Recent Developments in the Synthesis and Applications of Pyridines

1st Edition - September 17, 2022
Imprint: Elsevier
Editor: Parvesh Singh
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 2 2 1 - 1
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 4 5 9 - 8

Recent Developments in the Synthesis and Applications of Pyridines　is a comprehensive　handbook　for　organic chemists　working on innovative approaches to the synthesis of py… Read more

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Recent Developments in the Synthesis and Applications of Pyridines　is a comprehensive　handbook　for　organic chemists　working on innovative approaches to the synthesis of pyridines.　Written　by scientists in both academia and industry and designed to be a standalone reference, the book　features　reviews, research results and case studies　on　synthetic methods　and　applications　of pyridine-based　chemotypes.　The book will　bridge　the gap between industry and academia by presenting　recent innovative approaches to the synthesis of pyridines,　diverse application of pyridines in drug development, heterogeneous catalysis and material science, as well as benchtop to shelf narratives of pyridine-based compounds in the industry.　

The role of computational chemistry in the development of pyridine-based bioactive molecules　is also included. This reference is essential for researchers　in organic chemistry both in academic and industrial settings, postgraduates in chemistry and medicinal chemistry.　

Cover Image
Title Page
Copyright
Table of Contents
Contributors
Preface
Chapter 1 Role of pyridine and its privileged derivatives as anti-infective agents
1.1 Introduction to infectious diseases
1.2 Anti-infective agents
1.3 Pyridine & its derivatives
1.4 Synthesis of pyridine derivatives
1.5 Bioisosteres and pyridine bioisosterism
1.6 Conclusion
Acknowledgment
References
Chapter 2 Pyridine-based polymers and derivatives: Synthesis and applications
2.1 Introduction
2.2 Properties of pyridine
2.3 Pyridine-based polymers of heterocyclic compounds
2.4 Polymers of pyridine
2.5 Vinyl pyridine-based polymers
2.6 Applications of pyridine-based polymers
2.7 Conclusions
References
Chapter 3 Synthetic strategies of functionalized pyridines and their therapeutic potential as multifunctional anti-Alzheimer's agents
3.1 Introduction
3.2 Synthetic strategies of pyridine based heterocycles
3.3 Therapeutic potential of pyridine scaffolds as anti-Alzheimer's agents
3.4 Conclusions
References
Chapter 4 Design, synthesis, and in vitro anticancer activity of thiophene substituted pyridine derivatives
4.1 Introduction
4.2 Materials and characterization
4.3 Purification of the compounds
4.4 Analytical characterization
4.5 In vitro anticancer activity of the compounds (5 a–h)
4.6 Anticancer activity
4.7 Biological properties
4.8 Conclusion
Acknowledgments
Authors Contributions
Conflict of Interest
Data Availability
Funding
References
Chapter 5 The role of pyridine derivatives on the treatment of some complex diseases: A review
5.1 Introduction
5.2 Pyridines in general
5.3 Synthesis of pyridines derivatives
5.4 Life cycle of the malaria parasites
5.5 Pyridine containing drugs for malaria treatment
5.6 Cancer
5.7 Diabetes
5.8 Conclusion and future perspectives
Acknowledgments
Conflict of Interest
References
Chapter 6 Pyridines in Alzheimer's disease therapy: Recent trends and advancements
6.1 Introduction
6.2 Pyridine and its role in prevention of Alzheimer's disease
6.3 Synthetic routes of some pyridine derivatives used in AD
6.4 Toxicological manifestations of pyridine
6.5 Molecular modeling and computational simulation of pyridine in AD
6.6 Pyridine in AD research (marketed drugs as well as preclinical trial drug having pyridine)
6.7 Conclusion
References
Chapter 7 Pyridine derivatives as anti-Alzheimer agents
7.1 Introduction
7.2 Target-based evaluation of pyridine derivatives as anti-Alzheimer agents
7.3 Summary
References
Chapter 8 Role of pyridines as enzyme inhibitors in medicinal chemistry
8.1 General introduction
8.2 Marketed drugs based on pyridine nucleus
8.3 Synthesis of pyridine derivatives
8.4 Medicinal importance of pyridine
References
Chapter 9 Contemporary development in the synthesis and biological applications of pyridine-based heterocyclic motifs
9.1 Introduction
9.2 Synthesis of pyridine
9.3 Green approach for the synthesis of pyridine
9.4 Synthesis and antimicrobial activity of some pyridine derivatives
9.5 Synthesis and antitubercular activity of some pyridine derivatives
9.6 Synthesis and anticancer activity of some pyridine derivatives
9.7 Synthesis and anti-inflammatory activity of some pyridine derivatives
9.8 Synthesis and antimalarial activity of some pyridine derivatives
9.9 Synthesis and anti-infective activity of some pyridine derivatives
9.10 Conclusion
9.11 Graphical conclusion
Acknowledgments
References
Chapter 10 Synthesis of pyridine derivatives using multicomponent reactions
10.1 Introduction
10.2 Importance of pyridine and its derivatives
10.3 Classification of pyridines
10.4 Multicomponent reactions: its importance and green features
10.5 Synthesis of simple pyridine derivatives using multicomponent reactions
10.6 Conclusion
Acknowledgments
References
Chapter 11 Recent green synthesis of pyridines and their fused systems catalyzed by nanocatalysts
11.1 Introduction
11.2 Recent green synthesis of polysubstituted pyridines by using heterogeneous nanocatalyst systems
11.3 Recent green synthesis of some selected fused heterocyclic-pyridine derivatives by using heterogeneous nanocatalyst systems
11.4 Conclusion
References
Chapter 12 Pyridine ring as an important scaffold in anticancer drugs
12.1 Introduction
12.2 Pyridine-containing APIs in clinical use for treatment of cancer
References
Chapter 13 Recent developments in the synthesis of pyridine analogues as a potent anti-Alzheimer's therapeutic leads
13.1 Introduction
13.2 Role of pyridine in drug discovery
13.3 Pyridine analogues as Alzheimer's disease (AD) drug agents
13.4 Structure–activity relationship studies (SARs)
13.5 Clinical approaches
13.6 Summary
Acknowledgments
References
Chapter 14 Pyridine-based probes and chemosensors
14.1 Introduction
14.2 Pyridine-based colorimetric chemosensors
14.3 Pyridine-based fluorescent chemosensors
14.4 Pyridine-based dual-mode chemosensors
14.5 Conclusions and future prospects
Acknowledgments
Reference
Chapter 15 Recent advances in catalytic synthesis of pyridine derivatives
15.1 Introduction
15.2 Basic catalysts
15.3 Acidic catalysts
15.4 Ionic liquids and molten salts
15.5 Transition metal catalysis
15.6 Heterogeneous catalytic systems
15.7 Organocatalysis
15.8 Conclusion
Acknowledgments
References
Chapter 16 Pyridine as a potent antimicrobial agent and its recent discoveries
16.1 Introduction
16.2 Pyridine as antimicrobial agents
16.3 Pharmacophoric features
16.4 Conclusion
16.5 Authors contribution
References
Chapter 17 Synthesis of pyridine derivatives for diverse biological activity profiles: A review
17.1 Introduction
17.2 Synthetic strategy
17.3 Biological activity profiles
17.4 Conclusion
Acknowledgment
References
Index

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Recent Developments in the Synthesis and Applications of Pyridines

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