Receptor Endocytosis and Signalling in Health and Disease - Part A

1st Edition, Volume 194 - January 9, 2023
Imprint: Academic Press
Editors: Indra Mani, Vijai Singh
Language: English
Hardback ISBN:
9 7 8 - 0 - 4 4 3 - 1 9 1 8 5 - 5
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 9 1 8 6 - 2

Receptor Endocytosis and Signalling in Health and Disease, Volume 194 in the Progress in Molecular Biology and Translational Science, highlights new advances in the field. Chapt… Read more

Receptor Endocytosis and Signalling in Health and Disease - Part A

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Receptor Endocytosis and Signalling in Health and Disease, Volume 194 in the Progress in Molecular Biology and Translational Science, highlights new advances in the field. Chapters in this release include An overview on receptor endocytosis and signaling, Signaling molecules: Importance in health and disease conditions, Emerging tools for studying of receptor endocytosis and signaling, Endocytosis of EGFR: Signalling in cancer, Endocytosis of AT1 and AT2 receptors: Signalling in the kidney, Regulation of transferrin receptor trafficking by optineurin and its disease-associated mutants, Endocytosis of Insulin receptor: Signalling in the regulation of glucose homeostasis, Endocytosis of VEGFR: Role in the regulation of angiogenesis, and more.

Other sections in this new release include Lymphocyte and monocyte/macrophage receptors mediating immune recognition of tumors, Lymphocyte and monocyte/macrophage receptors triggering immune suppression of tumor immunity, Prion receptors and prion internalization and intra- and inter-cellular transport, Multifunctional role of the ubiquitin proteasome pathway in phagocytosis, Adrenoceptors and SCD1 in adipocytes/adipose tissues: the expression and variation in health and obesity, Frizzled receptors and SFRP5 in lipid metabolism: current findings and potential applications.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Chapter One: An overview of receptor endocytosis and signaling
Abstract
1: Introduction
2: Role of clathrin in endocytosis
3: Role of adaptor protein in internalization of the receptor
4: Subcellular trafficking
5: Receptor trafficking in non-traditional subcellular organelles
6: Role of short-sequence motif in the internalization and trafficking of the receptors
7: Signaling
8: Conclusions and future perspectives
Conflict of interest
Reference
Chapter Two: Emerging tools for studying receptor endocytosis and signaling
Abstract
1: Introduction
2: Radioligand binding assay
3: Western blot
4: Co-immunoprecipitation and immunoblotting
5: Northern blotting
6: Real-time reverse transcription PCR (qRT PCR)
7: Immunofluorescence and confocal microscopy
8: MicroRNA/small interference RNA
9: Bioassay
10: Conclusion and future perspectives
Conflict of interest
References
Chapter Three: Mas receptor endocytosis and signaling in health and disease
Abstract
1: Introduction
2: Gene structure and expression of MasR
3: MasR trafficking
4: MasR signaling and receptor trafficking in pathological situations
5: Concluding remarks
References
Chapter Four: Regulation of transferrin receptor trafficking by optineurin and its disease-associated mutants
Abstract
1: Introduction
2: Role of OPTN in TFRC trafficking and recycling
3: Glaucoma-associated mutations of OPTN impair TFRC trafficking and recycling
4: Function of OPTN in trafficking of TFRC and associated membrane to autophagosomes
5: Unconventional endocytic trafficking of TFRC
6: Concluding remarks
References
Chapter Five: The insulin receptor endocytosis
Abstract
1: Introduction
2: Clathrin-mediated endocytosis of the insulin receptor
3: Caveolae-mediated IR endocytosis
4: Dysfunction of insulin receptor endocytosis
5: Discussion
6: Conclusion
References
Chapter Six: VEGFR endocytosis: Implications for angiogenesis
Abstract
1: Introduction
2: Vascular endothelial growth factors and membrane receptors
3: VEGFR endocytosis
4: Integration of VEGFR signaling, trafficking and proteolysis
5: VEGFR post-translational modifications
6: Implications of VEGFR endocytosis in vascular physiology
7: Conclusions
Acknowledgments
References
Chapter Seven: Endocytosis and signaling of angiotensin II type 1 receptor
Abstract
1: Introduction
2: Ligand-stimulated internalization of AT1 receptor
3: Role of clathrin adaptor proteins in internalization of AT1R
4: Subcellular trafficking of AT1 receptor
5: Role of a short amino acid motif in the internalization and trafficking of AT1R
6: Signaling of AT1 receptor
7: Concluding remarks and future perspectives
Conflict of interest
References
Chapter Eight: B cell receptor (BCR) endocytosis
Abstract
1: Introduction to the B cell receptor
2: B cell receptor structure
3: B cell receptor signaling and regulation
4: Mechanism of B cell receptor endocytosis
5: Clathrin mediated endocytosis
6: Clathrin independent endocytosis (CIE)
7: B cell receptor signaling and endocytosis in leukemia and lymphoma
8: Chronic lymphocytic leukemia
9: Diffuse large B cell lymphoma
10: Conclusions
Acknowledgments
References
Chapter Nine: Multifunctional role of the ubiquitin proteasome pathway in phagocytosis
Abstract
1: Introduction
2: The phagocytes
3: Distinct steps of phagocytosis
4: Phagocytosis: Connection with endoplasmic reticulum (ER)
5: Role of ubiquitin proteasome pathway (UPP) in phagocytosis
6: Aberrations of UPP in phagocytosis and human diseases
7: Phagosomal machinery of parasites and role of UPP
8: Future perspectives
Acknowledgments
References
Chapter Ten: Receptors of immune cells mediates recognition for tumors
Abstract
1: Introduction: Inflammation in tumor microenvironment and cancer
2: Tumor initiation
3: Tumor promotion
4: Role of pattern recognition receptors (PRRs) in tumor progression
5: Immune evasion and angiogenesis
6: Macrophages function in tumor recognition
7: Lymphocytes driven immune surveillance
8: Role of B cell receptor in tumor
9: Natural killer (NK) cells and receptors
10: Concluding remarks
Reference
Chapter Eleven: Role of lymphocytes, macrophages and immune receptors in suppression of tumor immunity
Abstract
1: Introduction
2: Differentiation and polarization of tumor-associated macrophages
3: Role of TAM receptors in suppressing tumor immunity
4: Role of lymphocytes promotion and suppression of tumor immunity
5: Suppression of anti-tumor immunity via pro-tumorigenic factors and cytokine production by B cells
6: T-lymphocyte inhibitory receptors and their role in suppressing tumor immunity
7: Concluding remark
References
Chapter Twelve: Adrenoceptors and SCD1 in adipocytes/adipose tissues: The expression and variation in health and obesity
Abstract
1: Introduction
2: Methods to study the expression and variation of adipose adrenoceptors and SCD1
3: Adrenoceptors and adipose tissues/adipocytes
4: Stearoyl-CoA desaturase-1 and adipose tissues/adipocytes
5: Mechanisms underlying interaction between adrenoceptors and SCD1 in adipocytes/adipose tissues
6: Conclusion
Acknowledgments
References
Chapter Thirteen: Low density lipoprotein receptor endocytosis in cardiovascular disease and the factors affecting LDL levels
Abstract
1: Introduction
2: Receptor-mediated endocytosis of LDL
3: Factors influencing LDL levels
4: Conclusion and future perspectives
Acknowledgment
References
Chapter Fourteen: Endocytosis of LXRs: Signaling in liver and disease
Abstract
1: Introduction
2: Liver X receptor: Master regulator for lipid metabolism and homeostasis
3: Liver X receptor agonists and antagonists
4: Diet on LXR signaling
5: Endocytosis of liver X receptor
6: Role of LXRs in human disease
7: Future prospects of LXR endocytosis in therapeutics
8: Conclusion
References
Chapter Fifteen: Frizzled receptors and SFRP5 in lipid metabolism: Current findings and potential applications
Abstract
1: Introduction
2: Frizzled receptors and lipid metabolism
3: Secreted frizzled-related protein 5 (SFRP5) in lipid metabolism
4: Mechanisms underlying interaction between frizzled receptors and SFRP5 in lipid metabolism
5: Potential applications of findings on frizzled receptors and SFRP5 in lipid metabolism
6: Conclusion
Acknowledgments
References
Index

