Principles of Biomaterials Encapsulation: Volume Two

1st Edition - April 10, 2023
Editors: Farshid Sefat, Gholamali Farzi, Masoud Mozafari
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 4 3 4 5 - 9
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 3 3 0 - 9

Principles of Biomaterials Encapsulation: Volume Two provides an expansive and in-depth resource covering the key principles, biomaterials, techniques and applications of encapsula… Read more

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Principles of Biomaterials Encapsulation: Volume Two provides an expansive and in-depth resource covering the key principles, biomaterials, techniques and applications of encapsulation in translational medicine. The book details the various biomaterials available for encapsulation, including polymers, natural and synthetic biomaterials, porous materials, and more. The advantages and disadvantages of conventional and contemporary biomaterials for encapsulations are reviewed, along with advice on the most effective materials for both shell and core. The final part of the book describes a broad range of applications in regenerative medicine, uniquely bringing encapsulation into the worlds of translational medicine and tissue engineering.

This book enables readers to learn about the pros and cons of different biomaterials for encapsulation, as well as how they can be utilized in many bodily systems and tissues, such as the respiratory, digestive, endocrine and cardiovascular systems. Written and edited by well-versed materials scientists with extensive clinical, biomedical and regenerative medicine experience, this book offers a deeply interdisciplinary look at encapsulation in translational medicine.

