Scientific and Engineering Principles
Proceedings of the Sixth International Fermentation Symposium Held in London, Canada, July 20-25, 1980
- 1st Edition - January 1, 1981
- Imprint: Pergamon
- Editors: Murray Moo-Young, Campbell W. Robinson, Claude Vezina
- Language: English
- Paperback ISBN:9 7 8 - 1 - 4 8 3 1 - 1 6 0 3 - 7
- eBook ISBN:9 7 8 - 1 - 4 8 3 1 - 4 8 4 5 - 8
Advances in Biotechnology, Volume I: Scientific and Engineering Principles is the first of a series of three volumes and is based on the proceedings of the Sixth International… Read more
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Request a sales quoteAdvances in Biotechnology, Volume I: Scientific and Engineering Principles is the first of a series of three volumes and is based on the proceedings of the Sixth International Fermentation Symposium (IFS-6) held in London, Ontario, Canada, 20-25 July 1980. This volume is organized into 13 sections and contains 111 papers which represent about 80% of the total submitted. Section I contains papers on microbial cultures. Section II presents studies on recombinant DNA and microbial genetics. The papers in Section III deal with plant and animal cell and tissue culture. Section IV examines the microbial oxidation of hydrocarbons. Sections V and VI focus on continuous cultures and free-cell fermentation, respectively. Section VII examines process dynamics and control. Section VIII takes up computer applications in biotechnology, while Section IX covers process instrumentation and analytical methods. Section X contains papers on transport phenomena, mixing and scale-up. Section XI examines the design and operation of unconventional bioreactors. Sections XII covers fixed-, fluidized- and semi-fluidized bed bioreactors, while Section XIII presents studies on immobilization bioreactors. The volume also includes invited keynote addresses of Nobel Laureate, Professor Joshua Lederberg, and Professor Elmer L. Gaden, Jr. Abstracts of the round-table discussion on Technology Transfer and Economics, and on Biotechnology Training Programs are presented as appendices.
Preface
Guest Editorial I. Biochemical Engineering: Where Has it Been and Where is it Going?
Guest Editorial II. Genetics and Industrial Microbiology: Still Further Horizons
Section I. Microbial Cultures: Screening, Improvement, Patents
1. Strain Improvement Programs in Antibiotic-Producing Microorganisms - Present and Future Strategies
2. New Organisms of Economic Importance: the Case of Frankia
3. Mixed Cultures in Industrial Processes
4. Cultures and Patents
5. Production of Pharmacologically Active Agents from Microbial Origin
6. Screening of Basidiomycetes for the Production of New Antibiotics
7. Screening of Bacterial Isolates for Antigonococcal Activities
8. Isolation of Carboxyl Proteinases of Microbial Origin on Pepstatinsepharose Resin
9. Rapid Strain Selection for Citric Acid Production
10. Use of Cerulenin in Selecting Improved Mutants of Daunorubicin-Producing Streptomycete
11. Improvement of the Daunorubicin Fermentation Realized at 10,000 Liter Fermentor Scale
12. Studies on the Avermectin Fermentation
13. The Influence of Oxygen Concentration on Microbial Insecticide Production
Section II. Recombinant DNA and Microbial Genetics
14. Enzymatic Hydrolysis of some Penicillins and Cephalosporins by Cloned Escherichia coli Acylase
15. Expansion of the Host Range of Pl and Mu Phages and Gene Transfer between Intergeneric Bacteria
16. Stability of trp Operon Recombinant Plasmid in E. coli
17. Genetic Control of Dikaryotic Fruiting in the Basidiomycete
Section III. Cell and Tissue Culture - Plant and Animal
18. Advances in Plant Cell Culture towards Improved Yields of Secondary Products (Alkaloids)
19. Aspects on Scale-up and Mass Cultivation of Plant Tissue Culture
20. Present and Future Trends in Plant Tissue Culture
21. Effects of Media Constituents on the Formation of Secondary Products in Cell Suspension Cultures of Catharanthus roseus
22. Hormonal Regulation of Scopoletin and Scopolin Productions in Tobacco Tissue Culture
23. Engineering Characterization of Animal Cell and Virus Production Using Controlled Charge Microcarriers
