Remington and Klein's Infectious Diseases of the Fetus and Newborn Infant
- 9th Edition - March 11, 2024
- Imprint: Elsevier
- Editors: Yvonne Maldonado, Victor Nizet, Elizabeth D. Barnett, Kathryn M. Edwards, Richard Malley
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 7 9 5 2 5 - 8
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 7 9 5 2 6 - 5
**Selected for Doody’s Core Titles® 2024 in Infectious Disease**A must-have reference for all clinicians who need comprehensive, in-depth advice and recommendations in this com… Read more
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A must-have reference for all clinicians who need comprehensive, in-depth advice and recommendations in this complex field, Remington and Klein's Infectious Diseases of the Fetus and Newborn Infant, 9th Edition, provides expert coverage from the world’s leading authorities in immunology and infectious diseases. It offers the most up-to-date and complete guidance on infections found in utero, during delivery, and in the neonatal period in both premature and term infants—indispensable information for all clinicians who are involved in the care and well-being of these vulnerable patient populations. Three new associate editors and many new contributing authors bring new insight and a fresh perspective throughout the text.
A must-have reference for all clinicians who need comprehensive, in-depth advice and recommendations in this complex field, Remington and Klein's Infectious Diseases of the Fetus and Newborn Infant, 9th Edition, provides expert coverage from the world’s leading authorities in immunology and infectious diseases. It offers the most up-to-date and complete guidance on infections found in utero, during delivery, and in the neonatal period in both premature and term infants—indispensable information for all clinicians who are involved in the care and well-being of these vulnerable patient populations. Three new associate editors and many new contributing authors bring new insight and a fresh perspective throughout the text.
- Provides a detailed summation of existing information on fetal and neonatal infections, ideal for all clinicians who encounter infections for which they need additional background and guidance on the best approach.
- Helps you form a definitive diagnosis and create optimal treatment plans using evidence-based recommendations and expert guidance from world authorities.
- Contains two new chapters on SARS-CoV-2 and Zika, plus thorough updates throughout the volume that incorporate new knowledge and current practice in this fast-changing field.
- Reorganizes existing chapters to provide more in-depth discussions on bacterial sepsis, meningitis, pneumocystis, and less common fungal infections.
- Covers all recent major advances in both biology and medicine that have contributed greatly to our understanding of infections that affect the fetus and newborn.
- Gives special attention to the prevention and treatment of diseases found in developing countries as well as the latest findings about new antimicrobial agents, Gram-negative infections and their management, and recommendations for immunizations in pregnancy.
- Uses a consistent, reader-friendly format that features a full-color design with hundreds of illustrations, photographs, diagrams radiographic images, and drawings.
- Includes sequelae of infections that affect older children and adults; infection in the adult is described whenever pertinent to recognition of infection during pregnancy, which may affect the developing fetus and newborn infant.
- An eBook version is included with purchase. The eBook allows you to access all of the text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
All clinicians interested in the care and well-being of the fetus and newborn infant: pediatric and infectious diseases residents and fellows, practicing pediatricians and ID specialists, ob/gyns, family medicine
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Dedication
- In Memoriam
- Contributors
- Preface
- Appendix
- List of Illustrations
- List of Tables
- SECTION I. General Information
- 1. Current concepts of infections of the fetus and newborn infant
- Overview
- Infections of the fetus
- Infections acquired by the newborn infant during birth
- Infections of the newborn infant in the first month of life
- References
- References-online
- 2. Neonatal infections: A global perspective
- Introduction
- Global burden of neonatal infections
- Selected neonatal infections
- Indirect causes of neonatal death related to infection
- Strategies to prevent and treat infection in the neonate
- Conclusion
