Smart Polymeric Nano-Constructs in Drug Delivery
Concept, Design and Therapeutic Applications
- 1st Edition - November 12, 2022
- Imprint: Academic Press
- Editors: Suresh P Vyas, Udita Agrawal, Rajeev Sharma
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 1 2 4 8 - 8
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 1 3 9 9 - 7
Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications provides a thorough discussion of the most state of the art material and polyme… Read more
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Request a sales quoteSmart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications provides a thorough discussion of the most state of the art material and polymer exploitations for the delivery of bioactive(s) as well as their current and clinical status. The book enables researchers to prepare a variety of smart drug delivery systems to investigate their properties as well as to discover their uses and applications. The novelty of this approach addresses an existing need of exhaustively understanding the potential of the materials including polymeric drug delivery systems that are smartly designed to deliver bioactive(s) into the body at targeted sites without showing side effects. The book is helpful for those in the health sector, specifically those developing nanomedicine using smart material-based nano-delivery systems. Polymers have unique co-operative properties that are not found with low-molecular-weight compounds along with their appealing physical and chemical properties, constituting the root of their success in drug delivery. Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications discusses smart and stimuli responsive polymers applicable in drug delivery, followed detailed information about various concepts and designing of polymeric novel drug delivery systems for treatment of various type of diseases, also discussing patents related to the field. The book helps readers to design and develop novel drug delivery systems based on smart materials for the effective delivery of bioactive that take advantage of recent advances in smart polymer-based strategies. It is useful to those in pharmaceutical sciences and related fields in developing new drug delivery systems.
- Provides comprehensive overview of the potential role of polymeric systems in drug delivery
- Explores the design, synthesis, and application of different smart material-based delivery systems
- Includes fundamental and clinical applications
Pharmaceutical scientists, post graduate students, clinical researchers, and specialists working in targeted drug delivery; Researchers and advanced students in chemistry and pharmacy and those in the field of polymers and nanotechnology
- Cover
- Title page
- Table of Contents
- Copyright
- Contributors
- Chapter 1: Introduction to smart polymers and their application
- Abstract
- Acknowledgments
- 1: Introduction
- 2: Types of smart polymers
- 3: Application of smart polymers
- 4: Conclusions
- References
- Chapter 2: Thermoresponsive polymers: Phase behavior, drug delivery, and biomedical applications
- Abstract
- 1: Introduction
- 2: Thermoresponsive polymers
- 3: Applications of thermoresponsive polymers in biomedical and drug delivery
- 4: Conclusion and future prospects
- References
- Further reading
- Chapter 3: pH-sensitive polymeric nanocarriers for enhanced intracellular drug delivery
- Abstract
- 1: Introduction
- 2: pH-dependent cellular microenvironments
- 3: Different strategies for the development of pH-sensitive polymeric nanocarriers
- 4: Mechanism of drug release from pH-sensitive nanocarriers
- 5: pH-responsive nanocarriers for drug delivery and targeting
- 6: pH-responsive nanocarriers for disease diagnosis
- 7: Challenges in the design of pH-sensitive nanocarriers
- 8: Future perspectives
- 9: Concluding remarks
- References
- Chapter 4: Photoresponsive nanocarriers for the delivery of bioactives
- Abstract
- Acknowledgment
- 1: Introduction
- 2: Photoresponsiveness: Light as source for triggering drug release
- 3: Development of photosensitive nanocarriers
- 4: Mechanisms of photoresponsive nanoparticles for drug release
- 5: Photoresponsive drug delivery nanocarriers
- 6: Conclusions and future prospects
- References
- Chapter 5: Magnetically responsive polymeric gels and elastomeric system(s) for drug delivery
- Abstract
- 1: Introduction
- 2: Polymer gels and elastomers
- 3: Magnetic modulation of polymer gels and elastomers
- 4: Transport phenomenon in magnetic drug delivery
- 5: For disease therapy
- 6: Concluding remarks and future prognosis
- References
- Chapter 6: Bioadhesive and phase change polymers for drug delivery
- Abstract
- 1: Introduction
- 2: Bioadhesive polymers in drug delivery
