Seldin and Giebisch's The Kidney

Physiology and Pathophysiology

6th Edition - June 1, 2025
Editors: Robert J. Alpern, Michael J. Caplan, Orson W. Moe, Susan E. Quaggin
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 1 5 3 8 9 - 5
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 1 5 3 9 0 - 1

Seldin and Giebisch’s The Kidney, Sixth Edition: Physiology and Pathophysiology provides a common language for nephrology researchers, fellows and practicing nephrologists to dis… Read more

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Seldin and Giebisch’s The Kidney, Sixth Edition: Physiology and Pathophysiology provides a common language for nephrology researchers, fellows and practicing nephrologists to discuss normal and abnormal renal physiology and the development and diagnosis of a wide range of renal diseases. Guided by a team of four distinguished authorities in nephrology, experts from all areas of renal research and practice take readers from the structure and function of normal renal physiology, to the specific cellular and molecular mechanisms underlying disease development, and into the management of renal disease through physiologic regulation.This classic nephrology reference for nearly 30 years combines basic and clinical sciences that provides authoritative, concise and readily accessible information. Academic, medical and pharma researchers save valuable time by quickly accessing the very latest details on renal physiology and pathophysiology as opposed to searching through thousands of journal articles.

Volume 1
I: Epithelial and Nonepithelial Transport and Regulation

1. Epithelial Cell Structure and Polarity
KARLS. MATLIN AND MICHAEL J. CAPLAN

2. Mechanisms of Ion Transport across Cell Membranes
LUIS REUSS AND GUILLERMO A. ALTENBERG

3. Renal Ion-Translocating ATPases
DOMINIQUE ELADARI, UOO HASLER AND ERIC FERAILLE

4. Mechanisms of Water Transport Across Cell Membranes and Epithelia
GUILLERMO A. ALTENBERG AND LUIS REUSS

5. Cell Volume Control
FLORIAN LANG

6. Solute Transport, Energy Consumption, and Production in the Kidney
TAKASHI SEK INE AND HITOSHI ENDOU

7. Electrophysiological Analysis of Transepithelial Transport
HENRY SACKIN AND LAWRENCE G. PALMER

8. Renal Ion Channels, Electrophysiology of Transport, and Channelopathies
JAMES D. STOCKAND

9. Microvascular Permeability and the Exchange of Water and Solutes Across Microvascular WallsC.
CHARLES MICHEL

10. External Balance of Electrolytes and Acids and Alkali
MAN S.OH

11. Renal Cilia Structure, Function, and Physiology
JAY N. PIECZYNSKI AND BRADLEY K. YODER

12. Intercellular Junctions
ALAN S.L. YU, FIONA HANNER AND J ANOS PETI-PETERDI

13. Principles of Cell Signaling
LLOYD CANTLEY

14. Scaffolding Proteins in Transport Regulation
PAUL A. WELLING

15. The Renin–Angiotensin System
THU H. LE, STEVEN D. CROWLEY, SUSAN B. GURLEY AND THOMAS M. COFFMAN

16. Neural Control of Renal Function
EDWARD J. JOHNS AND ULLA C. KOPP

17. Eicosanoids and Renal Function
MATTHEW D. BREYER, RAYMOND C. HARRIS AND RICHARD M. BREYER

18. Extracellular Nucleotides and Renal Function
DAVID G. SHIRLEY, MATTHEW A. BAILEY, SCOTT S.P. WILDMAN, FREDERICK W.K. TAM AND ROBERT J. UNWIN

19. Paracrine Regulation of Renal Function by Dopamine
PEDRO A. JOSE, ROBIN A. FELDER AND GILBERT M. EISNER

II: Structural and Functional Organization of the Kidney

20. Structural Organization of the Mammalian Kidney
WILHELM KRIZ AND BRIGITTE KAISSLING

21. Biophysical Basis of Glomerular Filtration
SCOTT C. THOMSON AND ROLAND C. BLANTZ

22. Glomerular Cell Biology
YOSHIRO MAEZAWA, DAVIDE CIN A AND SUSAN E. QUAGGIN

23. Function of the Juxtaglomerular Apparatus: Control of Glomerular Hemodynamics and Renin Secretion
JURGEN B. SCHNERMANN AND HAYO CASTROP

