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Protein Modificomics
From Modifications to Clinical Perspectives
- 1st Edition - May 18, 2019
- Editors: Tanveer Ali Dar, Laishram Rajendrakumar Singh
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 1 1 9 1 3 - 6
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 1 1 9 5 0 - 1
Protein Modificomics: From Modifications to Clinical Perspectives comprehensively deals with all of the most recent aspects of post-translational modification (PTM) of proteins,… Read more
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Request a sales quoteProtein Modificomics: From Modifications to Clinical Perspectives comprehensively deals with all of the most recent aspects of post-translational modification (PTM) of proteins, including discussions on diseases involving PTMs, such as Alzheimer’s, Huntington’s, X-linked spinal muscular atrophy-2, aneurysmal bone cyst, angelman syndrome and OFC10. The book also discusses the role PTMs play in plant physiology and the production of medicinally important primary and secondary metabolites. The understanding of PTMs in plants helps us enhance the production of these metabolites without greatly altering the genome, providing robust eukaryotic systems for the production and isolation of desired products without considerable downstream and isolation processes.
- Provides thorough insights into the post translational modifications (PTMs) of proteins in both the plant and animal kingdom
- Presents diagrammatic representations of various protein modification and estimation mechanisms in four-color
- Includes coverage of diseases involving post translational modifications
Researchers in protein/proteomics field
1. Emerging roles of posttranslational modifications in biological processes and their implications in associated diseases
Irfan-Ur-Rauf Tak, Fasil Ali, Jehangir Shafi Dar, Aqib Rehman Magray, Bashir A. Ganai, M.Z. Chishti
2. Clinical perspective of posttranslational modifications
Iram Ashaq Kawa, Akbar Masood, Shajrul Amin, Mir Faisal Mustafa, Fouzia Rashid
3. Phosphorylation and acetylation of proteins as posttranslational modification: implications in human health and associated diseases
Sana Quasain, Hemalatha Srinivasan, Shazia Jamal, Mohammad Nasiruddin, Md. Khurshid Alam Khan
4. Protein modifications and lifestyle disorders
Shivani Arora, Anju Katyal
5. Ubiquitin mediated posttranslational modification of proteins involved in various signaling diseases
V. Lavanyav, Shazia Jamal, Neesar Ahmed
6. Improving pharmacological efficacy of protein pharmaceuticals by glycosylation
Parvaiz Ahmad Dar, Usma Manzoor, Snowber Shabir Wani, Fasil Ali, Tanveer Ali Dar
7. Posttranslational modification in human therapeutics heterologously produced in plant host expression systems
Ayyagari Archana, Lakshna Mahajan, Safikur Rahman, Rinki Minakshi
8. Protein modification in plants in response to abiotic stress
Hilal Ahmad Qazi, Nelofer Jan, Salika Ramazan, Riffat John
9. Posttranslational modifications associated with cancer and their therapeutic implications
Aniket Kumar Bansal, Laishram Rajendrakumar Singh, Majid R. Kamli
10. Nonenzymatic posttranslational protein modifications: mechanisms and associated disease pathologies
Sheeza Khan, Ajaz A. Bhat
11. Protein covalent modification by homocysteine: consequences and clinical implications
Gurumayum Suraj Sharma, Reshmee Bhattacharya, Laishram Rajendrakumar Singh
12. Posttranslational modifications in algae: role in stress response and biopharmaceutical production
Parvez Ahmad, Fareha Bano
13. Protein glycosylation: an important tool in diagnosis or early detection of diseases
Humayra Bashir, Barqul Afaq Wani, Bashir A. Ganai, Shabir Ahmad Mir
- No. of pages: 387
- Language: English
- Edition: 1
- Published: May 18, 2019
- Imprint: Academic Press
- Paperback ISBN: 9780128119136
- eBook ISBN: 9780128119501
TD
Tanveer Ali Dar
Dr. Tanveer Ali Dar, affiliated with University of Kashmir, stands as a pioneer in the dynamic and evolving field of osmolyte-protein biology. Holding advanced degrees in his field, Dr. Dar has dedicated his career to advancing scientific knowledge and innovation in osmolyte research. Utilizing a multidisciplinary approach that combines biochemical, biophysical, and molecular biology techniques, Dr. Dar explores the dynamic interplay between osmolytes and proteins at the molecular level. His research sheds light on how osmolytes modulate protein structure and dynamics, enabling cells to adapt and thrive under stressful conditions such as osmotic stress, temperature fluctuations, and disease states. He has to his credit several breakthrough contributions in the area of exploring the osmolyte induced structural-functional integrity of proteins and their implications in protein misfolding disease interventions. Besides focusing on several aspects of osmolyte research, his research particularly emphasizes on understanding the roles of osmolytes and intrinsically disordered proteins in cellular function and disease pathogenesis. His pioneering investigations have shed light on the dynamic interplay between these molecular entities, unraveling fundamental mechanisms underlying cellular resilience and disease progression. Dr. Dar is recognized for his contributions to both theoretical understanding and practical applications in the osmolyte-field, and his work has been published in numerous peer-reviewed international journals. Moreover, he has to his credit a couple of books published by Springer International Ltd., Apple academic Press and Elsevier, USA. Dr. Dar is also a recipient of Indian National Science Academy visiting fellowship and is a member of various international and national scientific societies like ASBMB, Canadian Society of Molecular Biosciences, National Academy of Sciences India, India Biophysical society etc. He is a prolific reviewer, editor and editorial board member of a number of prestigious journals. As an educator, he is committed to nurturing the next generation of scientists, mentoring students and guiding them towards excellence in research.
Affiliations and expertise
Associate Professor, Department of Clinical Biochemistry, University of Kashmir, Srinagar, Jammu and Kashmir, India.LS
Laishram Rajendrakumar Singh
Prof. Laishram R. Singh is a pioneer in the field of osmolyte research. He has made several landmark contributions in understanding protein folding mechanism by osmolytes and harnessing the basic knowledge in designing strategies for the therapeutic intervention of human diseases caused by protein folding defects. He obtained his doctoral degree (in the year 2006) from Jamia Millia Islamia, New Delhi from where he begins his research on osmoprotectants, unveiling their role in protein folding landscape and thermodynamics of protein folding. He then expanded his expertise during his postdoctoral studies at Fox Chase Cancer Cancer, Philadelphia by employing these molecules for restoring functions to disease causing mutant proteins related to homocystinuria. Nowadays, metabolomic studies has further expanded the repertoire of osmolytic molecules that are upregulated or downregulated under various disease conditions including neurodegenerative diseases. Presently, at the University of Delhi, he is engaged on identifying specific brain osmolytes that could regulate the functional activity of acetylcholinesterase and carbonic anhydrase (important target enzymes of Dementia). He is also interested in using these osmolytes to correct folding defects of some of the folding deficient brain proteins including, Aβ, α-synuclein, transthyretin whose toxic inclusions are the emblematic signatures of Dementia. He has published more than 85 articles related to the avenue “osmolyte research” in various journals of high international repute. He is a prolific reviewer, guest editors, and is in the editorial board members of prestigious journals.
Affiliations and expertise
Professor, Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi, New Delhi, India.Read Protein Modificomics on ScienceDirect