Smart Nanomaterials for Bioencapsulation

1st Edition - September 30, 2022
Imprint: Elsevier
Editors: Guillermo R. Castro, Ashok Kumar Nadda, Swati Sharma, Ram K. Gupta, Tuan Anh Nguyen
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 2 2 9 - 7
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 3 9 7 - 3

Smart Nanomaterials for Bioencapsulation focuses on the fundamentals, synthesis methods and matrix design for the encapsulation of drugs, drug release, food and nutraceut… Read more

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Smart Nanomaterials for Bioencapsulation focuses on the fundamentals, synthesis methods and matrix design for the encapsulation of drugs, drug release, food and nutraceuticals, mechanisms of nano- encapsulated drugs on liposomes, micelles, silica composites, carbon nanotubes, dendrimers, and protein inorganic nanohybrids. Providing detailed information on the encapsulation of food and drug derivatives, the book helps create new and modern approaches for both pharmaceutical and nutritional science. The target delivery of pharmacological agents, as well as food additives under various conditions is covered, including sections on systemic release of drug molecules, minimum loss at non-target sites, the accumulation of diseased tissue or organs, and more.

Smart nanomaterial-based nanocarriers protect the loaded molecules from premature degradation in the biological environment and enhance bioavailability for cellular uptake. The tuned properties of smart nanomaterials, such as porosity, pore-volume, surface area-to-volume ratio, coating with inert and labile materials, and more help determine the in vivo performance of the bioencapsulated food and drug derivatives.

