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Precision Nutrition
The Science and Promise of Personalized Nutrition and Health
- 1st Edition - October 20, 2023
- Editors: David Heber, Zhaoping Li, José Ordovas
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 5 3 1 5 - 0
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 5 3 1 6 - 7
Precision Nutrition: The Science and Promise of Personalized Nutrition and Health organizes and integrates information on the diverse special areas of scientific expertise… Read more
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Request a sales quotePrecision Nutrition: The Science and Promise of Personalized Nutrition and Health organizes and integrates information on the diverse special areas of scientific expertise involved in Precision Nutrition in order to inform health professionals and inspire researchers to advance this field while applying the general principles into health care and medical research now.
Broken into three sections, this book addresses the fundamentals of precision nutrition, applications of precision nutrition in health and disease, and the future directions of precision nutrition.
Nutrition scientists, geneticists, physicians, dietitians, postdoctoral fellows, and epidemiologists seeking to understand Precision Nutrition will benefit from this timely reference.
.- Applies precision nutrition to diet and lifestyle conditions, including heart disease, diabetes and cancer
- Identifies future aspects of precision nutrition utilizing AI, machine learning and superfast computers
- Outlines promising areas of research
- Cover Image
- Title Page
- Copyright
- Contents
- Contributors
- Introduction
- Section 1 Fundamentals of precision nutrition
- Chapter 1 Nutrient Composition of Foods: The First Step in Precision Nutrition
- Introduction
- Nutrient Databases
- USDA's Food and Nutrient Databases
- International Food Composition Databases
- Dietary Supplement Ingredient Database
- Future Nutrient Composition Databases and the Dark Matter of Nutrition
- Capturing Nutrient Density of Food Through Nutrient Profiling
- The Impact of Dietary Guidelines on Nutrient Profiling
- Healthy Eating Index and Healthy Dietary Pattern Analysis
- NOVA Food Classification, Ultra-Processed Food, and Food Quality
- Phytonutrients and Plant-Based Diets
- Biodiversity and the Dark Matter of Nutrition
- Dietary Assessment Tools
- The Future of Dietary Intake Assessment and Precision Nutrition
- Conclusion
- References
- Chapter 2 Nutrigenetics and Nutrigenomics
- Introduction
- Current Methods of Nutritional Genomics
- Relationship Between Personalized and Precision Nutrition
- Nutrigenetic and Nutrigenomic Tests
- Conclusion
- References
- Chapter 3 The Use of Chrono Nutrition in Precision Nutrition
- Introduction
- Biological Rhythms in Human Physiology
- Chronotypes
- Human eating time patterns
- The challenges of chrono nutrition and time-restricted eating
- The bidirectional relation of time and food
- Sleep, nutrition, and health
- The role of the microbiota in biological rhythms, nutrition, and health
- Shift work, nutrition, and health
- Chrono Nutrition, Gene-Diet Interactions, and Precision Nutrition
- Conclusion
- References
- Chapter 4 Epigenetics and Modification of Gene Expression in Metabolism
- Introduction
- DNA Methylation
- Histone Modifications
- Non-Coding RNAs
- DNA Methylation Clocks and Aging
- Methyl Donors, Epigenetics, and Precision Nutrition
- Polyphenols, Phytonutrients, and Epigenetics
- Selenium and Epigenetics
- Conclusion and Future Directions
- References
- Chapter 5 The Role of Metabolomics Profiles in Precision Nutrition
- Introduction
- Untargeted and Targeted Metabolomics
- Computational Tools
- Nutrient Analysis, Nutrient Databases, and Food Biomarkers
- The Human Metabolome Database
- Gut Microbiome, Host Metabolite Interactions
- Polyphenol metabolites and metabotypes
- Xenometabolites, beyond polyphenols
- Metabolomics Applications and Promise in Personalized Nutrition
- Conclusion
- References
- Chapter 6 The Microbiome, Metabolism, and Networks in Precision Nutrition
- Introduction
- Microbiota in Early Development
- Diet and the Microbiota
- Microbiota, Metabolism, and Metabolic Diseases
- Macronutrients, microbiome, and metabolism
- Carbohydrates
- Proteins
- Fat
- Polyphenols
- Food emulsifiers and sweeteners
- Dietary Patterns and Microbiome
- Host and Microbiome Metabolites and Their Pathways
- Probiotics, Prebiotics, and Postbiotics
- Fermented Foods
- The Future of Precision Nutrition
- Conclusion
- Acknowledgment
- References
- Chapter 7 Phenotyping, Body Composition, and Precision Nutrition