- References
- References-online
- 3. Obstetric factors associated with infections of the fetus and newborn infant
- Overview
- Infection as a cause of preterm birth
- Premature rupture of membranes
- Conclusion
- References
- References-online
- 4. Developmental immunology and role of host defenses in fetal and neonatal susceptibility to infection
- Introduction
- Innate immunity
- Complement and other humoral mediators of innate immunity
- Innate immune pattern recognition receptors and secreted peptides/proteins
- Epithelial cell innate immunity and barrier function
- Phagocytes
- Adaptive immunity
- T cells and antigen presentation
- B cells and immunoglobulin
- References
- References-online
- 5. Human milk
- Introduction
- Developmental anatomy of the mammary gland
- Physiology of lactation
- Components of human milk and their potential benefits for the breastfed infant
- Benefits and risks of human milk
- Current trends in breastfeeding
- Summary and conclusions
- References
- References-online
- SECTION II. Bacterial Infections
- 6. Neonatal bacteremia and sepsis
- Bacteriology
- Epidemiology
- Pathogenesis
- Pathology
- Diagnosis
- Management
- Prevention
- Outcomes
- Conclusion
- References
- References-online
- 7. Meningitis
- Introduction
- Epidemiology
- Pathology
- Diagnosis
- Management
- Prevention
- Outcomes
- Conclusion
- References
- References-online
- 8. Bacterial infections of the respiratory tract
- Infections of the oral cavity and nasopharynx pharyngitis, retropharyngeal cellulitis, and retropharyngeal abscess
- Otitis media
- Pneumonia
- References
- References-online
- 9. Bacterial infections of the bones and joints
- Introduction
- Epidemiology
- References
- References-online
- 10. Bacterial infections of the urinary tract
- Introduction
- Epidemiology
- Clinical manifestations
- Microbiology
- Pathogenesis
- Diagnosis
- Management and prevention
- Prognosis
- Acknowledgment
- References
- References-online
- 11. Focal bacterial infections
- Infections of the liver
- Splenic abscess
- Infections of the biliary tract
- Infections of the adrenal glands
- Appendicitis
- Peritonitis
- Necrotizing enterocolitis
- Endocarditis
- Pericarditis
- Mediastinitis
- Esophagitis
- Infections of endocrine organs
- Infections of the salivary glands
- Infections of the skin and subcutaneous tissue
- Conjunctivitis and other eye infections
- Acknowledgments
- References
- References-online
- 12. Microorganisms responsible for neonatal diarrhea
- Introduction
- Enteric host defense mechanisms
- Protective factors in human milk
- Bacterial pathogens
- Other bacterial agents and fungi
- Parasites
- Giardia intestinalis
- Viruses
- Differential diagnosis for neonatal infectious diarrhea
- References
- References-online
- 13. Group B streptococcal infections
- Introduction
- Organism
- Epidemiology and transmission
- Immunology and pathogenesis
- Clinical manifestations
- Diagnosis
- Treatment
- Prevention
- Vaccine development
- References
- References-online
- 14. Listeriosis
- Introduction
- The organism
- Typing and epidemiology
- Pathogenesis and virulence
- Pathology
- Clinical manifestations
- Diagnosis
- Therapy
- Prognosis
- Prevention, public health, and nuanced exposure histories
- References
- References-online
- 15. Staphylococcal infections
- Introduction
- Epidemiology and transmission
- Microbiology
- Pathogenesis of disease
- Clinical manifestations
- Antibiotic treatment (see also Chapter 37)
- Prevention
- Conclusion
- References
- References-online
- 16. Gonococcal infections
- Introduction
- Epidemiology and transmission
- Microbiology
- Pathogenesis
- Pathology
- Clinical manifestations
- Diagnosis
- Differential diagnosis
- Treatment
- Prognosis
- Prevention
- References
- References-online
- 17. Syphilis
- Introduction
- Organism
- Transmission
- Epidemiology
- Pathogenesis
- Pathology
- Clinical manifestations
- Diagnosis
- Differential diagnosis
- Therapy
- Follow-up
- Prevention
- Global efforts for eradication
- References
- References-online
- 18. Borrelia infections: Lyme disease and relapsing fever
- Lyme disease
- Relapsing fever
- References
- References-online
- 19. Tuberculosis
- Introduction
- Brief history
- Epidemiology
- Bacteriology
- Pathogenesis and pathology
- Clinical presentation
- Diagnosis
- Management
- Prognosis
- Infection control
- Prevention
- Special considerations in human immunodeficiency virus infection or exposure
- Special considerations in drug-resistant tuberculosis
- References
- References-online
- 20. Chlamydia infections
- Epidemiology and transmission
- Microbiology
- Pathogenesis
- Pathology
- Clinical manifestations
