Seldin and Giebisch's The Kidney
Physiology and Pathophysiology
- 6th Edition - April 24, 2026
- Latest edition
- Editors: Robert J. Alpern, Michael J. Caplan, Orson W. Moe, Susan E. Quaggin
- Language: English
Seldin and Giebisch’s The Kidney: Physiology and Pathophysiology, Sixth Edition provides a common language for nephrology researchers, fellows, and practicing nephrologists t… Read more
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Description
Description
Seldin and Giebisch’s The Kidney: Physiology and Pathophysiology, Sixth Edition provides a common language for nephrology researchers, fellows, and practicing nephrologists to discuss normal and abnormal renal physiology and the development and diagnosis of a wide range of renal diseases. Guided by a team of four distinguished authorities in nephrology, experts from all areas of renal research and practice take readers from the structure and function of the normal kidney, to the specific cellular and molecular mechanisms underlying disease development, and into the management of renal disease through physiologic regulation. This classic nephrology reference for nearly 30 years combines basic and clinical sciences that provides authoritative, concise, and readily accessible information. Academic, medical, and pharma researchers save valuable time by quickly accessing the very latest details on renal physiology and pathophysiology as opposed to searching through thousands of journal articles.
Key features
Key features
- Presents the most comprehensive, translational source for all aspects of normal renal physiology and pathophysiology of kidney diseases in one reference work
- Offers clear translational presentations by the top basic and clinical researchers in each specific renal disease, including fluid and electrolyte disorder, genetic disorders, glomerular diseases, diabetic nephropathy, preeclampsia, dialysis and transplantation
Readership
Readership
Medical and pharmaceutical researchers in nephrology and related renal diseases (renal cancer, diabetes, glomerulosclerosis, preeclampsia, lupus), fellows and academic clinicians in nephrology, researchers of renal diseases in the related fields of physiology, developmental biology, cell biology, and genetics
