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Science and Technology of Silkworm Sericin
Extractions, Modifications and Applications
- 1st Edition - May 1, 2025
- Editors: Sabu Thomas, Rangam Rajkhowa, Sneha Sabu Mathew, Hanna J Maria
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 2 1 7 3 6 - 4
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 1 7 3 7 - 1
Science and Technology of Silkworm Sericin: Extractions, Modifications and Applications focuses on the development and performance of many novel strategies for sericin extractio… Read more
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Request a sales quoteScience and Technology of Silkworm Sericin: Extractions, Modifications and Applications focuses on the development and performance of many novel strategies for sericin extraction, modification, and its application.
This book includes contributions from leading researchers in the fields of materials science, medical science, chemical science, and nanotechnology from companies, university, government, and private research institutes all around the world.
Graduates and postgraduates, as well as research experts, will find this book to be an invaluable resource (primarily in the field of materials science, medicinal chemistry, organic chemistry and nanoscience and nanotechnology).
In addition, nearly every analytical approach has been covered. As a result, academics, students, industry, scientists, and end-users will be able to benefit from it.
- All available characterization techniques of sericin structures rigorously addressed
- Application-focused chapters, as most of the research is being done on biomedical applications such as wound healing, pharmaceutical uses, and cancer treatment
- Reviews the theory, modeling, and simulation of sericin-based biomaterials are explored as a novel area of competence
- Provides assessment based on environmental implications, which is now seen as an integral part of science in the new research culture, as well as the circular economy in the silk sector, is examined
- Offers in-depth coverage of emerging areas of sericin-based research, such as sericin in nutraceuticals
University professors, researchers, undergraduate and graduate students, scientists working in the fields of materials science, bioscience, biochemistry, biomedical engineering, applied chemistry, drug delivery systems, and nanotechnology, researchers and academicians working in the disciplines specified above, Industrial research related to textile industry, cosmetics industry, pharmaceuticals, and other sectors
1. Sericin-An Introductory Outlook
1. Introduction
2. Sericin based biomaterial: A general overview
3. Why biobased?
4. Applications of sericin based biomaterials: Highlights
5. About this book
2. Sources of Sericin
1. Introduction
2. Conventional and non-conventional sources of sericin
3. Sericin from Bombyx Mori silk cocoons
4. Sericin from fibroin-deficient mutant silkworm cocoons
5. Comparative study on morphological structure, protein quality, protein structure, molecular weight
6. Conclusions
3. Different extraction routes for degumming
1. Introduction
2. Chemical treatments
3. Enzymatic treatments
4. Boiling in water
5. Non-conventional methods
6. Conclusions and future outlooks
4. Chemical and enzymatic modifications of sericin to produce new functional materials with improved properties.
1. Introduction
2. Modifications: General Outlook
3. Chemical modifications
4. Enzymatic modifications
5. Conclusions and future outlooks
5. Physical modifications of sericin for high performance materials.
1. Introduction
2. Modifications: General Outlook
3. Physical modifications on sericin
4. Conclusions and future outlooks
6. Microscopic and optical characterisations of sericin structures
1. Introduction
2. Microscopic studies on sericin structures
3. Optical studies on sericin structures
4. Conclusions and future outlooks
7. Advanced characterisation techniques
1. Introduction
2. Cell viability by MTT assay
3. Cytometry
4. Antimicrobial activity
5. Antioxidant, antitumor activity
6. Conclusions and future outlooks
8. Mechanical, rheological, viscoelastic properties and gelation behaviour of sericin based materials
1. Introduction
2. Mechanical properties
3. Rheological and viscoelastic properties
4. Temperature dependent gelation behaviour
5. Conclusions
9. Effect of molecular weight on critical properties of various forms of sericin (Sponges, films, gels and other nano composites of sericin)