- 3: Advantages of bioadhesive polymers in drug delivery
- 4: Theories of bioadhesion
- 5: Requirements for an ideal bioadhesive polymer
- 6: Factors affecting the bioadhesive polymers
- 7: Classification of bioadhesive polymers
- 8: Commonly employed bioadhesive polymers in drug delivery
- 9: Phase change polymers
- 10: Application of bioadhesive and phase change polymers in drug delivery
- 11: Conclusions
- References
- Chapter 7: Block copolymer micelles as long-circulating drug vehicles
- Abstract
- 1: Introduction
- 2: Design criteria of block copolymers for self-assembly of polymeric micelles
- 3: Micelle preparation method
- 4: General considerations and characteristics of micelles
- 5: Synthesis of amphiphilic block copolymers possessing PEG chain for stealth effect
- 6: Fate of polymeric systems upon systemic delivery
- 7: Avoiding rapid clearance from systemic circulation
- 8: Future trends
- 9: Conclusions
- References
- Chapter 8: Polymer-drug conjugates: Origins, progress to date, and future directions
- Abstract
- 1: Introduction
- 2: Advantages of polymer-drug conjugates
- 3: Origins of polymer-drug conjugates
- 4: Types of polymer-drug conjugates for drug targeting
- 5: Targeted vs nontargeted conjugates
- 6: Approaches for designing the polymer-drug conjugates
- 7: Gap between the current studies and clinical application for polymeric-drug conjugates
- 8: Approaches for the enhancing the transportation of polymer-drug conjugates
- 9: Clinical status of polymer-drug conjugates
- 10: Future prospects of polymer-drug conjugates
- References
- Chapter 9: Molecularly imprinted polymers for drug delivery and biomedical applications
- Abstract
- 1: Introduction
- 2: Concept behind the molecularly imprinted polymers
- 3: Designing MIPs for drug delivery
- 4: MIP-based drug delivery systems
- 5: Stimuli-responsive molecularly imprinted polymers
- 6: MIPs for drug delivery and biomedical applications
- 7: Conclusions
- References
- Chapter 10: Dendritic polymer macromolecular carriers for drug delivery
- Abstract
- 1: Introduction
- 2: Properties of dendritic polymer macromolecular carriers
- 3: Synthesis of dendrimers
- 4: Toxicity of dendritic polymer macromolecules
- 5: Types of dendritic polymer macromolecular carriers
- 6: Drug delivery strategies
- 7: Applications of dendritic macromolecules
- 8: Conclusions
- References
- Chapter 11: Advances in hydrogel-based controlled drug-delivery systems
- Abstract
- 1: Introduction
- 2: Hydrogels
- 3: Structure of hydrogels
- 4: Classification of hydrogels
- 5: Preparation of hydrogels
- 6: Characterization of hydrogels
- 7: Therapeutic application of hydrogels
- 8: Current research and future prospects
- References
- Chapter 12: Stimuli-responsive protein fibers for advanced applications
- Abstract
- 1: Introduction
- 2: Synthesis
- 3: Various responsive systems
- 4: Preclinical studies
- 5: Clinical trial studies
- 6: Applications of self-assembled peptide nanofibers
- 7: Marketed preparations
- 8: Conclusion and future prospects
- References
- Chapter 13: Smart drug delivery systems and their clinical potential
- Abstract
- 1: Introduction
- 2: Potential stimuli-responsive nanocarriers
- 3: Stimuli-responsive DDSs: Design, rationale, and types
- 4: Dual/multistimuli-responsive DDSs
- 5: Clinical scenario of stimuli-responsive DDS
- 6: Conclusions
- Conflict of interests
- References
- Chapter 14: Novel biomimetic polymersomes as polymer therapeutics for drug delivery
- Abstract
- 1: Introduction
- 2: Background
- 3: Need and importance
- 4: Variants of polymersomes
- 5: Chemistry and preparation of polymersomes
- 6: Therapeutic applications
- 7: Beyond polymersomes
- 8: Conclusions
- References
- Chapter 15: Bioinspired and biomimetic conjugated drug delivery system(s): A biohybrid concept combining cell(s) and drug delivery carrier(s)
- Abstract
- Acknowledgment
- 1: Bioinspired systems: An insight
- 2: Methods for active drug delivery of bioconjugates
- 3: Virus-inspired bioactive delivery systems
- 4: Mammalian cell-based bioactive delivery systems
- 5: Cell-inspired bioactive delivery systems
- 6: Polymer-based bioactive delivery systems
- 7: Bioactive(s) delivery via biomacromolecular systems
- References
- Chapter 16: Conductive polymers and composite-based systems: A quantum leap in the drug delivery arena and therapeutics
- Abstract
- 1: Introduction
- 2: Conductive polymers
- 3: Synthesis of conductive polymers (CPs)
- 4: Types of CPs
- 5: CP composites
- 6: Synthesis of CP composites
- 7: Types of CP composites
- 8: Applications of CPs and composites
- 9: Conclusions
- 10: Future prospects
- References
- Chapter 17: Nanomedicine: Principles, properties, and regulatory issues
- Abstract
- 1: Introduction
