Sleep and Brain Activity
- 1st Edition - July 25, 2012
- Latest edition
- Editor: Marcos G. Frank
- Language: English
In the last few decades, scientists have discovered that far from being a time of neural silence, sleep is characterized by complex patterns of electrical, neurochemical, and me… Read more
In the last few decades, scientists have discovered that far from being a time of neural silence, sleep is characterized by complex patterns of electrical, neurochemical, and metabolic activity in the brain. Sleep and the Brain presents some of the more dramatic developments in our understanding of brain activity in sleep. The book discusses what parts of the brain are active in sleep and how, and presents research on the function of sleep in memory, learning, and further brain development. Coverage encompasses the network and membrane mechanisms responsible for waking and sleeping brain activity, the roles of glial cells in the sleeping brain, the molecular basis of sleep EEG rhythms, and research on songbirds, rodents, and humans indicating the function of sleep.
- Collates material dispersed across a wide gamut of primary literature into one place
- Focuses on the most interesting and prolific research results on brain activity as it relates to sleep
- Practical real data discussion includes functional brain imaging and EEG research
Neuroscientists and psychologists studying sleep and/or brain activity
Preface
List of Contributors
Chapter 1. Neuronal Oscillations in the Thalamocortical System during Sleeping and Waking States
Neuronal Synchronization
Basic Thalamocortical States
Thalamocortical Rhythmic Activities
Origin of Slow Waves: Cortex versus Thalamus
Origin of Slow Waves: Horizontal and Vertical Propagation
Acknowledgements
REFERENCES
Chapter 2. Corticothalamic Rhythms during States of Reduced Vigilance
The Alpha Rhythm of Relaxed Wakefulness and the Theta Waves of Early NREM Sleep
The Slow (<1 Hz) EEG Rhythm of NREM Sleep
Concluding Remarks
Acknowledgments
REFERENCES
Chapter 3. Glial Modulation of Sleep and Electroencephalographic Rhythms
Introduction
Early Concepts of Glial Roles in Sleep
Glia, Neural Metabolism, and Sleep
Ion Buffering and EEG Activity
Glial Secretion of Somnogenic Substances: Astrocytes
Glial Secretion of Somnogenic Substances: Microglia and Oligodendrocytes
Unanswered Questions and Future Directions
REFERENCES
Chapter 4. Genetic Mechanisms Underlying Rhythmic EEG Activity during Sleep
Introduction
Genetics of the Human EEG: Twin, Linkage, and Candidate-Gene Studies
Genetics of the EEG: Mouse Studies
Regulation of Sleep: Time-of-Day versus Time-Spent-Awake
Genetics of the Homeostatic Regulation of Sleep
A Non-Circadian Role for Clock Genes in Sleep Homeostasis
REFERENCES
Chapter 5. Evoked Electrophysiological and Vascular Responses across Sleep
Introduction
Electrical Markers of Sleep and Sleepiness
Evoked Vascular and Hemodynamic Relationships to Sleep
Conclusions
Acknowledgments
REFERENCES
Chapter 6. Sleep and Learning in Birds
Sleep Research from the Ethological Perspective
The Organization of Sleep in Birds
Towards an Animal Model: Sleep-Dependent Memory Consolidation in Humans
The Hippocampal System and Sleep-Dependent Memory Consolidation: Limited Evidence of Behavioral Consequences
European Starlings and Sleep-Dependent Memory Consolidation: Behavior
Functional Organization of the Starling Auditory System
An Introduction to Birdsong Production Learning and the Role of Sleep
The Bird Song System
Neuronal Replay in the Song System
Neuronal Replay in Adult Song Birds
Sleep and Sensorimotor Song Learning: Behavioral Evidence
Neuronal Replay and Song Development
Old and New Ideas Regarding Sleep in a New Theory of Song Learning
Summary and Final Conclusions
REFERENCES
Chapter 7. Phasic Pontine-Wave (P-Wave) Generation
Introduction
Description of PGO/P-Waves
Cellular and Molecular Characteristics of the PGO/P-Wave Generator
Mechanisms of P-Wave Activity Generation
Evidence to Link the P-Wave Generator with Memory Consolidation
Conclusions
Acknowledgements
REFERENCES
Chapter 8. Neural Correlates of Human Sleep and Sleep-Dependent Memory Processing
Introduction
NREM Sleep
REM Sleep
Functional Neuroimaging of Memory Processing during Sleep
Conclusions
Acknowledgements
REFERENCES
Chapter 9. Sleep EEG Rhythms and System Consolidation of Memory
Memory and Sleep
Mechanisms of Sleep-Dependent Memory Consolidation
Concluding Remarks
Acknowledgements
REFERENCES
Chapter 10. Sleep Slow Oscillations and Cortical Maturation
Slow Waves and Sleep Homeostasis
Slow Wave Sleep is the Price Paid for Plasticity in a Complex Neural System
The Development of Slow Waves Parallels Cortical Maturation
Active Role of Slow Waves?
Translation into Clinics
REFERENCES
Index
- Edition: 1
- Latest edition
- Published: July 25, 2012
- Language: English
MF
Marcos G. Frank
Dr. Frank has been working in the field of sleep biology for over 25 years He received his PhD in neuroscience at Stanford and managed his own sleep laboratories at UPENN and WSU. During this time, his lab made seminal discoveries about the role of glia in sleep. In 2009, they provided the first evidence that glia influence sleep regulation in vivo. That study was published in the prestigious journal Neuron and to date has been cited 852 times. Since then, his lab has published several other important papers on this topic (e.g. Current Biology 2020, Journal of Neuroscience, 2023), and he has presented this work at several conferences and invited talks. He has also published several reviews on this topic and has experience editing scientific books on the topic of sleep.
Affiliations and expertise
Washington State University, Gleason Institute for Neuroscience, USARead Sleep and Brain Activity on ScienceDirect