Resident Stem Cells and Regenerative Therapy

Sources and Clinical Applications

2nd Edition - September 7, 2023
Editors: Regina Coeli dos Santos Goldenberg, Antonio Carlos Campos de Carvalho
Language: English
Hardback ISBN:
9 7 8 - 0 - 4 4 3 - 1 5 2 8 9 - 4
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 5 2 9 0 - 0

Resident Stem Cells and Regenerative Therapy: Sources and Clinical Applications, Second Edition presents the main findings to date and the important factors to be considere… Read more

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Resident Stem Cells and Regenerative Therapy: Sources and Clinical Applications, Second Edition presents the main findings to date and the important factors to be considered when contemplating resident stem cells in regenerative therapies. Chapters on cardiac, brain, neural, liver, kidney, skeletal muscle, bone, pancreatic, skin and lung resident stem cells will assist in defining the level of success that has been achieved and the direction for the road ahead. With contributions from leading laboratories, open questions related to resident stem cells and regenerative therapies will also be presented for debate.

In the last several decades, stem cells have greatly impacted the scientific and lay communities, providing huge advances in the treatment of devastating human diseases, including myocardial infarction, diabetes, muscular dystrophy, cystic fibrosis, cirrhosis, and osteoporosis. Alongside debates of induced pluripotent stem cells and embryonic stem cells has been the discovery of adult stem cells in many different tissues. While these organ resident or progenitor stem cells offer prospects to contribute to tissue regeneration, they also present challenges because of the complexity of organ structures.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Foreword
Chapter 1. Book Overview
Chapter 2. Cardiac Stem Cells: Fact or Fiction?
The Change of Paradigm: The Heart Can Regenerate Itself
Conclusions and Future Directions
Chapter 3. Resident Liver Stem Cells
Introduction
Liver Development
Liver Regeneration: The Hierarchy for Cell Response
Fetal Hepatic Stem Cell Niche
Adult Liver Stem/Progenitor Cell Niche
Liver Regenerative Therapy: Bioengineering Strategies
Human-Scaled Bioengineered Livers
Chapter 4. Lung-Resident Stem Cells
Lung Structure
Hierarchy of Lung-Resident Stem Cells
Resident Epithelial Progenitor Cells
Resident Endothelial Progenitor Cells
Resident Mesenchymal Progenitor Cells
Lung-Resident Stem Cells in Respiratory Diseases
Main Challenges for The Identification of Lung-Resident Stem Cells
Chapter 5. Pancreatic Stem Cells and Regenerative Medicine of Endocrine Pancreas
Introduction
Embryonic/Fetal Pancreas Development
Anatomy, Physiology, and Function of The Adult Pancreas
Adult Pancreas Regeneration
Pancreatic Stem Cells and Regulators
Regenerative Medicine
Chapter 6. Pericytes as a Source of MSCs
Pericytes
Relationship Between Pericytes and MSCs
The Plasticity Issue
Pericytes as a Source of MSCs in the Body
Conclusion
Chapter 7. Resident Neural Stem Cells
Neurogenesis in the Adult Brain
Neurogenesis During Development
The Ventricular-Subventricular Zone
Human Ventricular-Subventricular Zone
Subgranular Zone
Human Subgranular Zone
Neural Stem Cell Markers
Neurogenesis's Regulators
Clinical Applications
Chapter 8. Resident Stem Cells in Kidney Tissue
Introduction
Brief Description of the Structural Organization of the Mammalian Adult Kidney
Stem Cells in Kidney Organogenesis
Kidney Stem/Progenitor Cells: Niches and Isolation
New Model to Study Organogenesis and Stem Cell Niche
Role of Kidney Resident Stem/Progenitor Cells in the Establishment and Progression of Renal Disorders
The Role of Stem/Progenitor Cells in Kidney Regeneration
Cell Therapy Application: The Paracrine Mechanism
Extracellular Vesicles as Therapeutic Tools for Kidney Regeneration
Stem/Progenitor Cells in Kidney: Features for Therapeutic Use in Clinical Trials
Chapter 9. Skin Resident Stem Cells
Introduction
Interfollicular Epidermal Stem Cells
Hair Follicle and Associated Structures Stem Cells
Melanocyte Stem Cell
Dermal Resident Stem Cells
Hypodermal Resident Stem Cells
Clinical Applications of Resident Skin Stem Cells
Chapter 10. Skeletal Resident Stem Cells
Bone Tissue
Bone Marrow as a Source of MSCs and Stem Cells for Bones
Mesenchymal Cells in Orthopedic Bioengineering and Bone Repair
Skeletal Stem Cells and Vascular System Impact Bone Formation and Repair
Combined Action: Therapeutic Use of Mesenchymal Progenitors and Angiogenic Progenitors
Cell Therapy in Nonunions
Cell Therapy in Avascular Necrosis of The Femoral Head (Osteonecrosis)
Chapter 11. The Neural Crest and The Stem Cells of Neural Crest
Introduction
Concluding Remarks
Chapter 12. Telocytes and Stem Cells
What are Telocytes?
What Defines Telocytes as a Unique, Distinct Cell type?
Where are Telocytes Located?
Telocyte Intercellular Relationships
Phenotype “Portrait”
Telocyte Functions in Physiology and Pathology
Telocytes: An Emerging Component of the Stem Cell Niche Microenvironment
A Hope for Regenerative Medicine
Future Research Directions
Chapter 13. Adipose Tissue Resident Stem Cells
Introduction
Subcutaneous Adipose Tissue and Regenerative Medicine
Adipose Tissue-Derived Stem/Stromal Cells of Subcutaneous Adipose Tissue
Adipose Tissue Engineering for 3D Models
Conclusions
Chapter 14. Bone Marrow–Resident Stem Cells
Introduction
Niche
Role of Different Cells in the Regulation of HSC’s Biology During all Stages of Life
Hematopoietic Signaling Pathways
Lineage Commitment
Cell Surface Antigenic Markers
Clinical Use
Index

