Research and Clinical Applications of Targeting Gastric Neoplasms
- 1st Edition - July 17, 2021
- Imprint: Academic Press
- Editor: Brendan Jenkins
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 8 5 5 6 3 - 1
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 8 5 5 4 - 6
Research and Clinical Applications of Targeting Gastric Neoplasms provides a comprehensive overview of gastrointestinal cancers, covering preclinical research and clinical… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteResearch and Clinical Applications of Targeting Gastric Neoplasms provides a comprehensive overview of gastrointestinal cancers, covering preclinical research and clinical findings related to risk factors, current treatment regimens (including immunotherapy), screening/detection methods, etiology of disease, precision medicine and future perspectives. Gastrointestinal cancers rank among the most lethal and common worldwide, and as such, there is intense research into their diverse causes and treatment options. This reference provides a consolidation of the research, making it a perfect resource for basic science and clinical researchers as well as oncologists who work in gastroenterology and GI tract cancer fields.
- Provides comprehensive coverage of preclinical research and the clinical aspects of gastric cancer
- Presents future perspectives from leading researchers in the field who provide the potential for furthering research topics
- Combines the expertise of researchers in GI tracts, cancer, immunity, immunology, infectious disease and microbiology for an interdisciplinary approach
Basic science and clinical researchers of the gastric system; as well as oncologists, in the gastroenterology and GI tract cancer fields. Gastroenterologists, Immunologists and Cancer Biologists
- Cover Image
- Title Page
- Copyright
- Dedcation
- Table of Contents
- Contributors
- Foreword
- Chapter 1 Stomach corpus stem cells in homeostasis, tissue repair, and cancer
- Abstract
- Introduction
- A historical perspective of stem cell markers and their relationship to cell-of-origin in the corpus
- The controversy of chief cell dedifferentiation and the origin of cancer
- Conclusions
- Acknowledgments
- References
- Chapter 2 The role of inflammation in gastric tumorigenesis
- Abstract
- Introduction
- Activation of the COX-2/PGE2 pathway in metaplastic hyperplasia in the stomach
- Cooperation of Wnt signaling activation and COX-2/PGE2 pathway for gastric tumorigenesis
- Cooperation between COX-2/PGE2 and Toll-like receptor signaling pathways promotes an inflammatory microenvironment
- Inflammatory cytokine signaling for gastric tumorigenesis: TNF-α
- Inflammatory cytokine signaling for gastric tumorigenesis: IL-1β and IL-11
- Inflammation-associated NOX1/ROS signaling for gastric tumorigenesis
- Inflammation-induced dysregulation of tumor-associated microRNA
- Autoimmune gastritis mouse model
- Conclusions and perspectives
- References
- Chapter 3 Unravelling the pro-tumorigenic role of innate immune pattern recognition receptors in the gastric compartment
- Abstract
- Introduction
- Pattern recognition receptors: overview of structure and signaling
- Biological functions of pattern recognition receptors
- Pattern recognition receptors in disease
- Pattern recognition receptors in cancer
- Interactions between pattern recognition receptors and gastric pathogens associated with gastric immunopathology
- Recognition of EBV by PRRs
- Pattern recognition receptors implicated in gastric carcinogenesis
- Conclusions and perspectives, including potential therapeutic interventions
- References
- Chapter 4 Helicobacter pylori-induced gastric carcinogenesis
- Abstract
- The link between bacteria and gastric disease
- A causal role for H. pylori in gastric cancer
- Chronic H. pylori infection promotes gastric B cell lymphoma
- Histopathological changes leading to gastric adenocarcinoma in response to H. pylori infection
- Epidemiology of H. pylori infection and gastric cancer incidence
- Current trends in H. pylori infection and gastric cancer incidence
- H. pylori eradication as a strategy against gastric cancer
- H. pylori virulence factors associated with gastric carcinogenesis
- Contribution of the gastric microbiota to carcinogenesis
- Host factors associated with gastric cancer
- Environmental factors associated with gastric cancer
- Gerbil model of H. pylori-induced gastric disease
- Conclusions
- References
- Chapter 5 The role of Helicobacter pylori CagA oncoprotein in neoplastic transformation of gastric epithelial cells
- Abstract
- Introduction
- Delivery of CagA into gastric epithelial cells via the Type IV secretion system
- Structure and sequence variation of H. pylori CagA
- EPIYA phosphorylation-dependent scaffold function of CagA
- CM motif-dependent scaffold function of CagA
- Scaffold function of N-terminal CagA
- CagA as a bacterial protein that promotes carcinogenesis in metazoans
- CagA and cell reprogramming
- Hit-and-run mechanism of CagA-mediated gastric carcinogenesis
- Conclusions
- Acknowledgements
- References
- Chapter 6 Epigenetic aberrations by Epstein–Barr virus infection to develop gastric cancer
- Abstract
- Introduction
- Latent EBV infection
- Aberrant DNA hypermethylation in EBV(+) GC
- Target genes and the mechanism of DNA methylation induction in EBV(+) GC
- EBV infection and H. pylori infection
- Aberrant enhancer activation associated with oncogenes after EBV infection
- Enhancer rewiring by “Enhancer infestation”
- Summary and future perspectives
- References
- Chapter 7 In vivo and in vitro models of gastric cancer
- Abstract
- Introduction
- History and methods of in vitro studies
- Organoids
- Advancements of in vitro cell culture
- History and methods of in vivo studies
- Bigger questions, larger datasets, and better answers
- Concluding remarks
- References
- Chapter 8 Premalignant lesions of the stomach and management of early neoplastic lesions
- Abstract
- Introduction
- Classification of gastric cancer
- The Correa model of gastric cancer
- Clinical associations of intestinal metaplasia
- Risk factors associated with intestinal metaplasia
- Operative link for intestinal metaplasia assessment
- Intestinal metaplasia: a breaking point in the process of carcinogenesis?
