Seldin and Giebisch's The Kidney
Physiology and Pathophysiology
- 6th Edition - May 8, 2026
- Latest edition
- Editors: Robert J. Alpern, Michael J. Caplan, Orson W. Moe, Susan E. Quaggin
- Language: English
Seldin and Giebisch’s The Kidney: Physiology and Pathophysiology, Sixth Edition provides a common language for nephrology researchers, fellows, and practicing nephrologists t… Read more
Description
Description
Seldin and Giebisch’s The Kidney: Physiology and Pathophysiology, Sixth Edition provides a common language for nephrology researchers, fellows, and practicing nephrologists to discuss normal and abnormal renal physiology and the development and diagnosis of a wide range of renal diseases. Guided by a team of four distinguished authorities in nephrology, experts from all areas of renal research and practice take readers from the structure and function of the normal kidney, to the specific cellular and molecular mechanisms underlying disease development, and into the management of renal disease through physiologic regulation. This classic nephrology reference for nearly 30 years combines basic and clinical sciences that provides authoritative, concise, and readily accessible information. Academic, medical, and pharma researchers save valuable time by quickly accessing the very latest details on renal physiology and pathophysiology as opposed to searching through thousands of journal articles.
Key features
Key features
- Presents the most comprehensive, translational source for all aspects of normal renal physiology and pathophysiology of kidney diseases in one reference work
- Offers clear translational presentations by the top basic and clinical researchers in each specific renal disease, including fluid and electrolyte disorder, genetic disorders, glomerular diseases, diabetic nephropathy, preeclampsia, dialysis and transplantation
Readership
Readership
Table of contents
Table of contents
Section I: Epithelial and nonepithelial transport and regulation
1. Epithelial cell structure and polarity
Michael J. Caplan
2. Mechanisms of ion and water transport across cell membranes and epithelia
Guillermo A. Altenberg
3. Renal ion-translocating ATPases
Eric Féraille, Dominique Eladari
4. Cell volume control
Florian Lang, Jakob Voelkl
5. Solute transport, energy consumption and production in the kidney
Nasim Wiegley, Baback Roshanravan
6. Electrophysiological analysis of transepithelial transport
Henry Sackin, Lawrence G. Palmer
7. Renal ion channels, electrophysiology of transport and channelopathies
Oleh Pochynyuk, James D. Stockand
8. Microvascular permeability and the exchange of water and solutes across microvascular walls
C. Charles Michel
9. Renal cilia structure, function, and physiology
Dustin Z. Revell, Bentley Ford, Bradley K. Yoder
10. Intercellular junctions and cell–matrix interactions
Alan S.L. Yu, Dale R. Abrahamson
11. Principles of cell signaling
Shuta Ishibe, Lloyd Cantley
12. Scaffolding proteins in transport regulation
Paul A. Welling
13. The renin–angiotensin system
Katrina M. Mirabito Colafella, Steven D. Crowley, Thu H. Le, Thomas M. Coffman, Susan B. Gurley
14. Neural control of renal function
Olaf Grisk, Edward J. Johns, Ulla C. Kopp
15. Eicosanoids and renal function
Matthew D. Breyer, Richard M. Breyer
16. Extracellular nucleotides, metabolites, and renal function
Robert I. Menzies, Karen Dwyer, Frederick W.K. Tam, Maria Prendecki, Matthew A. Bailey, Robert J. Unwin
Section II: Structural and functional organization of the kidney
17. Structural organization of the mammalian kidney
Wilhelm Kriz, Michel Le Hir, Brigitte Kaissling
18. Biophysical basis of glomerular filtration
Börje Haraldsson, Jenny Nyström
19. Glomerular cell biology
Rizaldy P. Scott, Susan E. Quaggin