24. Renal Cortical and Medullary Microcirculations: Structure and Function
THOMAS L. PALLONE AND CHUNHUA CAO

25. Molecular and Cellular Mechanisms of Kidney Development
KEVIN T. BUSH, HIROYUKI SAKURAI AND SANJAY K. NIGAM

26. Molecular and Cellular Mechanisms of Glomerular Capillary Development
JEFFREY H. MINER AND DALE R. ABRAHAMSON

27. Postnatal Renal Development
MICHEL BAUM, JYOTHSNA GATTINENI AND LISA M. SATLIN

28. Renal Hyperplasia and Hypertrophy
PAUL T. BRINKKOETTER, SIAN V. GR IFFIN AND STUART J. SHANKLAND

29. Stem Cells and Generation of New Cells in the Adult Kidney
JUAN A. OLIVER AND QAIS AL-AWQATI

III: Fluid and Electrolyte Regulation and Dysregulation

30. Epithelial Na+ Channels
SHAOHU SHENG, KENNETH R. HALLOWS AND THOMAS R. KLEYMAN

31. Anion Channels
OWEN M. WOODWARD AND WILLIAM B. GUGGINO

32. Physiology and Pathophysiology of the NaCl Co-Transporters in the Kidney
GERARDO GAMBA

33. Sodium and Chloride Transport: Proximal Nephron
ALAN M. WEINSTEIN

34. Sodium Chloride Transport in the Loop of Henle, Distal Convoluted Tubule, and Collecting Duct
GERARDO GAMBA, WENHUI WANG AND LAURENT SCHILD

35. Mineralocorticoid Action in the Aldosterone Sensitive Distal Nephron
OLIVIER STAUB AND JOHANNES LOFFING

36. Inherited Disorders of Renal Salt Homeostasis: Insights from Molecular Genetics Studies
UTE I. SCHOLL AND RICHARD P. LIFTON

37. Natriuretic Hormones
DAVID L. VESELY

38. Pathophysiology of Sodium Retention and Wastage
BIFF F. PALMER, ROBERT J . ALPERN AND DONALD W. SELDIN

39. Physiology and Pathophysiology of Hypertension
JOHN E. HALL, J OEY P. GRANGER AND MICHAEL E. HALL

40. Physiology and Pathophysiology of Diuretic Action
DAVID H. ELLISON41. Aquaporin Water Channels in Mammalian KidneyS0REN NIELSEN, TAE-HWAN KWON, HENRIK DIMKE, MARTIN SKOTT AND J0RGEN FR0KIIER

42. Thirst and Vasopressin
GARY L. ROBERTSON

43. The Urine Concentrating Mechanism and Urea Transporters
JEFF M. SANDS AND HAROLD E. LAYTON

44. Hyponatremia
RICHARD H. STERNS, STEPH EN M. SILVER AND J . KEVIN HIX

45. Hypernatremic States
CHRISTOPHER j. RIVARD, WEI WANG AND LAURENCE CHAN

46. Polyuria and Diabetes Insipidus
DANIEL G. BICHET

47. The Molecular Biology of Renal K+ Channels
WENHUI WANG AND CHOU-LONG HUANG

48. Extrarenal Potassium Metabolism
VAIBHAV SAHNI , ALEKSANDRA GMURCZYK AND ROBERT M. ROSA

49. Regulation of K+ Excretion
GERHARD MALNIC, GERHARD GIEBISCH, SHIGEAKI MUTO, WENHUI WANG, MATTHEW A. BAILEY AND LISA M. SATLIN