Section IV. Microbial Oxidation of Hydrocarbons
24. Uptake and Oxidation of Hydrocarbons by a Mutant Derived from Itaconate-Producing Yeast
25. Study of Hydroxylase and its Components in Candida tropioalis Grown on Alkane
26. Plasmid Involvement in Bacterial Degradation of Phenanthrene
27. Induction of Enzymes for n-Alkane Degradation in Two Strains of Pseudomonas aeruginosa
28. Structural Changes of the TOL Plasmid pWWO
29. Utilization of n-Alkanes by Microorganisms: Biological Aspects of Transport
Section V. Continuous Cultures
30. The Utility of Chemostat Cultures in Studies of Microbial Physiology
31. Continuous Culture: Some Contemporary Problems from Another Viewpoint
32. Nutrient Control of Growth at the Cellular Level: Some Studies Conducted with Candida utilis in Continuous Phased Culture
33. Continuous Culture: Its Influence on Engineering Practice
34. The Enzyme Activity as Growth Rate Limiting Step in a Chemostat
35. Selection of Escherichia coli with Increased Endoenzyme Synthesis in Continuous Culture
36. Continuous Process for Production of Citric Acid
37. Kinetics of Virus Replication and Glucoamylase Biosynthesis in Aspergillus niger Repeated Fed-Batch Culture
38. Auto-Selection of Very Rapidly Growing Microorganisms
39. Gel-Forming Exopolysaccharide Production by Alcaligenes faecalis Grown in Nitrogen-Limited Continuous Culture
40. New Developments in the Elucidation of the Mechanisms of the Pasteur and Crabtree Effects in Bacteria
41. The Crabtree Effect in Saccharomyces cerevisiae: Primary Control Mechanism or Transient?
42. Regulatory Aspects in Yeast Metabolism
43. Growth of Hansenula polymorpha on Mixed Substrates and Regulation of Alcohol Oxidase Synthesis
44. A Quantitative Description of the Growth of Saccharomyces cerevisiae CBS 426 in Continuous Cultures on a Mixture of Two Carbon Sources
45. Cellular Yields and Maintenance Requirements of Alcaligenes eutrophus during Hydrogen Oxidation
46. Light Supply and Quantum Efficiencies in a Model Reactor for Continuous Phototrophic Growth
47. Properties of the Green Alga Chlorgonium elongatum during Light-Limited Continuous Culture in the Phauxostat
Section VI. Free-Cell Fermentation: Modeling, Simulation and Process Development
48. Optimal Conditions for Production of Cephalosporin C in Fed-Batch Culture
49. Kinetics of Substrate Utilization in Repeated Fed-Batch Culture and Fitting Computer Simulation Data to Experimental Data of Antibiotic Biosynthesis
50. A Model for the Growth and Product Kinetics of Facultative Anaerobes Based on ATP Synthesis and Consumption
51. An Unstructured Model of Algal Growth in Continuous Culture
52. The Development of a Semi-Solid Fermentation System for the Production of Lysine-Enriched Yeast and Ethanol
53. Effect of Oxygen on Amino Acids Fermentation
54. The Influence of Low Dissolved Oxygen Levels in Fermentors on Ethanol Production by Candida tropicalis
55. Effect of Water Activity on Microbial Growth
56. Death Rates of Bacterial Spores at High Temperature in a Continuous Stirred Tank Reactor
Section VII. Process Dynamics and Control
57. Analysis of Basic Principles of Fermentation Process Control
58. Production of Cellulase in Fed-Batch Culture
59. Dynamics and Control of a Biological Phenol Wastewater Treatment Reactor
60. The Redox Potential, a Hitherto Seldom Used Parameter in Fermentation Systems
61. Determination of Kinetic Process Parameters by Dynamic Methods Taking into Account the Inertia of Measuring Instrument
62. Application of Experimental Methods to Identify Process Dynamics of Fermentation Processes
Section VIII. Computer Applications in Biotechnology
63. Direct Monitoring of a Fermentation in a Computer-Mass Spectrometer-Fermemtor Systems
64. State Estimation for Computer Control of Biochemical Reactors
65. An Approach to On-Line Optimization of Biomass Production in Continuous Processes
66. Automatic Control of Dissolved Oxygen Concentration with Microcomputer
67. Ethanol- and Ro-Based Computer Control in Fed Batch Culture of Baker's Yeast
68. Progress with Computer-Coupled Mammalian Cell Culture Investigations
Section IX. Process Instrumentation and Analytical Methods
69. A New Sensor, the "Filtration Probe", to Monitor and Control Antibiotic Fermentations