20. Function of the juxtaglomerular apparatus: control of glomerular hemodynamics and renin secretion
Jurgen B. Schnermann, Hayo Castrop
21. Vasculature of the kidney cortex and medulla
David A. Long, Saif N. Malik, Daniyal J. Jafree
22. The development of the kidney
Thomas J. Carroll, Leif Oxburgh, Jordan A. Kreidberg, Denise K. Marciano
23. Molecular and cellular mechanisms of glomerular capillary development
Eudora Eng, Michael D. Donnan
Section III: Fluid and electrolyte regulation and dysregulation
24. Epithelial Na + channels
Shaohu Sheng, Ossama B. Kashlan, Kenneth R. Hallows, Thomas R. Kleyman
25. Anion channels
Owen M. Woodward, William B. Guggino
26. Physiology and pathophysiology of the NaCl cotransporters in the kidney
María Castañeda-Bueno, Héctor Carbajal-Contreras, Silvana Bazúa-Valenti, Gerardo Gamba
27. Balance and the pathophysiology of acid–base, fluid, and electrolyte disorders
Kamel S. Kamel, Martin Schreiber, Mitchell L. Halperin
28. Sodium and chloride transport in the proximal tubule
R. Todd Alexander, Henrik Dimke
29. Mineralocorticoid action in the aldosterone-sensitive distal nephron
Olivier Staub, Johannes Loffing
30. Genetic disorders of renal salt homeostasis and blood pressure
Ute I. Scholl, Richard P. Lifton
31. Pathophysiology of sodium retention and wastage
Biff F. Palmer, Robert J. Alpern, Donald W. Seldin
32. Physiology and pathophysiology of hypertension
Qi Fu, Scott A. Smith, Wanpen Vongpatanasin
33. Aquaporin water channels in mammalian kidney
Jørgen Frøkiær, Robert A. Fenton, Hyun Jun Jung, Tae-Hwan Kwon
34. Thirst and vasopressin
Gary L. Robertson
35. The urine-concentrating mechanism and urea transporters
Anta T. Layton, Jeff M. Sands
36. Hyponatremia
Richard H. Sterns, Stephen M. Silver, J. Kevin Hix
37. Hypernatremic states
Daniel G. Bichet
38. The function and regulation of renal K + channels
Wenhui Wang, Chou-Long Huang
39. Extrarenal potassium metabolism
Shubhada N. Ahya, Aleksandra Gmurczyk, Robert M. Rosa
40. Regulation of K⁺ excretion
Paul A. Welling, Wenhui Wang, Lisa M. Satlin
41. Physiopathology of potassium deficiency
Francesco Trepiccione, Miriam Zacchia, Giovambattista Capasso
42. Clinical disorders of hyperkalemia
Miriam Zacchia, Francesco Trepiccione, Giovambattista Capasso
Volume 2
Section III: Fluid and electrolyte regulation and dysregulation (contd)
43. Intracellular pH homeostasis
Ian M. Thornell, Marie Michenkova, Sara Taki, Mark O. Bevensee, Walter F. Boron
44. SLC4 sodium-coupled bicarbonate and carbonate transporters
Ira Kurtz
45. Anion exchangers of the SLC4 gene family
Mark D. Parker, Emmanuelle Cordat
46. Cellular mechanisms of renal tubular acidification
L. Lee Hamm, Patricia A. Preisig, Robert J. Alpern
47. Renal ammonium ion production and transport
Dominique Eladari, Norman P. Curthoys, Nazih L. Nakhoul
48. Clinical syndromes of metabolic alkalosis
Orson W. Moe, Robert J. Alpern, Donald W. Seldin
49. Clinical syndromes of metabolic acidosis
Reto Krapf, Donald W. Seldin, Henry N. Hulter, Robert J. Alpern
50. Respiratory acid–base disorders
Nicolaos E. Madias, Horacio J. Adrogué
51. Mechanisms and disorders of magnesium metabolism
Karl P. Schlingmann, Martin Konrad
52. Calcium channels
Joost G.J. Hoenderop, Jenny van der Wijst, René J.M. Bindels
53. The calcium-sensing receptor
Marianna Ranieri, Martin Shepelmann, Daniela Riccardi, Giovanna Valenti, John P. Geibel
54. Renal calcium metabolism
José F. Bernardo, Jojanneke H.J. Huck, Peter A. Friedman, Joost G.J. Hoenderop
55. Kidney stones
Khashayar Sakhaee, Orson W. Moe
56. Proximal tubular handling of phosphate
Carsten A. Wagner, Nati Hernando
57. Clinical disturbances of phosphate homeostasis
Kittrawee Kritmetapak, Theresa J. Berndt, Rajiv Kumar
58. Glucose reabsorption in the kidney
Charles S. Hummel, Ernest M. Wright