- Introduction
- Methods for Body Composition
- Adipose Tissue Phenotypes
- Body Protein and Muscle Mass
- Anthropometry and Body Shape Scanning
- Conclusion and Future Directions
- References
- Chapter 8 Integration of Multiple Big Data Sources for Modeling Precision Nutrition
- Introduction
- Integration of Big Data Through the Precision Nutrition Modeling Pipeline
- Conclusion
- References
- Section 2 Applications of Precision Nutrition in Health and Disease
- Chapter 9 Future Visions of Personalized and Precision Nutrition
- Introduction
- Advancing Nutrient Analysis is Fundamental to the Future of Precision Nutrition
- Future Vision of Gene-Nutrient Interaction Sciences in Precision Nutrition
- Future Vision of Chronobiology in Precision Nutrition
- Future Vision of Wearables for Precision Nutrition
- Future Vision of Nutritional Epidemiology in Precision Nutrition
- Future Vision of Artificial Intelligence and Machine Learning in Precision Nutrition
- Conclusion
- References
- Chapter 10 A Multifaceted Approach to Precision Nutrition: The Genome, Epigenome, and Microbiome in the Prevention and Therapy of Cardiovascular Diseases
- Introduction
- The Power of Nutrition in the Prevention and Therapy of CVD: From Diet to Heart Health
- Genetics in CVD Risk Prediction: Unraveling the Blueprint for Personalized Prevention
- Precision Nutrition: A Personalized Approach to Cardiovascular Health
- Nutriepigenomics: The Dynamic Interface Between Diet and Gene Expression
- The Role of the Microbiome in PrN for the Prevention of CVD
- Conclusion
- References
- Chapter 11 Precision Nutrition in Diabetes
- Introduction
- Diabetes: An Evolution of Treatment Strategies
- The Complex Genomics and Epigenetics of Diabetes
- Prediction of Personalized Glucose Responses
- Continuous Glucose Monitoring in Precision Nutrition
- Gestational Diabetes and Nutritional Programming in Utero of the Risk for Type 2 Diabetes Mellitus
- Current and Future Status of Precision Nutrition in Diabetes Prevention and Treatment
- References
- Chapter 12 Precision Nutrition, Epigenome, and Male Reproductive Health
- Introduction
- Undernutrition and Male Reproduction
- Overnutrition, Obesity, and Male Reproduction
- Precision Nutrition, Obesity, and Male Reproduction
- Nutrition, Obesity, Epigenetics, and Intergenerational Health
- Conclusion
- References
- Chapter 13 Precision Nutrition in Female Reproductive Health
- Introduction
- Polycystic Ovarian Syndrome
- Abdominal Fat and Insulin Resistance in PCOS
- Adipose Stem Cells in Subcutaneous Fat and PCOS
- Genetic Evolution of PCOS Phenotypes
- Infertility and Nutritional Effects on Female Reproductive Health
- Standard American Diet
- Plant-Based Diets
- Chronic Inflammation in Obesity and PCOS
- Obesity and Female Reproductive Health
- Underweight and Eating Disorders in Female Reproductive Health
- Exercise
- Precision Nutrition Research Opportunities in PCOS and Female Reproductive Health
- References
- Chapter 14 Precision Nutrition in Aging and Brain Health
- Introduction
- Normal Brain Function, Nutrition, and Aging
- Cognitive Disorders and Depression
- Alzheimer's Disease: Pathophysiology and Genetic Risk Factors
- Apolipoprotein E and Nutrition
- Epigenetics and Nutrition
- Microbiota-Gut-Brain Axis and Nutrition
- Psychobiotics and the Brain
- Metabolic Disorders
- Nutritional Supplements
- Whole Diet Approaches
- Summary
- References
- Chapter 15 Precision Nutrition and Cancer
- Introduction
- The Linkage of Nutrition, Aging, and Cancer
- Combining Precision Oncology and Precision Nutrition
- Precision Oncology Current Status and Future Prospects
- Selective Tyrosine Kinase and Small Molecule Inhibitors
- Immunotherapy
- Metabolic Reprogramming in Cancer Cells
- The Tumor Microenvironment and Metabolic Reprogramming of Immune Cells
- Metastasis
- Engineering Immune Cells against Cancer with Adoptive Cell Therapies
- The Microbiome
- Current and Future Potential of Precision Nutrition in Cancer Prevention and Treatment
- Conclusion
- References
- Chapter 16 Precision Nutrition in Allergy and Immune Function
- Introduction
- Innate and Adaptive Immunity
- Gut-Associated Lymphoid Tissue, Microbiome, and Nutrition
- Food Allergies and Food Intolerance
- Immune Function Development and Immunosenescence
- Micronutrients and Immune Function
- Caloric Restriction and Fasting Mimicking Diets
- Conclusion
- References
- Chapter 17 Precision Nutrition and Obesity
- Introduction
- Genetics of Obesity
- Epigenetics of Obesity
- Metabolomics of Obesity
- Microbiome, Immune Function, and Obesity