Cover image
Title page
Table of Contents
Copyright
Contributors
Section 1: Biomaterials for encapsulation
Chapter 1: Encapsulation with polymers
Abstract
1.1: Introduction
1.2: Classification of polymers
1.3: Natural polymers
1.4: Synthetic polymers
1.5: Regenerated polymers
References
Chapter 2: Encapsulation of natural materials
Abstract
2.1: Introduction
2.2: Natural biomaterials for encapsulation
2.3: Production and testing of natural biomaterials for encapsulation
2.4: Complications associated with natural biomaterials
2.5: Advantages and disadvantages
2.6: Summary
References
Further reading
Chapter 3: Encapsulation of porous materials
Abstract
Acknowledgments
3.1: Introduction
3.2: Introduce of encapsulated porous materials in drug delivery
3.3: Conclusions
References
Chapter 4: Encapsulation: Shell and core
Abstract
4.1: Introduction
4.2: Core-shell particle shapes
4.3: Synthesis approaches
4.4: Materials
References
Chapter 5: Encapsulation: Controlled drug delivery
Abstract
5.1: Introduction
5.2: Drug release mechanisms
5.3: Encapsulated drug delivery systems
5.4: Smart encapsulation for controlled drug delivery
5.5: Biomaterial used in drug delivery
References
Section 2: Applications of encapsulation in translational and regenerative medicine
Chapter 6: Encapsulation for in vitro systems
Abstract
6.1: Introduction
6.2: In vitro models
6.3: Biomaterial used in in vitro systems
6.4: Encapsulation
6.5: Encapsulation techniques
6.6: Therapeutic applications of in vitro encapsulation systems
6.7: Conclusion
References
Chapter 7: Encapsulation for in vivo systems
Abstract
7.1: Introduction
7.2: Physiology and anatomy of in vivo systems
7.3: Associated diseases
7.4: Encapsulation techniques
7.5: Conclusion
References
Chapter 8: Encapsulation in artificial organs
Abstract
8.1: Introduction
8.2: Organ manufacturing requirements
8.3: Encapsulation of cells in artificial organ to treat several human diseases
8.4: Microcapsules characteristics
8.5: Manufacturing technologies for bioartificial organs
8.6: Future perspectives and conclusions
References
Chapter 9: Encapsulation in respiratory system
Abstract
9.1: Introduction
9.2: Overview of the respiratory system
9.3: Respiratory disorders
9.4: Encapsulation
9.5: Therapeutic applications of encapsulation in the respiratory system
9.6: Conclusion
References
Chapter 10: Encapsulation in the urinary system
Abstract
10.1: Introduction
10.2: Urinary system anatomy and physiology
10.3: Common diseases of the urinary system
10.4: Encapsulation techniques of the urinary system
10.5: Conclusion
References
Chapter 11: Encapsulation in digestive system
Abstract
11.1: Introduction
11.2: Overview of the digestive system
11.3: Main processes in the digestive system
11.4: Digestive disorders and encapsulation methods
11.5: Conclusion
References
Further reading
Chapter 12: Encapsulation in the ocular system
Abstract
12.1: Introduction
12.2: Ophthalmic pathway drug delivery systems
12.3: Summary
References
Chapter 13: Encapsulation in the endocrine system
Abstract
13.1: Introduction
13.2: Anatomy and physiology of the endocrine system
13.3: Encapsulation
13.4: Cell encapsulation system based on hydrogels for the treatment of T1DM
13.5: Encapsulation for ovarian allograft to restore endocrine function
13.6: Summary
References
Chapter 14: Encapsulation in nervous system
Abstract
14.1: Introduction
14.2: Anatomy and physiology of the nervous system
14.3: Diseases and disorders associated with the nervous system
14.4: Encapsulation
14.5: Cell encapsulation
14.6: Encapsulation in the nervous system
14.7: Conclusion
References
Chapter 15: Encapsulation in dentistry
Abstract
15.1: Introduction
15.2: Tooth structure and dental stem cells
15.3: Regenerative approaches in dentistry
15.4: Biomaterials and scaffolds for dental encapsulation
15.5: Types of scaffolds
15.6: Cellular/Bioactive compound encapsulation in dentistry
15.7: Conclusion and future challenges
References
Chapter 16: Encapsulation in cardiac repair
Abstract
Acknowledgment
16.1: Introduction
16.2: Cardiac biology and diseases
16.3: Encapsulation strategies
16.4: Cell delivery
16.5: Bioactive molecules encapsulation for cardiac repair
16.6: Conclusions
References
Chapter 17: Encapsulation in skeletal muscle
Abstract
17.1: Introduction
17.2: Skeletal muscles anatomy and physiology
17.3: Problems associated with skeletal muscles
17.4: Skeletal muscle regeneration
17.5: Encapsulation
17.6: Conclusion
References
Chapter 18: Encapsulation of bone marrow cells
Abstract
18.1: Introduction
18.2: Encapsulation techniques
18.3: Encapsulation biomaterials
18.4: Summary
References
Chapter 19: Encapsulation of stem cells
Abstract
19.1: Introduction
19.2: Encapsulation process technologies
19.3: Encapsulation technology for stem cells studies
19.4: Application of encapsulation technology for regenerative medicine
19.5: Conclusion
References
Chapter 20: Encapsulation of cartilage cells
Abstract
20.1: Introduction
20.2: Types of cartilage defects
20.3: Scaffolds and biomaterials for cartilage tissue engineering (CTE)
20.4: Cell sources for encapsulation in CTE
20.5: Cell encapsulation
20.6: Advanced manufacturing bioprinting techniques for cartilaginous hydrogel constructs
20.7: Challenges of cell-laden hydrogels for CTE
20.8: Applications and clinical trials
20.9: Conclusions and outlook
References
Chapter 21: Encapsulation in tendon and ligament regeneration
Abstract
21.1: Introduction
21.2: Tendon and ligament anatomy and physiology
21.3: Tendinopathy
21.4: Tendon healing
21.5: Tissue engineering
21.6: Growth factor
21.7: Cell-laden
21.8: Drug-laden
21.9: Conclusion
References
Further Reading
Chapter 22: Encapsulation for general cancer treatment
Abstract
22.1: Introduction
22.2: Encapsulation for carcinoma
22.3: Encapsulation for sarcoma
22.4: Encapsulation for leukemia
22.5: Encapsulation for myeloma
22.6: Encapsulation for lymphoma
22.7: Summary
References
Chapter 23: Encapsulation for breast cancer treatment
Abstract
23.1: Introduction
23.2: Breast cancer
23.3: Existing breast cancer treatments
23.4: Breast cancer treatment using encapsulation
23.5: Encapsulation versus “traditional” treatment for breast cancer
23.6: Summary
References
Further reading
Chapter 24: Encapsulation strategies for the treatment of CNS disorders
Abstract
Acknowledgments
24.1: Introduction
24.2: CNS: Anatomy and function
24.3: Encapsulations strategies at multiscale
24.4: Synergistic approaches
24.5: Conclusion
References
Chapter 25: Future of encapsulation in regenerative medicine
Abstract
25.1: Introduction
25.2: Cell encapsulation strategy
25.3: Hydrogels
25.4: Technology for cell encapsulation in hydrogel
25.5: Material for cell encapsulation
25.6: Application
25.7: Challenges and future prospects
25.8: Conclusion
References
Index