- 2: Dynamic behavior of polymeric nanomedicine
- 3: Preparation methods of polymeric nanomedicines
- 4: Characterization of polymeric nanomedicines
- 5: Sterility and pyrogenicity
- 6: Pharmacokinetics and pharmacodynamics
- 7: Nanotoxicity and risk assessment
- 8: Challenges in the manufacturing scale-up and reproducibility
- 9: Regulatory issues
- 10: Example and list of currently approved polymeric nanomedicines released into the market
- References
- Chapter 18: Polymer-matrix nanocomposites and its potential applications
- Abstract
- 1: Introduction
- 2: Processing methods of polymer-matrix nanocomposites
- 3: Conclusions
- References
- Index
- Edition: 1
- Published: November 12, 2022
- No. of pages (Paperback): 624
- No. of pages (eBook): 624
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780323912488
- eBook ISBN: 9780323913997
SP
Suresh P Vyas
Dr Vyas has over 36 years of teaching and research experience at postgraduate level. He is a pioneer scientist in the field of nano-biotechnology and immunology. He has over 325 research publications to his credit published in journals of high scientific impact and has authored 18 reference books including Pharmaceutical Biotechnology, Liposomal Therapeutics, Novel Controlled Drug Delivery Systems, Targeted Drug Delivery Systems, Theory and Practices in Novel Drug Delivery Systems. He is a commonwealth postdoctoral fellowship awardee and has worked under fellowship at School of Pharmacy University of London (U.K.). He is a recipient of Best Scientist award by Association of Pharmacy Professionals (APP) 2014 and many other honors. He serves on the editorial board of multiple international scientific publications including International Journal of Pharmaceutics (Elsevier).
Affiliations and expertise
Pioneer Scientist, Department of Pharmaceutical Sciences, IndiaUA
Udita Agrawal
Dr. Agrawal has over 6 years of teaching and research experience at postgraduate level. She served as associate professor at Sagar Institute of Research and Technology Bhopal and Oriental College of Pharmacy Bhopal. She is Gold Medalist in B. Pharm and M. Pharm from Dr. H. S. Gour University and has been awarded with Pharmaceutical Science Alumi Award, Prof. C. S. Chauhan gold medal and Nagarjuna Award from Dr. H. S. Gour University Sagar (MP). She has received various awards in the field of drug delivery for her outstanding innovative research work including M. P Young Scientist Award 2016, Adina Young Scientist Award 2016 in the field of pharmaceutical and medical sciences and many best poster and oral presentation awards. She has more than 40 publications and book chapters in journals of international repute. She is currently working on targeted drug and peptides delivery systems exploiting polymers and nanobiotechnology.
Affiliations and expertise
Associate Professor, Department of Pharmaceutical Sciences, Sagar (Madhya Pradesh) 470003, IndiaRS
Rajeev Sharma
Rajeev Sharma is an Assistant Professor at the Amity Institute of Pharmacy, Amity University, Madhya Pradesh, Gwalior, India. He earned his B.Pharm, M.Pharm, and Ph.D. in Pharmaceutical Sciences from Dr. H. S. Gour Central University, Sagar, India. Dr. Sharma has approximately 13 years of experience in both teaching and industry. He has served as a Junior Research Fellow under AICTE, an ICMR-SRF, and a CSIR-RA Fellow during his research career, and has worked as an Assistant Professor in academia and as a Senior Formulation Development Scientist in the R&D industry. Dr. Sharma has edited two international and two national books and has authored over 30 publications and 21 book chapters in international reference books. His work focuses on recent concepts in immunology, nanobiotechnology, novel drug delivery systems, and targeted and controlled drug delivery of bioactives for the treatment of diseases such as cancer and diabetes. He is a life member of the Association of Pharmaceutical Teachers of India (APTI). Dr. Sharma's work has been cited approximately 1,200 times, and he has an h-index of 17. The cumulative impact factor of his published papers is around 120, according to SCOPUS. He is currently working on a research project funded by the Madhya Pradesh Council of Science and Technology (MPCST). Dr. Sharma has received several awards for his research, including the Young Research Scholar award and various awards for best oral and poster presentations at national and international conferences. His current research interest is in nanocarrier-based targeted approaches for the effective delivery of bioactives.
Affiliations and expertise
Assistant Professor, Amity institute of Pharmacy, Amity University, Gwalior, Madhya Pradesh, IndiaRead Smart Polymeric Nano-Constructs in Drug Delivery on ScienceDirect