59. Kidney transport of amino acids and oligopeptides and aminoacidurias
Simone M.R. Camargo, Victoria Makrides, Robert Kleta, François Verrey
60. Renal filtration, transport, and metabolism of albumin and albuminuria
Rikke Nielsen, Kathrin Weyer, Erik Ilsø Christensen, Henrik Birn
Section IV: Pathophysiology of renal disease
61. Physiologic principles in the clinical evaluation of electrolyte, water, and acid–base disorders
Daniel Batlle, Sheldon Chen, Vivek Paul
62. Acute kidney injury biomarkers
Swetha Reddy, Claudio Ronco, Kianoush Kashani
63. Pathophysiology of acute kidney injury
Jeremie M.P. Lever, Anupam Agarwal
64. Ischemic renal disease
Alfonso Eirin, Lilach O. Lerman, Stephen C. Textor
65. Pathophysiology and pathogenesis of diabetic kidney disease
Mark E. Cooper, Merlin C. Thomas
66. Autosomal dominant polycystic kidney disease
Stefan Somlo, Vicente E. Torres, Michael J. Caplan
67. Renal physiology and disease in pregnancy
S. Ananth Karumanchi
68. Glomerular disorders
Ali Mehdi, Korey R. Bartolomeo, Roulan Abu Hweij, John R. Sedor
69. Immunologic mechanisms of vasculitis
Jonathon W. Homeister, J. Charles Jennette, Ronald J. Falk, Manish Kanti Saha, Koyal Jain
70. Genetic abnormalities in glomerular function
Jenny A. Hurcombe, Richard J.M. Coward
71. Mechanisms of drug nephrotoxicity
Paisit Paueksakon, Agnes B. Fogo
72. Role of proteinuria in the progression of renal disease
Ariela Benigni, Norberto Perico, Giuseppe Remuzzi
73. Oxidative stress and signaling in renal physiology and kidney diseases
Manoj Bhattarai, Soumya Maity, Kumar Sharma
74. Pathogenesis and management of disordered mineral metabolism in patients with chronic kidney disease
Rebecca Frazier, Aline Martin, Tamara Isakova
75. Individualizing the dialysate to address electrolyte disturbances in the dialysis patient
Biff F. Palmer
76. Mechanisms of allograft rejection
Aravind Cherukuri, Fadi G. Lakkis, Martin H. Oberbarnscheidt
77. Homeostasis of solute and water by the transplanted kidney
Kerim Mutig, Eleanor Lederer, Kamalanathan K. Sambandam
Product details
Product details
- Edition: 6
- Latest edition
- Published: May 8, 2026
- Language: English
About the editors
About the editors
RA
Robert J. Alpern
Dr. Robert J. Alpern has performed research in the area of epithelial physiology, focusing on the mechanisms and regulation of acid transport. He received his MD degree from the University of Chicago and then trained in internal medicine at Columbia Presbyterian. Following postdoctoral training in the Cardiovascular Research Institute at the University of California, San Francisco, Alpern joined the faculty at UCSF, then moved to the University of Texas Southwestern Medical School as Chief of Nephrology and later Dean of the Medical School. He then moved to Yale as the Dean of Yale School of Medicine and is now Ensign Professor of Medicine and Cellular and Molecular Physiology at Yale.
MC
Michael J. Caplan
OM
Orson W. Moe
SQ
Susan E. Quaggin
Dr. Susan E. Quaggin, MD, FASN, is a graduate of the University of Toronto, where she completed her residency and served as Chief Medical Resident for the University’s St. Michael’s Hospital. She completed her nephrology fellowship at the University of Toronto and Yale University, where she also completed research and postdoctoral training. Dr. Quaggin also trained in the developmental biology program at the University of Toronto’s Samuel Lunenfeld Research Institute. Dr. Quaggin now serves as Editor for Current Opinion in Nephrology and Hypertension and The Kidney, and as an Editorial Board Member for JCI, Disease Models and Mechanisms, and Kidney International. Currently, Charles Horace Mayo Professor of Medicine at Northwestern University and a Finnish Distinguished Professor (2012–17). Dr. Quaggin has been the recipient of many awards and honors.