Sex, Gender, and Epigenetics
From Molecule to Bedside
- 1st Edition - May 23, 2023
- Latest edition
- Editors: Marianne Legato J., Dov Feldberg, Marek Glezerman
- Language: English
Sex, Gender, and Epigenetics: From Molecule to Bedside explores our expanding knowledge of the science of epigenetics in which gene expression is modified as a consequence of sma… Read more
Description
Description
Sex, Gender, and Epigenetics: From Molecule to Bedside explores our expanding knowledge of the science of epigenetics in which gene expression is modified as a consequence of small chemical additions to various components of the genome. The book provides an overview of the field, describing the epigenetic phenomena that unite biological sex and environmental experience to create the unique phenome of each individual. The book also analyzes the impact of ancestors’ environmental experience on subsequent generations through the sex-specific transmission of environmentally induced epigenetic modifications.
Here, international leaders in the field discuss both sex-specific normal physiology and the experience of disease, with chapters dedicated to fetal programming, the microbiome, cancer, bipolar disorder and schizophrenia, embryogenesis, and oocyte aging, among other topics.
Key features
Key features
- Examines the impact of biological sex and gender on gene expression through epigenetic mechanisms, and its relationship to human biology and disease
- Presents the current state of our understanding of how environmental experience is translated to future generations in a sex specific manner
- Features chapter contributions from international leaders in the field
Readership
Readership
Human geneticists, human genomicists, translational researchers in genomic medicine, epigenetics, biochemistry, molecular biology, oncology, reproductive biology, gender medicine, pediatrics, and bioinformatics, life science researchers, biotechnologists, developmental biologists, genetic counselors
Table of contents
Table of contents
1. Exploring how we become what we are
Marianne J. Legato
2. A critical view of the revolution of precision medicine. Genetics, epigenetics, sex, and gender
Marek Glezerman, Aaron Ciechanover, and Marianne J. Legato
3. Genetic and epigenetic contributions to female-biased lupus disease: X-chromosome inactivation in immune cells
Montserrat C. Anguera
4. Genetic, molecular, and cellular determinations of sex-specific cardiovascular traits
Felix Vaura
5. Epigenetics and mental and physical health of children born after ART
Dov. Feldberg
6. Epigenetic aspects of male infertility treatment
Olena M. Kocur, Stephanie Cheung, Philip Xie, Zev Rosenwaks, and Gianpiero D. Palermo
7. Evidence for assisted reproductive technology associated epigenetic variation in humans
Boris Novakovic, Jasmine Dennison, Stephanie Cheng, Mark Green, Sharon Lewis, Jane Halliday, and Richard Saffery
8. Deconvoluting the functional role of DNA methylation in trauma; Implications for epigenetic therapy and prospects of targeted “epigenetic therapy”
Gal Warhaftig, Daniel Sapozhnikov, Gal Yadid, and Moshe Szyf
9. Antenatal Origins of Health and Disease—A clinician’s perspective
Marek Glezerman
10. Maternal anxiety during pregnancy and the lack of fetal DNA methylation in cord blood
Jari M. Lahti
11. DNA methylation and other epigenetic modifications mediating the transgenerational impacts of paternal exposures on offspring phenotypes
Coralina Collar-Ferna´ndez, Lucas B. Hoffmann, Katie A. Fennell, Terence Y. Pang, and Anthony J. Hannan
12. Epigenetics and psychiatry
Jacob Peedicayil
13. Integrative transcriptomics reveals sexually dimorphic control of the cholinergic/neurokine interface in schizophrenia and bipolar disorder
Hermona Soreq
14. Gender specific neurobehavioral and gene expression changes in a valproic acid (VPA)–induced mouse model of autistic like behavior and correction by S-adenosylmethionine (SAMe)
Asher Ornoy, Liza Weinstein-Fudim, Maria Becker, Denis Gorobetc, and Moshe Szyf