Table of contents
Table of contents
Volume 1
I: Epithelial and Nonepithelial Transport and Regulation
1. Epithelial Cell Structure and Polarity
KARLS. MATLIN AND MICHAEL J. CAPLAN
2. Mechanisms of Ion Transport across Cell Membranes
LUIS REUSS AND GUILLERMO A. ALTENBERG
3. Renal Ion-Translocating ATPases
DOMINIQUE ELADARI, UOO HASLER AND ERIC FERAILLE
4. Mechanisms of Water Transport Across Cell Membranes and Epithelia
GUILLERMO A. ALTENBERG AND LUIS REUSS
5. Cell Volume Control
FLORIAN LANG
6. Solute Transport, Energy Consumption, and Production in the Kidney
TAKASHI SEK INE AND HITOSHI ENDOU
7. Electrophysiological Analysis of Transepithelial Transport
HENRY SACKIN AND LAWRENCE G. PALMER
8. Renal Ion Channels, Electrophysiology of Transport, and Channelopathies
JAMES D. STOCKAND
9. Microvascular Permeability and the Exchange of Water and Solutes Across Microvascular WallsC.
CHARLES MICHEL
10. External Balance of Electrolytes and Acids and Alkali
MAN S.OH
11. Renal Cilia Structure, Function, and Physiology
JAY N. PIECZYNSKI AND BRADLEY K. YODER
12. Intercellular Junctions
ALAN S.L. YU, FIONA HANNER AND J ANOS PETI-PETERDI
13. Principles of Cell Signaling
LLOYD CANTLEY
14. Scaffolding Proteins in Transport Regulation
PAUL A. WELLING
15. The Renin–Angiotensin System
THU H. LE, STEVEN D. CROWLEY, SUSAN B. GURLEY AND THOMAS M. COFFMAN
16. Neural Control of Renal Function
EDWARD J. JOHNS AND ULLA C. KOPP
17. Eicosanoids and Renal Function
MATTHEW D. BREYER, RAYMOND C. HARRIS AND RICHARD M. BREYER
18. Extracellular Nucleotides and Renal Function
DAVID G. SHIRLEY, MATTHEW A. BAILEY, SCOTT S.P. WILDMAN, FREDERICK W.K. TAM AND ROBERT J. UNWIN
19. Paracrine Regulation of Renal Function by Dopamine
PEDRO A. JOSE, ROBIN A. FELDER AND GILBERT M. EISNER
II: Structural and Functional Organization of the Kidney
20. Structural Organization of the Mammalian Kidney
WILHELM KRIZ AND BRIGITTE KAISSLING
21. Biophysical Basis of Glomerular Filtration
SCOTT C. THOMSON AND ROLAND C. BLANTZ
22. Glomerular Cell Biology
YOSHIRO MAEZAWA, DAVIDE CIN A AND SUSAN E. QUAGGIN
23. Function of the Juxtaglomerular Apparatus: Control of Glomerular Hemodynamics and Renin Secretion
JURGEN B. SCHNERMANN AND HAYO CASTROP
24. Renal Cortical and Medullary Microcirculations: Structure and Function
THOMAS L. PALLONE AND CHUNHUA CAO
25. Molecular and Cellular Mechanisms of Kidney Development
KEVIN T. BUSH, HIROYUKI SAKURAI AND SANJAY K. NIGAM
26. Molecular and Cellular Mechanisms of Glomerular Capillary Development
JEFFREY H. MINER AND DALE R. ABRAHAMSON
27. Postnatal Renal Development
MICHEL BAUM, JYOTHSNA GATTINENI AND LISA M. SATLIN
28. Renal Hyperplasia and Hypertrophy
PAUL T. BRINKKOETTER, SIAN V. GR IFFIN AND STUART J. SHANKLAND
29. Stem Cells and Generation of New Cells in the Adult Kidney
JUAN A. OLIVER AND QAIS AL-AWQATI
III: Fluid and Electrolyte Regulation and Dysregulation
30. Epithelial Na+ Channels
SHAOHU SHENG, KENNETH R. HALLOWS AND THOMAS R. KLEYMAN
31. Anion Channels
OWEN M. WOODWARD AND WILLIAM B. GUGGINO
32. Physiology and Pathophysiology of the NaCl Co-Transporters in the Kidney
GERARDO GAMBA
33. Sodium and Chloride Transport: Proximal Nephron
ALAN M. WEINSTEIN
34. Sodium Chloride Transport in the Loop of Henle, Distal Convoluted Tubule, and Collecting Duct
GERARDO GAMBA, WENHUI WANG AND LAURENT SCHILD
35. Mineralocorticoid Action in the Aldosterone Sensitive Distal Nephron
OLIVIER STAUB AND JOHANNES LOFFING
36. Inherited Disorders of Renal Salt Homeostasis: Insights from Molecular Genetics Studies
UTE I. SCHOLL AND RICHARD P. LIFTON
37. Natriuretic Hormones
DAVID L. VESELY
38. Pathophysiology of Sodium Retention and Wastage
BIFF F. PALMER, ROBERT J . ALPERN AND DONALD W. SELDIN
39. Physiology and Pathophysiology of Hypertension
JOHN E. HALL, J OEY P. GRANGER AND MICHAEL E. HALL
40. Physiology and Pathophysiology of Diuretic Action
DAVID H. ELLISON41. Aquaporin Water Channels in Mammalian KidneyS0REN NIELSEN, TAE-HWAN KWON, HENRIK DIMKE, MARTIN SKOTT AND J0RGEN FR0KIIER
