
Sex and Gender Differences in Cardiovascular-Renal-Metabolic Physiology and Pathophysiology
Sex, Gender and Function
- 1st Edition - November 29, 2024
- Imprint: Academic Press
- Editors: Jane Reckelhoff, Licy L. Yanes Cardozo, Noha Shawky
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 2 2 2 6 6 - 5
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 2 2 6 7 - 2
Sex and Gender Differences in Cardiovascular-Renal-Metabolic Physiology and Pathophysiology: Sex, Gender and Function, the latest release in the Fundamentals of Physiology s… Read more

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Request a sales quoteSex and Gender Differences in Cardiovascular-Renal-Metabolic Physiology and Pathophysiology: Sex, Gender and Function, the latest release in the Fundamentals of Physiology series, provides a fundamental overview on sex and gender differences in all aspects of physiology. The book shares information on sex and gender differences in a variety of topics in a single comprehensive volume. This book, published in association with the International Union of Physiological Sciences acts as a primer of information scientists can build upon with their own research in sex and gender-based research.
- Discusses how sex contributes to human cardiovascular/renal/metabolic disease (i.e., sex steroids, chromosomes, genes)
- Provides hot topics in sex/gender research
- Written by global leaders in their field of expertise
- Title of Book
- Cover image
- Title page
- Table of Contents
- Editorial advisory board
- Copyright
- Contributors
- Preface
- Chapter 1. Sex differences in cardiovascular, renal, and metabolic responses to androgens
- Androgen biosynthesis, actions, and quantification
- Androgen excess in women
- Polycystic Ovary Syndrome (PCOS)
- PCOS diagnosis
- Androgen excess and cardiovascular diseases in women
- The adipose tissue is a key organ that mediates sex differences in cardiometabolic diseases
- The interplay between androgens and adipose tissue
- Cardiometabolic complications caused by an excess of androgens in female rodents
- Androgen excess and blood pressure regulation
- Mechanisms implicated in androgen-mediated increases in blood pressure: The renin-angiotensin system
- Insulin resistance and androgens
- Mechanisms mediating insulin resistance in androgen excess
- Adiponectin
- Leptin
- β-cell dysfunction
- Endogenous opioid signaling
- Oxidative stress and low-grade inflammation
- Other conditions associated with elevated androgen levels in women
- Androgen deficits in women
- Cardiometabolic management in PCOS
- Lifestyle interventions
- Insulin sensitizers
- Antiandrogens
- Myo-inositol
- Androgens in men and transmen
- Estrogen production and action
- Conclusions
- Funding
- Chapter 2. Long-term cardiovascular adaptations in women and her offspring following a pregnancy complicated by preeclampsia: Insight from clinical and experimental studies
- Introduction
- Physiological adaptations during pregnancy
- Cardiovascular risk during pregnancy: Introduction to preeclampsia
- Risk factors for preeclampsia
- Etiology of preeclampsia
- Long-term cardiovascular adaptations and risk: Maternal outcomes
- Introduction
- Clinical studies
- Preclinical studies
- Summary and perspectives
- Long-term cardiovascular adaptations and risk: Offspring
- Introduction
- Clinical studies
- Preclinical studies
- Summary and perspectives
- Maternal interventions
- Summary and perspectives
- Author contributions
- Chapter 3. Cardiovascular consequences in offspring of women with polycystic ovary syndrome. Does sex matter?
- Introduction
- Intrauterine environment in PCOS pregnancies
- Birth weight in PCOS offspring. Is it a risk factor for later CVD?
- PCOS and lactation
- Animal models of hyperandrogenemic intrauterine environment
- Considerations for studying the impact of maternal PCOS on offspring health using experimental models
- Do experimental models of maternal PCOS also have abnormal birth weight offspring?
- Cardiovascular diseases in PCOS daughters and sons
- Mechanisms for increased BP in animal models of female offspring exposed to in-utero hyperandrogenemia
- Mechanisms for increased BP in animal models of male offspring exposed to in-utero hyperandrogenemia
- Conclusion
- Funding
- Chapter 4. Physiology of exercise at environmental extremes: Sex as a biological variable
- Introduction
- Physiological responses to environmental heat and cold stress
- Sex differences in physiological and pathophysiological responses to environmental heat stress
- Physiological responses to cold exposure
- Behavioral responses to cold exposure
- Sex differences in physiological and pathophysiological responses to cold exposure
- Peripheral vascular responses to cold exposure
- Biophysical/anthropometric aspects of thermoregulation
- Metabolic responses to cold exposure
- Nonshivering thermogenesis – brown adipose tissue
- Nonshivering thermogenesis – skeletal muscle
- Thermal behavior
- Pathophysiology and cold injury
- Sex differences in the pathophysiology of cold injury
- Physiological responses and adaptations to high terrestrial altitude
- Sex differences in physiological and pathophysiological responses to altitude exposure
- Ventilatory responses
- Cardiovascular and exercise performance
- Hemoglobin, hematocrit, and erythropoiesis
- Sympathoadrenal responses
- Acute mountain sickness and altitude pathophysiology
- Overall summary & conclusions
- Disclaimer
- Chapter 5. Dietary sodium, mineralocorticoid receptor, and sex differences in endothelial function
- Abbreviations
- Introduction
