Simulated Moving Bed Technology

AuthorsPrefaceAcknowledgmentChapter 1. Principles of Simulated Moving Bed1.1. History: From Batch Chromatography to Continuous Countercurrent Chromatography1.2. The Simulated Moving Bed Concept1.3. Simulated Moving Bed Applications: “Old” and “New”1.4. Nonconventional Modes of Operation1.5. Concluding RemarksNomenclature2. Modeling and Simulation of Simulated Moving Bed Separation Processes2.1. Strategies of Modeling2.2. Process Performance Parameters: Purity, Recovery, Productivity, and Desorbent Consumption2.3. Effect of Model Parameters and Operating Variables on Process Performance2.4. Numerical Solution of SMB and TMB Models2.5. Concluding RemarksNomenclature3. Design of Simulated Moving Bed for Binary or Pseudo-Binary Separations3.1. Equilibrium Theory for Linear Isotherms (Triangle Theory)3.2. Extension to Nonlinear Isotherms3.3. Mass Transfer Effects3.4. Analytical Solution of True Moving Bed for Linear Systems3.5. The Concept of Separation Volume3.6. Optimization of the Simulated Moving Bed Operation3.7. Concluding RemarksNomenclature4. Process Development for Liquid-Phase Simulated Moving Bed Separations: Methodology and Applications4.1. Methodology4.2. Chiral Separations4.3. The FlexSMB-LSRE® Unit4.4. ConclusionsNomenclature5. The Parex Process for the Separation of p-Xylene5.1. p-Xylene Production5.2. The Parex Process5.3. Performance5.4. Concluding RemarksNomenclature6. Multicomponent Separations by Simulated Moving Bed (SMB)-Based Processes6.1. Pseudo-SMB JO Process6.2. MCSGP Process6.3. Sequential Multicolumn Chromatography6.4. Concluding RemarksNomenclature7. Gas-Phase Simulated Moving Bed7.1. Introduction7.2. SMB Design Using Equilibrium Theory Methodology7.3. SMB Design Using Mathematical Models7.4. Concluding RemarksNomenclature8. Simulated Moving Bed Reactor8.1. Process Intensification: Coupling Reversible Reactions with Adsorption8.2. SMBR Design Methodology8.3. SMBR Performance Parameters8.4. SMBR Mathematical Model8.5. Analytical Solution for Linear Isotherms and Linear Reaction8.6. Development of SMBR for the Synthesis of Oxygenates8.7. Other SMBR Applications: Acetals Production8.8. SMBR Concluding RemarksNomenclature9. Process Reintensification: PermSMBR9.1. Combining the Simulated Moving Bed Reactor with Permeable Membranes: The Concept of PermSMBR9.2. PermSMBR Applications9.3. Case Study: Dibutyl Acetal Production Process Development by PermSMBR9.4. Permsmbr Concluding RemarksNomenclature10. Sequential Centrifugal Partition Chromatography10.1. Solid Support-Free Liquid Chromatography10.2. Sequential Centrifugal Partition Chromatography10.3. Example10.4. Concluding Remarks11. Conclusions and PerspectivesIndex