Receptor Endocytosis and Signalling in Health and Disease - Part A

1st Edition - January 9, 2023

Editors: Indra Mani, Vijai Singh

Hardback ISBN:

9 7 8 - 0 - 4 4 3 - 1 9 1 8 5 - 5

eBook ISBN:

9 7 8 - 0 - 4 4 3 - 1 9 1 8 6 - 2

Receptor Endocytosis and Signalling in Health and Disease, Volume 194 in the Progress in Molecular Biology and Translational Science, highlights new advances in the field.… Read more

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Receptor Endocytosis and Signalling in Health and Disease, Volume 194 in the Progress in Molecular Biology and Translational Science, highlights new advances in the field. Chapters in this release include An overview on receptor endocytosis and signaling, Signaling molecules: Importance in health and disease conditions, Emerging tools for studying of receptor endocytosis and signaling, Endocytosis of EGFR: Signalling in cancer, Endocytosis of AT1 and AT2 receptors: Signalling in the kidney, Regulation of transferrin receptor trafficking by optineurin and its disease-associated mutants, Endocytosis of Insulin receptor: Signalling in the regulation of glucose homeostasis, Endocytosis of VEGFR: Role in the regulation of angiogenesis, and more.

Other sections in this new release include Lymphocyte and monocyte/macrophage receptors mediating immune recognition of tumors, Lymphocyte and monocyte/macrophage receptors triggering immune suppression of tumor immunity, Prion receptors and prion internalization and intra- and inter-cellular transport, Multifunctional role of the ubiquitin proteasome pathway in phagocytosis, Adrenoceptors and SCD1 in adipocytes/adipose tissues: the expression and variation in health and obesity, Frizzled receptors and SFRP5 in lipid metabolism: current findings and potential applications.

Preface

Indra Mani and Vijai Singh

1. An overview of receptor endocytosis and signaling

Indra Mani and Vijai Singh

2. Emerging tools for studying receptor endocytosis and signaling

Pratiksha Pandita, Rhea Bhalla, Ashok Saini and Indra Mani

3. Mas receptor endocytosis and signaling in health and disease

Natalia L. Rukavina Mikusic and Mariela M. Gironacci

4. Regulation of transferrin receptor trafficking by optineurin and its disease-associated mutants

Shivranjani C Moharir, Kapil Sirohi and Ghanshyam Swarup

5. The insulin receptor endocytosis

Jiayi Wu, Stella Hayoung Park and Eunhee Choi

6. VEGFR endocytosis: Implications for angiogenesis

Queen Saikia, Hannah Reeve, Areej Alzahrani, William R. Critchley, Elton Zeqiraj, Aysha Divan, Michael A. Harrison and Sreenivasan Ponnambalam

7. Endocytosis and signaling of angiotensin II type 1 receptor

Indra Mani

8. B cell receptor (BCR) endocytosis

Aleah D. Roberts and Justin W. Taraska

9. Multifunctional role of the ubiquitin proteasome pathway in phagocytosis

Angela Lalnunthangi, Gyaltsen Dakpa and Swati Tiwari

10. Receptors of immune cells mediates recognition for tumors

Vandana Anang, Aayushi Singh, Sarat Kumar Kottarath and Chaitenya Verma

11. Role of lymphocytes, macrophages and their receptors in mediating suppression of tumor immunity

Aayushi Singh, Vandana Anang, Komal Kumari, Sarat Kumar Kottarath and Chaitenya Verma

12. Adrenoceptors and SCD1 in adipocytes/adipose tissues: The expression and variation in health and obesity

Dinh-Toi Chu, Nhat-Le Bui and Ngoc Hoan Le

13. Low density lipoprotein receptor endocytosis in cardiovascular disease and factors affecting LDL levels

Rupesh Maurya, Gargi Bhattacherjee, Nisarg Gohil, Khushal Khambhati, Shreya Shakhreliya, Aaradhya Bhatnagar, Priyanka Singh, Suresh Ramakrishna and Vijai Singh

14. Endocytosis of LXRs: Signaling in liver

Mettle Brahma, Soumika Ghosal, Mulaka Maruthi and Suresh K. Kalangi

15. Frizzled receptors and SFRP5 in lipid metabolism: Current findings and potential applications

Dinh-Toi Chu and Thanh-Lam Nguyen

Indra Mani

Dr. Indra Mani is an Assistant Professor in the Department of Microbiology, Gargi College, University of Delhi (DU), New Delhi, India. He received M.Sc. in Microbiology from Bundelkhand University (BU), Jhansi, UP, India and Ph.D. in Biochemistry from Banaras Hindu University (BHU), Varanasi, UP, India. He completed postdoctoral training in the Department of Physiology, School of Medicine, Tulane University, New Orleans, USA. He has also worked as a Senior Research Officer (SRO) in the Department of Medicine, All India Institute of Medical Sciences (AIIMS), New Delhi, India. He has more than 10 years of research and teaching experience in Microbiology, Molecular Genetics, Cell Signaling, and Bioinformatics. He has published 49 articles in peer reviewed journals and 22 book chapters. He has presented several papers in the different national and international conferences. He has extensive experience in fluorescence/confocal microscopy, receptor internalization, trafficking and signaling, molecular cytogenetics, microbial characterization, and in silico analysis. He serves as a reviewer of peer-reviewed journals and also a member of national and international societies.

Affiliations and expertise

Assistant Professor, Department of Microbiology, Gargi College, University of Delhi (DU), New Delhi, India

Vijai Singh

Dr Vijai Singh is an Associate Professor and Dean (Research & Innovation) at School of Sciences, Indrashil University, Rajpur, Mehsana, Gujarat, India. He was an Assistant Professor in the Department of Biological Sciences and Biotechnology at the Institute of Advanced Research, Gandhinagar, India and also an Assistant Professor in the Department of Biotechnology at the Invertis University, Bareilly, India. Prior to that, he was a Postdoctoral Fellow in the Synthetic Biology Group at the Institute of Systems and Synthetic Biology, Paris, France and School of Energy & Chemical Engineering at the Ulsan National Institute of Science and Technology, Ulsan, South Korea. He received his Ph.D. in Biotechnology (2009) from the National Bureau of Fish Genetic Resources, Uttar Pradesh Technical University, Lucknow, India with a research focus on the development of molecular and immunoassays for diagnosis of Aeromonas hydrophila. His research interests are focused on building novel biosynthetic pathways for production of medically and industrially important biomolecules. Additionally, his laboratory is working on CRISPR-Cas9 tools for genome editing. He has more than 8 years of research and teaching experience in synthetic biology, metabolic engineering, bioinformatics, microbiology, and industrial microbiology. He has published 79 articles, 51 chapters, 15 books and 4 patents. He serves as an associate editor, editorial board member, and reviewer of several peer-reviewed journals. He is also a member of the Board of Study and Academic Council of Indrashil University and is the Member Secretary of the Institutional Biosafety Committee (IBSC) at the same University.

Affiliations and expertise

Department of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana, India