Redox Signaling in Wound Healing in Elderly Populations: Clinical Approach, Part 2

1st Edition, Volume 3 - January 20, 2025
Imprint: Academic Press
Editors: Ufuk Cakatay, Mehmet Can Atayik
Language: English
Hardback ISBN:
9 7 8 - 0 - 4 4 3 - 3 4 5 1 5 - 9
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 3 4 5 1 6 - 6

Redox Signaling in Wound Healing in Elderly Populations: Clinical Approach, Part Two, Volume Three covers wounds in different types and locations (diabetic, ischemic, post-o… Read more

Redox Signaling in Wound Healing in Elderly Populations: Clinical Approach, Part 2

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Redox Signaling in Wound Healing in Elderly Populations: Clinical Approach, Part Two, Volume Three covers wounds in different types and locations (diabetic, ischemic, post-operational) in subcellular and macro dimensions, examining their relationship with aging with an aim to target deteriorating redox signaling cascades and highlight promising therapeutic approaches. Understanding the indication for the use of new therapeutics targeting the illuminated pathways in wound healing helps adjust treatment regimens befitting modern medicine. Ineffective redox adaptation and disseminated oxidative injury are the hallmarks of continuing oxidative stress.

However, oxidative stress cannot be simply described as the imbalance between ROS formation and antioxidant defense capacity. This also covers impairment in redox sensing and signaling pathways. The term oxidative stress is an expression that is losing its use in modern redox biology. It is now an accepted fact that ROS cannot be described as an apparent enemy or friend. Its optimum level modulates signal transduction and stress responses by acting as a second messenger for redox-sensitive cascades.

Redox Signaling in Wound Healing in Elderly Populations: Clinical Approach, Part 2
Cover image
Title page
Table of Contents
Copyright
Dedication
Contributors
Preface
Chapter One Redox state of aging skin: A double-edged sword in wound healing
Abstract
Keywords
1 Redox homeostasis and redox signaling
2 Aging skin
2.1 Normal skin structure and function
2.2 Skin degeneration with aging
2.3 Intrinsic and extrinsic factors of skin aging
2.4 Aging skin and reduced redox-stress response capacity
3 Chronic wound healing in the aging population
3.1 Emergence of skin issues in the aging population
3.2 Classification of skin wounds
3.3 Common chronic wounds in the aging population
3.4 Altered wound repair in chronic wounds with aging
4 Strategies focusing on redox milieu in chronic wound healing
4.1 TIME framework
4.2 H2O2 application
4.3 Mitochondrial-targeted antioxidants
4.4 Senolytic or senomorphic agents
4.5 AGEs inhibitors
5 Summary
References
Chapter Two Redox signaling in pressure ulcers within older population: Role of the of antioxidants in their prevention and management
Abstract
Keywords
1 Introduction
1.1 Risk factors for pressure injury
2 Overview of the skin
3 Changes in homeostasis redox in aging
3.1 Antioxidant system in the normal skin
4 Pathophysiology of pressure injury and oxidative stress
4.1 Oxidative stress in older skin
4.2 Oxidative stress and pressure injury
4.3 Antioxidant status in damage skin
5 New approaches and potential antioxidant therapies
5.1 The role of the diet and nutrition in older adults
6 Conclusion
References
Chapter Three Redox signaling in intestinal mucosal wound healing
Abstract
Keywords
1 Introduction
2 General concepts of redox homeostasis and redox signaling
2.1 Redox signaling
2.2 A brief overview of intestinal mucosal wound healing (patho)physiology
3 Redox signaling pathways orchestrating gut barrier restitution and mucosal wound healing
3.1 Redox signaling and maintenance of protective mucus barrier
3.2 Redox signaling in processes related to epithelial restitution, proliferation, and differentiation
3.3 Redox homeostasis and immune response in mucosal wound healing
3.4 Gut microbiota and redox signaling in mucosal wound healing
4 Conclusion
Conflict of interest
References
Chapter Four Gastrointestinal system senility, postsurgical wound healing, and redox signaling pathways
Abstract
Keywords
1 Prolog
2 Understanding the gastrointestinal system
2.1 A brief summary of gastrointestinal system disorders
2.2 Gastrointestinal system and senility
3 Basics of gastrointestinal anastomotic healing
3.1 Gastrointestinal anastomoses
3.2 Gastrointestinal anastomotic healing
4 Redox and signaling pathways in gastrointestinal system
4.1 Basics of redox reactions
4.2 Redox-based reactions in gastrointestinal system
4.3 Redox signaling pathways in gastrointestinal system
5 Conclusion
References
Chapter Five Redox signaling in age-related vascular disease and wound healing
Abstract
Keywords
1 Prolog
2 Vascular aging and fundamentals
2.1 Vascular biology and cells
2.2 Vascular redox signaling pathways and its regulation
3 Vascular redox dysregulation and related pathologies
3.1 Peripheral arterial diseases
3.2 Chronic venous ulcers
4 Conclusion
References
Chapter Six Redox signaling in age-related ocular diseases and healing
Abstract
Keywords
1 Introduction
2 Redox signaling in ocular tissues
2.1 Redox homeostasis in ocular tissue health
2.2 Role of ROS and reactive nitrogen species (RNS) in redox signaling
2.3 Iron-mediated redox signaling and its implications in ocular redox biology
3 Ocular redox dysregulation and possible therapeutic targets
3.1 Redox imbalance and ocular diseases
3.2 Therapeutic interventions targeting redox signaling
4 Conclusion
Conflict of interest
References
Chapter Seven ROS-mediated redox signaling in diabetic wound healing
Abstract
Keywords
1 Introduction
2 An overview of redox signaling and homeostasis
3 Pathophysiology of wound healing in diabetes
4 Redox signaling in wound healing
5 Free radicals in cellular homeostasis during wound healing
6 Hemostasis: Intervention of ROS and redox signaling
7 Inflammation: Intervention of ROS and redox signaling
8 Re-epithelialization: Intervention of ROS and redox signaling
9 Vascularization: Intervention of ROS and redox signaling
10 NF-κB/toll-like receptor (TLR) pathway in wound healing
11 Nrf2 pathway in wound healing
12 MMP pathway in wound healing
13 ROS and protection from wound infection
14 Angiogenesis and ROS
15 The impact of ROS-mediated redox signaling on diabetic wound healing processes
16 Conclusion and future perspectives
References
Further reading
Chapter Eight Nanotherapeutic approach for diabetic wound healing: Cross-talk between redox molecules
Abstract
Keywords
1 Introduction
1.1 Normal wound healing process
1.2 Diabetic wound healing
2 Conventional therapeutic approaches for diabetic wound healing
3 Nanotherapeutic-based drug delivery system
4 Nanotherapeutics and redox molecules cross-talk
5 Novel redox molecule-based nanotherapeutics for diabetic wounds
5.1 Antioxidant nanoparticles
5.2 Emerging nanotherapeutics for enhanced diabetic wound healing
5.3 Challenges and future perspectives
6 Conclusion
References
Chapter Nine Cerium oxide-based redox active antioxidant and anti-inflammatory biomaterial for wound healing applications
Abstract
Keywords
1 Introduction
1.1 Stages of wound healing
2 Skin tissue engineering
3 Cerium oxide nanoparticles: Properties and synthesis
3.1 Ball milling method
3.2 Precipitation and co-precipitation methods
3.3 Hydrothermal method
3.4 Microemulsion method
4 Properties of CeO2 NPs for wound healing
4.1 Antioxidant and anti-inflammatory properties
4.2 Antibacterial properties of cerium oxide
4.3 Angiogenic properties
5 Biomaterial applications of cerium oxide in wound healing
6 Conclusion
Declaration of AI and AI-assisted technologies in the writing process
References
Chapter Ten The redox signaling of ozone in wound repair in the elderly. Perspectives for a thorough review about oxygen-ozone adjunct therapy in diabetic, vascular, traumatic, and post-surgical wounds
Abstract
Keywords
1 Introduction
2 Ozone in wound repair
3 Tissue repair and aging: The role of ozone
4 Conclusions
Conflict of interest
References
Chapter Eleven Contemporary redox-related therapeutic approach to burn wounds in the elderly
Abstract
Keywords
1 Prolog
2 Redox dyshomeostasis and burn wound
3 Clinical aspects of the burn wound
3.1 Acute and long-term activities of inflammatory cytokines in burn wounds
3.2 T cells and macrophages and burn wound
3.3 Adaptive/defensive responses and burn wound
3.4 Current clinical treatment algorithms
3.5 Impaired wound healing-related area and the amputation choice
3.6 Promising redox-based therapeutic approaches
4 Conclusion
References

