Semiconducting Silicon Nanowires for Biomedical Applications

2nd Edition - September 14, 2021
Imprint: Woodhead Publishing
Editor: Jeffery L. Coffer
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 1 3 5 1 - 3
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 1 3 1 - 2

In its second, extensively revised second edition, Semiconducting Silicon Nanowires for Biomedical Applications reviews the fabrication, properties, and biomedical applic… Read more

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In its second, extensively revised second edition, Semiconducting Silicon Nanowires for Biomedical Applications reviews the fabrication, properties, and biomedical applications of this key material.

The book begins by reviewing the basics of growth, characterization, biocompatibility, and surface modification of semiconducting silicon nanowires. Attention then turns to use of these structures for tissue engineering and delivery applications, followed by detection and sensing. Reflecting the evolution of this multidisciplinary subject, several new key topics are highlighted, including our understanding of the cell-nanowire interface, latest advances in associated morphologies (including silicon nanoneedles and nanotubes for therapeutic delivery), and significantly, the status of silicon nanowire commercialization in biotechnology.

Semiconducting Silicon Nanowires for Biomedical Applications is a comprehensive resource for biomaterials scientists who are focused on biosensors, drug delivery, and the next generation of nano-biotech platforms that require a detailed understanding of the cell-nanowire interface, along with researchers and developers in industry and academia who are concerned with nanoscale biomaterials, in particular electronically-responsive structures.