1. Introduction
2. Control of inherent properties of raw materials
3. Control of processing conditions on various forms
4. Effect on structural, mechanical and other properties
5. Conclusions and future outlooks
10. Sericin based nano spheres and other nano formulations for various applications
1. Introduction
2. Fabrication of sericin nanoparticles
3. Nanoparticles chemistry and stability in solution
4. Sericin nanoparticles for gene delivery
5. Biochemical activity, DNA sericin interaction and DNA transport efficiency
6. Conclusions and future outlooks
11. Sericin based hydrogels
1. Introduction
2. Sericin based multi-layered hydrogels
3. Sericin based injectable hydrogels
4. Sericin based self-healing hydrogels
5. Sericin based shape memory hydrogels
6. Conclusions and future outlooks
12. Stimuli-responsive and self-assembled sericin materials for various applications.
1. Introduction
2. What are stimuli responsive materials
3. Advances in self-assembled sericin based materials
4. Conclusions and future outlook
13. Electro spun nanofibers based on silk sericin
1. Introduction
2. Governing factors of electrospinning
3. Morphology and properties of electro spun sericin fibres
4. Electrospun sericin materials for various applications
5. Conclusions and future outlook
14. Blended polymer composites of sericin
1. Introduction
2. Sericin blends with various polymer materials (biobased and synthetic (Thermosets, thermoplastics, elastomers)
3. Polymer micelles, nano micelles, polymer hydrogels, nanogels, polymersomes, and liposomes and other forms.
4. Conclusions and future outlook
15. Novel developments and scope of nano and micro structured sericin materials for drug delivery system
1. Introduction
2. Silk sericin microparticles
3. Silk sericin micro drug delivery system
4. Silk sericin nanoparticles
5. Silk sericin micro drug delivery system
6. Conclusions and future outlook
16. Applications of sericin hybrid materials in wound healing
1. Introduction
2. Beneficial effects of sericin in wound healing
3. Case Studies based on wound healing applications
4. Conclusion and future outlooks
17. Applications of sericin hybrid materials in pharmaceutical applications
1. Introduction
2. Beneficial effects of sericin in pharma industry
3. Case studies based on sericin pharma applications
4. Conclusion and future outlooks
18. Applications of sericin hybrid materials in cancer treatment
1. Introduction
2. High throughput assay methodologies in cancer treatments
3. Case studies based on sericin based materials
4. Conclusion and future outlooks
19. Sericin in nutraceutical, food engineering and packaging applications
1. Introduction
2. Sericin and its derivatives as food additives
3. Functional ingredient and health beneficial effects
4. Sericin molecule in active packaging
5. Chelation of undesirable compounds
6. Conclusions and future outlooks
20. Applications of sericin hybrid materials in textile Industry
1. Introduction
2. Beneficial effects of sericin in textile industry
3. Case studies based on sericin in textile industry
4. Conclusions and future outlooks
21. Applications of sericin hybrid materials in cosmetics industry
1. Introduction
2. Beneficial effects of sericin in cosmetics industry
3. Case studies based on sericin in cosmetics industry
4. Conclusions and future outlooks
22. Challenges and toxicity assessment of sericin materials in biobased applications
1. Introduction
2. Dose–response assessment
3. Sub chronic Studies
4. Hazard Identification
5. Exposure Assessment
6. Risk Characterization
7. Conclusion
23. Life cycle assessment (LCA), and environmental aspects of Sericin based biomaterials
1. Introduction
2. Hazard identification
3. Exposure and potential toxicity
4. Environmental, health and safety (EHS) roadmap
5. Conclusion and outlooks
24. Theory, modelling and simulation of Sericin based biomaterials
1. Introduction
2. Overview on modelling of sericin sponges, aerogels, hydrogels.
3. Summary and outlook
25. Circular economy in silk industry
1. Introduction
2. Importance of sustainable development
3. Non renewability of petrochemicals
4. Sericulture industry
5. Valorisation of silk industry waste-Sericin
6. Conclusions and future outlooks
1. Introduction
2. Sericin based biomaterial: A general overview
3. Why biobased?
4. Applications of sericin based biomaterials: Highlights
5. About this book
2. Sources of Sericin
1. Introduction
2. Conventional and non-conventional sources of sericin
3. Sericin from Bombyx Mori silk cocoons
4. Sericin from fibroin-deficient mutant silkworm cocoons
5. Comparative study on morphological structure, protein quality, protein structure, molecular weight
6. Conclusions
3. Different extraction routes for degumming
1. Introduction
2. Chemical treatments
3. Enzymatic treatments
4. Boiling in water
5. Non-conventional methods
6. Conclusions and future outlooks
4. Chemical and enzymatic modifications of sericin to produce new functional materials with improved properties.
1. Introduction
2. Modifications: General Outlook
3. Chemical modifications
4. Enzymatic modifications
5. Conclusions and future outlooks
5. Physical modifications of sericin for high performance materials.
1. Introduction
2. Modifications: General Outlook
3. Physical modifications on sericin
4. Conclusions and future outlooks
6. Microscopic and optical characterisations of sericin structures
1. Introduction
2. Microscopic studies on sericin structures
3. Optical studies on sericin structures
4. Conclusions and future outlooks
7. Advanced characterisation techniques
1. Introduction
2. Cell viability by MTT assay
3. Cytometry
4. Antimicrobial activity
5. Antioxidant, antitumor activity
6. Conclusions and future outlooks
8. Mechanical, rheological, viscoelastic properties and gelation behaviour of sericin based materials
1. Introduction
2. Mechanical properties
3. Rheological and viscoelastic properties
4. Temperature dependent gelation behaviour
5. Conclusions
9. Effect of molecular weight on critical properties of various forms of sericin (Sponges, films, gels and other nano composites of sericin)