- Diagnosis
- Differential diagnosis
- Prognosis
- Therapy
- Prevention
- References
- References-online
- 21. Mycoplasmal infections
- Summary
- Biology and pathogenesis of mollicutes
- Colonization and diseases of the urinary and reproductive tracts in adults
- Chorioamnionitis, clinical amnionitis, and maternal septicemia
- Adverse pregnancy outcome
- Transmission of ureaplasma and mycoplasma hominis to the fetus and newborn
- Perinatal ureaplasma and mycoplasma hominis infection
- Other mycoplasmas
- Diagnosis
- Antimicrobial treatment
- Treatment of other neonatal mycoplasmal and ureaplasmal infections
- References
- References-online
- 22. Bordetella pertussis and other Bordetella spp. infections
- Introduction
- Organisms
- Epidemiology and transmission
- Pathogenesis and immunogenicity
- Pathology
- Clinical; Bordetella pertussis infections
- Other Bordetella infections
- Diagnosis
- Treatment
- Prognosis
- The effectiveness of DTaP vaccines compared with the effectiveness of DTwP vaccines
- References
- References-online
- SECTION III. Viral Infections
- 23. Human immunodeficiency virus/acquired immunodeficiency syndrome in the infant
- Introduction
- Epidemiology
- Mother-to-child transmission
- Molecular biology
- Immunopathogenesis
- Diagnosis
- Revised classification of human immunodeficiency virus infection in children
- Clinical manifestations and pathology
- Prognosis
- Human immunodeficiency virus–exposed uninfected infants
- Treatment
- Prevention
- Challenges, opportunities, and future goals to elimination of mother-to-child human immunodeficiency virus transmission
- References
- References-online
- 24. Varicella, measles, and mumps
- Introduction
- Varicella and zoster
- Measles
- Mumps
- References
- References-online
- 25. Cytomegalovirus
- Introduction
- The virus
- Epidemiology
- Virologic risk factors and congenital infection
- Maternal immunity and congenital transmission
- Pathogenesis
- Pathology
- Diagnosis
- Differential diagnosis
- Treatment
- Behavioral prevention
- References
- References-online
- 26. Enterovirus and parechovirus infections
- Introduction
- Virology overview
- Epidemiology and transmission
- Clinical manifestations
- Manifestations of specific nonpolio enteroviruses
- Pathogenesis
- Pathology
- Diagnosis of enteroviral and parechoviral infections
- Prognosis after neonatal enteroviral or parechoviral infections
- Therapy
- Prevention
- References
- References-online
- 27. Hepatitis
- Introduction
- Hepatitis A virus
- Hepatitis B virus and hepatitis D virus
- Hepatitis C virus
- Hepatitis E virus
- Other hepatotropic viruses
- Conclusion
- References
- References-online
- 28. Herpes simplex virus infections
- Introduction
- Herpes simplex virus
- Epidemiology and transmission
- Immunologic response
- Neonatal infection
- Diagnosis
- Treatment
- Prevention
- Conclusion
- Acknowledgments
- References
- References-online
- 29. Human parvovirus
- Introduction
- The virus
- Epidemiology
- Pathogenesis
- Pathology in the fetus
- Clinical manifestations
- Differential diagnosis
- Diagnosis
- Treatment/management
- Prognosis of fetal infection
- Prevention
- References
- References-online
- 30. Rubella
- Introduction
- Virus
- Epidemiology
- Transmission in utero
- Natural history
- Pathogenesis
- Pathology
- Clinical manifestations
- Laboratory diagnosis
- Management issues
- Prevention of congenital rubella
- References
- References-online
- 31. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and multisystem inflammatory syndrome in children (MIS-C)
- Severe Acute Respiratory Syndrome Coronavirus 2
- Severe Acute Respiratory Syndrome Coronavirus 2
- Epidemiology and transmission
- Maternal infection
- Potential transmission of infection to the fetus
- Incidence of newborn infection
- Neonatal infection
- Diagnosis
- Treatment
- Prevention
- Conclusion
- Multisystem inflammatory syndrome in children
- Background
- Epidemiology
- Clinical manifestations
- Immunopathogenesis
- Genetic predisposition
- Diagnosis
- Treatment
- Conclusion
- Acknowledgments
- References
- References-online
- 32. Less common viral infections
- Human papillomavirus
- Epstein-Barr virus
- Human herpesvirus 6
- Human herpesvirus 7
- Influenza A and B
- Respiratory syncytial virus
- Lymphocytic choriomeningitis virus
- Molluscum contagiosum
- Rabies virus
- West Nile virus
- Smallpox
- Dengue
- Chikungunya
- References
- References-online
- SECTION IV. Protozoan, Helminth, and Fungal Infections
- 33. Toxoplasmosis
- Introduction
- Biology of the parasite
- Pathogenesis of congenital toxoplasmosis
- Pathology in congenital toxoplasmosis