Cover Image
Title Page
Copyright
Table of Contents
Contributors
About the Editor
Foreword
CHAPTER ONE An overview of semiconducting silicon nanowires for biomedical applications
Abstract
1.1 Introduction
1.2 Historical origins
1.3 The structure of this book
1.4 Final comments
References
CHAPTER TWO Growth and Characterization of Silicon Nanowires for Biomedical Applications
Abstract
2.1 Introduction
2.2 Synthesis methods
2.3 Characterization methods
2.4 Example: Synthesis of semiconductor Si NWs by the CVD method
2.5 Conclusion
2.6 Future trends
References
CHAPTER THREE Surface Modification of Silicon Nanowires for Biosensing
Abstract
3.1 Introduction
3.2 Fabrication of silicon nanowires
3.3 Chemical activation/passivation of silicon nanowires
3.4 Modification of native oxide layer
3.5 Modification of hydrogen-terminated silicon nanowires
3.6 Site-specific immobilization strategy of biomolecules on silicon nanowires
3.7 Control of non-specific interactions
3.8 Photochemistry
3.9 Inorganic functionalization
3.10 Conclusion
References
CHAPTER FOUR Biocompatibility of Semiconducting Silicon Nanowires
Abstract
4.1 Introduction
4.2 In vitro biocompatibility of silicon nanowires
4.3 In vivo biocompatibility of silicon nanowires
4.4 Methodology issues
4.5 Future trends
4.6 Conclusion
References
CHAPTER FIVE Functional Silicon Nanowires for Cellular Binding and Internalization
Abstract
5.1 Developing a nano biomodel system for rational design in nanomedicine
5.2 Non-linear optical characterization and surface functionalization of silicon nanowires
5.3 Applications: In vivo imaging and in vitro cellular interaction of functional Si NWs
5.4 Understanding internalization pathways for silicon nanowires
5.5 Conclusions and future trends
References
CHAPTER SIX Functional Semiconducting Silicon Nanowires and their Composites as Tissue Scaffolds
Abstract
6.1 Introduction
6.2 NW surface etching processes to induce biomineralization
6.3 NW surface functionalization strategies to induce biomineralization
6.4 Construction of Si NW – polymer scaffolds: mimicking trabecular bone
6.5 The role of Si NW orientation on cellular attachment, proliferation, and differentiation in the nanocomposite
6.6 Viability assays of MSCs on Si NW/PCL composites
6.7 Differentiation of MSC on Si NW/PCL composites
6.8 Recent advances in neural-based tissue engineering
6.9 Conclusions and prospects for the future
Acknowledgement
References
CHAPTER SEVEN Mediated Differentiation of Stem Cells by Engineered Silicon Nanowires
Abstract
7.1 Introduction
7.2 Methods for silicon nanowire fabrication/in vitro experiments
7.3 Regulated differentiation for human mesenchymal stem cells
7.4 Silicon nanowires fabricated by an electroless metal deposition method and their controllable spring constants
7.5 Mediated differentiation of stem cells by engineered silicon nanowires
7.6 Conclusions and future trends
7.8 Acknowledgements
References
CHAPTER EIGHT Nanoneedle Devices for Biomedicine
Abstract
8.1 Introduction
8.2 Drug delivery
8.3 NN interface with cell membrane
8.4 Bioelectronics
8.5 Sensing, spectroscopy, and trapping
8.6 Conclusion
References
CHAPTER NINE Therapeutic Platforms Based on Silicon Nanotubes
Abstract
9.1 Introduction
9.2 Computational studies of single-walled silicon nanotubes
9.3 Fabrication and characterization of silicon nanotubes
9.4 Chemical modification strategies of Si NT surfaces with implications in therapeutics
9.5 Biodegradation properties of silicon nanotubes
9.6 Biocompatibility of silicon nanotubes
9.7 Nanotube interior filling with superparamagnetic nanoparticles for potential magnetic field-assisted drug delivery
9.8 Formation of a nanohybrid composed of Si NTs and metal nanoparticles with relevant anticancer properties
9.9 Conclusions
Acknowledgement
References
CHAPTER TEN Cellular Nanotechnologies: Orchestrating Cellular Processes by Engineering Silicon Nanowires Architectures
Abstract
10.1 Introduction
10.2 Engineering of tunable vertically aligned nanostructure arrays
10.3 Surface functionalization of Si NW arrays for intracellular delivery applications
10.4 The influence of Si NW array geometries on fundamental cell behavior
10.5 Vertically aligned nanostructure mediated intracellular signaling
10.6 Vertically aligned nanostructure mediated intracellular delivery
10.7 Vertically aligned nanostructure mediated electroporation
10.8 Conclusion
References
CHAPTER ELEVEN Nanowire Array Fabrication for High Throughput Screening in the Biosciences
Abstract
11.1 Introduction
11.2 Fabrication methods
11.3 Examples/applications
11.4 Conclusions
11.5 Future trends
References
CHAPTER TWELVE Nanostructured Silicon for Biological Modulation
Abstract
12.1 Introduction
12.2 Synthetic methods
12.3 Biocompatibility
12.4 Precision medicine
12.5 Microbial modulation
12.6 Conclusion and outlook
References
CHAPTER THIRTEEN CMOS-Compatible Silicon Nanowire Field-Effect Transistors: Where Nanotechnology Pushes the Limits in Biosensing
13.1 Introduction
13.2 Device configuration and fabrication methods
13.3 Sample delivery configurations
13.4 Performance limitations of nanowire sensors
13.5 Biosensing applications: from direct to indirect measurement
13.6 Concept of multiplexed biosensors
13.7 What is expected for the next decade?
References
CHAPTER FOURTEEN Semiconducting Silicon Nanowires and Nanowire Composites for Biosensing and Therapy
Abstract
14.1 Introduction
14.2 Fabrication of silicon nanowires and two-dimensional silicon nanowire architectures
14.3 Silicon nanowires for biosensing applications
14.4 Fabrication of silicon nanowire-polymer composite systems
14.5 Biomedical applications of silicon nanowire-polymer composites
14.6 Conclusions and future trends
References
CHAPTER FIFTEEN The Competition: Non-Silicon Nanowire/Nanotube Strategies in Nanomedicine
Abstract
15.1 Introduction
15.2 Alumina nanotubes
15.3 Boron nitride nanotubes
15.4 Single-wall carbon nanotubes
15.5 Titanium oxide (titania) nanotubes
15.6 Titania nanotubes – therapeutic relevance
15.7 Zinc oxide nanotubes
15.8 Summary
Acknowledgement
References
CHAPTER SIXTEEN Commercialization of Silicon Nanowire-Based Biotechnologies
Abstract
16.1 Introduction
16.2 Device integration challenges
16.3 Fabrication options
16.4 Existing companies and product development
16.5 Future perspectives
Acknowledgement
References
Index

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Semiconducting Silicon Nanowires for Biomedical Applications

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Jeffery L. Coffer

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