42. Thirst and Vasopressin
GARY L. ROBERTSON
43. The Urine Concentrating Mechanism and Urea Transporters
JEFF M. SANDS AND HAROLD E. LAYTON
44. Hyponatremia
RICHARD H. STERNS, STEPH EN M. SILVER AND J . KEVIN HIX
45. Hypernatremic States
CHRISTOPHER j. RIVARD, WEI WANG AND LAURENCE CHAN
46. Polyuria and Diabetes Insipidus
DANIEL G. BICHET
47. The Molecular Biology of Renal K+ Channels
WENHUI WANG AND CHOU-LONG HUANG
48. Extrarenal Potassium Metabolism
VAIBHAV SAHNI , ALEKSANDRA GMURCZYK AND ROBERT M. ROSA
49. Regulation of K+ Excretion
GERHARD MALNIC, GERHARD GIEBISCH, SHIGEAKI MUTO, WENHUI WANG, MATTHEW A. BAILEY AND LISA M. SATLIN
50. Physiopathology of Potassium Deficiency
FR ANCESCO TREPICCIONE, MIRIAM ZACCHIA AND GIOVAMBATTISTA CAPASSO
Volume II
51. Clinical Disorders of Hyperkalemia
KAMEL S. KAMEL, SHIH-HUA LIN, SUNG-SEN YANG AND MITCHELL HALPERIN
52. Control of Intracellular pH
MARK 0. BEVENSEE AND WALTER F. BORON
53. SLC4 Sodium-Driven Bicarbonate Transporters
IRA KURTZ
54. The SLC4 Anion Exchanger Gene Family
ANDREW K. STEWART AND SETH L. ALPER
55. Cellular Mechanisms of Renal Tubular Acidification
L. LEE HAMM, ROBERT]. ALPERN AND PATRICIA A. PREISIG
56. Chemoreceptors, Breathing and pH
EUGENE NATTIE
57. Renal Ammonium Ion Production and Excretion
NORMAN P. CURTHOYS
58. Clinical Syndromes of Metabolic Alkalosis
ORSON W. MOE, ROBERT]. ALPERN AND DONALD W. SELDIN
59. Clinical Syndromes of Metabolic Acidosis
RETO KRAPF, DONALD W. SELDIN AND ROBERT]. ALPERN
60. Respiratory Acid–Base Disorders
N ICOLAOS E. MADIAS AND HORACIO ]. ADROGUE
61. Mechanisms and Disorders of Magnesium Metabolism
KARL P. SCHLINGMANN, GARY A. QUAMME AND MARTIN KONRAD
62. Calcium Channels
JOOST G.]. HOENDEROP AND RENE J.M. BINDELS
63. The Calcium-Sensing Receptor
EDWARD M. BROWN , STEVEN C. HEBERT, DANIELA RICCARDI AND J OHN P. GEIBEL
64. Renal Calcium Metabolism
JOSE F. BERNARDO AND PETER A. FRIEDMAN
65. The Hormonal Regulation of Calcium Metabolism
PETER]. TEBBEN AND RAJIV KUMAR
66. Disorders of Calcium Metabolism
CRISTINA DUMITRU AND J OHN WYSOLMERSKI
67. Pathogenesis and Treatment of Nephrolithiasis
FREDRIC L. COE, ANDREW EVAN AND ELAINE WORCESTER
68. Proximal Tubular Handling of Phosphate
HEINl MURER, I AN C. FORSTER, NAT!HERN ANDO AN D JURG BIBER
69. Clinical Disturbances of Phosphate Homeostasis
THERESA]. BERNDT AND RAJ IV KUMAR
70. Glucose Reabsorption in The Kidney
CHARLES S. HUMMEL AND ERNEST M. WRIGHT
71. Kidney Transport of Amino Acids and Oligopeptides, and Aminoacidurias
SIMON E M.R. CAMARGO, V!CfORIA MAKRIDES, ROBERT KLETA AND FRAN<;::OIS VERREY
72. Organic Anion and Cation Transporters in Renal Elimination of Drugs
GERHARD BURCKHARDT AND HERMANN KOEPSELL
73. Renal Filtration, Transport, and Metabolism of Albumin and Albuminuria
ERIK ILS0 CHRISTENSEN, RIKKE NIELSEN AND HENRIK BIRN
IV: Pathophysiology of Renal Disease
74. Physiologic Principles in the Clinical Evaluation of Electrolyte, Water, and Acid–Base Disorders
DANIEL BATLLE, SHELDON CHEN AND SYED K. HAQUE