Farshid Sefat

Dr. Farshid Sefat is Associate Professor and Programme Leader in the Biomedical and Electronic Engineering Department at the University of Bradford (UK). He was head of Biomedical Engineering Department at King Faisal University (Saudi Arabia) and Visiting Professor at Stevens Institute of Technology (New Jersey, USA). He completed his post doctorate research assistant at University of Sheffield (UK) in cornea tissue engineering. Dr. Sefat received his Ph.D. and BEng. degrees from University of Bradford in Biomedical Engineering. His research is based on developing biomaterials to control cellular behavior with particular emphasis in developing engineered materials for various tissue engineering applications. He’s an author of >150 peer-reviewed journal articles, editorials, and review papers and >80 book chapters/edited books. He’s on the editorial boards and reviewer of >30 numerous journals including Materials Today, Acta Biomaterialia, IEEE, Bone, MDPI, Journal of Orthopaedics & Rheumatology, Materials Science and Engineering C and Journal of Biomechanics.

Affiliations and expertise

Associate Professor, Biomedical and Electronic Engineering Department, University of Bradford, UK

Gholamali Farzi

Dr. Gholamali Farzi is a Professor of Polymer Engineering at Faculty of Engineering in Hakim Sabzevari University, Sabzevar, Iran, where he is teaching polymer engineering and polymer composite materials for students in Ph.D. and MSc level. Dr. Farzi obtained his Ph.D. from the University of Lyon (France) in 2007, then he completed his post-doctoral fellowship in University of Lyon 1. Dr Farzi doing extensive research in the field of polymer encapsulation and he has very close collaboration with French universities.

Affiliations and expertise

Professor, Polymer Engineering, Faculty of Engineering, Hakim Sabzevari University, Sabzevar, Iran

Masoud Mozafari

Dr. Masoud Mozafari is a Fellow at Lunenfeld Tanenbaum Research Institute, Mount Sinai Health Hospital, University of Toronto. He was previously Assistant Professor and Director of the Bioengineering Lab, at the Nanotechnology and Advanced Materials Department, Materials and Energy Research Center, Cellular and Molecular Research Center, and Department of Tissue Engineering and Regenerative Medicine of the Iran University of Medical Sciences (IUMS), Tehran, Iran. Dr. Mozafari’s research interests range across biomaterials, nanotechnology, and tissue engineering, and he is known for the development of strategies for the treatment of damaged tissues and organs, and controlling biological substances for targeted delivery into the human body. Dr. Mozafari has received several awards, including the Khwarizmi Award and the Julia Polak European Doctorate Award for outstanding translational research contributions to the field of biomaterials. He has also received the WIPO Medal for Inventors from The World Intellectual Property Organization (WIPO), in recognition of his contributions to economic and technological development. Dr. Mozafari is currently working on the editorial board of several journals.

Affiliations and expertise

Research Fellow, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Canada