
- General principles of anaesthesia
- Transplant recipients undergoing non-transplant procedures
- Anaesthesia for organ transplantation and transplant recipients: organ-specific considerations
- Further reading
- CHAPTER 49 Intensive care
- Syllabus References
- Staffing an intensive care unit
- ICU admission and ethical decision making
- Assessment of patients
- Monitoring in ICU
- Instituting intensive care
- Other aspects of intensive care
- Outcomes after intensive care
- Death in intensive care
- Organ donation
- Discharge from intensive care
- Further reading
- Index
- Edition: 8
- Published: January 1, 2025
- Imprint: Elsevier
- No. of pages: 990
- Language: English
- Paperback ISBN: 9780443126680
- eBook ISBN: 9780443126468
JT
Jonathan Thompson
Affiliations and expertise
Honorary Professor and Consultant in Anaesthesia and Critical Care, University of Leicester and University Hospitals of Leicester NHS Trust, Leicester, UKIM
Iain Moppett
Affiliations and expertise
Professor of Anaesthesia & Perioperative Medicine and Honorary Consultant Anaesthetist, University of Nottingham and Nottingham University Hospitals NHS Trust, UKMW
Matthew Wiles
Matthew Wiles is a Consultant in the Department of Anaesthesia at Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
Affiliations and expertise
Consultant in Anaesthesia and Critical Care, Sheffield Teaching Hospitals NHS Foundation Trust and Honorary Clinical Senior Lecturer, University of Sheffield, Sheffield, UK