50. Physiopathology of Potassium Deficiency
FR ANCESCO TREPICCIONE, MIRIAM ZACCHIA AND GIOVAMBATTISTA CAPASSO

Volume II

51. Clinical Disorders of Hyperkalemia
KAMEL S. KAMEL, SHIH-HUA LIN, SUNG-SEN YANG AND MITCHELL HALPERIN

52. Control of Intracellular pH
MARK 0. BEVENSEE AND WALTER F. BORON

53. SLC4 Sodium-Driven Bicarbonate Transporters
IRA KURTZ

54. The SLC4 Anion Exchanger Gene Family
ANDREW K. STEWART AND SETH L. ALPER

55. Cellular Mechanisms of Renal Tubular Acidification
L. LEE HAMM, ROBERT]. ALPERN AND PATRICIA A. PREISIG

56. Chemoreceptors, Breathing and pH
EUGENE NATTIE

57. Renal Ammonium Ion Production and Excretion
NORMAN P. CURTHOYS

58. Clinical Syndromes of Metabolic Alkalosis
ORSON W. MOE, ROBERT]. ALPERN AND DONALD W. SELDIN

59. Clinical Syndromes of Metabolic Acidosis
RETO KRAPF, DONALD W. SELDIN AND ROBERT]. ALPERN

60. Respiratory Acid–Base Disorders
N ICOLAOS E. MADIAS AND HORACIO ]. ADROGUE

61. Mechanisms and Disorders of Magnesium Metabolism
KARL P. SCHLINGMANN, GARY A. QUAMME AND MARTIN KONRAD

62. Calcium Channels
JOOST G.]. HOENDEROP AND RENE J.M. BINDELS

63. The Calcium-Sensing Receptor
EDWARD M. BROWN , STEVEN C. HEBERT, DANIELA RICCARDI AND J OHN P. GEIBEL

64. Renal Calcium Metabolism
JOSE F. BERNARDO AND PETER A. FRIEDMAN

65. The Hormonal Regulation of Calcium Metabolism
PETER]. TEBBEN AND RAJIV KUMAR

66. Disorders of Calcium Metabolism
CRISTINA DUMITRU AND J OHN WYSOLMERSKI

67. Pathogenesis and Treatment of Nephrolithiasis
FREDRIC L. COE, ANDREW EVAN AND ELAINE WORCESTER

68. Proximal Tubular Handling of Phosphate
HEINl MURER, I AN C. FORSTER, NAT!HERN ANDO AN D JURG BIBER

69. Clinical Disturbances of Phosphate Homeostasis
THERESA]. BERNDT AND RAJ IV KUMAR

70. Glucose Reabsorption in The Kidney
CHARLES S. HUMMEL AND ERNEST M. WRIGHT

71. Kidney Transport of Amino Acids and Oligopeptides, and Aminoacidurias
SIMON E M.R. CAMARGO, V!CfORIA MAKRIDES, ROBERT KLETA AND FRAN<;::OIS VERREY

72. Organic Anion and Cation Transporters in Renal Elimination of Drugs
GERHARD BURCKHARDT AND HERMANN KOEPSELL

73. Renal Filtration, Transport, and Metabolism of Albumin and Albuminuria
ERIK ILS0 CHRISTENSEN, RIKKE NIELSEN AND HENRIK BIRN

IV: Pathophysiology of Renal Disease

74. Physiologic Principles in the Clinical Evaluation of Electrolyte, Water, and Acid–Base Disorders
DANIEL BATLLE, SHELDON CHEN AND SYED K. HAQUE

75. Biomarkers for Assessment of Renal Function During Acute Kidney Injury
PRASAD DEVARAJAN

76. Pathophysiology of Acute Kidney Injury
BRUCE A. MOLITORIS AND ASIF SHARFUDDIN

77. Ischemic Renal Disease
WILLIAM L. HENRICH

78. Pathophysiology and Pathogenesis of Diabetic Nephropathy
SHELDON CHEN, CHARBEL KHOURY AND FUAD N. ZIYADEH

79. Renal Failure in Cirrhosis
PERE GINES, ANDRES CARDENAS AND ROBERT W. SCHRIER

80. Autosomal Dominant Polycystic Kidney Disease
STEFAN SOMLO, VICENTE E. TORRES AND MICHAEL J. CAPLAN

81. Renal Physiology and Disease in Pregnancy
MARSHALL D. LINDHEIMER, KIRK P. CONRAD AND S. ANANTH KARUMANCHI

82. Immune and Inflammatory Glomerular Diseases
ANUP MANOHARON, JEFFREY R. SCHELLING, MATTHEW DIAMOND, MOONJA CHUNG-PARK, MICHAEL MADAIO AND JOHN R. SEDOR

83. Immunologic Mechanisms of Vasculitis
JONATHON W. HOMEISTER, J . CHARLES JENNETTE AND RONALD J. FALK

84. Genetic Abnormalities in Glomerular Function
YOAV SEGAL AND CLIFFORD E. KASHTAN

85. Cellular Mechanisms of Drug Nephrotoxicity
ROBERT J AMES WALKER AND ZOLTAN HUBA ENDRE

86. Role of Glomerular Mechanical Stress in the Pathogenesis of Chronic Kidney Disease
CLARICE KAZUE FUJIHARA AND ROBERTO ZATZ

87. Role of Proteinuria in the Progression of Renal Disease
MAURO ABBATE, DANIELA MACCON I, GIUSEPPE REMUZZI AND CAR LA ZOJA

88. The Inflammatory Response to Ischemic Acute Renal Injury
CHRISTOPHER Y. LU

89. Catalytic (Labile) Iron in Kidney Disease
MOHAN RAJAPURKAR, RADHAKRISHNA BALIGA AND SUDHIR V. SHAH

90. Chronic Kidney Disease: Pathophysiology and the Influence of Dietary Protein
BIRUH T. WORKENEH AND WILLIAM E. MITCH

91. Management of Calcium and Bone Disease in Renal Patients
L. DARRYL QUARLES

92. Hematopoiesis and the Kidney
ARM IN KURTZ, ROLAND H. WENGER AND KAI-UWE ECKARDT

93. Individualizing the Dialysate to Address Electrolyte Disturbances in the Dialysis Patient
BIFF F PALMER

94. Homeostasis of Solute and Water by the Transplanted Kidney
J. HAROLD HELDERMAN, HEIDI SCHAEFER, ANTHONY]. LANGONE AND SIM IN GORAL

95. Renal Disposition of Drugs and Translation to Dosing Strategies

Robert J. Alpern

Dr. Alpern has performed research in the area of epithelial physiology, focusing on the mechanisms and regulation of acid transport. He received his MD degree from the University of Chicago and then trained in Internal Medicine at Columbia Presbyterian. Following postdoctoral training in the Cardiovascular Research Institute at the University of California, San Francisco, Alpern joined the faculty at UCSF, then moved to the University of Texas Southwestern Medical School as Chief of Nephrology and later Dean of the medical school. He is now Dean of Yale School of Medicine and Ensign Professor.