Cover Image
Title Page
Copyright
Table of Contents
Contributors
Chapter 1 Hybrid systems in bio-encapsulation
1.1 Introduction
1.2 Crystalline calcium carbonate
1.3 Synthesis of CaCO3 particles
1.4 Characterization of crystalline calcium carbonate
1.5 Cytocompatibility of CaCO3 particles
1.6 CaCO3 particles as drug carriers
1.7 Conclusion
Declaration of competing interest
Acknowledgements
References
Chapter 2 Polysaccharides as natural nanoencapsulants for controlled release of compounds
2.1 Introduction
2.2 Structure, properties, and health benefits of natural polysaccharide
2.3 Development of smart polysaccharide-based delivery systems of bioactive compounds
2.4 Interactions between biopolymers for nanoencapsulation
2.5 Polysaccharide-based nanocompounds as potential delivery systems for bioactive compounds: applications and future perspectives
2.6 Conclusion and further remarks
References
Chapter 3 Application in gene therapy and DNA/RNA vaccines
3.1 Introduction
3.2 Gene therapy: principles and strategies for DNA/RNA editing approaches
3.3 DNA and RNA vaccines: general concepts, mechanisms of action and their advantages and limitations
3.4 DNA/RNA delivery methods: viral versus nonviral vectors
3.5 Nanomedicines as vaccine adjuvants
3.6 Current status of nanomedicines for gene therapy and DNA/RNA vaccines: preclinical and clinical studies
3.7 Conclusions
References
Chapter 4 Delivery of bioencapsulated proteins
4.1 Introduction
4.2 Protein bioencapsulation development
4.3 Challenges in protein and peptides bioencapsulation
4.4 Nanomaterials and strategies for protein nanoencapsulation
4.5 Conclusion
Acknowledgment
References
Chapter 5 Smart bio-encapsulation for immunotherapy
5.1 Introduction (Immunotherapy)
5.2 Immunotherapy strategies
5.3 Checkpoint inhibitors
5.4 Cytokine
5.5 Vaccines
5.6 Immune cell therapy
5.7 Smart nanocarriers for immunotherapy
5.8 Conclusion
References
Chapter 6 Bioencapsulation for protein delivery
6.1 Introduction
6.2 The characteristics of proteins for bioencapsulation
6.3 Coating components in bioencapsulation
6.4 Methods of bioencapsulation
6.5 Bioencapsulation using smart polymers
6.6 Bioencapsulation by nanoparticle and microparticle system for protein delivery
6.7 Advantages of bioencapsulating proteins
6.8 Challenges in bioencapsulation of proteins
6.9 Future prospects and conclusion
Acknowledgment
References
Chapter 7 Bioencapsulation for probiotics
7.1 Introduction to probiotics
7.2 Bioencapsulation of probiotics
7.3 Characterization and properties of encapsulated probiotics
7.4 Issues and challenges in the bioencapsulation for probiotics
7.5 Future of the bioencapsulation for probiotics
References
Chapter 8 Bioencapsulation for the functional foods and nutraceuticals
8.1 Food additives
8.2 Bioencapsulation for food additives
8.3 Characterization and properties of encapsulated food additive
8.4 Issues in the bioencapsulation for food additive
8.5 Future and challenges of the bioencapsulation for food additives
References
Chapter 9 Bioencapsulation of proteins in therapeutics
9.1 Introduction
9.2 Characteristics of therapeutic proteins
9.3 Therapeutic proteins of biotechnological origin
9.4 Strategies for modeling the pharmacokinetic and pharmacodynamic characteristics of therapeutic proteins
9.5 Methods and materials for encapsulation of therapeutic proteins
9.6 Conclusions and future prospects
References
Chapter 10 Bioencapsulation for food additives
10.1 Introduction
10.2 Encapsulation processes
10.3 Coating materials
10.4 Characterization of encapsulated materials
10.5 Encapsulation applications in food industry
10.6 Encapsulation of lactic acid bacteria and probiotics
10.7 The use of encapsulation technology for inhibition of pathogens
10.8 The use of encapsulatıon technology for the prevention of fish oil oxidation
10.9 The use of encapsulation technology to improve the quality of meat products
10.10 Results and future suggestions
References
Chapter 11 Theragnostic applications
11.1 Introduction
11.2 Evolution of theragnosis
11.3 In vivo imaging modalities
11.4 Treatment strategies
11.5 Nanotheragnostics
11.6 Nanomaterials with theragnostic applications
11.7 Radionuclides associated with nanocarriers
11.8 Metallic nanoparticles
11.9 Future of clinical studies
References
Chapter 12 Nanotechnology in agriculture and bioencapsulation of probiotics/food additives
12.1 Introduction
12.2 Application of nanotechnology in agriculture
12.3 Bioencapsulation for probiotics and food additives
12.4 Conclusion
Acknowledgement
References
Chapter 13 Smart systems in bio-encapsulation for cancer therapy
13.1 Introduction
13.2 Smart nanocarrier-based delivery systems
13.3 The tumor microenvironment as the target site for smart systems
13.4 Conclusion and perspectives
References
Chapter 14 Nanoencapsulation for production of fermented foods and pigments
14.1 Introduction
14.2 Nanoencapsulation methods
14.3 Strategies for the production of nanoparticles
14.4 Methods for removal of solvent
14.5 Materials used to produce nanomaterials
14.6 Applications
14.7 Future perspectives
14.8 Conclusion
References
Chapter 15 Nanoencapsulation of tyrosine kinase inhibitors for oncological therapeutics
15.1 Introduction to the lung cancer
15.2 Epidermal growth factor receptor (EGFR) gene and mutation in lung cancer
15.3 Cancer management by TKIs
15.4 Targeted cancer and lung cancer therapies
15.5 Nanoencapsulation of TKIs for lung cancer treatment
15.6 Limitations of nanoencapsulations/nanoparticles/nanomedicines in cancer treatment
References
Chapter 16 Nanoencapsulation for chemical intermediate, biocides, and bio-based binder
16.1 Introduction
16.2 Material used in nanoencapsulation
16.3 Techniques for encapsulation
16.4 Nanoencapsulation for chemical intermediates
16.5 Nanoencapsulation for biocides
16.6 Nanoencapsulation for bio based binder
16.7 Future perspectives
16.8 Conclusion
References
Index

Guillermo R. Castro

Guillermo R. Castro is a Full Professor at the Max Planck Laboratory for Structural Biology, Chemistry and Molecular Biophysics of Rosario (MPLbioR, UNR-MPIbpC), which is a partner Laboratory of the Max Planck Institute for Biophysical Chemistry (MPIbpC, MPG), at the Centro de Estudios Interdisciplinarios (CEI), Universidad Nacional de Rosario, Rosario, Santa Fe, Argentina. His areas of research are microbial and biomedical biotechnology, non-aqueous enzymology, bio-transformations. biopolymers (production and industrial uses), controlled release of molecules, nanobiotechnology, and hybrid materials.

