Principles of Multiple-Liquid Separation Systems

Interaction, Application and Advancement

1st Edition - January 12, 2023
Imprint: Elsevier
Editors: Kit Wayne Chew, Shir Reen Chia, Pau Loke Show
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 7 2 8 - 5
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 8 6 4 6 - 5

Principles of Multiple-Liquid Separation Systems: Interaction, Application and Advancement describes the basic principles and advancements of multiple-liquid separation system… Read more

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Principles of Multiple-Liquid Separation Systems: Interaction, Application and Advancement describes the basic principles and advancements of multiple-liquid separation systems in downstream processing. Several important elements are included, such as the fundamental process and mechanisms of the multiple-liquid separation system, key principles of the interaction between different solvents and phase components, applications, and green solvents for the separation system. Furthermore, the book gives insights in commercializing this separation technique to industrial scale and making the process environmentally and economically sustainable. The book also presents constructive critics of this separation technique for both past and the latest findings.

Cover Image
Title Page
Copyright
Table of Contents
Contributors
Chapter 1 Polymer–polymer interaction
1.1 Introduction
1.2 Phase diagram
1.3 Parameters influencing phase diagram
1.4 Application of aqueous two-phase system
1.5 Genetic materials
1.6 Future perspective
1.7 Conclusion
References
Chapter 2 Polymer–salt interaction
2.1 Introduction
2.2 Mechanism and working principles
2.3 Key process parameters
2.4 Applications
2.5 Limitation and future challenges
Conclusion
References
Chapter 3 Alcohol–salt interaction
3.1 Introduction
3.2 Background and basic principle of alcohol/salt-based liquid biphasic system
3.3 Influence of key parameters
3.4 Applications of alcohol/salt-based LBS
3.5 Limitations and advancements to the alcohol/salt-based liquid biphasic system
3.6 Conclusions
References
Chapter 4 Sugar-based deep eutectic solvent-aqueous two-phase system
4.1 Introduction
4.2 Sugar-based deep eutectic solvent
4.3 Sugar-based deep eutectic solvent-aqueous two-phase system
4.4 Effect of parameters
4.5 Application of sugar-based deep eutectic solvent-aqueous two-phase system
4.6 Advancement of sugar-based deep eutectic solvent-aqueous two-phase system over the last 5 years
4.7 Recycling of sugar-based deep eutectic solvent
4.8 Conclusions
References
Chapter 5 Ionic liquid–salt interaction
5.1 Introduction
5.2 Fundamentals of ionic liquid–salt: thermodynamic and properties
5.3 Determination of solution concentration in both phases
5.4 Factors that influence the two-phase separation in ionic liquid/salt ATPS
5.5 Applications of Ionic liquid/salt ATPS
5.6 Conclusion
References
Chapter 6 T-butanol–salt three-phase interaction
6.1 Introduction
6.2 Process description
6.3 Principle of three-phase partitioning
6.4 Application of three-phase systems
6.5 Future perspectives and challenges
6.6 Conclusion
References
Chapter 7 Green solvents for multiphase systems
7.1 Introduction
7.2 Green extraction solvents, principles, and reasons for its use
7.3 Increase of usage and future trend
7.4 Economical factor
7.5 Conclusion
References
Chapter 8 Recyclability and reusability of the solvents
8.1 Introduction
8.2 Solvents for bioseparation
8.3 Benefits of recycling solvents
8.4 Requirements on solvent recycling
8.5 Solvent recycling
8.6 Methods for solvent recovery and recycling
8.7 Feasibility of solvent recovery process
References
Chapter 9 Conventional designs for multiphase liquid separation
9.1 Introduction
9.2 Principles of three-phase partitioning
9.3 Variables that affect TPP
9.4 Types of assisted TPP
9.5 Applications of TPP
9.6 Future prospects
9.7 Conclusion
References
Chapter 10 Advancement in system designs for multiphase liquid separation
10.1 Introduction
10.2 Liquid biphasic system
10.3 Liquid biphasic flotation
10.4 Ultrasound-assisted liquid biphasic system
10.5 Magnetic-assisted liquid biphasic system
10.6 Electricity-assisted liquid biphasic system
10.7 Microwave-assisted liquid biphasic system
10.8 Future prospects
References
Chapter 11 Economical sustainability of multiphase systems
11.1 Economic sustainability
11.2 Advantages of liquid–liquid separation over conventional method
11.3 Three-phase interactions
11.4 Costing in liquid separation system
11.5 Value of end product from biochemical engineering separation
11.6 Cost–benefit analysis of ATPS and conventional separation method
11.7 ATPS process cost/benefits evaluation—polymer–salt interaction
11.8 Conventional protein A affinity chromatography cost/benefits analysis
11.9 Conclusion
References
Chapter 12 Environmental sustainability of multiphase systems
12.1 Introduction
12.2 Environmental impact caused by conventional extraction method
12.3 Nonconventional extraction method
12.4 Comparison between alternative extraction methods
12.5 Environmental sustainability-related industrial applications
12.6 Conclusion
References
Chapter 13 Potential upscaling of multiphase systems
13.1 Introduction
13.2 Chromatography
13.3 Membrane
13.4 Aqueous two-phase system
13.5 Precipitation
13.6 Conclusion
References
Chapter 14 Integrated systems for multiphase development
14.1 Introduction
14.2 Ultrasonic-assisted extraction
14.3 Microwave-assisted extraction
14.4 Enzyme-assisted extraction
14.5 Conclusion
References
Chapter 15 Precursors for promoting liquid–liquid phase separation
15.1 Introduction
15.2 Fundamentals of aqueous two-phase systems and its application
15.3 Parameters affecting ATPS
15.4 Future prospects and challenges of ATPS
15.5 Conclusion
References
Chapter 16 Considerations in designing a multiphase separation system
16.1 Introduction
16.2 Basis of separation
16.3 Considerations for designing multiphase bioseparation system
16.4 Conclusion
References
Chapter 17 Life-cycle environmental and economical assessment of multiphase systems
17.1 Introduction
17.2 Introduction of liquid biphasic system/technologies
17.3 Application of multiphase systems
17.4 Life-cycle assessment of multiphase systems
17.5 Case studies
17.6 Challenges
17.7 Conclusion
References
Index

