Resident Stem Cells and Regenerative Therapy
- 1st Edition - September 26, 2012
- Editors: Regina Coeli dos Santos Goldenberg, Antonio Carlos Campos de Carvalho
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 4 1 6 0 1 2 - 5
- eBook ISBN:9 7 8 - 0 - 1 2 - 3 9 1 4 4 1 - 5
In the last 3 decades, stem cells have greatly impacted the scientific and lay communities, providing huge advances in the treatment of devastating human diseases, including my… Read more
In the last 3 decades, stem cells have greatly impacted the scientific and lay communities, providing huge advances in the treatment of devastating human diseases, including myocardial infarction, diabetes, muscular dystrophy, cystic fibrosis, cirrhosis, and osteoporosis. Alongside debates of induced pluripotent stem cells and embryonic stem cells has been the discovery of adult stem cells in many different tissues. While these organ resident or progenitor stem cells offer prospects to contribute to tissue regeneration, they also present challenges because of the complexity of organ structures.
This book will present the main findings to date and the important factors to be considered when considering resident stem cells in regenerative therapies. Chapters on cardiac, brain, neural, liver, kidney, skeletal muscle, bone, pancreatic, skin, and lung resident stem cells will assist in defining the level of success that has been achieved and the direction for the road ahead. With contributions from leading laboratories, open questions related to resident stem cells and regenerative therapies will also be presented for debate.
- Highlights basic research in tissue specific stem cells, experiments with animal models and clinical trials that are transforming the field of regeneration
- Provides a clear understanding of endogenous stem cells, their role in current regenerative therapies, and prospects for future research
- Reports on the main-stream clinical approaches and in vivo experiments published in primary literature to help categorizes the advances in various aspects of regenerative therapy and illustrate opportunities for clinical applications
Advanced researchers and students in stem cell biology, regenerative medicine, bioengineering, tissue engineering, molecular biology, evolutionary and developmental biology
Dedication
Foreword
List of Contributors
Chapter 1. Resident Stem Cells in Kidney Tissue
Introductory Remarks
Brief Description of the Structural Organization of the Mammalian Adult Kidney
Stem Cells in Kidney Organogenesis
Kidney Stem/Progenitor Cells: Niches and Isolation
The Role of Stem/Progenitor Cells in Kidney Regeneration
Role of Kidney Resident Stem/Progenitor Cells in the Establishment and Progression of Renal Disorders
Glomerularsclerosis
Tubular Lesions
Progenitor/Resident Stem Cells and Renal Cancer
Stem/Progenitor Cells in Kidney: Features for Therapeutic Use after the Few Trials with Bone Marrow Cells?
References
Chapter 2. Pancreatic Stem Cells
Introduction
Embryogenesis and Organogenesis
References
Chapter 3. Tissue Engineering and the Role of Biomaterial Scaffolds: The Evolution of Cardiac Tissue Engineering
Introduction to Tissue Engineering
Role of Biomaterials in Tissue Engineering
Clinical Translation and Commercialization
Future of Tissue Engineering
Cardiac Tissue Engineering
Future of Cardiac Tissue Engineering
References
Chapter 4. Resident Neural Stem Cells
Neurogenesis in the Adult Brain
Neurogenesis during Development
Neural Stem Cells
The Subventricular Zone
Subgranular Zone
Neural Stem Cell Markers
Neurogenesis’s Regulators
Cell Therapy
References
Chapter 5. Resident Stem Cell in Skin
Introduction
Interfollicular Epidermis
Hair Follicle and Associated Structures
Melanocytes
Dermis
Cell Therapies and Clinical Application of Skin Stem Cells
References
Chapter 6. Lung Resident Stem Cells
Lung Structure
Hierarchy of Lung Resident Stem Cells
Resident Epithelial Progenitor Cells
Resident Endothelium Progenitor Cells
Resident Mesenchymal Progenitor Cells
Lung Resident Stem Cells in Respiratory Diseases
Main Challenges for the Identification of Lung Resident Stem Cells
References
Chapter 7. Skeletal Resident Stem Cells
Bone Tissue
Bone Marrow as a Source of Mesenchymal Stem Cells–Stem Cells for Bones
Mesenchymal Cells in Orthopedic Bioengineering and Bone Repair
Skeletal Stem Cells and the Vascular System
Combined Action: Therapeutic Use of Mesenchymal Progenitors and Angiogenic Progenitors
Cell Therapy in Pseudarthrosis
Cell Therapy in Avascular Necrosis of the Femoral Head (Osteonecrosis)
Acknowledgments
References
Chapter 8. Cardiac Stem Cells
c-Kit Positive Cells
Cardiosphere-Derived Cells
Side Population
Islet-1 Positive Cells
Conclusions and Future Directions
References
Chapter 9. The Neural Crest and the Stem Cells of Neural Crest
Introduction
The Neural Crest
Neural Crest-Derived Stem Cells (NCSCs)
Are NC Cells a Source of Mesenchymal Stem Cells (MSCs)?
