Salmonella Biofilms, Infection, and Therapeutic Management

1st Edition - March 1, 2025
Imprint: Academic Press
Editors: Awanish Kumar, Aditya Upadhyay
Language: English
Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 2 2 0 5 5 - 5
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 2 2 0 5 6 - 2

Salmonella Biofilms, Infection, and Therapeutic Management provides an overview of salmonella biofilms, their detection and identification, associated salmonellosis infection… Read more

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Salmonella Biofilms, Infection, and Therapeutic Management provides an overview of salmonella biofilms, their detection and identification, associated salmonellosis infection, prevention and treatment.

The book discusses salmonella, the formation of biofilm, and biofilm associated bacterial infection. It aims to provide insight on how salmonellosis and biofilm relate to one another as well as how they relate to other diseases in the host. It also discusses the therapeutic strategy for reducing salmonella infection and current treatment options. Salmonella Biofilms, Infection, and Therapeutic Management is a useful reference for those engaged in the study of the study of salmonella biofilm, its formation, disease manifestation, and management.

Title of Book
Cover image
Title page
Table of Contents
Copyright
Contributors
Author biographies
Foreword
Preface
Acknowledgments
Introduction
Chapter 1. Introduction of salmonellosis and biofilm
1 Introduction
2 Classification of Salmonella
3 Pathogenesis of the Salmonella infection
4 Salmonella biofilm formation cycle and Salmonella biofilm compositions
5 Role of the biofilm in the devolvement of the Salmonella antibiotic resistance
6 Conclusion
Chapter 2. Regulation mechanism and virulence of Salmonella biofilm
1 Introduction
2 Components of Salmonella biofilm
3 Genetic structure of the Salmonella biofilm with virulence
4 Molecular mechanism of the regulation of the Salmonella biofilm
5 Corelationship between the Salmonella biofilm and virulence
5.1 How regulatory mechanism affect virulence factor
5.2 The impact of biofilm on virulence
6 Clinical significance of Salmonella biofilm regulation and virulence
6.1 Role in chronic infection
6.2 Role of diagnostic process
6.3 Treatment implications
7 Conclusion
Chapter 3. Salmonella Typhi with biofilm
1 Introduction
1.1 Overview of Salmonella typhi and its role in typhoid fever
1.2 Importance of biofilm in bacterial infection
1.3 Role of biofilm in the life of Salmonella typhi
2 Factors influencing biofilm formations
3 Molecular structure of the Salmonella typhi biofilm
4 Regulation of the Salmonella typhi biofilm
5 Possible treatment of the Salmonella typhi biofilm
6 Conclusion
Chapter 4. Salmonella Paratyphi biofilm
1 Introduction
2 Formation of biofilms
2.1 Biofilm surface
2.2 Biofilm microenvironment
2.3 Persister cells
3 Disease linked to the biofilms
4 Salmonella biofilms
5 Molecular mechanisms of Salmonella biofilm formation
5.1 Role of CsgD in Salmonella biofilm formation
6 Treatment methods
7 Conclusion
Chapter 5. Salmonella Typhimurium biofilm
1 Introduction
2 Growth of Salmonella Typhimurium biofilms
2.1 In host body
2.2 In laboratorial condition
3 Effect of biofilm growth
4 Summary
Declarations
Chapter 6. Salmonella enteritidis biofilm
1 Introduction
2 Biofilm formation in Salmonella enteritidis
3 Strategies to disrupt the Salmonella biofilm for treatment
4 Conclusion
Chapter 7. Deciphering the relationship between Salmonella biofilm development and antibiotic resistance genes: Implications for infection pathogenesis and therapeutic intervention
1 Introduction
1.1 An overview of the pathogenicity of Salmonella
1.2 Significance of antibiotic resistance in Salmonella
1.3 Importance of biofilm formation in Salmonella
2 Antibiotic resistance mechanisms in Salmonella
2.1 Horizontal gene transfer and resistance gene acquisition
2.2 The role of mutation in antibiotic resistance
2.3 Role of plasmids in disseminating resistance genes
3 Biofilm formation in Salmonella
