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Principles of Regenerative Medicine

  • 2nd Edition - December 7, 2010
  • Editors: Anthony Atala, Robert Lanza, James A. Thomson, Robert Nerem
  • Language: English

Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the… Read more

Description

Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure.

Key features

  • Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology
  • The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine
  • New discoveries from leading researchers on restoration of diseased tissues and organs

Readership

Advanced researchers in bioengineering, stem cell biology, and developmental biology.

Table of contents

1 Molecular Organization of Cells

2 Cell-ECM interactions In Repair and Regeneration

3 Developmental Mechanisms of Regeneration

4 The molecular basis of pluripotency in Principles of Regenerative Medicine

5 How cells change their phenotype

6 Scarless Wound Healing

7 Somatic Cloning and Epigenetic Reprogramming in Mammals

8 Engineered Proteins for Manipulating Gene Expression and Genome Sequence

9 Genetic Approaches in Human Embryonic Stem Cells and Their Derivatives

10 Embryonic Stem Cells: Derivation and Properties

11 Alternate Sources of human embryonic stem cells

12 Stem cells derived from amniotic fluid and placenta

13 Induced Pluripotent stem cells

14 Mesenchymal Stem cells Derived from Bone Marrow

15 Multipotent adult progenitor cells

16 Mesenchymal Stem cells

17 Hepatic Stem Cells and Therapy

18 Cardiac stem cells

19 Skeletal muscle stem cells

20 Stem Cells Derived from Fat

21 Stem Cells Derived from Peripheral Blood

22 Islet Cell Therapy and Pancreatic Stem Cells

23 Regenerative Medicine for Diseases of the Retina

24 Somatic cells: Growth and expansion potential of T Lymphocytes

25 Mechanical Determinants of Tissue Development

26 Morphogenesis and Morphogenic Proteins

27 Physical stress as a factor in tissue growth and remodeling

28 Intelligent Surfaces for Cell Sheet Engineering

29 Applications of Nanotechnology in Regenerative Medicine

30 Design Principles in Biomaterials and Scaffolds

31 Natural Origin Materials- Processing, Modification and Performance

32 Synthetic Polymers

33 Collagen Based Scaffold Materials

34 Hydrogels

35 Surface Modification of Biomaterials

36 Histogenesis in Three-Dimensional Scaffolds

37 Biocompatibility and Bioresponse to biomaterials

38 Mechano-inducible systems for stem cells

39 Biomineralization and Bone Regeneration

40 Cell therapy for blood substitutes

41 Articular Cartilage

42 Implantation of Myogenic Cells in Skeletal Muscles

43 Clinical islet transplantation

44 Fetal Tissues

45 Engineering of Large Diameter Vessels

46 Engineering of Small Diameter Vessels

47 Cardiac Tissue

48 Regenerative Medicine in the Cornea

49 Alimentary Tract

50 Extracorporeal Kidney Support

51 Tissue Engineering of the Reproductive System

52 Cartilage Tissue Engineering

53 Functional Tissue Engineering of Ligament and Tendon Injuries

54 Central Nervous System

55 Peripheral Nervous System

56 Tissue Engineeing of Skin

57 Tissue Engineering of the Respiratory Tree

58 Ethical Considerations

59 US Stem Cell Research Policy

60 Overview of FDA Regulatory Process

Product details

About the editors

AA

Anthony Atala

Anthony Atala, M.D., is the Director of the Wake Forest Institute for Regenerative Medicine, and the W.H. Boyce Professor and Chair of the Department of Urology at Wake Forest University. Dr. Atala is a practicing surgeon and a researcher in the area of regenerative medicine. His current work focuses on growing new human cells, tissues and organs.

Dr. Atala works with several journals and serves in various roles, including Editor-in-Chief of Current Stem Cell Research and Therapy, and Therapeutic Advances in Urology; as Associate Editor of the Journal of Tissue Engineering and Regenerative Medicine, The Journal of Rejuvenation Research, Nanotechnology in Engineering and Medicine, Gene Therapy and Regulation, and Current Reviews in Urology; as Executive Board Member or Section Editor of the journal Tissue Engineering and International Journal of Artificial Organs, and as Editorial Board member of the International Journal of Stem Cells, Stem Cell Review Letters, Expert Opinion on Biological Therapy, Biomedical Materials, Recent Patents on Regenerative Medicine, the Journal of the American College of Surgeons, the Journal of Urology, BMC Urology, Urology, and Current Opinion in Urology.

Dr. Atala is a recipient of the US Congress funded Christopher Columbus Foundation Award, bestowed on a living American who is currently working on a discovery that will significantly affect society, and the Gold Cystoscope Award for advances in his field. Dr. Atala was named by Scientific American as a Medical Treatments Leader of the Year for his contributions to the fields of cell, tissue and organ regeneration. In 2006, he was named by Fast Company magazine as one of 50 people who “will change how we work and live over the next 10 years. Dr. Atala’s work was listed as Discover Magazine`s Number 1 Top Science Story of the Year in the field of medicine, and as Time Magazine’s top 10 medical breakthroughs of the year in 2007. A Time Magazine poll ranked Dr. Atala as the 56th most influential person of the year in 2007. Esquire Magazine in 2008 named Dr. Atala one of the 75 most influential persons of the 21st century. Fast Company Magazine named Dr. Atala one of 100 Most Creative People in Business in 2009. Dr. Atala was featured in U.S. News & World Report as one of “14 Medical Pioneers Who Aren’t Holding Back.”

Dr. Atala has led or served several national professional and government committees, including the National Institutes of Health working group on Cells and Developmental Biology, and the National Institutes of Health Bioengineering Consortium. He is currently an NIH “Quantum Grant” awardee. Dr. Atala heads a team of over 250 physicians and researchers. Ten applications of technologies developed in Dr. Atala's laboratory have been used clinically. He is the editor of nine books, including Minimally Invasive Urology, Methods of Tissue Engineering, Principles of Regenerative Medicine, and Foundations of Regenerative Medicine, and has published more than 300 journal articles and has applied for or received over 200 national and international patents.

Affiliations and expertise
Director, Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA

RL

Robert Lanza

Robert Lanza is an American scientist and author whose research spans the range of natural science, from biology to theoretical physics. TIME magazine recognized him as one of the “100 Most Influential People in the World,” and Prospect magazine named him one of the Top 50 “World Thinkers.” He has hundreds of scientific publications and over 30 books, including definitive references in the fields of stem cells, tissue engineering, and regenerative medicine. He’s a former Fulbright Scholar and studied with polio-pioneer Jonas Salk and Nobel laureates Gerald Edelman (known for his work on the biological basis of consciousness) and Rodney Porter. He also worked closely (and co-authored papers in Science on self-awareness and symbolic communication) with noted Harvard psychologist BF Skinner. Dr. Lanza was part of the team that cloned the world’s first human embryo, the first endangered species, and published the first-ever reports of pluripotent stem cell use in humans.
Affiliations and expertise
Astellas Institute for Regenerative Medicine, Westborough, MA, USA

JT

James A. Thomson

Affiliations and expertise
Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, USA

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