- Sex discrepancy in salt sensitivity, clinical and interventional studies
- Impaired renal function and salt handling: Predominance in males
- Vaso-dysfunction theory: Predominance in females
- Sex-specific vascular endothelial dysfunction & female prevalence of endothelial MR expression
- Conclusion
- Chapter 6. Sex differences in the cardiometabolic consequences of maternal weight loss in the offspring
- Scientific pregnancy investigations
- Sex as a biological variable
- Models of diet induced obesity
- Early intervention of maternal weight loss
- Offspring outcomes from adverse pregnancies
- Effect of maternal weight loss in a sex-dependent manner
- Rodent models of maternal cardiometabolic disease and offspring outcomes
- Pregnancy and offspring microbiome
- Microbial changes with maternal weight loss and effects on cardiometabolic disease
- Conclusions
- Chapter 7. Sex differences in relaxin responses in adults and with aging
- Introduction
- Expression of RLN family peptide receptors
- RLN signal transduction pathways
- RLN and tissue fibrosis
- Stimulation of NO production
- Inhibition of TGF-beta 1 signaling
- Upregulation of MMPs
- RLN and vasodilation
- Vasodilatory action of RLN in animal models of disease
- The vasodilatory actions of RLN directly affect renal function
- Interaction between estrogen, RLN and the RAS
- RLN and the AT2R in females
- Reinstating the RLN-RXFP1-AT2R axis in aged, hypertensive female rats
- Serelaxin clinical trials for heart failure
- Development of RLN mimetics
- Summary
- Chapter 8. Sex-biased mechanisms of metabolic syndrome-induced cardiovascular and retinal complications
- Introduction
- Metabolic syndrome
- Definition and prevalence
- Risk factors
- Pathophysiology
- Insulin resistance
- Chronic inflammation
- Oxidative stress
- Sex-biased mechanisms of MetS
- Sex-biased mechanisms in MetS-induced cardiovascular complications
- Sex-biased mechanisms in MetS-induced retinal complications
- Conclusions
- Chapter 9. Cardiovascular consequences of androgen gender affirming therapy in transmasculine individuals
- Highlighting the concern
- Quick definitions of terms
- Pharmacological use of androgens in people assigned female at birth (AFAB)
- Testosterone in gender-affirming hormone therapy (testo-GAHT)
- Cardiovascular effects of testo-GAHT
- Cardiovascular risk markers
- Blood pressure
- Changes in lipid metabolism
- Immunological components and hematological parameters
- End-organ damage
- Cardiovascular outcomes
- Potential mechanisms involved in the harmful cardiovascular effects induced by testo-GAHT
- Direct mechanisms whereby testosterone produces cardiovascular damage/dysfunction
- Effects on the heart
- Effects on the vasculature
- Indirect mechanisms whereby testosterone impacts cardiovascular performance
- Activation of the central and sympathetic nervous system
- Oxidative stress
- Renin-angiotensin-aldosterone system
- Immune mechanisms
- Lipid metabolism
- Research challenges on the impact of testo-GAHT in the cardiovascular system
- Final remarks and future directions
- Chapter 10. Sex differences in stroke
- Introduction
- Definition
- Epidemiology
- Risk factors of stroke
- Age
- Atrial fibrillation
- Sex-specific risk factors
- Pregnancy
- Oral contraceptive and hormone therapy in menopause
- Nonhormonal biological intrinsic sex differences
- Acute stroke management
- Symptoms
- Stroke severity
- Intravenous thrombolysis
- Endovascular thrombectomy
- Treatment of carotid artery stenosis
- Postacute stroke management
- Secondary prevention
- Rehabilitation
- Stroke outcome
- Disparity in clinical trials and the academic field
- Conclusion
- Chapter 11. Cardiovascular diseases in menopause
- Introduction
- Physiopatology mechanisms in menopause
- Factors contributing to hypertension in postmenopausic women
- Hypertension and cardiovascular disease in menopause
- Treatment
- Coronary heart disease and CV risk in women
- Dyslipidemias and women
- Conclusions
- Chapter 12. Androgens and acid–base homeostasis
- Introduction
- Renal ammonia metabolism overview
- Sex differences in renal ammonia metabolism
- Sexual dimorphisms in the response to acid challenges
- Testosterone alters renal ammonia metabolism
- Renal androgen receptor localization
- Role of the androgen receptor in renal ammonia metabolism
- Renal structure sexual dimorphisms and the role of androgens
- What is still needed in the field
- Chapter 13. Sex differences in hypertension
- Introduction
- Hypertension is age- and sex-dependent
- Age of onset
- Higher CVD risk at lower blood pressure thresholds
- Differences in awareness
- Sex-specific risk factors for hypertension
- Menarche
- Reproductive health
- Hormonal contraception
- Polycystic ovarian syndrome (PCOS)
- Endometriosis
- Uterine fibroids
- Pregnancy
- Hypertensive disorders of pregnancy (HDP)
- Gestational diabetes (GDM)
- Preterm birth and small for gestational age (SGA)
- Menopause
- Menopausal hormone replacement therapy (HRT)
- Mechanisms contributing to sex differences in hypertension
- Sex hormone milieu
- Renin-angiotensin-aldosterone system (RAAS)
- Endothelin (ET) system
- Salt sensitivity
- Obesity
- Arterial pathophysiology
- Response to treatment
- Summary
- Chapter 14. Impact of androgens on cardiovascular risk in women with polycystic ovary syndrome and transgender men
- Transgender male identity
- Cardiovascular risk in transgender men
- Summary
- Index
- Edition: 1
- Published: November 29, 2024
- Imprint: Academic Press
- No. of pages: 312
- Language: English
- Hardback ISBN: 9780443222665
- eBook ISBN: 9780443222672
JR
Jane Reckelhoff
LC
Licy L. Yanes Cardozo
NS