70. A Porous Membrane-Carrier Gas Measurement System for Dissolved Gases and volatiles in Fermentation Systems
71. Fermentor Monitoring and Control by Enzyme Thermistors
72. Measurement of the Solubility of Oxygen during Fermentations
73. Determination of Adenosine Nucleotides with Luciferin/Luciferase from Crude Firefly Lantern Extract on a Bioluminescence Analyzer
Section X. Transport Phenomena, Mixing and Scale-up
74. Physical Transport Phenomena in Bubble Column Bioreactors - I: Gas-liquid Mass Transfer
75. Physical Transport Phenomena in Bubble Column Bioreactors - II: Liquid-solid Mass Transfer, Mixing and Heat Transfer
76. The Two-Zone Model: A Quantitative Description of the Oxygen Mass Transfer in Bubble Columns and Three-Phase Fluidized Beds
77. Turbine Agitated Gas Dispersion: Power, Flooding and Hold-up
78. Bubble Coalescence and Break-up in Fermentations
79. Gas Liquid Contacting in Highly Viscous Liquids
80. Power and Hold-up in the Mixing of Aerated Highly Viscous Non-Newtonian Fluids
81. Gas Absorption with Simultaneous Biochemical Reaction
82. Some Scale-up Considerations for Fermentation Mixers
83. Circulation times of Various Fluids in Stirred Fermentors
84. Modeling and Scale-up of Anaerobic Conversion of Dissolved Fatty Acids
Section XI. Unconventional Bioreactors: Design and Operating Characteristics
85. High Productivity Anaerobic Fermentation with Dense Cell Culture
86. Mass Transfer and Liquid Mixing in External-Circulation-Loop Contactors
87. Gas-Liquid Dispersion Characteristics in Airlift Fermentors
88. Liquid Velocity as an Important Design Parameter for Airlift Loop-Fermentors
89. Single and Multi-Stage Countercurrent Bubble Column Loop Reactor Performance
90. Penicillin Production in a Bubble Column Airlift Loop Reactor
91. Oxygen Transfer and Biological Effects in a Deep-Tank Aeration System
92. Effectiveness of Energy Introduced into Fermentors
93. Novel Reactor Configuration for Small-Scale Microbiological Leaching
94. On-Line Extraction Fermentation Processes
95. Modification of Non-Newtonian Mycelial Fermentation Broth through Confinement of Growth Using Microscopic Beads
Section XII. Fixed-, Fluidized- and Semi-Fluidized Bed Bioreactors
96. Optimum Operation Policy for a Fixed and Moving Bed Reactor with Deactivating Enzyme Catalyst: Optimum Temperature and Optimal Temperature Profile
97. Ethanol Fermentation in a Yeast Immobilized Column Fermentor
98. Fluidization Principles and Applications to Biotechnology
99. Oxygen Transfer in Three Phase Fluidized Beds
100. Tapered Fluidized Bed Bioreactors for Environmental Control and Fuel Production
101. Fluidized Bed Reactor for the Production of Methane from Sugar Cane Bagasse
102. Semifluidized Bed Bioreactor
Section XIII. Immobilization Bioreactors
103. Optimal Operation and Replacement Policies for Decaying Immobilized Enzyme
104. Dextran Production by Free and Immobilized Dextransucrase
105. Immobilized ß-Glucanase in Brewing
106. The Effects of Solvents on the Hydrolysis of Lipids by Free and Immobilized Microbial Lipase
107. Immobilization of a Penicillium duponti Proteolytic Enzyme and its Application in Solubilization of Soybean Protein in a Spiral-Wound Recycle Reactor
108. Glucoamylase Hollow Fiber Reactors
109. Immobilized Live Cells
110. Magnetic Immobilized Microorganisms
111. Macromolecular NAD+-derivative of High Coenzyme Activity and its Application for a Model Reaction
Appendices
Appendix IA. Overview of Technology Transfer and Economics I
Appendix IB. Overview of Technology Transfer and Economics II
Appendix II. Overview of Training Programs in Biotechnology and Biochemical Engineering
Contents of Other Volumes
Volume II. Fuels, Chemicals, Foods and Waste Treatment
Volume III. Fermentation Products
Contents of "Current Developments in Yeast Research" (ISY-5)
Author Index
Subject Index
- Edition: 1
- Published: January 1, 1981
- No. of pages (eBook): 808
- Imprint: Pergamon
- Language: English
- Paperback ISBN: 9781483116037
- eBook ISBN: 9781483148458
MM
Murray Moo-Young
Affiliations and expertise
University of Waterloo, CanadaRead Scientific and Engineering Principles on ScienceDirect