Recent Advancements in Microbial Diversity

Macrophages and their Role in Inflammation

1st Edition - March 17, 2022
Editor: Jae Youl Cho
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 2 3 6 8 - 0
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 2 3 6 9 - 7

In recent years, researchers around the globe have deep dived into the fascination world of the Macrophage and its diverse role in tissue development, angiogenesis, and wound… Read more

Recent Advancements in Microbial Diversity

Purchase options

LIMITED OFFER

Save 50% on book bundles

Immediately download your ebook while waiting for your print delivery. No promo code needed.

Institutional subscription on ScienceDirect

Request a sales quote

In recent years, researchers around the globe have deep dived into the fascination world of the Macrophage and its diverse role in tissue development, angiogenesis, and wound healing, and above all the untapped mystery of the wondering immune system within our body. Macrophages and their role in inflammation includes all the latest information of macrophages and inflammation as well as it provides an in-depth understanding of this complex and rapidly progressing field of study.

Cover image
Title page
Table of Contents
Copyright
Dedication
List of contributors
Preface
Acknowledgments
Section 1: Biology
Chapter 1. Introduction to macrophages
Abstract
1.1 Macrophage and immunity; exploration of macrophage in immune system
1.2 Macrophages are versatile and plastic cells; diverse roles of macrophages
1.3 Origin of macrophages; hematopoiesis and their location in the body
1.4 Activation and polarization of macrophages; M1/M2 polarization
References
Chapter 2. Basic biology of macrophages
Abstract
2.1 Introduction
2.2 Origin and development of macrophages
2.3 Differentiation of macrophages
2.4 Activation and polarization of macrophages
2.5 Conclusion
References
Section 2: Inflammation processes
Chapter 3. Overview of inflammation
Abstract
3.1 Introduction to inflammation
3.2 Causes of inflammation
3.3 Morphological patterns of inflammation
3.4 Mechanism of inflammation
3.5 Mediators of inflammation
3.6 Cell-derived mediators
3.7 Archidonic acid metabolites
3.8 Cytokines
3.9 Others
3.10 Plasma protein-derived mediators
3.11 Complement cascade
3.12 Factor XII (Hageman)
3.13 Antiinflammatory agents
3.14 Cancer and inflammation
3.15 Conclusion
References
Chapter 4. The role of macrophages in inflammation
Abstract
4.1 Introduction
4.2 Development of macrophages
4.3 Role of macrophages in inflammation
4.4 Conclusion
References
Chapter 5. Molecular signaling of inflammatory responses in macrophages
Abstract
5.1 Introduction
5.2 Molecular signaling of priming in macrophage-mediated inflammatory responses
5.3 Molecular signaling of triggering in macrophage-mediated inflammatory responses
5.4 Summary and perspectives
References
Chapter 6. Biomaterials modulate macrophage polarization and inflammatory responses
Abstract
6.1 Introduction
6.2 Nanoparticle and macrophages
6.3 Nanofiber and macrophages
6.4 Hydrogel and macrophages
6.5 Conclusion
References
Section 3: Role of macrophages in systemic inflammation
Chapter 7. Role of macrophages in tumor development
Abstract
7.1 Introduction
7.2 Origin and recruitment of TAMs
7.3 Differentiation and polarization of TAMs
7.4 Derivatives of TAM proteins
7.5 Functions of TAMs
7.6 Mechanisms of TAMs in tumor development
7.7 Relationship between TAMs and tumor cells via paracrine signaling networks
7.8 TAMs as potential diagnostic biomarkers for cancer
7.9 TAMs as problem and prospect for cancer therapy
7.10 TAMs as cancer prognostic biomarkers
7.11 Conclusions
References
Chapter 8. Macrophages and their antitumor activity
Abstract
8.1 Introduction
8.2 Macrophages in tumors
8.3 Macrophage-targeted cancer therapeutics
8.4 Conclusion
References
Chapter 9. Microglia and macrophages in central nervous systems
Abstract
9.1 Introduction
9.2 Microglia and macrophages in healthy CNS
9.3 Microglia and macrophages in pathological CNS
9.4 Therapeutic approaches targeting macrophages and microglia in pathological CNS
9.5 Conclusion
References
Chapter 10. Adipose tissue
Abstract
10.1 Introduction
10.2 Association between adipocytes and macrophages
10.3 Inflammation and related diseases in adipose