- Intestinal metaplasia subtypes
- How and why does intestinal metaplasia develop?
- Molecular progression to gastric cancer
- Multifocal versus unifocal intestinal metaplasia
- Spasmolytic polypeptide expressing metaplasia
- Intestinal metaplasia animal models
- Spasmolytic peptide expressing metaplasia animal models
- Intestinal metaplasia surveillance
- Early gastric cancer and current management strategies
- Conclusion and future directions
- References
- Chapter 9 Updated perspective and directions on hereditary diffuse gastric cancer
- Abstract
- Introduction
- Hereditary diffuse gastric cancer syndrome: from the basics to histopathology
- Main causal germline defects of hereditary diffuse gastric cancer
- Other causal germline defects causing hereditary diffuse gastric cancer: CTNNA1 germline variants
- Yield of endoscopic technologies in hereditary diffuse gastric cancer
- Prophylactic total gastrectomy in carriers of germline CDH1 variants: the perspective of a surgeon
- Approaches to the chemoprevention of hereditary diffuse gastric cancer
- Model systems for hereditary diffuse gastric cancer chemoprevention
- Future directions and conclusions
- References
- Chapter 10 Systems biology and molecular characterization of subtypes to guide targeted therapies in gastric cancer
- Abstract
- Introduction
- Genetics
- Molecular subtyping of gastric cancer
- Targeted therapies: current state and discovery
- Future perspectives
- Conclusion
- References
- Chapter 11 Current state of chemotherapy and immunotherapy regimens in gastric cancer
- Abstract
- Introduction
- Locally advanced gastric cancer
- Subgroups of interest
- Advanced gastric cancer
- First-line therapy: HER2 nonamplified gastric cancer
- HER2-targeted therapy
- Subgroups of interest
- Second-line therapy and beyond
- Future directions
- Conclusions
- Uncited references
- References
- Chapter 12 Case studies highlighting the multiple facets of gastric cancer: one diagnosis, multiple approaches
- Abstract
- Introduction
- Case 1: metastatic gastric adenocarcinoma—non-HER2 amplified, pMMR, PD-L1 unknown
- Case 2: metastatic gastric adenocarcinoma—HER2 amplified, pMMR, PD-L1 unknown
- Case 3: metastatic gastric adenocarcinoma and immunotherapy—HER2 non-amplified, pMMR, PD-L1 unknown
- Case 4: metastatic gastric neuroendocrine carcinoma
- Conclusion
- References
- Index
- Edition: 1
- Published: July 17, 2021
- No. of pages (Paperback): 370
- No. of pages (eBook): 370
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780323855631
- eBook ISBN: 9780323885546
BJ
Brendan Jenkins
Prof. Brendan Jenkins is an internationally renowned researcher who studies inflammation-associated cancers of the stomach, pancreas and lung, the latter of which is also linked to chronic obstructive pulmonary disease (COPD). His vision is to identify and develop new diagnostics and immunotherapies for these diseases. Prof. Jenkins is head of the Cancer and Immune Signaling Laboratory of the Hudson Institute of Medical Research in Victoria, Australia, and he is also a Professor in the Faculty of Medicine, Nursing and Health Sciences of Monash University. He has received over 20 national and international awards for his research and is a Senior Research Fellow of the Australian National Health and Medical Research Council (2014-2023); prior to that he held a prestigious Viertel Senior Medical Research Fellowship (2009-2013). He received his PhD in Medicine from the University of Adelaide, South Australia in 1998.
Affiliations and expertise
Head, Cancer and Immune Signaling Laboratory, Hudson Institute of Medical Research; Professor, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, AustraliaRead Research and Clinical Applications of Targeting Gastric Neoplasms on ScienceDirect