Proteins: Form and Function

Protein Primary Structure. Highlights of protein structural analysis (J.E. Shively, R.J. Pacton and T.D. Lee). Micro-level protein and peptide separations (K.J. Wilson). Site-directed mutagenesis and protein engineering (M. Smith). From analysis to synthesis: new ligand binding sites on the lactate dehydrogenase framework (A.R. Clarke, T. Atkinson and J.J. Holbrook). Subtilisin: an enzyme designed to be engineered (J.A. Wells and D.A. Estell). &Bgr;-galactoside transport in E. coli: functional dissection of lac permease (H.R. Kaback, E. Bibi and P.D. Roepe). Similar amino acid sequences revisited (R.F. Doolittle). Protein Conformation. Protein crystallagraphy: more surprises ahead (D. Eisenberg and C. Hill). Catalysis in enzyme crystals (J. Hadju et al). What can two-dimensional NMRT tell us about proteins? (P.E. Wright). Chiroptical methods in protein analysis (G. Snatzke). Protein conformational prediction (G.D. Fasman). Membrane protein models: possibilities and probabilities (M. Engelman and J. Popot). From comparisons of protein sequences and structures to protein modelling and design (A. Sali, J.P. Overington, M.S. Johnson and T.L. Blundell). Protein motifs and data-base searching (J.M. Thornton and S.P. Gardner). The de novo design of protein structures (J.S. Richardson and D.C. Richardson). Conformational stability of globular proteins (C.N. Pace). How does protein folding get started? (R.L. Baldwin). Co- and Post-Translational Modifications. Protein translocation and turnover in eukaryotic cells (R.A. Bradshaw). Post-translational modification of proteins: some problems left to solve (S.C.B. Yan, B.W. Grinnell and F. Wold). Proteolytic processing and physiological regulation (H. Neurath). Glycoproteins: what are the sugar chains for? (J.C. Paulson). Nuclear and cytoplasmic glycosylation: novel saccharide linkages in unexpected places (G.W. Hart et al.). Molecular Recognition. Secretion and membrane assembly (W. Wickner). A novel pathway for secretory proteins? (A. Muesch and T. Rapoport et al). The regulation of protein polymerization (C. Frieden). Structural basis of DNA-protein recognition (R.G. Brennan and B.W. Matthews). Helix-turn-helix, zinc-finger and leucine-zipper motifs for eukaryotic transcriptional regulatory proteins (K. Struhl).