15. Genetics and epigenetics of the onecarbon metabolism pathway in autism spectrum disorder: Role of a sex-specific brain epigenome
Donato Gemmati and Veronica Tisato
16. Novel mechanisms for gene regulation: Chemical tags on RNA molecules
Zeenal H. Patel and Ina Anreiter
17. Genes, environments, and epigenetics
Mila Gorchkova, Ina Anreiter, and Marla B. Sokolowski
18. Epigenetic mechanisms linking poor maternal nutrition during pregnancy to the cardio-metabolic health of offspring
Luciana Pellegrini Pisani and Susan Ozanne
19. Epigenetic aspects of human reproduction and early pregnancy
Dov. Feldberg
20. Sex-specific impact of maternal metabolic environment on the development of the offspring, from gametogenesis to infancy and beyond
Anne Gabory and Claudine Junien
21. Mitochondria as epigenetic regulators of reproductive aging
Keshav K. Singh
22. The fetal programming of telomere biology hypothesis
Sonja Entringer
23. Brain organoids modeling of genetic and environmental impact on neurodevelopmental traits
Nicolo` Caporale, Sarah Stucchi, Cristina Cheroni, and Giuseppe Testa
Marianne J. Legato
2. A critical view of the revolution of precision medicine. Genetics, epigenetics, sex, and gender
Marek Glezerman, Aaron Ciechanover, and Marianne J. Legato
3. Genetic and epigenetic contributions to female-biased lupus disease: X-chromosome inactivation in immune cells
Montserrat C. Anguera
4. Genetic, molecular, and cellular determinations of sex-specific cardiovascular traits
Felix Vaura
5. Epigenetics and mental and physical health of children born after ART
Dov. Feldberg
6. Epigenetic aspects of male infertility treatment
Olena M. Kocur, Stephanie Cheung, Philip Xie, Zev Rosenwaks, and Gianpiero D. Palermo
7. Evidence for assisted reproductive technology associated epigenetic variation in humans
Boris Novakovic, Jasmine Dennison, Stephanie Cheng, Mark Green, Sharon Lewis, Jane Halliday, and Richard Saffery
8. Deconvoluting the functional role of DNA methylation in trauma; Implications for epigenetic therapy and prospects of targeted “epigenetic therapy”
Gal Warhaftig, Daniel Sapozhnikov, Gal Yadid, and Moshe Szyf
9. Antenatal Origins of Health and Disease—A clinician’s perspective
Marek Glezerman
10. Maternal anxiety during pregnancy and the lack of fetal DNA methylation in cord blood
Jari M. Lahti
11. DNA methylation and other epigenetic modifications mediating the transgenerational impacts of paternal exposures on offspring phenotypes
Coralina Collar-Ferna´ndez, Lucas B. Hoffmann, Katie A. Fennell, Terence Y. Pang, and Anthony J. Hannan
12. Epigenetics and psychiatry
Jacob Peedicayil
13. Integrative transcriptomics reveals sexually dimorphic control of the cholinergic/neurokine interface in schizophrenia and bipolar disorder
Hermona Soreq
14. Gender specific neurobehavioral and gene expression changes in a valproic acid (VPA)–induced mouse model of autistic like behavior and correction by S-adenosylmethionine (SAMe)
Asher Ornoy, Liza Weinstein-Fudim, Maria Becker, Denis Gorobetc, and Moshe Szyf
15. Genetics and epigenetics of the onecarbon metabolism pathway in autism spectrum disorder: Role of a sex-specific brain epigenome
Donato Gemmati and Veronica Tisato
16. Novel mechanisms for gene regulation: Chemical tags on RNA molecules
Zeenal H. Patel and Ina Anreiter
17. Genes, environments, and epigenetics
Mila Gorchkova, Ina Anreiter, and Marla B. Sokolowski
18. Epigenetic mechanisms linking poor maternal nutrition during pregnancy to the cardio-metabolic health of offspring
Luciana Pellegrini Pisani and Susan Ozanne
19. Epigenetic aspects of human reproduction and early pregnancy
Dov. Feldberg
20. Sex-specific impact of maternal metabolic environment on the development of the offspring, from gametogenesis to infancy and beyond
Anne Gabory and Claudine Junien
21. Mitochondria as epigenetic regulators of reproductive aging
Keshav K. Singh
22. The fetal programming of telomere biology hypothesis
Sonja Entringer
23. Brain organoids modeling of genetic and environmental impact on neurodevelopmental traits
Nicolo` Caporale, Sarah Stucchi, Cristina Cheroni, and Giuseppe Testa