75. Biomarkers for Assessment of Renal Function During Acute Kidney Injury
PRASAD DEVARAJAN
76. Pathophysiology of Acute Kidney Injury
BRUCE A. MOLITORIS AND ASIF SHARFUDDIN
77. Ischemic Renal Disease
WILLIAM L. HENRICH
78. Pathophysiology and Pathogenesis of Diabetic Nephropathy
SHELDON CHEN, CHARBEL KHOURY AND FUAD N. ZIYADEH
79. Renal Failure in Cirrhosis
PERE GINES, ANDRES CARDENAS AND ROBERT W. SCHRIER
80. Autosomal Dominant Polycystic Kidney Disease
STEFAN SOMLO, VICENTE E. TORRES AND MICHAEL J. CAPLAN
81. Renal Physiology and Disease in Pregnancy
MARSHALL D. LINDHEIMER, KIRK P. CONRAD AND S. ANANTH KARUMANCHI
82. Immune and Inflammatory Glomerular Diseases
ANUP MANOHARON, JEFFREY R. SCHELLING, MATTHEW DIAMOND, MOONJA CHUNG-PARK, MICHAEL MADAIO AND JOHN R. SEDOR
83. Immunologic Mechanisms of Vasculitis
JONATHON W. HOMEISTER, J . CHARLES JENNETTE AND RONALD J. FALK
84. Genetic Abnormalities in Glomerular Function
YOAV SEGAL AND CLIFFORD E. KASHTAN
85. Cellular Mechanisms of Drug Nephrotoxicity
ROBERT J AMES WALKER AND ZOLTAN HUBA ENDRE
86. Role of Glomerular Mechanical Stress in the Pathogenesis of Chronic Kidney Disease
CLARICE KAZUE FUJIHARA AND ROBERTO ZATZ
87. Role of Proteinuria in the Progression of Renal Disease
MAURO ABBATE, DANIELA MACCON I, GIUSEPPE REMUZZI AND CAR LA ZOJA
88. The Inflammatory Response to Ischemic Acute Renal Injury
CHRISTOPHER Y. LU
89. Catalytic (Labile) Iron in Kidney Disease
MOHAN RAJAPURKAR, RADHAKRISHNA BALIGA AND SUDHIR V. SHAH
90. Chronic Kidney Disease: Pathophysiology and the Influence of Dietary Protein
BIRUH T. WORKENEH AND WILLIAM E. MITCH
91. Management of Calcium and Bone Disease in Renal Patients
L. DARRYL QUARLES
92. Hematopoiesis and the Kidney
ARM IN KURTZ, ROLAND H. WENGER AND KAI-UWE ECKARDT
93. Individualizing the Dialysate to Address Electrolyte Disturbances in the Dialysis Patient
BIFF F PALMER
94. Homeostasis of Solute and Water by the Transplanted Kidney
J. HAROLD HELDERMAN, HEIDI SCHAEFER, ANTHONY]. LANGONE AND SIM IN GORAL
95. Renal Disposition of Drugs and Translation to Dosing Strategies
I: Epithelial and Nonepithelial Transport and Regulation
1. Epithelial Cell Structure and Polarity
KARLS. MATLIN AND MICHAEL J. CAPLAN
2. Mechanisms of Ion Transport across Cell Membranes
LUIS REUSS AND GUILLERMO A. ALTENBERG
3. Renal Ion-Translocating ATPases
DOMINIQUE ELADARI, UOO HASLER AND ERIC FERAILLE
4. Mechanisms of Water Transport Across Cell Membranes and Epithelia
GUILLERMO A. ALTENBERG AND LUIS REUSS
5. Cell Volume Control
FLORIAN LANG
6. Solute Transport, Energy Consumption, and Production in the Kidney
TAKASHI SEK INE AND HITOSHI ENDOU
7. Electrophysiological Analysis of Transepithelial Transport
HENRY SACKIN AND LAWRENCE G. PALMER
8. Renal Ion Channels, Electrophysiology of Transport, and Channelopathies
JAMES D. STOCKAND
9. Microvascular Permeability and the Exchange of Water and Solutes Across Microvascular WallsC.
CHARLES MICHEL