Regina Coeli dos Santos Goldenberg

Dr. Goldenberg is a Full Professor at the University of Rio de Janeiro in Brazil. She is a Collaborating Professor at UFRJ and Evaluating Professor at SINAES-INEP-Ministry of Education. She works in the area of Physiology, with emphasis on Cardiovascular and Hepatic Physiology, in the area of Cell Biology, with emphasis on cell culture, and in the area of Tissue Bioengineering, with emphasis on the generation of bio-artificial livers. Areas of focus in research involve intercellular communication, stem cells and cell therapies in heart and liver disease. Dr. Goldenberg is a member of the board of the Brazilian Association of Cell and Gene Therapy, Deputy Technical Responsible for the Cell Technology Center of the National Institute of Cardiology, and a member of the Latin Commission American Affairs Committee of Tissue Engineering and Regenerative Medicine International Society (TERMIS) since 2018.

Affiliations and expertise

Professor, Institute of Biophysics, Federal University of Rio de Janeiro, Brazil

Antonio Carlos Campos de Carvalho

Dr. Campos de Carvalho is a physiologist and a Full Professor at the Federal University of Rio de Janeiro. He’s also Visiting Professor at the Albert Einstein College of Medicine in New York and has experience in Physiology and Biophysics, with emphasis on Cardiovascular Physiology, working mainly on the following topics: intercellular communication, stem cells and cell therapies. He has published over 200 full papers in indexed journals, edited 3 books and written 24 book chapters. He is a member of the Brazilian Academy of Sciences and the Academy of Sciences of the Developing World (TWAS). In 2012-2013 he held the positions of Director of the Brazilian Academy of Sciences and Regional Director of TWAS for Latin America and the Caribbean. In 2008 he was awarded the National Order of Scientific Merit and in 2010 the National Order of Medical Merit.

Affiliations and expertise

Professor, Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health