Affiliations and expertise

Senior Visiting Professor at the Nanomedicine Research Unit (Nanomed), Center for Natural and Human Sciences, Federal University of ABC (UFABC), Brazil

Ashok Kumar Nadda

Ashok Kumar is an Assistant Professor, in the Department of Biotechnology and Bioinformatics, at Jaypee University of Information Technology, Waknaghat, India. His research areas are in enzymology, biocatalysis, biopolymers, enzyme immobilization, and bioenergy.

Affiliations and expertise

Assistant Professor, Jaypee University of Information Technology

Swati Sharma

Dr. Swati Sharma (MSc, Dr. Yashwant Singh Parmar University of Horticulture and Forestry, Nauni Solan H.P. India; PhD. University Malaysia, Pahang, Malaysia) is Assistant Professor at University Institute of Biotechnology, the Chandigarh University Mohali, India. She worked as a visiting researcher in the College of Life and Environmental Sciences at Konkuk University, Seoul, South Korea. She has also worked as a program co-coordinator at the Himalayan Action Research Center (HARC), Dehradun, and Senior Research Fellow at the India Agricultural Research Institute in 2013-2014. Presently, Dr. Sharma's research is in the field of bioplastics, hydrogels, keratin nano-fibers and nano-particles, biodegradable polymers and polymers with antioxidant and anticancer activities and sponges. Dr. Swati has published numerous books and papers in various internationally reputed journals.

Affiliations and expertise

Assistant Professor, Chandigarh University, India

Ram K. Gupta

Ram K. Gupta is a Professor in the Department of Chemistry at Pittsburg State University, USA. His research interests include green energy production and storage using conducting polymers, 2D materials, nanostructured materials and composites, polymers from renewable resources for industrial applications, polymer recycling for sustainable future, bio-compatible nanofibers and thin films for tissue regeneration, scaffolds, bio-degradable metallic implants, and antibacterial applications.

Affiliations and expertise

Professor, Department of Chemistry, Kansas Polymer Research Center, Pittsburg State University, Pittsburg, KS, USA

Tuan Anh Nguyen

Tuan Anh Nguyen is a Senior Principal Research Scientist at the Institute for Tropical Technology, Vietnam Academy of Science and Technology, Hanoi, Vietnam. He received a BS in physics from Hanoi University in 1992, a BS in economics from Hanoi National Economics University in 1997, and a PhD in chemistry from the Paris Diderot University, France, in 2003. He was a Visiting Scientist at Seoul National University, South Korea, in 2004, and the University of Wollongong, Australia, in 2005. He then worked as a Postdoctoral Research Associate and Research Scientist at Montana State University, United States in 2006-09. In 2012 he was appointed as the Head of the Microanalysis Department at the Institute for Tropical Technology. His research areas of interest include smart sensors, smart networks, smart hospitals, smart cities, complexiverse, and digital twins. He has edited more than 74 books for Elsevier, 12 books for CRC Press, 1 book for Springer, 1 book for RSC, and 2 books for IGI Global. He is the Editor-in-Chief of Kenkyu Journal of Nanotechnology & Nanoscience.

Affiliations and expertise

Senior Principal Research Scientist, Institute for Tropical Technology, Vietnam Academy of Science and Technology, Hanoi, Vietnam

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Smart Nanomaterials for Bioencapsulation

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Guillermo R. Castro

Ashok Kumar Nadda

Swati Sharma

Ram K. Gupta

Tuan Anh Nguyen

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