10. External Balance of Electrolytes and Acids and Alkali
MAN S.OH
11. Renal Cilia Structure, Function, and Physiology
JAY N. PIECZYNSKI AND BRADLEY K. YODER
12. Intercellular Junctions
ALAN S.L. YU, FIONA HANNER AND J ANOS PETI-PETERDI
13. Principles of Cell Signaling
LLOYD CANTLEY
14. Scaffolding Proteins in Transport Regulation
PAUL A. WELLING
15. The Renin–Angiotensin System
THU H. LE, STEVEN D. CROWLEY, SUSAN B. GURLEY AND THOMAS M. COFFMAN
16. Neural Control of Renal Function
EDWARD J. JOHNS AND ULLA C. KOPP
17. Eicosanoids and Renal Function
MATTHEW D. BREYER, RAYMOND C. HARRIS AND RICHARD M. BREYER
18. Extracellular Nucleotides and Renal Function
DAVID G. SHIRLEY, MATTHEW A. BAILEY, SCOTT S.P. WILDMAN, FREDERICK W.K. TAM AND ROBERT J. UNWIN
19. Paracrine Regulation of Renal Function by Dopamine
PEDRO A. JOSE, ROBIN A. FELDER AND GILBERT M. EISNER
II: Structural and Functional Organization of the Kidney
20. Structural Organization of the Mammalian Kidney
WILHELM KRIZ AND BRIGITTE KAISSLING
21. Biophysical Basis of Glomerular Filtration
SCOTT C. THOMSON AND ROLAND C. BLANTZ
22. Glomerular Cell Biology
YOSHIRO MAEZAWA, DAVIDE CIN A AND SUSAN E. QUAGGIN
23. Function of the Juxtaglomerular Apparatus: Control of Glomerular Hemodynamics and Renin Secretion
JURGEN B. SCHNERMANN AND HAYO CASTROP
24. Renal Cortical and Medullary Microcirculations: Structure and Function
THOMAS L. PALLONE AND CHUNHUA CAO
25. Molecular and Cellular Mechanisms of Kidney Development
KEVIN T. BUSH, HIROYUKI SAKURAI AND SANJAY K. NIGAM
26. Molecular and Cellular Mechanisms of Glomerular Capillary Development
JEFFREY H. MINER AND DALE R. ABRAHAMSON
27. Postnatal Renal Development
MICHEL BAUM, JYOTHSNA GATTINENI AND LISA M. SATLIN
28. Renal Hyperplasia and Hypertrophy
PAUL T. BRINKKOETTER, SIAN V. GR IFFIN AND STUART J. SHANKLAND
29. Stem Cells and Generation of New Cells in the Adult Kidney
JUAN A. OLIVER AND QAIS AL-AWQATI
III: Fluid and Electrolyte Regulation and Dysregulation
30. Epithelial Na+ Channels
SHAOHU SHENG, KENNETH R. HALLOWS AND THOMAS R. KLEYMAN
31. Anion Channels
OWEN M. WOODWARD AND WILLIAM B. GUGGINO
32. Physiology and Pathophysiology of the NaCl Co-Transporters in the Kidney
GERARDO GAMBA
33. Sodium and Chloride Transport: Proximal Nephron
ALAN M. WEINSTEIN
34. Sodium Chloride Transport in the Loop of Henle, Distal Convoluted Tubule, and Collecting Duct
GERARDO GAMBA, WENHUI WANG AND LAURENT SCHILD
35. Mineralocorticoid Action in the Aldosterone Sensitive Distal Nephron
OLIVIER STAUB AND JOHANNES LOFFING
36. Inherited Disorders of Renal Salt Homeostasis: Insights from Molecular Genetics Studies
UTE I. SCHOLL AND RICHARD P. LIFTON
37. Natriuretic Hormones
DAVID L. VESELY
38. Pathophysiology of Sodium Retention and Wastage
BIFF F. PALMER, ROBERT J . ALPERN AND DONALD W. SELDIN
39. Physiology and Pathophysiology of Hypertension
JOHN E. HALL, J OEY P. GRANGER AND MICHAEL E. HALL
40. Physiology and Pathophysiology of Diuretic Action