Ufuk Cakatay

Ufuk Çakatay (May 09, 1965 –) is a Turkish biochemist and biogerontologist. He is a full professor of medical biochemistry at Istanbul-University Cerrahpaşa in Istanbul, Turkey. He has a long-standing interest in oxidative protein damage, redox signaling, and biomarkers of proteostasis. Much less is known about the relationship between redox signaling events and senescent cells. However, it has been shown that the number of senescent cells in many tissues increases with age and that senescent cells are found in various age-related diseases. The development of experimental animal models for age-related disorders and the optimization of various bioanalytical techniques for the assessment of redox status in aging tissue are among his major research interests. Professor Çakatay has authored more than 100 publications in several leading journals, including research papers, book chapters, editorials, and invited reviews on free radical biology, aging, diabetes, redox signaling, and senotherapeutics. He has been a guest editor, reviewer, and editorial board member for more than 50 journals. In addition, Professor Çakatay has a keen interest in mentoring medical students and promoting their research careers. He has received several prestigious awards, including the Top Reviewer Award from Elsevier Science Publishing, and was a former member of the Animal Research and Ethics Committee of Istanbul University.

Affiliations and expertise

Cerrahpasa Faculty of Medicine, Department of Medical Biochemistry, Istanbul University-Cerrahpasa, Istanbul, Turkey

Mehmet Can Atayik

Dr. Atayik is currently working in the Department of General Surgery at Hacettepe University Faculty of Medicine. He has been working as a scientist and researcher with Prof. Ufuk Çakatay since 2017. His research interests are in the fields of aging, age-related disorders, redox biology, oncogenetics, melatonin, mitochondria, surgical advances, and developing novel techniques for modern surgery. Dr. Atayik has conducted clinical research and experimental studies. He has published many scientific papers, such as research papers, narrative reviews, and book chapters, and has worked as an author, referee, editorial assistant, and guest editor, and editor in many prominent publishing houses. He was awarded the Young Investigator Presentation Prize at the VIII. International Congress of Molecular Medicine, which was held in Istanbul, Turkey, in November 2021.

Affiliations and expertise

Scientist and Researcher, Department of General Surgery, Hacettepe University Faculty of Medicine, Turkey

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