- Homeostatic Mechanisms in Obesity
- Hedonic and Behavioral Factors in Obesity
- The Exposome and Hedonic Eating
- Precision Nutrition Approaches to Obesity
- References
- Chapter 18 Precision Nutrition in Exercise and Sports Performance
- Introduction
- Cardiopulmonary Function and Fitness
- The Metabolic Threshold, Lactate Threshold, or Anaerobic Threshold and Critical Power
- Fatigue and Critical Power
- Resistance Training, Dietary Protein, and Muscle
- Combining Aerobic and Resistance Training
- Genomics and Epigenomics of Exercise Responses
- Transcriptomic Studies of Exercise Responses
- The Microbiome and Exercise
- Conclusion and Future Directions
- References
- Chapter 19 Precision Nutrition and Racial and Ethnic Minority Health Disparities
- Introduction
- Key Social Determinants or Structural Drivers of Health (SDoH)
- Precision Nutrition and Basic Mechanisms
- Cardiometabolic Disease is Common and Associated with Profound Racial/Ethnic and Socioeconomic Disparities
- The All of Us Research Program
- The Nutrition for Precision Health Program
- Patient and Community Engagement Strategies
- The Way Forward
- References
- Section 3 The Future Directions of Precision Nutrition
- Chapter 20 Network Science and Machine Learning for Precision Nutrition
- Abbreviations
- Introduction
- Food Composition
- Existing Knowledge of Food Composition
- Knowledge Extraction Using Machine Learning
- Analysis of Food Composition by Mass Spectrometry
- Spectra Annotation and Machine Learning
- Unveiling Health Effects With Network Medicine
- Collecting Association Data for Network Medicine
- Network-Based Modules and Proximity
- Individual Mechanisms of Action
- Combinatorial Mechanisms of Action
- Machine Learning Assisted Network Medicine
- Conclusion
- Acknowledgment
- References
- Chapter 21 Point of Care Genomics, Proteomics, Biomarkers, and Precision Nutrition: Emerging Point of Care Sensors for Precision Nutrition
- Introduction
- Precision Nutrition and Health
- Strategies and Challenges for Nutrition Monitoring
- Point of care biosensors
- Wearable biosensors
- Conclusion and Perspectives
- References
- Chapter 22 The Key Role of Cooking and Food Preparation in Affecting Nutrient Composition of Foods
- Introduction
- The Composition of Food
- Methods of Cooking
- What Happens to Proteins During Cooking?
- How are Carbohydrates Influenced by Cooking?
- Fats and Oxygen Do not Always Get Along
- Water is the Great Equalizer
- Go Easy on the Vitamins
- Phytochemicals from Plants can be Lost or Gained
- References
- Chapter 23 Balancing Public Health/Population Nutrition and Precision Nutrition in the Development of Dietary Guidelines
- Introduction
- Current Scenario in Dietary Guidelines
- The Need for Balance
- Hypothetical cases of how current population-level genetic knowledge could be incorporated into future dietary guidelines
- The Role of AI and Machine Learning in Precision Nutrition and Public Health
- Harmonizing Precision Nutrition, Public Health, and Sustainability
- Ethical Considerations in Integrating Precision Nutrition into Public Health and Dietary Guidelines
- Precision Public Health
- Conclusion and Future Perspectives
- References
- Index
- No. of pages: 468
- Language: English
- Edition: 1
- Published: October 20, 2023
- Imprint: Academic Press
- Paperback ISBN: 9780443153150
- eBook ISBN: 9780443153167
DH
David Heber
ZL
Zhaoping Li
Dr. Zhaoping Li is Professor of Medicine and Lynda & Steward Resnick Endowed Chair in Human Nutrition at the David Geffen School of Medicine at UCLA. She currently serves as the Director of Center for Human Nutrition and Chief of Division of Clinical Nutrition at Department of Medicine, UCLA. She is also the Chair of Medicine at the VA Greater Los Angeles Health Care System.
Dr. Li is board certified in internal medicine and a physician nutrition specialist. She is a fellow of the American College of Physicians, a former President of the National Board of Physician Nutrition Specialists and a member of the Board of Directors of the American Society for Nutrition. She is a council member of International Union of Nutritional Sciences (IUNS). Her research centers on gene-nutrient interaction, nutritional modulation of the microbiome, and health impacts of phytonutrients. Dr. Li has been a principal investigator for over 100 investigator-initiated National Institutes of Health and industry-sponsored clinical trials and published over 240 peer-reviewed scientific papers. Dr. Li has co-Authored textbook “Primary Care Nutrition: Writing the Nutrition Prescription” in 2017, and is a co-editor of “Nutritional Oncology” in 2021.
JO