Review quotes
Review quotes
“This specialized book is intended for a limited number of researchers who are experts in epigenetic phenomena and want to deepen their understanding of the biological basis of epigenetic effects…. Each chapter is highly detailed and data rich and could stand alone as a research paper. …[F]illed with new data and analysis examining how epigenetic modifications emerge, how epigenetic changes to DNA lead to phenotypes, and how historical experience can affect gene expression. [A] worthy book and valuable contribution for researchers who are deeply interested in the subject matter.” —©Doody’s Review Service, 2023, Mark F. Sanders, PhD (UC Davis College of Biological Sciences)
Product details
Product details
- Edition: 1
- Latest edition
- Published: May 23, 2023
- Language: English
About the editors
About the editors
ML
Marianne Legato J.
Marianne Legato, MD, PhD (hon c), Emerita Professor of Clinical Medicine at Columbia University and founder of the Foundation for Gender-Specific Medicine, is an internationally known academic physician, author, lecturer, and specialist in gender-specific medicine. She was a charter member of the Advisory Committee on Research on Women's Health of the NIH Office of Research on Women's Health. She has published extensively on gender- and sex-specific medicine both for the scientific and for the lay public. The third edition of her textbook, Principles of Gender-Specific Medicine, and her most recent book, The Plasticity of Sex, both won Prose Awards from the American Association of Editors in 2021 and 2022, respectively.
Affiliations and expertise
Emerita Professor, Clinical Medicine, Columbia University College of Physicians and Surgeons and Adjunct Professor, Medicine at Johns Hopkins Medical School, USADF
Dov Feldberg
Dr. Dov Feldberg, MD is a very active clinically and academically Ob/Gyn specialist mainly in the field of reproductive medicine for 37 years. He obtained his expertise in Reproductive Medicine at the Yale and Cornell Hospitals and Universities in USA and became one of the pioneers in the field of ART in Israel. He was an Acting Chairman and Vice Chairman of the Ob/Gyn Division at the Rabin Medical Center in Israel. For many years he was the secretary and treasurer of the The Israel Society for Gender-and Sex Conscious Medicine (IsraGem) and the treasurer of the International Society of Gender Medicine (IGM). He is the president of the Israeli Society of Psychosomatics in Ob/Gyn. He published about 130 scientific articles in the field of Reproductive Medicine and many chapters in books. He organizes national and international meetings in the field of his interest and activities.
Affiliations and expertise
Professor, Department of Obstetrics & Gynecology, Tel Aviv University School of Medicine, Tel Aviv, IsraelMG
Marek Glezerman
Dr. Marek Glezerman, MD has chaired for 25 years in succession three large departments of Obstetrics and Gynecology at major health care centers in Israel. He has also acted for 14 years as chairman of the National Steering Committee of ObGyn at the Maccabi Health Care Services in Israel. Since 20108, he has been deeply involved in research and promotion of Gender and Sex Conscious Medicine and is regarded as one of its pioneers on a national and international level. Prof. Glezerman is founding president of the Israel Society for Gender- and Sex-Conscious Medicine and past-president of the International Society for Gender Medicine. He is currently Head of Gender- and Sex-Conscious Medicine at Tel Aviv University. He has written/edited 6 books and published more than 340 scientific articles in professional journals and chapters in textbooks.
Affiliations and expertise
Professor (emeritus) of Obstetrics and Gynecology, Faculty of Medicine, Tel Aviv University, Isreal
Current Head of Gender and Sex Conscious Medicine , Chairman of the Ethics Committee, Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelView book on ScienceDirect
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