Resident Stem Cells and Regenerative Therapy
Sources and Clinical Applications
- 2nd Edition - September 7, 2023
- Editors: Regina Coeli dos Santos Goldenberg, Antonio Carlos Campos de Carvalho
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 5 2 8 9 - 4
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 5 2 9 0 - 0
Resident Stem Cells and Regenerative Therapy: Sources and Clinical Applications, Second Edition presents the main findings to date and the important factors to be considere… Read more

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Request a sales quoteResident Stem Cells and Regenerative Therapy: Sources and Clinical Applications, Second Edition presents the main findings to date and the important factors to be considered when contemplating resident stem cells in regenerative therapies. Chapters on cardiac, brain, neural, liver, kidney, skeletal muscle, bone, pancreatic, skin and lung resident stem cells will assist in defining the level of success that has been achieved and the direction for the road ahead. With contributions from leading laboratories, open questions related to resident stem cells and regenerative therapies will also be presented for debate.
In the last several decades, stem cells have greatly impacted the scientific and lay communities, providing huge advances in the treatment of devastating human diseases, including myocardial infarction, diabetes, muscular dystrophy, cystic fibrosis, cirrhosis, and osteoporosis. Alongside debates of induced pluripotent stem cells and embryonic stem cells has been the discovery of adult stem cells in many different tissues. While these organ resident or progenitor stem cells offer prospects to contribute to tissue regeneration, they also present challenges because of the complexity of organ structures.
- Highlights basic research in tissue specific stem cells, experiments with animal models, and clinical trials that are transforming the field of regeneration
- Provides a clear understanding of endogenous stem cells, their role in current regenerative therapies, and prospects for future research
- Reports on the main-stream clinical approaches and in vivo experiments published in primary literature to help categorizes the advances in various aspects of regenerative therapy and illustrate opportunities for clinical applications
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Foreword
- Chapter 1. Book Overview
- Chapter 2. Cardiac Stem Cells: Fact or Fiction?
- The Change of Paradigm: The Heart Can Regenerate Itself
- Conclusions and Future Directions
- Chapter 3. Resident Liver Stem Cells
- Introduction
- Liver Development
- Liver Regeneration: The Hierarchy for Cell Response
- Fetal Hepatic Stem Cell Niche
- Adult Liver Stem/Progenitor Cell Niche
- Liver Regenerative Therapy: Bioengineering Strategies
- Human-Scaled Bioengineered Livers
- Chapter 4. Lung-Resident Stem Cells
- Lung Structure
- Hierarchy of Lung-Resident Stem Cells
- Resident Epithelial Progenitor Cells
- Resident Endothelial Progenitor Cells
- Resident Mesenchymal Progenitor Cells
- Lung-Resident Stem Cells in Respiratory Diseases
- Main Challenges for The Identification of Lung-Resident Stem Cells
- Chapter 5. Pancreatic Stem Cells and Regenerative Medicine of Endocrine Pancreas
- Introduction
- Embryonic/Fetal Pancreas Development
- Anatomy, Physiology, and Function of The Adult Pancreas
- Adult Pancreas Regeneration
- Pancreatic Stem Cells and Regulators
- Regenerative Medicine
- Chapter 6. Pericytes as a Source of MSCs
- Pericytes
- Relationship Between Pericytes and MSCs
- The Plasticity Issue
- Pericytes as a Source of MSCs in the Body
- Conclusion
- Chapter 7. Resident Neural Stem Cells
- Neurogenesis in the Adult Brain
- Neurogenesis During Development
- The Ventricular-Subventricular Zone
- Human Ventricular-Subventricular Zone
- Subgranular Zone
- Human Subgranular Zone
- Neural Stem Cell Markers
- Neurogenesis's Regulators
- Clinical Applications
- Chapter 8. Resident Stem Cells in Kidney Tissue
- Introduction
- Brief Description of the Structural Organization of the Mammalian Adult Kidney
- Stem Cells in Kidney Organogenesis
- Kidney Stem/Progenitor Cells: Niches and Isolation
- New Model to Study Organogenesis and Stem Cell Niche
- Role of Kidney Resident Stem/Progenitor Cells in the Establishment and Progression of Renal Disorders
- The Role of Stem/Progenitor Cells in Kidney Regeneration
- Cell Therapy Application: The Paracrine Mechanism
- Extracellular Vesicles as Therapeutic Tools for Kidney Regeneration
- Stem/Progenitor Cells in Kidney: Features for Therapeutic Use in Clinical Trials
- Chapter 9. Skin Resident Stem Cells
- Introduction
- Interfollicular Epidermal Stem Cells
- Hair Follicle and Associated Structures Stem Cells
- Melanocyte Stem Cell
- Dermal Resident Stem Cells
- Hypodermal Resident Stem Cells
- Clinical Applications of Resident Skin Stem Cells
- Chapter 10. Skeletal Resident Stem Cells
- Bone Tissue
- Bone Marrow as a Source of MSCs and Stem Cells for Bones
- Mesenchymal Cells in Orthopedic Bioengineering and Bone Repair
- Skeletal Stem Cells and Vascular System Impact Bone Formation and Repair
- Combined Action: Therapeutic Use of Mesenchymal Progenitors and Angiogenic Progenitors
- Cell Therapy in Nonunions
- Cell Therapy in Avascular Necrosis of The Femoral Head (Osteonecrosis)
- Chapter 11. The Neural Crest and The Stem Cells of Neural Crest
- Introduction
- Concluding Remarks
- Chapter 12. Telocytes and Stem Cells
- What are Telocytes?
- What Defines Telocytes as a Unique, Distinct Cell type?
- Where are Telocytes Located?
- Telocyte Intercellular Relationships
- Phenotype “Portrait”
- Telocyte Functions in Physiology and Pathology
- Telocytes: An Emerging Component of the Stem Cell Niche Microenvironment
- A Hope for Regenerative Medicine
- Future Research Directions
- Chapter 13. Adipose Tissue Resident Stem Cells
- Introduction
- Subcutaneous Adipose Tissue and Regenerative Medicine
- Adipose Tissue-Derived Stem/Stromal Cells of Subcutaneous Adipose Tissue
- Adipose Tissue Engineering for 3D Models
- Conclusions
- Chapter 14. Bone Marrow–Resident Stem Cells
- Introduction
- Niche
- Role of Different Cells in the Regulation of HSC’s Biology During all Stages of Life
- Hematopoietic Signaling Pathways
- Lineage Commitment
- Cell Surface Antigenic Markers
- Clinical Use
- Index
- No. of pages: 408
- Language: English
- Edition: 2
- Published: September 7, 2023
- Imprint: Academic Press
- Hardback ISBN: 9780443152894
- eBook ISBN: 9780443152900
RC
Regina Coeli dos Santos Goldenberg
AC