Principles and Clinical Diagnostic Applications of Surface-Enhanced Raman Spectroscopy
- 1st Edition - September 17, 2021
- Imprint: Elsevier
- Editor: Yuling Wang
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 1 1 2 1 - 2
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 3 1 9 8 - 2
Principles and Clinical Diagnostic Applications of Surface-Enhanced Raman Spectroscopy summarizes the principles of surface-enhanced Raman scattering/spectroscopy (SERS) and plasmo… Read more
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Request a sales quotePrinciples and Clinical Diagnostic Applications of Surface-Enhanced Raman Spectroscopy summarizes the principles of surface-enhanced Raman scattering/spectroscopy (SERS) and plasmonic nanomaterials for SERS, with a focus on SERS applications in clinical diagnostics. This book covers the key concepts from the fundamentals, materials, experimental aspects, and applications of SERS in clinical diagnostics with discussions on label-free/direct SERS assay, design and synthesis of SERS nanotags, SERS nanotags for point-of-care diagnostics, microfluidic SERS assay, and in vitro and in vivo sensing and imaging. Written by experts from around the world, this comprehensive volume showcases the recent progress of SERS applications in clinical diagnostics and helps readers understand when and how to use SERS in a clinical setting.
- Introduces the basics of SERS and suitable nanomaterials for SERS application
- Gives an overview of the cutting-edge research on SERS applications for clinical diagnosis, including the latest advances in our understanding of underlying principles to enable material design and clinical applications
- Gradually builds from the fundamental concepts to the applications of SERS for clinical diagnostics
Graduate/postgraduate students, scientists and researchers in the field of SERS/Raman spectroscopy, researchers in plasmonic and nanomaterials engineering and clinicians; also, clinicians who have interest in using SERS for diagnosis
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Chapter 1. Principles of surface-enhanced Raman spectroscopy
- Abstract
- 1.1 Introduction
- 1.2 Surface plasmon resonance
- 1.3 Optical properties of metals
- 1.4 Local field enhancement
- 1.5 Surface-enhanced Raman spectroscopy enhancement and E4 approximation
- 1.6 Choice of metals
- 1.7 The effect of size and shape on the field enhancement
- 1.8 Hot spots and various configurations for SERS
- 1.9 Estimation of the surface enhancement factor
- 1.10 Chemical mechanism
- 1.11 Spectral analysis
- 1.12 Selection of SERS substrates
- 1.13 SERS detection modes
- 1.14 Key to the success of SERS measurements
- References
- Chapter 2. Nanoplasmonic materials for surface-enhanced Raman scattering
- Abstract
- 2.1 The role of nanoplasmonic materials in surface-enhanced Raman scattering enhancement
- 2.2 Metallic nanoplasmonic materials
- 2.3 Nonconventional surface-enhanced Raman scattering platforms
- 2.4 Conclusion and outlook
- References
- Chapter 3. Experimental aspects of surface-enhanced Raman scattering for biological applications
- Abstract
- 3.1 Combination ways of surface-enhanced Raman scattering substrates with the analytical systems
- 3.2 Laser-related issues
- 3.3 Reproducibility and reliability
- 3.4 Raman data-related issues
- References
- Chapter 4. Label-free surface-enhanced Raman scattering for clinical applications
- Abstract
- 4.1 General aspects
- 4.2 Label-free SERS and the complexity of biological samples
- 4.3 Clinical needs and analytical strategies
- 4.4 Experimental aspects
- 4.5 Study design and data analysis
- 4.6 Spectral interpretation
- 4.7 Perspectives and challenges
- References
- Chapter 5. Surface-enhanced Raman scattering nanotags design and synthesis
- Abstract
- 5.1 SERS nanotags and its optical properties
- 5.2 Clinical application of SERS nanotags: strategies and essence
- 5.3 SERS nanotags design and synthesis
- 5.4 Summary and prospect
- References
- Chapter 6. Surface-enhanced Raman spectroscopy for circulating biomarkers detection in clinical diagnosis
- Abstract
- 6.1 Introduction
- 6.2 Sample preparation and detection methods
- 6.3 Circulating tumor cells
- 6.4 SERS analysis of extracellular vesicles
- 6.5 SERS analysis of circulating tumor-derived nucleic acids
- 6.6 Tumor-associated proteins
- 6.7 Conclusions and perspectives
- References
- Chapter 7. Surface-enhanced Raman spectroscopy-based microfluidic devices for in vitro diagnostics
- Abstract
- 7.1 Introduction
- 7.2 Various surface-enhanced Raman spectroscopy-based microfluidic devices for in vitro diagnostics
- 7.3 Summary
- Acknowledgment
- References
- Chapter 8. SERS for sensing and imaging in live cells
- Abstract
- 8.1 Recent trends in SERS from animal cells: probe of cellular biochemistry
- 8.2 Biomolecular SERS from intracellular nanoprobes
- 8.3 Probing lipid-rich environments in pathology
- 8.4 SERS for monitoring of drug action
- 8.5 Composite SERS probes for intracellular applications with different physical functions
- Acknowledgments
- References
- Chapter 9. iSERS microscopy: point-of-care diagnosis and tissue imaging
- Abstract
- 9.1 Point-of-care diagnosis
- 9.2 Imaging
- 9.3 Summary and perspectives
- References
- Chapter 10. Surface-enhanced Raman spectroscopy for cancer characterization
- Abstract
- 10.1 Introduction
- 10.2 SERS diagnosis of cancer biomarkers
- 10.3 SERS detection of nucleic acid sequence indicators in cancer
- 10.4 SERS diagnosis based on other indicators
- 10.5 Multifunctional SERS substrates for diagnosis and therapy
- 10.6 SERS imaging for cancer imaging and delineation
- 10.7 Summary
- References
- Chapter 11. Multivariate approaches for SERS data analysis in clinical applications
- Abstract
- 11.1 Introduction
- 11.2 Data analysis for label-free surface-enhanced Raman spectroscopy measurements
- 11.3 Additional applications in labeling SERS measurements
- 11.4 Concluding remarks
- References
- Index
- Edition: 1
- Published: September 17, 2021
- No. of pages (Paperback): 464
- No. of pages (eBook): 464
- Imprint: Elsevier
- Language: English
- Paperback ISBN: 9780128211212
- eBook ISBN: 9780128231982
YW
Yuling Wang
Yuling Wang received her PhD from Chinese Academy of Sciences in 2009. She was then awarded an Alexander von Humboldt fellowship (2010) and the Individual Grant Fellowship from German Research Foundation (2012), working in University of Duisburg-Essen, Germany. In 2014, she received an Australian Research Council (ARC) Discovery Early Career Researcher Award (DECRA), worked in the University of Queensland (Australia). Towards the end of her ARC DECRA fellowship, she was appointed as a Senior Lecturer at Macquarie University in 2017 and was promoted to Associate Professor in 2020. She is also a Chief Investigator within ARC Excellence of Center for Nanoscale Biohotonic and leads the SERS program for in vitro diagnostics. Her research is mainly focused on plasmonic nanostructures for surface-enhanced Raman scattering/spectroscopy (SERS), biomarker sensing for point-of-care and in vitro diagnostics, and personalized nanomedicine by using SERS.
Affiliations and expertise
Associate Professor, Department of Molecular Sciences, Macquarie University, Sydney, AustraliaRead Principles and Clinical Diagnostic Applications of Surface-Enhanced Raman Spectroscopy on ScienceDirect