1. Introduction
2. Control of inherent properties of raw materials
3. Control of processing conditions on various forms
4. Effect on structural, mechanical and other properties
5. Conclusions and future outlooks
10. Sericin based nano spheres and other nano formulations for various applications
1. Introduction
2. Fabrication of sericin nanoparticles
3. Nanoparticles chemistry and stability in solution
4. Sericin nanoparticles for gene delivery
5. Biochemical activity, DNA sericin interaction and DNA transport efficiency
6. Conclusions and future outlooks
11. Sericin based hydrogels
1. Introduction
2. Sericin based multi-layered hydrogels
3. Sericin based injectable hydrogels
4. Sericin based self-healing hydrogels
5. Sericin based shape memory hydrogels
6. Conclusions and future outlooks
12. Stimuli-responsive and self-assembled sericin materials for various applications.
1. Introduction
2. What are stimuli responsive materials
3. Advances in self-assembled sericin based materials
4. Conclusions and future outlook
13. Electro spun nanofibers based on silk sericin
1. Introduction
2. Governing factors of electrospinning
3. Morphology and properties of electro spun sericin fibres
4. Electrospun sericin materials for various applications
5. Conclusions and future outlook
14. Blended polymer composites of sericin
1. Introduction
2. Sericin blends with various polymer materials (biobased and synthetic (Thermosets, thermoplastics, elastomers)
3. Polymer micelles, nano micelles, polymer hydrogels, nanogels, polymersomes, and liposomes and other forms.
4. Conclusions and future outlook
15. Novel developments and scope of nano and micro structured sericin materials for drug delivery system
1. Introduction
2. Silk sericin microparticles
3. Silk sericin micro drug delivery system
4. Silk sericin nanoparticles
5. Silk sericin micro drug delivery system
6. Conclusions and future outlook
16. Applications of sericin hybrid materials in wound healing
1. Introduction
2. Beneficial effects of sericin in wound healing
3. Case Studies based on wound healing applications
4. Conclusion and future outlooks
17. Applications of sericin hybrid materials in pharmaceutical applications
1. Introduction
2. Beneficial effects of sericin in pharma industry
3. Case studies based on sericin pharma applications
4. Conclusion and future outlooks
18. Applications of sericin hybrid materials in cancer treatment
1. Introduction
2. High throughput assay methodologies in cancer treatments
3. Case studies based on sericin based materials
4. Conclusion and future outlooks
19. Sericin in nutraceutical, food engineering and packaging applications
1. Introduction
2. Sericin and its derivatives as food additives
3. Functional ingredient and health beneficial effects
4. Sericin molecule in active packaging
5. Chelation of undesirable compounds
6. Conclusions and future outlooks
20. Applications of sericin hybrid materials in textile Industry
1. Introduction
2. Beneficial effects of sericin in textile industry
3. Case studies based on sericin in textile industry
4. Conclusions and future outlooks
21. Applications of sericin hybrid materials in cosmetics industry
1. Introduction
2. Beneficial effects of sericin in cosmetics industry
3. Case studies based on sericin in cosmetics industry
4. Conclusions and future outlooks
22. Challenges and toxicity assessment of sericin materials in biobased applications
1. Introduction
2. Dose–response assessment
3. Sub chronic Studies
4. Hazard Identification
5. Exposure Assessment
6. Risk Characterization
7. Conclusion
23. Life cycle assessment (LCA), and environmental aspects of Sericin based biomaterials
1. Introduction
2. Hazard identification
3. Exposure and potential toxicity
4. Environmental, health and safety (EHS) roadmap
5. Conclusion and outlooks
24. Theory, modelling and simulation of Sericin based biomaterials
1. Introduction
2. Overview on modelling of sericin sponges, aerogels, hydrogels.
3. Summary and outlook
25. Circular economy in silk industry
1. Introduction
2. Importance of sustainable development
3. Non renewability of petrochemicals
4. Sericulture industry
5. Valorisation of silk industry waste-Sericin
6. Conclusions and future outlooks
- No. of pages: 550
- Language: English
- Edition: 1
- Published: May 1, 2025
- Imprint: Elsevier
- Paperback ISBN: 9780443217364
- eBook ISBN: 9780443217371
ST
Sabu Thomas