Concluding Remarks
Acknowledgments
References
Chapter 10. Liver Resident Stem Cell
Introduction
Liver Development
Liver Regeneration: The Hierarchy for Cell Response
Stem/Progenitor Cells: The Second Front in Liver Regeneration
Fetal Hepatic Stem Cell Niche
Adult Liver Stem/Progenitor Cell Niche
Liver Stem/Progenitors Cells and Cell Therapy
References
Chapter 11. Telocytes and Stem Cells
What Are Telocytes?
What Defines Telocytes as a Unique, Distinct Cell Type?
Comparison with Fibroblasts
Where Are Telocytes Located?
Telocyte Intercellular Relationships
Phenotype “Portrait”
The Tandem Telocytes & Stem Cells
A Hope for Regenerative Medicine
Future Research Directions
References
Chapter 12. Pericytes as the Source of Mesenchymal Stem Cells
Pericytes
Relationship between Pericytes and MSCs
The Plasticity Issue
Pericytes as Stem Cells in the Body
Conclusion
Acknowledgments
References
Color Plates
Index
- Edition: 1
- Published: September 26, 2012
- Language: English
RC
Regina Coeli dos Santos Goldenberg
Dr. Goldenberg is a Full Professor at the University of Rio de Janeiro in Brazil. She is a Collaborating Professor at UFRJ and Evaluating Professor at SINAES-INEP-Ministry of Education. She works in the area of Physiology, with emphasis on Cardiovascular and Hepatic Physiology, in the area of Cell Biology, with emphasis on cell culture, and in the area of Tissue Bioengineering, with emphasis on the generation of bio-artificial livers. Areas of focus in research involve intercellular communication, stem cells and cell therapies in heart and liver disease. Dr. Goldenberg is a member of the board of the Brazilian Association of Cell and Gene Therapy, Deputy Technical Responsible for the Cell Technology Center of the National Institute of Cardiology, and a member of the Latin Commission American Affairs Committee of Tissue Engineering and Regenerative Medicine International Society (TERMIS) since 2018.
Affiliations and expertise
Professor, Institute of Biophysics, Federal University of Rio de Janeiro, BrazilAC
Antonio Carlos Campos de Carvalho
Dr. Campos de Carvalho is a physiologist and a Full Professor at the Federal University of Rio de Janeiro. He’s also Visiting Professor at the Albert Einstein College of Medicine in New York and has experience in Physiology and Biophysics, with emphasis on Cardiovascular Physiology, working mainly on the following topics: intercellular communication, stem cells and cell therapies. He has published over 200 full papers in indexed journals, edited 3 books and written 24 book chapters. He is a member of the Brazilian Academy of Sciences and the Academy of Sciences of the Developing World (TWAS). In 2012-2013 he held the positions of Director of the Brazilian Academy of Sciences and Regional Director of TWAS for Latin America and the Caribbean. In 2008 he was awarded the National Order of Scientific Merit and in 2010 the National Order of Medical Merit.
Affiliations and expertise
Professor, Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, BrazilRead Resident Stem Cells and Regenerative Therapy on ScienceDirect