DAVID H. ELLISON41. Aquaporin Water Channels in Mammalian KidneyS0REN NIELSEN, TAE-HWAN KWON, HENRIK DIMKE, MARTIN SKOTT AND J0RGEN FR0KIIER
42. Thirst and Vasopressin
GARY L. ROBERTSON
43. The Urine Concentrating Mechanism and Urea Transporters
JEFF M. SANDS AND HAROLD E. LAYTON
44. Hyponatremia
RICHARD H. STERNS, STEPH EN M. SILVER AND J . KEVIN HIX
45. Hypernatremic States
CHRISTOPHER j. RIVARD, WEI WANG AND LAURENCE CHAN
46. Polyuria and Diabetes Insipidus
DANIEL G. BICHET
47. The Molecular Biology of Renal K+ Channels
WENHUI WANG AND CHOU-LONG HUANG
48. Extrarenal Potassium Metabolism
VAIBHAV SAHNI , ALEKSANDRA GMURCZYK AND ROBERT M. ROSA
49. Regulation of K+ Excretion
GERHARD MALNIC, GERHARD GIEBISCH, SHIGEAKI MUTO, WENHUI WANG, MATTHEW A. BAILEY AND LISA M. SATLIN
50. Physiopathology of Potassium Deficiency
FR ANCESCO TREPICCIONE, MIRIAM ZACCHIA AND GIOVAMBATTISTA CAPASSO
Volume II
51. Clinical Disorders of Hyperkalemia
KAMEL S. KAMEL, SHIH-HUA LIN, SUNG-SEN YANG AND MITCHELL HALPERIN
52. Control of Intracellular pH
MARK 0. BEVENSEE AND WALTER F. BORON
53. SLC4 Sodium-Driven Bicarbonate Transporters
IRA KURTZ
54. The SLC4 Anion Exchanger Gene Family
ANDREW K. STEWART AND SETH L. ALPER
55. Cellular Mechanisms of Renal Tubular Acidification
L. LEE HAMM, ROBERT]. ALPERN AND PATRICIA A. PREISIG
56. Chemoreceptors, Breathing and pH
EUGENE NATTIE
57. Renal Ammonium Ion Production and Excretion
NORMAN P. CURTHOYS
58. Clinical Syndromes of Metabolic Alkalosis
ORSON W. MOE, ROBERT]. ALPERN AND DONALD W. SELDIN
59. Clinical Syndromes of Metabolic Acidosis
RETO KRAPF, DONALD W. SELDIN AND ROBERT]. ALPERN
60. Respiratory Acid–Base Disorders
N ICOLAOS E. MADIAS AND HORACIO ]. ADROGUE
61. Mechanisms and Disorders of Magnesium Metabolism
KARL P. SCHLINGMANN, GARY A. QUAMME AND MARTIN KONRAD
62. Calcium Channels
JOOST G.]. HOENDEROP AND RENE J.M. BINDELS
63. The Calcium-Sensing Receptor
EDWARD M. BROWN , STEVEN C. HEBERT, DANIELA RICCARDI AND J OHN P. GEIBEL
64. Renal Calcium Metabolism
JOSE F. BERNARDO AND PETER A. FRIEDMAN
65. The Hormonal Regulation of Calcium Metabolism
PETER]. TEBBEN AND RAJIV KUMAR
66. Disorders of Calcium Metabolism
CRISTINA DUMITRU AND J OHN WYSOLMERSKI
67. Pathogenesis and Treatment of Nephrolithiasis
FREDRIC L. COE, ANDREW EVAN AND ELAINE WORCESTER
68. Proximal Tubular Handling of Phosphate
HEINl MURER, I AN C. FORSTER, NAT!HERN ANDO AN D JURG BIBER
69. Clinical Disturbances of Phosphate Homeostasis
THERESA]. BERNDT AND RAJ IV KUMAR
70. Glucose Reabsorption in The Kidney
CHARLES S. HUMMEL AND ERNEST M. WRIGHT
71. Kidney Transport of Amino Acids and Oligopeptides, and Aminoacidurias
SIMON E M.R. CAMARGO, V!CfORIA MAKRIDES, ROBERT KLETA AND FRAN<;::OIS VERREY
72. Organic Anion and Cation Transporters in Renal Elimination of Drugs
GERHARD BURCKHARDT AND HERMANN KOEPSELL
73. Renal Filtration, Transport, and Metabolism of Albumin and Albuminuria
ERIK ILS0 CHRISTENSEN, RIKKE NIELSEN AND HENRIK BIRN
IV: Pathophysiology of Renal Disease