10.4 Pathology of NASH, NAFLD, and therapeutic targets
10.5 Conclusion
References
Chapter 11. Heart and circulatory system
Abstract
11.1 Introduction
11.2 Heart
11.3 Structure of the heart
11.4 Physiology of the heart
11.5 Physiology of fluid movement
11.6 Problems of the heart and circulatory system
11.7 Lymphatic system
11.8 Cardiac macrophages
11.9 Summary
11.10 Websites
References
Chapter 12. Macrophage and cardiovascular diseases
Abstract
12.1 Macrophage and cardiovascular disease
12.2 Macrophage classification
12.3 Macrophage and atherosclerosis
12.4 Macrophage and myocardial ischemia/reperfusion
12.5 Macrophage and diabetes mellitus
12.6 Conclusion
References
Chapter 13. Atherosclerosis
Abstract
13.1 Introduction
13.2 Atherosclerosis and low-density lipoprotein
13.3 Atherosclerosis involves the activation of inflammatory cascades
13.4 Atherosclerosis, platelet aggregation,thrombosis and cardiovascular-related diseases
13.5 Upcoming trends of platelet activation and thrombosis
13.6 Paraclinical and clinical studies of atherosclerosis and macrophage regulation
13.7 Conclusion
References
Chapter 14. The pathophysiological role of macrophages in colitis and their treatment
Abstract
14.1 Introduction
14.2 Functional roles and mechanisms of macrophage in the pathophysiology of colitis
14.3 Treatment of colitis targeting macrophage
14.4 Clinical evaluation
14.5 Conclusion
References
Chapter 15. Macrophages in respiratory system
Abstract
Graphical Abstract
15.1 Introduction
15.2 Types of respiratory tract macrophages
15.3 Origin of respiratory tract macrophages
15.4 Innate and acquired immunity by macrophages in respiratory tract
15.5 Macrophage against bacteria
15.6 Macrophage against viruses
15.7 Macrophages against fungi
15.8 Macrophage responses to inhaled particulate matter
15.9 Macrophage responses to particle size and chemical composition
15.10 Macrophage responses to other ambient chemicals
15.11 Macrophages in tissue damage control
15.12 Macrophage dysfunction in respiratory diseases
References
Chapter 16. Role of macrophages in systemic inflammation: wound healing
Abstract
16.1 Introduction
16.2 Wound healing
16.3 Sequence of events in wound healing
16.4 Factor affecting wound healing
16.5 Myeloid lineage cells during different stages of skin healing
16.6 Role of macrophages in wound healing
16.7 Classification of macrophage
16.8 Macrophage phenotype markers: a mystery between in vitro and in vivo models
16.9 Macrophage dysregulation and chronic wound
16.10 The use of macrophages in clinical practices
16.11 Macrophage therapy in preclinical studies
16.12 Recent clinical research of macrophage therapy
16.13 The potential advantages and disadvantages of macrophage therapy in current research and their implications for the future
16.14 Conclusion
References
Chapter 17. Kupffer cells and liver
Abstract
17.1 Introduction
17.2 The origin and polarization of KCs
17.3 The activation mechanisms of KCs
17.4 Role of KCs in the pathogenosis of liver diseases
17.5 The role of KCs in liver diseases
17.6 KCs in fatty liver disease
17.7 KCs in liver-ischemia-reperfusion injury
17.8 KCs in liver transplantation immunology
17.9 KCs in liver cancer and metastases
17.10 KCs-neutrophil interaction in host defense, immune tolerance and liver regeneration
17.11 Conclusion
References
Chapter 18. The role of macrophages in tuberculosis
Abstract
18.1 Tuberculosis: a global burden
18.2 Historical perspective of tuberculosis
18.3 Tuberculosis chemotherapy and vaccination
18.4 Macrophages (MΦs) heterogeneity and plasticity
18.5 Entry of Mtb and strategies to survive
18.6 MΦs artillery and strategies
18.7 Mtb strains and MΦs
18.8 Summary of strategies of Mtb and the host
18.9 Conclusion
References
Section IV: Conclusions
Chapter 19. The roles of macrophages in mediating the homeostatic process
Abstract
19.1 Introduction
19.2 The roles of macrophages in tissue-specific homeostasis
19.3 Epigenetic determinants of macrophage regulation in tissue/host-defense homeostasis
19.4 Conclusion and future perspective
References
Index

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Recent Advancements in Microbial Diversity

Macrophages and their Role in Inflammation

Purchase options

Save 50% on book bundles

Institutional subscription on ScienceDirect

Jae Youl Cho