Quantitative Biology introduces and implements quantitative and data-driven approaches for analyzing biological and bio-inspired systems, covering the foundations of mathematical modeling, analysis, and computation. The book presents a practical mix of both theory and computation for a variety of biological applications, with tied-in, engaging project activities, instruction, programming language, and technological tools. Modeling approaches in the book combine mathematical foundations, statistical reasoning, and computational thinking, with application in compartmental, agent-based, bio image, biological interaction, and neural network modeling, as well as machine learning, parameter identification, and more, with a later chapter considering applications across societal challenges. Each chapter includes exposure to models and modeling, a foundational instructional framework, benchmark applications, and numerical simulations with a literate programming guided style, helping readers go beyond replication models and into prediction and data-driven discovery. A companion website also features interactive code to accompany projects across each chapter.