Recent Advancements in Microbial Diversity
Macrophages and their Role in Inflammation
- 1st Edition - March 17, 2022
- Imprint: Academic Press
- Editor: Jae Youl Cho
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 2 3 6 8 - 0
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 2 3 6 9 - 7
In recent years, researchers around the globe have deep dived into the fascination world of the Macrophage and its diverse role in tissue development, angiogenesis, and wound… Read more
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Request a sales quoteIn recent years, researchers around the globe have deep dived into the fascination world of the Macrophage and its diverse role in tissue development, angiogenesis, and wound healing, and above all the untapped mystery of the wondering immune system within our body. Macrophages and their role in inflammation includes all the latest information of macrophages and inflammation as well as it provides an in-depth understanding of this complex and rapidly progressing field of study.
- Outlines the role of macrophages in inflammation
- Contains chapters by leading authors on the basic and translational aspects of macrophage biology
- Deals with internal and external treats
Researchers in Bioscience at PhD and Post-doc levels. Established researchers looking for tools to improve their knowledge about the roles of Macrophages in Health and Disease
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- List of contributors
- Preface
- Acknowledgments
- Section 1: Biology
- Chapter 1. Introduction to macrophages
- Abstract
- 1.1 Macrophage and immunity; exploration of macrophage in immune system
- 1.2 Macrophages are versatile and plastic cells; diverse roles of macrophages
- 1.3 Origin of macrophages; hematopoiesis and their location in the body
- 1.4 Activation and polarization of macrophages; M1/M2 polarization
- References
- Chapter 2. Basic biology of macrophages
- Abstract
- 2.1 Introduction
- 2.2 Origin and development of macrophages
- 2.3 Differentiation of macrophages
- 2.4 Activation and polarization of macrophages
- 2.5 Conclusion
- References
- Section 2: Inflammation processes
- Chapter 3. Overview of inflammation
- Abstract
- 3.1 Introduction to inflammation
- 3.2 Causes of inflammation
- 3.3 Morphological patterns of inflammation
- 3.4 Mechanism of inflammation
- 3.5 Mediators of inflammation
- 3.6 Cell-derived mediators
- 3.7 Archidonic acid metabolites
- 3.8 Cytokines
- 3.9 Others
- 3.10 Plasma protein-derived mediators
- 3.11 Complement cascade
- 3.12 Factor XII (Hageman)
- 3.13 Antiinflammatory agents
- 3.14 Cancer and inflammation
- 3.15 Conclusion
- References
- Chapter 4. The role of macrophages in inflammation
- Abstract
- 4.1 Introduction
- 4.2 Development of macrophages
- 4.3 Role of macrophages in inflammation
- 4.4 Conclusion
- References
- Chapter 5. Molecular signaling of inflammatory responses in macrophages
- Abstract
- 5.1 Introduction
- 5.2 Molecular signaling of priming in macrophage-mediated inflammatory responses
- 5.3 Molecular signaling of triggering in macrophage-mediated inflammatory responses
- 5.4 Summary and perspectives
- References
- Chapter 6. Biomaterials modulate macrophage polarization and inflammatory responses
- Abstract
- 6.1 Introduction
- 6.2 Nanoparticle and macrophages
- 6.3 Nanofiber and macrophages
- 6.4 Hydrogel and macrophages
- 6.5 Conclusion
- References
- Section 3: Role of macrophages in systemic inflammation
- Chapter 7. Role of macrophages in tumor development
- Abstract
- 7.1 Introduction
- 7.2 Origin and recruitment of TAMs
- 7.3 Differentiation and polarization of TAMs
- 7.4 Derivatives of TAM proteins
- 7.5 Functions of TAMs
- 7.6 Mechanisms of TAMs in tumor development
- 7.7 Relationship between TAMs and tumor cells via paracrine signaling networks
- 7.8 TAMs as potential diagnostic biomarkers for cancer
- 7.9 TAMs as problem and prospect for cancer therapy
- 7.10 TAMs as cancer prognostic biomarkers
- 7.11 Conclusions
- References
- Chapter 8. Macrophages and their antitumor activity
- Abstract
- 8.1 Introduction
- 8.2 Macrophages in tumors
- 8.3 Macrophage-targeted cancer therapeutics
- 8.4 Conclusion
- References
- Chapter 9. Microglia and macrophages in central nervous systems
- Abstract
- 9.1 Introduction
- 9.2 Microglia and macrophages in healthy CNS
- 9.3 Microglia and macrophages in pathological CNS
- 9.4 Therapeutic approaches targeting macrophages and microglia in pathological CNS
- 9.5 Conclusion
- References
- Chapter 10. Adipose tissue
- Abstract
- 10.1 Introduction
- 10.2 Association between adipocytes and macrophages
- 10.3 Inflammation and related diseases in adipose
- 10.4 Pathology of NASH, NAFLD, and therapeutic targets
- 10.5 Conclusion
- References
- Chapter 11. Heart and circulatory system
- Abstract
- 11.1 Introduction
- 11.2 Heart
- 11.3 Structure of the heart
- 11.4 Physiology of the heart
- 11.5 Physiology of fluid movement
- 11.6 Problems of the heart and circulatory system
- 11.7 Lymphatic system
- 11.8 Cardiac macrophages
- 11.9 Summary
- 11.10 Websites
- References
- Chapter 12. Macrophage and cardiovascular diseases
- Abstract
- 12.1 Macrophage and cardiovascular disease
- 12.2 Macrophage classification
- 12.3 Macrophage and atherosclerosis