Prof. Sabu Thomas is a Professor of Polymer Science and Engineering and the Director of the School of Energy Materials at Mahatma Gandhi University, India. Additionally, he is the Chairman of the Trivandrum Engineering Science & Technology Research Park (TrEST Research Park) in Thiruvananthapuram, India. He is the founder director of the International and Inter-university Centre for Nanoscience and Nanotechnology at Mahatma Gandhi University and the former Vice-Chancellor of the same institution.
Prof. Thomas is internationally recognized for his contributions to polymer science and engineering, with his research interests encompassing polymer nanocomposites, elastomers, polymer blends, interpenetrating polymer networks, polymer membranes, green composites, nanocomposites, nanomedicine, and green nanotechnology. His groundbreaking inventions in polymer nanocomposites, polymer blends, green bionanotechnology, and nano-biomedical sciences have significantly advanced the development of new materials for the automotive, space, housing, and biomedical fields. Dr. Thomas has been conferred with Honoris Causa (DSc) by the University of South Brittany, France.
Affiliations and expertise
Professor, School of Energy Materials, Mahatma Gandhi University, IndiaRR
Rangam Rajkhowa
Dr. Rangam Rajkhowa received his bachelor’s degree in Textile Technology from Anna University, India; a master’s degree in Fibre Science and Technology from Indian Institute of Technology, India and a PhD in Engineering from Deakin University. Australia. He leads the silk and natural fibre particle stream of research at the Institute for Frontier Materials. His research interests are silk based biomaterials, value addition and new applications from natural fibres and fibre wastes, sustainable fibre and textile processing, and circular economy. He set up the fibre powder research facility at Deakin University and his group investigate sustainable production and advanced applications of particles from silk and other natural fibres. The group works on fundamental understanding of fibre and particle structures and properties but also has strong focus on interdisciplinary research applications using fibres.
Affiliations and expertise
Associate Professor, Institute for Frontier Materials, Deakin University, AustraliaSS
Sneha Sabu Mathew
Sneha Sabu Mathew is a research scholar at Mahatma Gandhi University, India. She received a bachelor’s degree and master’s degree in Pure Chemistry from Mahatma Gandhi University, India. Her current research activities include the development of novel biobased biodegradable polymer composites for edible coating and packaging applications. Projects undertaken at the Mahatma Gandhi University, India, include: assisted extraction of nanocellulose from pineapple fibres and its characterization; assisted preparation of nanocellulose based edible coating using natural extracts; assisted preparation of TiO2 nanoparticle and doping for enhanced properties; assisted electrospun TiO2 nanocomposites for dye degradation, synthesis and characterisation of prepared nanofibers.
Affiliations and expertise
Research Scholar, Institute for Frontier Materials, Mahatma Gandhi University, IndiaHJ
Hanna J Maria
Dr. Hanna J Maria is a senior researcher at the International and Interuniversity Centre for Nanoscience and Nanotechnology (IIUCNN), Mahatma Gandhi University, India. She finished her Ph. D in the year 2015 from Mahatma Gandhi University. Soon after her Ph. D she completed work to improve the adhesion between the fibers and LDPE and evaluate the effect of plasma modification as part of her post-doctoral work at the Centre for Advanced Materials at Qatar University, India. She was also a postdoctoral fellow within the department of Mechanical Engineering at Yamaguchi University, Japan in a project with TOCLAS corporation. She got the Dr. D. S. Kothari Postdoctoral Fellowship (DSKPDF) with Prof Sabu Thomas, Professor Mahatma Gandhi University. She has 25 publications, 15 book chapters and 6 co-edited books edited to her credit. Earlier she had obtained her M.Sc. degree in analytical chemistry and later completed her M.Phil. in environmental chemistry. She has experience in working with natural rubber composites and their blends, thermoplastic composites, lignin, nanocellulose, bionanocomposites, nanocellulose, rubber based
composites and nanocomposites and hybridnanocomposites.
Affiliations and expertise
Senior Researcher, International and Interuniversity Centre for Nanoscience and Nanotechnology, Mahatma Gandhi University, Kottayam, Kerala, India