74. Physiologic Principles in the Clinical Evaluation of Electrolyte, Water, and Acid–Base Disorders
DANIEL BATLLE, SHELDON CHEN AND SYED K. HAQUE
75. Biomarkers for Assessment of Renal Function During Acute Kidney Injury
PRASAD DEVARAJAN
76. Pathophysiology of Acute Kidney Injury
BRUCE A. MOLITORIS AND ASIF SHARFUDDIN
77. Ischemic Renal Disease
WILLIAM L. HENRICH
78. Pathophysiology and Pathogenesis of Diabetic Nephropathy
SHELDON CHEN, CHARBEL KHOURY AND FUAD N. ZIYADEH
79. Renal Failure in Cirrhosis
PERE GINES, ANDRES CARDENAS AND ROBERT W. SCHRIER
80. Autosomal Dominant Polycystic Kidney Disease
STEFAN SOMLO, VICENTE E. TORRES AND MICHAEL J. CAPLAN
81. Renal Physiology and Disease in Pregnancy
MARSHALL D. LINDHEIMER, KIRK P. CONRAD AND S. ANANTH KARUMANCHI
82. Immune and Inflammatory Glomerular Diseases
ANUP MANOHARON, JEFFREY R. SCHELLING, MATTHEW DIAMOND, MOONJA CHUNG-PARK, MICHAEL MADAIO AND JOHN R. SEDOR
83. Immunologic Mechanisms of Vasculitis
JONATHON W. HOMEISTER, J . CHARLES JENNETTE AND RONALD J. FALK
84. Genetic Abnormalities in Glomerular Function
YOAV SEGAL AND CLIFFORD E. KASHTAN
85. Cellular Mechanisms of Drug Nephrotoxicity
ROBERT J AMES WALKER AND ZOLTAN HUBA ENDRE
86. Role of Glomerular Mechanical Stress in the Pathogenesis of Chronic Kidney Disease
CLARICE KAZUE FUJIHARA AND ROBERTO ZATZ
87. Role of Proteinuria in the Progression of Renal Disease
MAURO ABBATE, DANIELA MACCON I, GIUSEPPE REMUZZI AND CAR LA ZOJA
88. The Inflammatory Response to Ischemic Acute Renal Injury
CHRISTOPHER Y. LU
89. Catalytic (Labile) Iron in Kidney Disease
MOHAN RAJAPURKAR, RADHAKRISHNA BALIGA AND SUDHIR V. SHAH
90. Chronic Kidney Disease: Pathophysiology and the Influence of Dietary Protein
BIRUH T. WORKENEH AND WILLIAM E. MITCH
91. Management of Calcium and Bone Disease in Renal Patients
L. DARRYL QUARLES
92. Hematopoiesis and the Kidney
ARM IN KURTZ, ROLAND H. WENGER AND KAI-UWE ECKARDT
93. Individualizing the Dialysate to Address Electrolyte Disturbances in the Dialysis Patient
BIFF F PALMER
94. Homeostasis of Solute and Water by the Transplanted Kidney
J. HAROLD HELDERMAN, HEIDI SCHAEFER, ANTHONY]. LANGONE AND SIM IN GORAL
95. Renal Disposition of Drugs and Translation to Dosing Strategies
Product details
Product details
- Edition: 6
- Latest edition
- Published: April 24, 2026
- Language: English
About the editors
About the editors
RA
Robert J. Alpern
Dr. Robert J. Alpern has performed research in the area of epithelial physiology, focusing on the mechanisms and regulation of acid transport. He received his MD degree from the University of Chicago and then trained in internal medicine at Columbia Presbyterian. Following postdoctoral training in the Cardiovascular Research Institute at the University of California, San Francisco, Alpern joined the faculty at UCSF, then moved to the University of Texas Southwestern Medical School as Chief of Nephrology and later Dean of the Medical School. He then moved to Yale as the Dean of Yale School of Medicine and is now Ensign Professor of Medicine and Cellular and Molecular Physiology at Yale.