- 12.4 Macrophage and myocardial ischemia/reperfusion
- 12.5 Macrophage and diabetes mellitus
- 12.6 Conclusion
- References
- Chapter 13. Atherosclerosis
- Abstract
- 13.1 Introduction
- 13.2 Atherosclerosis and low-density lipoprotein
- 13.3 Atherosclerosis involves the activation of inflammatory cascades
- 13.4 Atherosclerosis, platelet aggregation,thrombosis and cardiovascular-related diseases
- 13.5 Upcoming trends of platelet activation and thrombosis
- 13.6 Paraclinical and clinical studies of atherosclerosis and macrophage regulation
- 13.7 Conclusion
- References
- Chapter 14. The pathophysiological role of macrophages in colitis and their treatment
- Abstract
- 14.1 Introduction
- 14.2 Functional roles and mechanisms of macrophage in the pathophysiology of colitis
- 14.3 Treatment of colitis targeting macrophage
- 14.4 Clinical evaluation
- 14.5 Conclusion
- References
- Chapter 15. Macrophages in respiratory system
- Abstract
- Graphical Abstract
- 15.1 Introduction
- 15.2 Types of respiratory tract macrophages
- 15.3 Origin of respiratory tract macrophages
- 15.4 Innate and acquired immunity by macrophages in respiratory tract
- 15.5 Macrophage against bacteria
- 15.6 Macrophage against viruses
- 15.7 Macrophages against fungi
- 15.8 Macrophage responses to inhaled particulate matter
- 15.9 Macrophage responses to particle size and chemical composition
- 15.10 Macrophage responses to other ambient chemicals
- 15.11 Macrophages in tissue damage control
- 15.12 Macrophage dysfunction in respiratory diseases
- References
- Chapter 16. Role of macrophages in systemic inflammation: wound healing
- Abstract
- 16.1 Introduction
- 16.2 Wound healing
- 16.3 Sequence of events in wound healing
- 16.4 Factor affecting wound healing
- 16.5 Myeloid lineage cells during different stages of skin healing
- 16.6 Role of macrophages in wound healing
- 16.7 Classification of macrophage
- 16.8 Macrophage phenotype markers: a mystery between in vitro and in vivo models
- 16.9 Macrophage dysregulation and chronic wound
- 16.10 The use of macrophages in clinical practices
- 16.11 Macrophage therapy in preclinical studies
- 16.12 Recent clinical research of macrophage therapy
- 16.13 The potential advantages and disadvantages of macrophage therapy in current research and their implications for the future
- 16.14 Conclusion
- References
- Chapter 17. Kupffer cells and liver
- Abstract
- 17.1 Introduction
- 17.2 The origin and polarization of KCs
- 17.3 The activation mechanisms of KCs
- 17.4 Role of KCs in the pathogenosis of liver diseases
- 17.5 The role of KCs in liver diseases
- 17.6 KCs in fatty liver disease
- 17.7 KCs in liver-ischemia-reperfusion injury
- 17.8 KCs in liver transplantation immunology
- 17.9 KCs in liver cancer and metastases
- 17.10 KCs-neutrophil interaction in host defense, immune tolerance and liver regeneration
- 17.11 Conclusion
- References
- Chapter 18. The role of macrophages in tuberculosis
- Abstract
- 18.1 Tuberculosis: a global burden
- 18.2 Historical perspective of tuberculosis
- 18.3 Tuberculosis chemotherapy and vaccination
- 18.4 Macrophages (MΦs) heterogeneity and plasticity
- 18.5 Entry of Mtb and strategies to survive
- 18.6 MΦs artillery and strategies
- 18.7 Mtb strains and MΦs
- 18.8 Summary of strategies of Mtb and the host
- 18.9 Conclusion
- References
- Section IV: Conclusions
- Chapter 19. The roles of macrophages in mediating the homeostatic process
- Abstract
- 19.1 Introduction
- 19.2 The roles of macrophages in tissue-specific homeostasis
- 19.3 Epigenetic determinants of macrophage regulation in tissue/host-defense homeostasis
- 19.4 Conclusion and future perspective
- References
- Index
- Edition: 1
- Published: March 17, 2022
- No. of pages (Paperback): 488
- No. of pages (eBook): 488
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780128223680
- eBook ISBN: 9780128223697
JC
Jae Youl Cho
Dr. Cho is a Professor at Sungkyunkwan University. His research areas are inflammatory and cancer signaling and development of anti-inflammatory and anti-cancer remedy from natural resources. His current research interests are to understand oncogene-related signaling cascade in cancer and inflammatory cells, and figure out the molecular mechanism of anti-inflammatory and anti-cancer actions of naturally-occurring components. He was working as an Editor-in-Chief of Journal of Ginseng Research (IF = 6.060) and is currently acting as a director of Research Institute of Biomolecule Control sponsored by National Research Foundation of Korea. He received B.Sc. and M.Sc. in Genetic Engineering from Sungkyunkwan University, in 1991 and 1993, and Ph.D. in Immunology and Molecular Pathology Department from University College London in 2001. After his Ph.D., he worked as a Postdoctoral fellow in Washington University in St. Louis for 2 years. Before his moving to Sungkyunkwan University, Dr. Cho was an assistant and associate professor of Kangwon National University for 8 years from 2003. He has published 500 peer-reviewed papers and 160 registered and applied patents.
Affiliations and expertise
Research Institute of Biomolecule Control
Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, Republic of KoreaRead Recent Advancements in Microbial Diversity on ScienceDirect