Quantitative Structure-Activity Relationships of Drugs

1st Edition - January 28, 1983

Editor: John Topliss

eBook ISBN:

9 7 8 - 0 - 3 2 3 - 1 4 6 8 7 - 6

Medicinal Chemistry, Volume 19: Quantitative Structure-Activity Relationships of Drugs is a critical review of the applications of various quantitative structure-activity… Read more

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Medicinal Chemistry, Volume 19: Quantitative Structure-Activity Relationships of Drugs is a critical review of the applications of various quantitative structure-activity relationship (QSAR) methodologies in different drug therapeutic areas and discusses the results in terms of their contribution to medicinal chemistry. After briefly describing the developments in QSAR research, this 12-chapter volume goes on discussing the contributions of QSAR methodology in elucidating drug action and rational development of drugs against bacterial, fungal, viral, and other parasitic infections of man. Other chapters explore the mode of action and QSAR of antitumor, cardiovascular, antiallergic, antiulcer, antiarthritic, and nonsteroidal antiinflammatory drugs (NSAID) agents. The discussion then shifts to the pharmacologic effects and QSAR analysis of central nervous system agents, steroids, and other hormones. A chapter examines the major chemicals affecting insects and mites, with particular emphasis on the parameters of binding correlation and reactivity for insect and mite enzymes. The concluding chapters cover the limitations of the QSAR approach in the quantitative treatment of drug absorption, distribution, and metabolism. This volume is of great value to medicinal chemists, scientists, and researchers.

Contributors

Preface

1. Introduction: A Review of QSAR Methodology

I. Introduction

II. Free Energy Models

III. Free-Wilson Mathematical Model

IV. Other Statistical Models

V. Pattern Recognition

VI. Topological Methods

VII. Experimental Design

VIII. Quantum Mechanical Methods

IX. Molecular Modeling

X. Conclusion

References

2. Synthetic Antiinfective Agents

I. Introduction

II. Antimicrobial Activity and Membrane Damage

III. Antibacterial Drugs

IV. Antifungal Drugs

V. Antimalarial Drugs

VI. Schistosomicidal Drugs

VII. Trichomonicidal Drugs

VIII. Antiviral Drugs

IX. Overview

References

3. Semisynthetic Antibiotics

I. Introduction

II. Inhibitors of Bacterial Protein Synthesis

III. Inhibitors of Nucleic Acid Synthesis

IV. Inhibitors of Cell Wall Biosynthesis: β-Lactam Antibiotics

V. Analysis of Several Cases

VI. Commentary on the Contribution of QSAR to the Study of Antibiotics

References

4. Antitumor Agents

I. Introduction

II. Quantitative Structure-Activity Relationships of Antitumor Compounds

III. Conclusion

References

5. Cardiovascular Agents

I. Introduction

II. Antianginal Agents

III. Antihypertensives

IV. Antiarrhythmics

V. Inotropic Agents

VI. Concluding Remarks

References

6. Antiallergic and Antiulcer Agents

I. Introduction

II. Histamine

III. Prostaglandins

IV. β-Adrenergic Agents

V. Regulatory Peptides

VI. Inhibitors of the Passive Cutaneous Anaphylactic (PCA) Response

VII. Miscellaneous Studies

VIII. Conclusion

References

7. Nonsteroidal Antiinflammatory and Antiarthritic Drugs

I. Introduction

II. Measuring Antiinflammatory Activity

III. Salicylates

IV. Phenols

V. Anthranilic Acids

VI. Enolic Compounds

VII. Carboxylic Acids

VIII. Conformational Studies of Aralkanoic Acids

IX. Miscellaneous Structures

X. Immunoregulant Agents

XI. Summary

References

8. Agents Affecting the Central Nervous System

I. Introduction

II. Analgesics

III. General Inhalation Anesthetics

IV. Antidepressants

V. Convulsants and Anticonvulsants

VI. Neuroleptics

VII. Psychotomimetics

VIII. Overview

References

9. Steroids and Other Hormones

I. Introduction and Scope

II. Steroids

III. Thyroid Hormones

IV. Peptide Hormones

V. Summary

References

10. Chemicals Affecting Insects and Mites

I. Introduction

II. Chemicals Affecting Insects and Mites

III. Summary

References

11. Absorption, Distribution, and Metabolism of Drugs

I. The Significance of Quantitative Relationships between Structure and Pharmacokinetic Properties of Chemical Compounds

II. Quantitative Relationships between Chemical Structure and Pharmacokinetic Properties

III. Conclusions

References

12. Commentary

Index