Kit Wayne Chew

Dr. Kit Wayne Chew is Assistant Professor in Nanyang Technological University’s School of Chemistry, Chemical Engineering and Biotechnology. He obtained his PhD from the University of Nottingham, where he began his research in sustainable bioprocess engineering for food and pharmaceutical products. His current research examines the utilization of algae biotechnology to develop cost-effective and environmentally friendly methods for the synthesis of functional ingredients. Dr. Chew’s professional appointments include Associate Member in the Institution of Chemical Engineers Malaysia (IChemE), Graduate Engineer registered with the Board of Engineers Malaysia, and Graduate Technologist registered with the Malaysia Board of Technologies. He is listed as the #5 author contributing research on the topic of “Microalgal Technology” on SciVal.

Affiliations and expertise

Assistant Professor, Nanyang Technological University’s School of Chemistry, Chemical Engineering and Biotechnology, Singapore

Shir Reen Chia

Dr. Shir Reen Chia is a research associate at the Department of Chemical and Environmental Engineering, Faculty of Engineering, University of Nottingham Malaysia (UNM). Her research focuses on downstream processing of biomolecules. She is working on the utilization of liquid bi-and triphasic partitioning of biomolecules from biomass.

Affiliations and expertise

Research Associate, Department of Chemical and Environmental Engineering, Faculty of Engineering, University of Nottingham Malaysia (UNM), Malaysia

Pau Loke Show

Professor Ir. Ts. Dr. Pau-Loke Show is currently a Full Professor in the Department of Chemical and Petroleum Engineering at Khalifa University, Abu Dhabi, United Arab Emirates. Also, he has been affiliated with University of Nottingham Malaysia, where he is the Professor of Biochemical Engineering. He is also the former President and Founder of International Bioprocessing Society based in Malaysia. Prof Ir. Ts. Dr. Show has successfully obtained his PhD in two years’ time after obtaining his bachelor’s degree from Universiti Putra Malaysia. In the year of 2022, he was elected as a Fellow of the Institution of Chemical Engineers IChemE (FIChemE). He is currently a Professional Engineer (PEng) registered with the Board of Engineers Malaysia (BEM), Chartered Engineer of the Engineering Council UK (CEng), Corporate Member of The Institution of Engineers, Malaysia (MIEM), and Professional Technologist (PTech) registered with the Malaysia Board of Technologists (MBOT). Prof Ir. Ts. Dr. Show obtained the Post Graduate Certificate of Higher Education (PGCHE) in 2014 and is now a Fellow of the Higher Education Academy (FHEA) UK. For more information, please refer to the follow webpage: https://showpauloke.com/

Affiliations and expertise

Full Professor, Department of Chemical Engineering, Khalifa University, Abu Dhabi, United Arab Emirates

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Principles of Multiple-Liquid Separation Systems

Interaction, Application and Advancement

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Kit Wayne Chew

Shir Reen Chia

Pau Loke Show

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