- Epidemiology
- Drugs effective against Toxoplasma gondii
- Epidemiology and diagnosis of infections in the mother and the unborn child
- Infection in the unborn child
- Treatment and prevention of infections in the mother and the unborn child
- Infection in the newborn
- Management of congenitally infected children and long-term outcome
- Effectiveness of current approaches to prevent congenital toxoplasmosis and its sequelae
- Proposal for improvement
- Acknowledgments
- References
- References-online
- 34. Chagas disease, malaria, and less common protozoan and helminth infections
- Introduction
- Ascaris
- American trypanosomiasis: Chagas disease
- African trypanosomiasis: African sleeping sickness
- Babesiosis
- Entamoeba histolytica
- Giardiasis
- Malaria
- Schistosomiasis
- Trichinellosis (trichinosis)
- Trichomonas vaginalis
- References
- References-online
- 35. Candidiasis
- Introduction
- Epidemiology and transmission
- Microbiology
- Pathogenesis
- Pathology
- Clinical manifestations
- Candidemia and disseminated candidiasis
- Diagnosis
- Treatment
- Prevention
- References
- References-online
- 36. Pneumocystis
- Pneumocystis jirovecii (formerly known as Pneumocystis carinii)
- References
- References-online
- 37. Less common fungal infections
- Introduction
- Aspergillosis
- Blastomycosis
- Histoplasmosis
- Coccidiodomycosis
- Cryptococcosis
- Malassezia
- Zygomycosis
- Dermatophytoses
- References
- References-online
- SECTION V. Diagnosis and Management
- 38. Health care–associated infections in the nursery
- Introduction
- Special issues for neonates
- Epidemiology
- Etiologic agents
- Device-related infections
- Preventing transmission of health care–associated infections
- Other related issues
- References
- References-online
- 39. Laboratory aids for diagnosis of neonatal sepsis
- Introduction
- Diagnostic utility of laboratory tests
- In search of the ideal laboratory test
- Blood cell counts, ratios, and flow cytometric markers
- Acute-phase reactants
- Other biomarkers of host inflammation
- Improvements in pathogen detection
- Combination laboratory diagnostic screening panels
- Why have we not yet identified a “best test”?
- Clinical risk scoring systems—a possible way forward
- Perspectives and conclusions
- References
- References-online
- 40. Clinical pharmacology of antiinfective drugs
- Introduction
- Basics principles of clinical pharmacology
- Placental transport of antimicrobial drugs
- Penicillin
- Ampicillin
- Anti-staphylococcal treatment
- Aminoglycosides
- Cephalosporins
- Broad-acting agents with activity against pseudomonas or anaerobes (Table 40.9)
- Antiviral medications
- Antifungal therapy
- Conclusions
- References
- References-online
- 41. Prevention of fetal and early life infections through maternal-neonatal immunization
- Overall principles
- Immunization in pregnancy
- Neonatal immunization
- Conclusions
- References
- References-online
- 42. Zika virus
- Introduction
- Epidemiology
- Zika virus transmission
- Virology
- Pathogenesis
- Clinical aspects of Zika virus infection
- Diagnosis and management of pregnant persons
- Diagnosis and management of infants with antenatal Zika virus exposure
- Prevention
- References
- References-online
- Index
- Edition: 9
- Published: March 11, 2024
- Imprint: Elsevier
- No. of pages: 1200
- Language: English
- Hardback ISBN: 9780323795258
- eBook ISBN: 9780323795265
YM
Yvonne Maldonado
Affiliations and expertise
Senior Associate Dean for Faculty Development and Diversity; Taube Endowed Professor of Pediatrics and of Epidemiology and Population Health; Chief, Division of Pediatric Infectious Diseases, Department of Pediatrics, Stanford University School of Medicine, Stanford, CaliforniaVN
Victor Nizet
Affiliations and expertise
Distinguished Professor and Vice Chair for Basic Research, Department of Pediatrics, Distinguished Professor of Pharmacy and Pharmaceutical Sciences, Chief, Division of Host-Microbe Systems and Therapeutics, University of California San Diego, La Jolla, CaliforniaEB
Elizabeth D. Barnett
Affiliations and expertise
Professor of Pediatrics, Boston University Chobanian & Avedisian School of Medicine; Chief, Section of Pediatric Infectious Diseases, Boston Medical Center, Boston, MassachusettsKE
Kathryn M. Edwards
Affiliations and expertise
Professor of Pediatrics EmeritaRM
Richard Malley
Affiliations and expertise
Kenneth McIntosh Chair, Pediatric Infectious Diseases, Boston Children’s Hospital; Professor, Department of Pediatrics, Harvard Medical School, Boston, MassachusettsRead Remington and Klein's Infectious Diseases of the Fetus and Newborn Infant on ScienceDirect