3.1 Definition and characteristics of biofilms
3.2 Factors influencing Salmonella biofilm formation
3.3 Biofilm architecture and composition
4 Antibiotic resistance determinants in Salmonella
4.1 Genes for extended-spectrum β-lactamase (ESBL)
4.2 Fluoroquinolone resistance genes
4.3 Multidrug resistance mechanisms in Salmonella
4.4 Antibiotic resistance and mobile genetic elements
5 The collaboration of biofilm formation and antibiotic resistance
5.1 Biofilm-mediated protection against antibiotics
5.2 Biofilm-associated resistance genes
5.3 Antibiotic tolerance and persistence in biofilms
6 Implications for treatment and control strategies
6.1 Challenges in eradicating Salmonella infections with biofilms
6.2 Antibiotic therapy considerations
6.3 Alternative approaches to target biofilm-forming Salmonella
7 Antibiotic resistance genes and biofilms detection and diagnosis
7.1 Molecular techniques for detecting resistance genes
7.2 Phenotypic assays and antibiotic susceptibility testing
7.3 Biofilm-specific assays and imaging techniques
8 Future perspectives and research directions
8.1 Development of novel antibiotics and therapies
8.2 Targeting biofilms for eradication strategies
8.3 Surveillance and epidemiological studies
8.4 One Health approach in combating Salmonella antibiotic resistance
Chapter 8. Salmonella biofilm correlation with other diseases
1 Introduction
2 Bacterial biofilm
3 Role of Salmonella biofilm in chronic gastrointestinal infection
4 Colon cancer
5 Bacteremia
6 Conclusion
Chapter 9. Biomonitoring of Salmonella biofilm
1 Introduction
1.1 Problem faced in the food industry
1.1.1 Dairy industry
1.1.2 Fish processing industry
1.1.3 Poultry industry
2 Need of biofilm monitoring
3 Currently available methods of Salmonella biofilm biomonitoring
3.1 Traditional techniques
3.1.1 Microscopic observation
3.1.2 Colony counting
3.1.3 Crystal violet staining
3.1.4 Total organic carbon analysis
3.1.5 Scanning electron microscopy and transmission electron microscopy
3.2 Modern techniques
3.2.1 Impedance-based methods
3.2.2 Raman spectroscopy
3.2.3 Microfluidic devices
3.2.4 Next-generation sequencing
4 Conclusion
Chapter 10. Currently available therapeutic approaches to control the Salmonella infection with biofilm
1 Introduction
2 Bacterial biofilm
3 Mechanism of biofilm resistance against drugs
4 Salmonella infection
5 Salmonella biofilm formation
5.1 Attachment to a surface through electrostatic and hydrophobic mediated processes
5.2 Maturation of biofilm
6 Structural components in Salmonella biofilm formation
6.1 Adherence substrate
6.1.1 Abiotic surfaces
6.1.2 Biotic surfaces
6.2 Extracellular matrix
6.2.1 Protein ECM
6.2.2 Polysaccharide ECM
6.2.3 Fatty acid and Lipopolysaccharides ECM
6.3 Regulation in Salmonella biofilm
6.3.1 CsgD
6.3.2 RpoS and Crl
6.3.3 c-Di-GMP
6.3.4 BarA/SirA and Csr system
6.3.5 The Rcs system
6.3.6 Role of quorum sensing
6.4 Therapeutic approaches against Salmonella infection
6.4.1 Use of antibiotics
6.4.2 Use of steroids
6.5 Prevention of Salmonella biofilm formation
6.5.1 Surfactants
6.5.2 Quorum sensing
6.5.3 Micro- and Nano-emulsion
6.5.4 Chitosan
6.5.5 Combination therapy
6.5.6 Specific antibiofilm compounds
6.5.7 Using probiotics
7 Conclusion and future prospectives
Chapter 11. Potential future corrective and preventative measures against the Salmonella biofilm
1 Introduction
2 Biofilm: What, how, pathogenicity and severity
3 Current treatment and their failure
4 New and innovative ways to treat biofilm infections
4.1 Chemicals/drug
4.1.1 Natural chemical compounds
4.1.2 Synthetic
4.1.3 Combinatorial
4.1.4 Nanoparticle-based formulations
4.2 Antibacterial peptides/Enzymes
4.3 Extracellular DNA
4.4 Probiotics
4.5 Bacteriophage mediated
4.6 Irradiation and other physical methods
5 Future concerns
6 Conclusion
Index

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Salmonella Biofilms, Infection, and Therapeutic Management

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Awanish Kumar

Aditya Upadhyay

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