Signal Transduction in Cancer and Immunity
- 1st Edition, Volume 361 - May 28, 2021
- Imprint: Academic Press
- Editors: Lorenzo Galluzzi, Thomas S. Postler
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 2 3 7 5 7 - 1
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 3 7 5 8 - 8
Signal Transduction in Cancer and Immunity, Volume 361 in the International Review of Cell and Molecular Biology series highlights new advances in the field, with this new volume… Read more
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Request a sales quoteSignal Transduction in Cancer and Immunity, Volume 361 in the International Review of Cell and Molecular Biology series highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics. Each chapter is written by an international board of authors.
- Provides the authority and expertise of leading contributors from an international board of authors
- Presents the latest release in the International Review of Cell and Molecular Biology series
- Updated release includes the latest information on signal transduction in cancer and immunity
Scientists and researchers in the field
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Chapter One: STAT signaling in the intestine
- Abstract
- 1: Introduction
- 2: Mechanisms of JAK-STAT signaling in inflammatory bowel diseases (IBD)
- 3: JAK-STAT inhibition in the treatment of IBD
- 4: STAT signaling in other diseases of the gut
- 5: Infection
- 6: Cancer
- 7: Conclusion
- Chapter Two: The RAL signaling network: Cancer and beyond
- Abstract
- 1: The RAS family of small GTPases
- 2: RAL GTPases: An introduction
- 3: Regulation of RAL activity and function
- 4: The RAL signaling network: Effector proteins and regulated processes
- 5: RAL signaling in cancer
- 6: RALopathies
- 7: Inhibition of RAL activity
- 8: Conclusion
- Acknowledgments
- Chapter Three: Implications of microgravity-induced cell signaling alterations upon cancer cell growth, invasiveness, metastatic potential, and control by host immunity
- Abstract
- 1: Introduction
- 2: Models of microgravity
- 3: Microgravity-mediated mechanical to biochemical changes
- 4: Changes in cytoskeleton signaling associated with cell viability
- 5: Microgravity-mediated changes in signaling pathways of cancer cells
- 6: Microgravity-mediated changes in signaling pathways of primary anti-cancer effector cells
- 7: Conclusion
- Chapter Four: Tyro3, Axl, Mertk receptor-mediated efferocytosis and immune regulation in the tumor environment
- Abstract
- 1: Introduction
- 2: Structure of TAM receptors
- 3: Ligand recognition of apoptotic cells
- 4: Virus molecular apoptotic mimicry
- 5: TAM receptor efferocytosis
- 6: TAM receptors in cancer
- Chapter Five: Charting protein dephosphorylation triggered by Toll-like receptor (TLR) signaling in macrophages and its role in health and disease
- Abstract
- 1: Introduction
- 2: Protein phosphorylation and TLR signaling
- 3: Phosphorylation sites downregulated in TLR-stimulated macrophages
- 4: Using mass spectrometry to identify downregulated phosphorylation sites
- 5: Considerations and open questions
- 6: Concluding remarks
- Chapter Six: The many-sided contributions of NF-κB to T-cell biology in health and disease
- Abstract
- 1: The NF-κB signaling pathway(s) in T cells
- 2: A short overview of T-cell flavors and functions in health and disease
- 3: NF-κB in T-cell homeostasis: Proliferation, survival, cytokine expression
- 4: NF-κB in CD4+ T cells
- 5: NF-κB in CD8+ T cells
- 6: NF-κB in other T-cell subsets
- 7: NF-κB in pathological conditions: Toward NF-κB-targeted therapies?
- 8: Concluding remarks
- Acknowledgments
- Chapter Seven: A most versatile kinase: The catalytic subunit of PKA in T-cell biology
- Abstract
- 1: A brief introduction to PKA biology
- 2: PKA as a regulator of NF-κB activity
- 3: The role of cAMP and PKA in T cells
- 4: The translational relevance of PKA
- Edition: 1
- Volume: 361
- Published: May 28, 2021
- No. of pages (Hardback): 328
- No. of pages (eBook): 328
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780128237571
- eBook ISBN: 9780128237588
LG
Lorenzo Galluzzi
Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology.
Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals:
OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience.
Affiliations and expertise
Assistant Professor of Cell Biology in Radiation Oncology, Department of Radiation Oncology, Weill Cornell Medical College, NY, USATP
Thomas S. Postler
Thomas Postler, PhD, is an Assistant Professor of Microbiology & Immunology at the Columbia University Medical Center where he studies transcriptional regulation in immune cells.
Affiliations and expertise
Assistant Professor of Microbiology and Immunology, Columbia University Medical Center, USARead Signal Transduction in Cancer and Immunity on ScienceDirect