Affiliations and expertise
Dean and Ensign Professor of Medicine, Yale University School of Medicine, New Haven, Connecticut, USAMC
Michael J. Caplan
Dr. Michael Caplan studies epithelial cell biology and physiology. His work focuses on the trafficking and regulation of renal ion transport proteins. His group also studies the signaling pathways involved in autosomal dominant polycystic kidney disease. He received his MD and PhD degrees from Yale University, having pursued his dissertation work in the Department of Cell Biology under the guidance of Drs. James D. Jamieson and George E. Palade. He is currently C.N.H. Long Professor and Chair of Yale University School of Medicine’s Department of Cellular and Molecular Physiology.
Affiliations and expertise
C.N.H. Long Professor and Chair, Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, USAOM
Orson W. Moe
Dr. Orson W. Moe received his MD degree from the University of Toronto, where he also did his internal medicine residency and clinical nephrology fellowship. Dr. Orson Moe moved to the University of Texas Southwestern Medical Center for research training in renal physiology. He is currently Professor of Internal Medicine and Physiology and member of the Nephrology Division at the University of Texas Southwestern Medical Center in Dallas. He is also Director of the Charles and Jane Pak Center of Mineral Metabolism and Clinical Research and holds the Charles and Jane Pak Chair in Mineral Metabolism Research and the Donald Seldin Professorship in Clinical Investigation. Dr. Moe conducts both basic science and patient-oriented research on renal physiology and metabolism, and epithelial biology.
Affiliations and expertise
Professor of Internal Medicine and Physiology, University of Texas Southwestern Medical Center, Dallas, Texas, USASQ
Susan E. Quaggin
Dr. Susan E. Quaggin, MD, FASN, is a graduate of the University of Toronto, where she completed her residency and served as Chief Medical Resident for the University’s St. Michael’s Hospital. She completed her nephrology fellowship at the University of Toronto and Yale University, where she also completed research and postdoctoral training. Dr. Quaggin also trained in the developmental biology program at the University of Toronto’s Samuel Lunenfeld Research Institute. Dr. Quaggin now serves as Editor for Current Opinion in Nephrology and Hypertension and The Kidney, and as an Editorial Board Member for JCI, Disease Models and Mechanisms, and Kidney International. Currently, Charles Horace Mayo Professor of Medicine at Northwestern University and a Finnish Distinguished Professor (2012–17). Dr. Quaggin has been the recipient of many awards and honors.
Affiliations and expertise
Director, Feinberg Cardiovascular Research Institute, Chicago; Chief, Division of Medicine-Nephrology, Professor in Medicine-Nephrology, Northwestern University, Evanston, IL, USA