Indra Mani

Dr. Indra Mani is an Assistant Professor in the Department of Microbiology, Gargi College, University of Delhi (DU), New Delhi, India. He received M.Sc. in Microbiology from Bundelkhand University (BU), Jhansi, UP, India and Ph.D. in Biochemistry from Banaras Hindu University (BHU), Varanasi, UP, India. He completed postdoctoral training in the Department of Physiology, School of Medicine, Tulane University, New Orleans, USA. He has also worked as a Senior Research Officer (SRO) in the Department of Medicine, All India Institute of Medical Sciences (AIIMS), New Delhi, India. He has more than 10 years of research and teaching experience in Microbiology, Molecular Genetics, Cell Signaling, and Bioinformatics. He has published 49 articles in peer reviewed journals and 22 book chapters. He has presented several papers in the different national and international conferences. He has extensive experience in fluorescence/confocal microscopy, receptor internalization, trafficking and signaling, molecular cytogenetics, microbial characterization, and in silico analysis. He serves as a reviewer of peer-reviewed journals and also a member of national and international societies.

Affiliations and expertise

Assistant Professor, Department of Microbiology, Gargi College, University of Delhi (DU), New Delhi, India

Vijai Singh

Dr Vijai Singh is a Professor and Dean (Research & Innovation) at School of Sciences, Indrashil University, Rajpur, Mehsana, Gujarat, India. He was an Associate Professor in the Department of Biosciences, School of Sciences, Indrashil University, Rajpur, Mehsana, Gujarat, India. Prior this this, he was an Assistant Professor in the Department of Biological Sciences and Biotechnology at the Institute of Advanced Research, Gandhinagar, India and also an Assistant Professor in the Department of Biotechnology at the Invertis University, Bareilly, India. Prior to that, he was a Postdoctoral Fellow in the Synthetic Biology Group at the Institute of Systems and Synthetic Biology, Paris, France and School of Energy & Chemical Engineering at the Ulsan National Institute of Science and Technology, Ulsan, South Korea. He received his Ph.D. in Biotechnology from the National Bureau of Fish Genetic Resources, Uttar Pradesh Technical University, Lucknow, India with a research focus on the development of molecular and immunoassays for diagnosis of Aeromonas hydrophila. His research interests are focused on building novel biosynthetic pathways for production of medically and industrially important biomolecules. Additionally, his laboratory is working on CRISPR-Cas9 tools for genome editing. He has more than 11 years of research and teaching experience in synthetic biology, metabolic engineering, bioinformatics, microbiology, and industrial microbiology. He has published 100 articles, 70 chapters, 15 books and 3 patents. He serves as an associate editor, editorial board member, and reviewer of several peer-reviewed journals. He is also a member of the Board of Study and Academic Council of Indrashil University and is the Member Secretary of the Institutional Biosafety Committee (IBSC) at the same University.

Affiliations and expertise

Department of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana, India

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health