1. Perspectives and overview (P. Politzer, J.S. Murray). 2. Development and biological applications of quantum mechanical continuum solvation models (C.J. Cramer, D.G. Truhlar). 3. Some effects of molecular structure on hydrogen-bonding interactions. Some macroscopic and microscopic views from experimental and theoretical results (R.W. Taft, J.S. Murray). 4. New solute descriptors for linear free energy relationships and quantitative structure-activity relationships (M.H. Abraham). 5. Hydrogen bonding in the gas phase and in solution. New experimental developments (J.-L.M. Abboud, R. Notario, V. Botella). 6. Solvent acidity and basicity in polar media and their role in solvation (W.R. Fawcett). 7. Using theoretical descriptors in linear solvation energy relationships (G.R. Famini, L.Y. Wilson). 8. A general interaction properties function (GIPF): An approach to understanding and predicting molecular interactions (J.S. Murray, P. Politzer). 9. Estimation of chemical reactivity and parameters and physical properties of organic molecules using SPARC (S.H. Hilal, A. Carreira, S.W. Karikhoff). Index.