Recent Advances in the use of Drosophila in Neurobiology and Neurodegeneration

Seizure and Epilepsy: Studies of Seizure Disorders in Drosophila

I. Introduction

II. Seizure Studies in Drosophila

III. Genetic Suppression of Seizure Susceptibility in Drosophila

IV. Chemical Suppression of Seizure Susceptibility in Drosophila

V. Concluding Remarks. Seizure Studies in Flies: Insights From Mutant Analyses, and Comparisons With Human Seizures

Acknowledgments

Homeostatic Cont of Neural Activity: A Drosophila Model for Drug Tolerance and Dependence

I. Introduction

II. Behavioral Analysis of Rapid Drug Tolerance in Drosophila

III. BK Channels and the Production of Rapid Tolerance

IV. The Synaptic Connection

V. Closing Remarks

Acknowledgments

Attention in Drosophila

I. Introduction: the Problem of Attention in Nonhuman Animals

II. Classical Behavioral Approaches: Tethered Flight

III. Adaptations to Electrophysiology

IV. Related Behavioral Measures

V. Neural Substrates of Visual Attention in Drosophila

VI. Conclusion and Future Directions

The Roles of Fruitless and Doublesex in the Control of Male Courtship

I. Introduction

II. The Behavior

III. The Genes, the Neurons

Acknowledgment

Circadian Plasticity: From Structure to Behavior

I. Introduction

II. Transmitting Molecular Oscillations to Neuronal Networks

III. From Oscillating Networks to Coherent Circadian Behaviors

IV. Conclusions

Acknowledgments

Learning and Memory in Drosophila: Behavior, Genetics, and Neural Systems

I. Behavioral Measures of Learning and Memory in Drosophila

II. Neural Structures Implicated in Memory

III. Genetics of Olfactory Memory Formation

IV. Common and Specific Genetic Mechanisms in Olfactory, Visual, and Spatial Memory Formation

V. Conclusion

Acknowledgments

Studying Sensorimotor Processing With Physiology in Behaving Drosophila

I. Motivation

II. A Brief History of Physiology in the Adult Drosophila Brain

III. Physiology in Behaving Flies

IV. Results From Recording in Behaving Drosophila

V. Outlook for the Future

Acknowledgment

Modeling Human Trinucleotide Repeat Diseases in Drosophila

I. Introduction

II. Results

III. Conclusion

From Genetics to Structure to Function: Exploring Sleep in Drosophila

I. Introduction

II. Successful (and Less Successful) Screenings of Sleep Phenotypes in Flies

III. Identified Sleep Mutants Suggest a Link Between Sleep and Brain Plasticity, Especially in the Mushroom Bodies

IV. Distinct Circadian Neurons Promote Either Wake or Sleep

V. Fly Sleep and Hypotheses on Sleep Functions

VI. Closing Remarks

Acknowledgments