Affiliations and expertise

Dean and Ensign Professor of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA

Michael J. Caplan

Dr. Caplan studies epithelial cell biology and physiology. His work focuses on the trafficking and regulation of renal ion transport proteins. His group also studies the signaling pathways involved in Autosomal Dominant Polycystic Kidney Disease. He received his MD and PhD degrees from Yale University, having pursued his dissertation work in the Department of Cell Biology under the guidance of Drs. James D. Jamieson and George E. Palade. Following postdoctoral work in the Department of Cellular and Molecular Physiology at Yale, Caplan joined that department as a faculty member. He is currently the C.N.H. Long Professor and Chair of Yale University School of Medicine’s Department of Cellular and Molecular Physiology.

Affiliations and expertise

C.N.H. Long Professor and Chair, Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, USA

Orson W. Moe

Dr. Moe received his medical degree from the University of Toronto where he also did his internal medicine residency and clinical nephrology fellowship. Orson Moe moved to the University of Texas Southwestern Medical Center for research training in renal physiology. He is currently Professor of Internal Medicine and Physiology and is a member of the Nephrology Division at the University of Texas Southwestern Medical Center in Dallas. He is also the Director of the Charles and Jane Pak Center of Mineral Metabolism and Clinical Research and holds the Charles and Jane Pak Chair in Mineral Metabolism Research and the Donald Seldin Professorship in Clinical Investigation. Orson Moe conducts both basic science and patient-oriented research on renal physiology and metabolism, and epithelial biology.

Affiliations and expertise

Professor of Internal Medicine and Physiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA

Susan E. Quaggin

Susan E. Quaggin, MD, FASN, is a graduate of the University of Toronto where she completed her residency and served as chief medical resident for the University’s St. Michael’s Hospital. She completed her nephrology fellowship at the University of Toronto and Yale University, where she also completed research and post-doctoral training. Dr. Quaggin also trained in the developmental biology program at the University of Toronto's Samuel Lunenfeld Research Institute. Dr. Quaggin also now serves as Editor for Current Opinion in Nephrology & Hypertension and The Kidney, and as an Editorial Board Member for JCI, Disease Models and Mechanisms, and Kidney International. Currently the Charles Horace Mayo professor of medicine at Northwestern University and a Finnish Distinguished Professor (2012-2017), Dr. Quaggin’s awards and honors include the International Society of Nephrology (ISN) Alfred Newton Richards Award for Basic Science, (2013); a Kidney Foundation of Canada Medal for Research Excellence, (2009); American Heart Association, Hypertension Council Donald Seldin Lecture and Award, (2012); Princesses’ Lectureship at the Victor Chang Cardiovascular Research Institute, (2013); a W. Berliner Lectureship at Yale University, (2015); a Ruth Abrahmson Visiting Lectureship, (2015); a Josh Thurman Visiting Lectureship, (2015); an Andreoli Lectureship, (2015); a Phillip A. Liverman Distinguished Lectureship, (2014); a Tisher Visiting Professor of Nephrology, (2012), a Mitch Lectureship (2016), the Shaul-Massry Visiting Professor (2017); a Gabor‐Zellerman Endowed Professorship in Renal Medicine, (2009‐2012); the University of Toronto's Department of Medicine Research Award, (2009) and William Goldie Prize in Internal Medicine, (2005); The Lloyd S.D. Fogler QC Award of Excellence, at Mount Sinai Hospital, (2004); Premier’s Research Excellence Award (PREA), (2003); and The Joe Doupe Canadian Society of Clinical Investigation Young Investigator Award, (2003). She served as Canada Research Chair in Vascular Biology from 2005 to 2010. She was elected to the American Society for Clinical Investigation in 2006 and the Association of American Physicians in 2013.

Affiliations and expertise

Director, Feinberg Cardiovascular Research Institute, Chicago; Chief, Division of Medicine-Nephrology, Professor in Medicine-Nephrology, Northwestern University, Evanston, IL, USA

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Seldin and Giebisch's The Kidney

Physiology and Pathophysiology

Purchase options

Save 50% on book bundles

Institutional subscription on ScienceDirect

Robert J. Alpern

Michael J. Caplan

Orson W. Moe

Susan E. Quaggin