
Robotic Cell Manipulation
- 1st Edition - May 31, 2022
- Imprint: Academic Press
- Author: Dong Sun
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 8 5 2 5 9 - 3
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 5 2 6 0 - 9
Robotic Cell Manipulation introduces up-to-date research to realize this new theme of medical robotics. The book is organized in three levels: operation tools (e.g., optical t… Read more

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Request a sales quoteRobotic Cell Manipulation introduces up-to-date research to realize this new theme of medical robotics. The book is organized in three levels: operation tools (e.g., optical tweezers, microneedles, dielectrophoresis, electromagnetic devices, and microfluidic chips), manipulation types (e.g., microinjection, transportation, rotation fusion, adhesion, separation, etc.), and potential medical applications (e.g., micro-surgery, biopsy, gene editing, cancer treatment, cell-cell interactions, etc.). The technology involves different fields such as robotics, automation, imaging, microfluidics, mechanics, materials, biology and medical sciences. The book provides systematic knowledge on the subject, covering a wide range of basic concepts, theories, methodology, experiments, case studies and potential medical applications.
It will enable readers to promptly conduct a systematic review of research and become an essential reference for many new and experienced researchers entering this unique field.
- Introduces the applications of robot-assisted manipulation tools in various cell manipulation tasks
- Defines many essential concepts in association with the robotic cell manipulation field, including manipulation strategy and manipulation types
- Introduces basic concepts and knowledge on various manipulation devices and tasks
- Describes some cutting-edge cell manipulation technologies and case studies
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Preface
- Acknowledgments
- 1. Introduction
- 1.1. Overview of robot-facilitated cell manipulation
- 1.2. Outline of the book
- 1.3. Conclusions
- 2. Cell manipulation tools
- 2.1. Introduction
- 2.2. Microneedle
- 2.3. Optical tweezers
- 2.4. Electrokinetics
- 2.5. Magnetic manipulator
- 2.6. Atomic force microscopy
- 2.7. Imaging for intracellular manipulation
- 2.8. Conclusions
- 3. Robotic cell injection
- 3.1. Introduction
- 3.2. Robot-assisted cell microinjection system with microneedles
- 3.3. Hybrid position and force control for automated batch injection of cells
- 3.4. Universal piezo-driven ultrasonic cell microinjection
- 3.5. Automated microinjection for small human cells
- 3.6. Automated high-productivity microinjection for adherent cells
- 3.7. Single-cell transfection through precise microinjection with quantitatively controlled injection volumes
- 3.8. Characterization of mechanical properties of cells through microinjection
- 3.9. Conclusions
- 4. Cell stretching and compression
- 4.1. Introduction
- 4.2. Cell stretching with optical tweezers
- 4.3. Probing cell biophysical behavior based on actin cytoskeleton modeling of cells and stretching manipulation with optical tweezers
- 4.4. Cell stretching with dielectrophoresis technology
- 4.5. Cell compression under mechanical confinement
- 4.6. Magnet-based cell deformation for intracellular delivery
- 4.7. Conclusions
- 5. Cell transport with optical tweezers
- 5.1. Introduction
- 5.2. Basic theory and methods
- 5.3. Motion and path planning for automatic cell transportation
- 5.4. Unified motion control design
- 5.5. Multiple cell transportation for cell pairing
- 5.6. Cell transportation for multiprocessing automation tasks
- 5.7. Conclusions
- 6. Cell rotation
- 6.1. Introduction
- 6.2. Automated in-plane rotation of cells using a robot tweezers manipulation system
- 6.3. Automated out-of-plane rotation of cells using a robot tweezers manipulation system
- 6.4. Conclusions
- 7. Three-dimensional image reconstruction and intracellular surgery
- 7.1. Introduction
- 7.2. 3D image reconstruction
- 7.3. Robot-assisted intracellular delivery with 3D image reconstruction information
- 7.4. Conclusions
- 8. Cell sorting and separation
- 8.1. Introduction
- 8.2. Cell sorting using combined optical tweezers and microfluidic chip technology
- 8.3. Cell isolation and deposition
- 8.4. A simplified sheathless cell separation approach
- 8.5. Conclusions
- 9. Cell stimulation and migration control
- 9.1. Introduction
- 9.2. Dynamic model of chemoattractant-induced cell migration
- 9.3. Cell migration control using a stimulus-induced robotic manipulation system
- 9.4. Electrical stimulation based on calcium spike patterns of MSCs to improve osteogenic differentiation
- 9.5. Conclusions
- 10. Cell patterning
- 10.1. Introduction
- 10.2. Cell patterning with robotically controlled optical tweezers
- 10.3. Cell patterning using a dielectrophoresis-based multilayer scaffold structure
- 10.4. Cell patterning using a gravitational sedimentation-based microfluidic approach
- 10.5. Conclusions
- 11. Cell adhesion
- 11.1. Introduction
- 11.2. Manipulating cell adhesion with optical tweezers
- 11.3. Adhesion-mediated cell–cell interaction
- 11.4. A case study of cell adhesion characterization
- 11.5. Conclusions
- 12. Cell fusion
- 12.1. Introduction
- 12.2. Laser-induced fusion with optical tweezers
- 12.3. Cell fusion with combined optical tweezers and microwell array technology
- 12.4. A case study of transforming liver cancer cells into tumor initiating-like cells by cell fusion
- 12.5. Conclusions
- 13. Cell navigation and delivery in vivo
- 13.1. Introduction
- 13.2. In vivo navigation of single cells with an optical tweezers-based manipulator
- 13.3. Magnetic microrobot for carrying and delivering cells in vivo
- 13.4. Precise delivery of stem cells for cancer therapy using magnet-driven and image-guided degradable microrobots
- 13.5. Conclusions
- 14. Organelle biopsy and gene editing of single cells
- 14.1. Introduction
- 14.2. Automated organelle biopsy of single cells using microneedles
- 14.3. Gene-delivery approaches for MSC function improvement
- 14.4. Automated optical tweezers manipulation for mitochondrial transfer
- 14.5. Conclusions
- 15. Summary
- 15.1. Operation tools for cell manipulations
- 15.2. Cell manipulation types
- 15.3. Potential medical applications
- Index
- Edition: 1
- Published: May 31, 2022
- Imprint: Academic Press
- No. of pages: 546
- Language: English
- Paperback ISBN: 9780323852593
- eBook ISBN: 9780323852609
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