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Recent Advances in iPSCs for Therapy
- 1st Edition - January 30, 2021
- Editor: Alexander Birbrair
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 2 2 2 9 - 4
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 5 1 8 6 - 2
The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Recent Advances in… Read more
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Request a sales quoteThe series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Recent Advances in iPSCs for Therapy, Volume 3 addresses the use of induced pluripotent stem cells for therapy of several disorders.
The volume teaches the reader about the biology of induced pluripotent stem cells and their possible use as cell therapy. Remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues and organs using state-of-art techniques.
This volume will cover what we know so far about the use of iPSCs for therapy of multiple diseases, such as: hair loss disorders, Parkinson’s disease, Huntington’s disease, ischemic stroke, Alzheimer’s disease, Glaucoma, Optic Neuropathy, Age-Related Macular Degeneration, Type 1 Diabetes, Heart Failure, liver diseases, infertility, Autoimmune Diseases, and more.
The volume is written for researchers and scientists interested in cell therapy, stem cell biology, regenerative medicine, and organ transplantation and is contributed by world-renowned authors in the field.
- Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine, and therapeutics
- Covers the possible use of iPSCs for hair loss disorders, Parkinson’s disease, Huntington’s disease, ischemic stroke, Alzheimer’s disease, Glaucoma, Optic Neuropathy, Age-Related Macular Degeneration, Type 1 Diabetes, Heart Failure, liver diseases, infertility, Autoimmune Diseases, and more
- Contributions from stem cell leaders around the world
Researchers and scientists in stem cell therapy, cell biology, regenerative medicine, and organ transplantation. Graduate and undergraduate students in the above fields
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Contributors
- About the editor
- Preface
- Chapter 1. Strategies to utilize iPS cells for hair follicle regeneration and the treatment of hair loss disorders
- 1. Introduction
- 2. HF morphology and physiology
- 3. Experimental approaches to HF regeneration
- 4. Relationship between HF and iPSCs: the HF as a favorable iPSC material
- 5. Regeneration of human HFs using hiPSCs
- 6. Strategies for treating hair loss disorders using hiPSCs
- 7. Conclusion
- List of abbreviations
- Chapter 2. iPSCs and cell therapy for Parkinson’s disease
- 1. Introduction
- 2. PD as an established target for cell therapy
- 3. Developing a cell therapy approach for PD
- 4. Clinical factors
- 5. Toward clinical implementation of iPSC-based therapy for PD
- 6. Perspective
- Abbreviations
- Chapter 3. Induced pluripotent stem cells as a potential treatment for Huntington’s disease
- 1. Huntington’s disease
- 2. HTT gene and protein function
- 3. Epigenetics and HD
- 4. Signs and symptoms of HD
- 5. Stem cell therapy for HD
- 6. Induced pluripotent stem cells (iPSCs)
- 7. Stem cells–based HD clinical trials
- 8. Summary and conclusions
- Chapter 4. Present and future of adult stem cells and induced pluripotent stem cells therapy for ischemic stroke
- 1. Introduction
- 2. Protective and recovery approaches for ischemic stroke
- 3. Adult stem cells: NSCs and mesenchymal stem cells
- 4. Induced pluripotent stem cells: a multifaceted role in the study of neurological diseases
- 5. Conclusion and future perspectives
- Glossary
- Chapter 5. Stem cell therapy in Alzheimer’s disease
- 1. Introduction
- 2. Preclinical studies on the use of stem cells in dementias
- 3. Endogenous approach
- 4. Exogenous approach
- 5. Previous human experience with MSCs
- Chapter 6. Stem cell therapies for glaucoma and optic neuropathy
- 1. Introduction
- 2. Retinal cell fate specification
- 3. Retinal cell transplantation
- 4. iPSCs for modeling of familial glaucoma
- 5. Summary and future directions
- Chapter 7. Induced Pluripotent Stem Cells (iPSC) in Age-related Macular Degeneration (AMD)
- 1. Background
- 2. Cellular Therapies for AMD
- 3. Future Directions
- Chapter 8. Considerations in using human pluripotent stem cell–derived pancreatic beta cells to treat type 1 diabetes
- 1. Introduction
- 2. hPSC-based clinical trials
- 3. Considerations for hPSCs for clinical trials
- 4. hiPSC biobanking efforts
- 5. Generation of hPSCs
- 6. Manufacturing hPSC-derived pancreatic beta cells for cell therapy
- 7. hPSC-based therapy for type 1 diabetes
- 8. Future outlook and concluding thoughts
- Chapter 9. Induced pluripotent stem cells for treatment of heart failure
- 1. Introduction
- 2. Trend of cell therapy
- 3. Production of iPSCs and establishment of a cardiogenic differentiation method
- 4. Large-scale cell culture for cell transplantation therapy
- 5. Proof of concept in iPSC-CM sheet for heart failure and immunologic study of iPSCs
- 6. Removal of undifferentiated iPSCs to confirm safety for clinical applications
- 7. Development of new drug-based heart failure therapy using disease-specific iPSCs
- Chapter 10. Induced pluripotent stem cells in liver disease
- 1. Introduction
- 2. Generation of iPSCs and differentiation into hepatic phenotype
- 3. Use of iPSCs in liver disease
- 4. iPSC for modeling liver disease
- 5. Hepatotoxicity studies
- 6. Conclusions
- Abbreviations
- Chapter 11. Induced pluripotent stem cells: potential therapeutic application for improving fertility in humans and animals
- 1. Biology of iPSC in mammals
- 2. Stem cells as candidates for in vitro germ cell derivation
- 3. Potential strategies for the use of iPSC-derived germ cells in human, livestock, and wild animal reproductive biotechnology
- 4. Paracrine control and gene signaling pathways involved in in vivo male germ differentiation: potential approaches for in vitro derivation of germ cells from iPSC
- 5. In vitro approaches for derivation of germ cells from iPSCs
- 6. Conclusion
- Chapter 12. Induced pluripotent stem cells in wound healing
- 1. Introduction
- 2. Background
- 3. Stem cell therapy in wound healing
- 4. Induced pluripotent stem cells
- 5. Challenges and solutions of iPSC in wound healing
- 6. Conclusion
- 7. Future directions
- Chapter 13. Induced pluripotent stem cells for periodontal regeneration
- 1. Prevalence of periodontal diseases
- 2. Overview of pathogenesis of periodontitis
- 3. Current therapies for periodontitis and their limitations
- 4. Development of the dental complex
- 5. Stem cells and tissue regeneration
- 6. iPSCs in regenerative dentistry
- 7. Clinical application of iPSCs
- 8. Conclusions and perspective
- Chapter 14. Current development in iPSC-based therapy for autoimmune diseases
- 1. Introduction
- 2. Cellular components in autoimmunity
- 3. Treg cells in autoimmune disease
- 4. Dendritic cells (DCs) in autoimmune disease
- 5. Autoimmune disease
- 6. Diabetes mellitus
- 7. Rheumatoid arthritis (RA)
- 8. Multiple sclerosis (MS)
- 9. Conclusion and future challenges
- Index
- No. of pages: 368
- Language: English
- Edition: 1
- Published: January 30, 2021
- Imprint: Academic Press
- Paperback ISBN: 9780128222294
- eBook ISBN: 9780323851862
AB
Alexander Birbrair
Dr. Alexander Birbrair received his bachelor’s biomedical degree from Santa Cruz State University in Brazil. He completed his PhD in Neuroscience, in the field of stem cell biology, at the Wake Forest School of Medicine under the mentorship of Osvaldo Delbono. Then, he joined as a postdoc in stem cell biology at Paul Frenette’s laboratory at Albert Einstein School of Medicine in New York. In 2016, he was appointed faculty at Federal University of Minas Gerais in Brazil, where he started his own lab. His laboratory is interested in understanding how the cellular components of different tissues function and control disease progression. His group explores the roles of specific cell populations in the tissue microenvironment by using state-of-the-art techniques. His research is funded by the Serrapilheira Institute, CNPq, CAPES, and FAPEMIG. In 2018, Alexander was elected affiliate member of the Brazilian Academy of Sciences (ABC), and, in 2019, he was elected member of the Global Young Academy (GYA), and in 2021, he was elected affiliate member of The World Academy of Sciences (TWAS). He is the Founding Editor and Editor-in-Chief of Current Tissue Microenvironment Reports, and Associate Editor of Molecular Biotechnology. Alexander also serves in the editorial board of several other international journals: Stem Cell Reviews and Reports, Stem Cell Research, Stem Cells and Development, and Histology and Histopathology.
Affiliations and expertise
Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Department of Radiology, Columbia University Medical Center, Medical Center, USARead Recent Advances in iPSCs for Therapy on ScienceDirect